Search Results - "HUNG-LIANG TAI"

Enhanced Proteolysis of Thiopurine S-methyltransferase (TPMT) Encoded by Mutant Alleles in Humans (TPMT3A, TPMT2): Mechanisms for the Genetic Polymorphism of TPMT Activity by Tai, Hung-Liang, Krynetski, Eugene Y., Schuetz, Erin G., Yanishevski, Yuri, Evans, William E.

“…TPMT is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including medications such as mercaptopurine and…”
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Thiopurine S-methyltransferase deficiency : Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians by HUNG-LIANG TAI, KRYNETSKI, E. Y, YATES, C. R, LOENNECHEN, T, FESSING, M. Y, KRYNETSKAIA, N. F, EVANS, W. E

“…The autosomal recessive trait of thiopurine S-methytransferase (TPMT) deficiency is associated with severe hematopoietic toxicity when patients are treated…”
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Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of D4T-phenyl methoxyalaninyl phosphate derivatives by Venkatachalam, T.K, Tai, Hung-Liang, Vig, Rakesh, Chen, Chun-Lin, Jan, Shyi-Tai, Uckun, Fatih M

“…d4T-5′-[ p-Bromophenyl methoxyalaninyl phosphate] (d4T-pBPMAP), a novel phenyl phosphate derivative of 2′,3′-didehydro-2′,3′-dideoxythymidine (d4T) that has an…”
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Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction by DRAHUSHUK, A. T, MCGARRIGLE, B. P, TAI, H.-L, KITAREEWAN, S, GOLDSTEIN, J. A, OLSON, J. R

“…The utilization of precision-cut liver slices in dynamic organ culture as an in vitro model was validated by comparing the induction of the biomarker responses…”
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Pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with antileukemic activity by CHEN, C.-L, TAI, H.-L, ZHU, D.-M, UCKUN, F. M

“…To examine the pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with potent antileukemic activity. HPLC-based…”
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Cytochrome P4501A1 mediates the metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat and human by Tai, H L, McReynolds, J H, Goldstein, J A, Eugster, H P, Sengstag, C, Alworth, W L, Olson, J R

“…Previous studies have established that TCDF is rapidly metabolized and excreted in rats and that pretreatment of rats with TCDD increases the rate of hepatic…”
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A salt-free isocratic high-pressure liquid chromatographic method for the quantitation of benzodiazepines in serum by Tai, H L, Osiewicz, R J, Bofinger, D P

“…A simple, rapid high-pressure liquid chromatography (HPLC) method was developed for detecting and quantifying benzodiazepines in serum. Seven major…”
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Validation of Precision-Cut Liver Slices in Dynamic Organ Culture as anin VitroModel for Studying CYP1A1 and CYP1A2 Induction by Drahushuk, Adam T., McGarrigle, Barbara P., Tai, Hung-Liang, Kitareewan, Sutisak, Goldstein, Joyce A., Olson, James R.

“…The utilization of precision-cut liver slices in dynamic organ culture as anin vitromodel was validated by comparing the induction of the biomarker responses…”
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Molecular diagnosis of thiopurine S-methyltransferase deficiency : Genetic basis for azathioprine and mercaptopurine intolerance by YATES, C. R, KRYNETSKI, E. Y, LOENNECHEN, T, FESSING, M. Y, TAI, H.-L, PUI, C.-H, RELLING, M. V, EVANS, W. E

“…Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (that is, inactivation) of mercaptopurine, azathioprine, and thioguanine and exhibits genetic…”
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Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT2, TPMT3A, TPMT3B or TPMT3C by Tai, H L, Fessing, M Y, Bonten, E J, Yanishevsky, Y, d'Azzo, A, Krynetski, E Y, Evans, W E

“…Inheritance of the TPMT*2, TPMT*3A and TPMT*3C mutant alleles is associated with deficiency of thiopurine S-methyltransferase (TPMT) activity in humans…”
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Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms by Krynetski, E Y, Tai, H L, Yates, C R, Fessing, M Y, Loennechen, T, Schuetz, J D, Relling, M V, Evans, W E

“…Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurines such as mercaptopurine and thioguanine. TPMT activity exhibits genetic…”
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Antileukemic activity and cellular metabolism of the aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) by UCKUN, Fatih M, TAI, Hung-Liang, D'CRUZ, Osmond J

“…The novel aryl phosphate derivative of bromo-methoxy zidovudine (ZDV/AZT) (compound WHI-07, CAS 213982-96-8) was found to be a potent antileukemic agent…”
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Enhanced proteolysis of thiopurine S-methyltranferase (TPMT) encoded by mutant alleles in humans (TPMT3A, TPMT2): Mechanims for the genetic polymorphism of TPMT activity by Tai, Hung-Liang, Krynetski, Eugene Y, Schuetz, Erin G, Yanishevski, Yuri, Evans, William E

“…A study establishes that erythrocyte TPMT activity was significantly related to the amount of TPMT protein on Western blots of erythrocytes from patients with…”
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