Search Results - "HUR, Junho"

Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells by Kim, Daesik, Kim, Jungeun, Hur, Junho K, Been, Kyung Wook, Yoon, Sun-heui, Kim, Jin-Soo

“…On-target and off-target specificities of Cfp1 are assessed and compared with SpCas9 in human cells. Programmable clustered regularly interspaced short…”
Get full text

Adenine base editors catalyze cytosine conversions in human cells by Kim, Heon Seok, Jeong, You Kyeong, Hur, Junho K, Kim, Jin-Soo, Bae, Sangsu

“…Adenine base editors comprise an adenosine deaminase, evolved in vitro, and a Cas9 nickase. Here, we show that in addition to converting adenine to guanine,…”
Get full text

Targeted mutagenesis in mice by electroporation of Cpf1 ribonucleoproteins by Hur, Junho K, Kim, Kyoungmi, Been, Kyung Wook, Baek, Gayoung, Ye, Sunghyeok, Hur, Junseok W, Ryu, Seuk-Min, Lee, Youn Su, Kim, Jin-Soo

Get full text

Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper by Webster, Alexandre, Li, Sisi, Hur, Junho K., Wachsmuth, Malte, Bois, Justin S., Perkins, Edward M., Patel, Dinshaw J., Aravin, Alexei A.

“…In Drosophila, two Piwi proteins, Aubergine (Aub) and Argonaute-3 (Ago3), localize to perinuclear “nuage” granules and use guide piRNAs to target and destroy…”
Get full text

Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state by Le Thomas, Adrien, Rogers, Alicia K, Webster, Alexandre, Marinov, Georgi K, Liao, Susan E, Perkins, Edward M, Hur, Junho K, Aravin, Alexei A, Tóth, Katalin Fejes

“…In the metazoan germline, piwi proteins and associated piwi-interacting RNAs (piRNAs) provide a defense system against the expression of transposable elements…”
Get full text

Epigenetic modification of gene expression in cancer cells by terahertz demethylation by Cheon, Hwayeong, Hur, Junho K., Hwang, Woochang, Yang, Hee-Jin, Son, Joo-Hiuk

“…Terahertz (THz) radiation can affect the degree of DNA methylation, the spectral characteristics of which exist in the terahertz region. DNA methylation is an…”
Get full text

Salivary gland organoid culture maintains distinct glandular properties of murine and human major salivary glands by Yoon, Yeo-Jun, Kim, Donghyun, Tak, Kwon Yong, Hwang, Seungyeon, Kim, Jisun, Sim, Nam Suk, Cho, Jae-Min, Choi, Dojin, Ji, Youngmi, Hur, Junho K., Kim, Hyunki, Park, Jong-Eun, Lim, Jae-Yol

“…Salivary glands that produce and secrete saliva, which is essential for lubrication, digestion, immunity, and oral homeostasis, consist of diverse cells. The…”
Get full text

Metagenomic characterization of sphingomyelinase C in the microbiome of humans and environments by Jeon, Jehyun, Kang, Seunghun, Hur, Junho K., Rho, Mina

“…Bacterial sphingomyelinases (SMases) hydrolyze sphingomyelin and play an important role in membrane dynamics and the host immune system. While the number of…”
Get full text

Latent turn-on fluorescent probe for the detection of toxic malononitrile in water and its practical applications by Jung, Yuna, Park, Nam Kyoo, Kang, Sangrim, Huh, Youngbuhm, Jung, Junyang, Hur, Junho K., Kim, Dokyoung

“…A latent turn-on fluorescent probe for the detection of malononitrile (NCCH2CN), a precursor of hydrogen cyanide (HCN) in the mammalian tissue metabolism, is…”
Get full text

Highly efficient and specific regulation of gene expression using enhanced CRISPR-Cas12f system by Oh, Yeounsun, Gwon, Lee Wha, Lee, Hyomin K., Hur, Junho K., Park, Kwang-Hyun, Kim, Kee-Pyo, Lee, Seung Hwan

“…The recently developed CRISPR activator (CRISPRa) system uses a CRISPR-Cas effector-based transcriptional activator to effectively control the expression of…”
Get full text

Applications of CRISPR technologies to the development of gene and cell therapy by Park, Chul-Sung, Habib, Omer, Lee, Younsu, Hur, Junho K.

