Search Results - "HUNTER, A. Jackie"

The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats by Piper, David C., Upton, Neil, Smith, Martin I., Hunter, A. Jackie

“…Orexin‐A is a novel neuropeptide initially isolated from hypothalamic extracts but now known to be present in fibres distributed throughout the rat CNS…”
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Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media by Parkinson, Nicholas, Hardisty-Hughes, Rachel E, Tateossian, Hilda, Tsai, Hsun-Tien, Brooker, Debra, Morse, Sue, Lalane, Zuzanna, MacKenzie, Francesca, Fray, Martin, Glenister, Pete, Woodward, Anne-Marie, Polley, Sian, Barbaric, Ivana, Dear, Neil, Hough, Tertius A, Hunter, A Jackie, Cheeseman, Michael T, Brown, Steve D M

“…Otitis media (OM), inflammation of the middle ear, remains the most common cause of hearing impairment in children. It is also the most common cause of surgery…”
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A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse by Hardisty-Hughes, Rachel E., Tateossian, Hilda, Morse, Susan A., Romero, M. Rosario, Middleton, Alice, Tymowska-Lalanne, Zuzanna, Hunter, A. Jackie, Cheeseman, Michael, Brown, Steve D.M.

“…Otitis media (OM), inflammation of the middle ear, is the most common cause of hearing impairment and surgery in children. Recurrent and chronic forms of OM…”
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Novel Mouse Model of Autosomal Semidominant Adult Hypophosphatasia Has a Splice Site Mutation in the Tissue Nonspecific Alkaline Phosphatase Gene Akp2 by Hough, Tertius A, Polewski, Monika, Johnson, Kristen, Cheeseman, Michael, Nolan, Patrick M, Vizor, Lucie, Rastan, Sohaila, Boyde, Alan, Pritzker, Kenneth, Hunter, A Jackie, Fisher, Elizabeth MC, Terkeltaub, Robert, Brown, Steve DM

“…Deactivating mutations in the TNSALP gene cause HPP. Akp2−/− mice model severe infantile HPP, but there is no model for the relatively mild adult form. Here we…”
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A New Primate Model of Focal Stroke: Endothelin-1-Induced Middle Cerebral Artery Occlusion and Reperfusion in the Common Marmoset by Virley, David, Hadingham, Sarah J., Roberts, Jenny C., Farnfield, Belinda, Elliott, Heather, Whelan, Greg, Golder, Jackie, David, Chris, Parsons, Andrew A., Hunter, A. Jackie

“…The purpose of the present set of studies was to develop a new primate model of focal ischemia with reperfusion for long-term functional assessment in the…”
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The innovative medicines initiative: a pre-competitive initiative to enhance the biomedical science base of Europe to expedite the development of new medicines for patients by Hunter, A. Jackie

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The deaf mouse mutant Jeff (Jf) is a single gene model of otitis media by Hardisty, Rachel E, Erven, Alexandra, Logan, Karen, Morse, Susan, Guionaud, Sylvia, Sancho-Oliver, Sara, Hunter, A Jackie, Brown, Steve D M, Steel, Karen P

“…Otitis media is the most common cause of hearing impairment in children and is primarily characterized by inflammation of the middle ear mucosa. Yet nothing is…”
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Integrating pharmacology and clinical pharmacology in pharmaceutical companies by Hunter, Jackie A

“…Integration of clinical and preclinical pharmacology in pharmaceutical companies could be improved by several key recommendations: Companies should ensure that…”
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Patterns of bromodeoxyuridine incorporation and neuropeptide immunoreactivity during arm regeneration in the starfish Asterias rubens by Moss, Claire, Jackie Hunter, A., Thorndyke, Michael C.

“…Asterias rubens…”
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Orexin A Activates Locus Coeruleus Cell Firing and Increases Arousal in the Rat by Hagan, Jim J., Leslie, Ron A., Patel, Sara, Evans, Martyn L., Wattam, Trevor A., Holmes, Steve, Benham, Christopher D., Taylor, Stephen G., Routledge, Carol, Hemmati, Panida, Munton, Richard P., Ashmeade, Tracey E., Shah, Ajit S., Hatcher, Jonathan P., Hatcher, Paula D., Declan N. C. Jones, Smith, Martin I., Piper, David C., Hunter, A. Jackie, Porter, Rod A., Upton, Neil

“…The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral…”
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Selective Antagonism of Endothelin-A-Receptors Improves Outcome in Both Head Trauma and Focal Stroke in Rat by Barone, Frank C, Ohlstein, Eliot H, Hunter, Jackie A, Campbell, Colin A, Hadingham, Sarah H, Parsons, Andrew A, Yang, Yu, Shohami, Esther