“…Advancements in gene and cell therapy have resulted in novel therapeutics for diseases previously considered incurable or challenging to treat. Among the…”
Get full text

Enhancement of target specificity of CRISPR–Cas12a by using a chimeric DNA–RNA guide by Kim, Hanseop, Lee, Wi-jae, Oh, Yeounsun, Kang, Seung-Hun, Hur, Junho K, Lee, Hyomin, Song, WooJeung, Lim, Kyung-Seob, Park, Young-Ho, Song, Bong-Seok, Jin, Yeung Bae, Jun, Bong-Hyun, Jung, Cheulhee, Lee, Dong-Seok, Kim, Sun-Uk, Lee, Seung Hwan

“…Abstract The CRISPR–Cas9 system is widely used for target-specific genome engineering. CRISPR–Cas12a (Cpf1) is one of the CRISPR effectors that controls target…”
Get full text

Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila by Hur, Junho K, Luo, Yicheng, Moon, Sungjin, Ninova, Maria, Marinov, Georgi K, Chung, Yun D, Aravin, Alexei A

“…The conserved THO/TREX (transcription/export) complex is critical for pre-mRNA processing and mRNA nuclear export. In metazoa, TREX is loaded on nascent RNA…”
Get full text

CRISPR and Target-Specific DNA Endonucleases for Efficient DNA Knock-in in Eukaryotic Genomes by Lee, Seung Hwan, Kim, Sunghyun, Hur, Junho K

“…The discovery and mechanistic understanding of target-specific genome engineering technologies has led to extremely effective and specific genome editing in…”
Get full text

Author Correction: Salivary gland organoid culture maintains distinct glandular properties of murine and human major salivary glands by Yoon, Yeo-Jun, Kim, Donghyun, Tak, Kwon Yong, Hwang, Seungyeon, Kim, Jisun, Sim, Nam Suk, Cho, Jae-Min, Choi, Dojin, Ji, Youngmi, Hur, Junho K., Kim, Hyunki, Park, Jong-Eun, Lim, Jae-Yol

Get full text

CRISPR Diagnosis and Therapeutics with Single Base Pair Precision by Lee, Seung Hwan, Park, Young-Ho, Jin, Yeung Bae, Kim, Sun-Uk, Hur, Junho K.

“…Clustered regularly interspaced short palindromic repeats, or CRISPR, has been widely accepted as a versatile genome editing tool with significant potential…”
Get full text

Prediction-based highly sensitive CRISPR off-target validation using target-specific DNA enrichment by Kang, Seung-Hun, Lee, Wi-jae, An, Ju-Hyun, Lee, Jong-Hee, Kim, Young-Hyun, Kim, Hanseop, Oh, Yeounsun, Park, Young-Ho, Jin, Yeung Bae, Jun, Bong-Hyun, Hur, Junho K., Kim, Sun-Uk, Lee, Seung Hwan

“…CRISPR effectors, which comprise a CRISPR-Cas protein and a guide (g)RNA derived from the bacterial immune system, are widely used for target-specific genome…”
Get full text

AIEgen-based nanoprobe for the ATP sensing and imaging in cancer cells and embryonic stem cells by Kim, Na Hee, Kim, Byeong Wook, Moon, Heechang, Yoo, Hajung, Kang, Rae Hyung, Hur, Junho K., Oh, Yohan, Kim, B. Moon, Kim, Dokyoung

“…A turn-on fluorescent nanoprobe (named AAP-1), based on an aggregation-induced emission luminogen (AIEgen), is disclosed for the detection of adenosine…”
Get full text

A novel therapeutic modality using CRISPR-engineered dendritic cells to treat allergies by Kim, Byoungjae, Lee, Young Eun, Yeon, Ji Woo, Go, Ga-Yeon, Byun, Junhyoung, Lee, Kijeong, Lee, Hyomin K., Hur, Junho K., Jang, Mihue, Kim, Tae Hoon

“…Despite the important roles of dendritic cells (DCs) in airway allergies, current therapeutic strategies such as drugs, allergen immunotherapy and biologics…”
Get full text

Systematic Degradation Rate Analysis of Surface-Functionalized Porous Silicon Nanoparticles by Kang, Rae Hyung, Lee, Seo Hyeon, Kang, Sangrim, Kang, Jinyoung, Hur, Junho K, Kim, Dokyoung

“…Porous silicon nanoparticles (pSiNPs) have been utilized within a wide spectrum of biological studies, as well as in chemistry, chemical biology, and…”
Get full text