“…Increased levels of endothelin (ET) have been demonstrated in the ischemic brain, and ET receptor antagonism has been shown to improve outcome in cerebral…”
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The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats by Foley, Andrew G, Hirst, Warren D, Gallagher, Helen C, Barry, Claire, Hagan, Jim J, Upton, Neil, Walsh, Frank S, Hunter, A Jackie, Regan, Ciaran M

“…While there is now substantial evidence that 5-HT(6) antagonism leads to significantly improved cognitive ability, the mechanism(s) and/or pathway(s) involved…”
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Targets for chemical intervention: How natural products can provide leads for new CNS therapeutics by Hunter, A. Jackie

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An ENU-induced mutation in the Ankrd11 gene results in an osteopenia-like phenotype in the mouse mutant Yoda by Barbaric, Ivana, Perry, Mark J, Dear, T. Neil, Rodrigues Da Costa, Alexandra, Salopek, Daniela, Marusic, Ana, Hough, Tertius, Wells, Sara, Hunter, A. Jackie, Cheeseman, Michael, Brown, Steve D. M

“…1 MRC Mammalian Genetics Unit, Harwell 2 Department of Anatomy, University of Bristol, Bristol 3 MRC Mary Lyon Centre, Harwell, United Kingdom 4 Department of…”
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Novel ENU-induced eye mutations in the mouse: models for human eye disease by Thaung, Caroline, West, Katrine, Clark, Brian J., McKie, Lisa, Morgan, Joanne E., Arnold, Karen, Nolan, Patrick M., Peters, Jo, Hunter, A. Jackie, Brown, Steve D. M., Jackson, Ian J., Cross, Sally H.

“…We have carried out a genome-wide screen for novel N-ethyl-N-nitrosourea-induced mutations that give rise to eye and vision abnormalities in the mouse and have…”
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The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti by TSAI, Hsun, HARDISTY, Rachel E, STEEL, Karen P, RHODES, Charlotte, KIERNAN, Amy E, ROBY, Phil, TYMOWSKA-LALANNE, Zuzanna, MBURU, Philomena, RASTAN, Sohaila, HUNTER, A. Jackie, BROWN, Steve D. M

“…The Notch signalling pathway has recently been implicated in the development and patterning of the sensory epithelium in the cochlea, the organ of Corti. As…”
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Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats by GARTLON, Jane, SZEKERES, Philip, DUXON, Mark, ASHMEADE, Tracey E, HARRISON, David C, MURDOCK, Paul, WILSON, Shelagh, ENNACEUR, Abdel, ATKINS, Alan, HEIDBREDER, Christian, HAGAN, Jim J, HUNTER, A. Jackie, PULLEN, Mark, JONES, Declan N. C, SARAU, Henry M, AIYAR, Nambi, SHABON, Usman, MICHALOVICH, David, STEPLEWSKI, Klaudia, ELLIS, Cathy, ELSHOURBAGY, Nabil

“…Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles…”
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A Mutation in Af4 Is Predicted to Cause Cerebellar Ataxia and Cataracts in the Robotic Mouse by Isaacs, Adrian M, Oliver, Peter L, Jones, Emma L, Jeans, Alexander, Potter, Allyson, Hovik, Berit H, Nolan, Patrick M, Vizor, Lucie, Glenister, Peter, Simon, A. Katharina, Gray, Ian C, Spurr, Nigel K, Brown, Steve D. M, Hunter, A. Jackie, Davies, Kay E

“…The robotic mouse is an autosomal dominant mutant that arose from a large-scale chemical mutagenesis program. It has a jerky, ataxic gait and develops…”
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Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation by Heidbreder, C A, Foxton, R, Cilia, J, Hughes, Z A, Shah, A J, Atkins, A, Hunter, A J, Hagan, J J, Jones, D N

“…Dopaminergic hypofunction in the medial prefrontal cortex (mPFC) has been associated with the aetiology of negative symptoms and cognitive dysfunction of…”
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Selective Antagonism of Endothelin-A-Receptors Improves Outcome in Both Head Trauma and Focal Stroke in Rat by Barone, Frank C, Ohlstein, Eliot H, Hunter, Jackie A, Campbell, Colin A, Hadingham, Sarah H, Parsons, Andrew A, Yang, Yu, Shohami, Esther

“…Increased levels of endothelin (ET) have been demonstrated in the ischemic brain, and ET receptor antagonism has been shown to improve outcome in cerebral…”
Get full text