Search Results - "HUNDAL, Harinder S"

Lipid modulation of skeletal muscle mass and function by Lipina, Christopher, Hundal, Harinder S

“…Loss of skeletal muscle mass is a characteristic feature of various pathologies including cancer, diabetes, and obesity, as well as being a general feature of…”
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Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling by Hundal, Harinder S, Taylor, Peter M

“…Amino acid transporters at the surface of cells are in an ideal location to relay nutritional information, as well as nutrients themselves, to the cell…”
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Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms by Lipina, Christopher, Hundal, Harinder S.

“…Gangliosides constitute a large family of sialic acid-containing glycosphingolipids which play a key regulatory role in a diverse array of cellular processes,…”
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Modulation of cellular redox homeostasis by the endocannabinoid system by Lipina, Christopher, Hundal, Harinder S.

“…The endocannabinoid system (ECS) and reactive oxygen species (ROS) constitute two key cellular signalling systems that participate in the modulation of diverse…”
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Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells by Dimopoulos, Nikolaos, Watson, Maria, Sakamoto, Kei, Hundal, Harinder S

“…An increase in circulating levels of specific NEFAs (non-esterified fatty acids) has been implicated in the pathogenesis of insulin resistance and impaired…”
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Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells by Watson, Maria L, Coghlan, Matthew, Hundal, Harinder S

“…Saturated fatty acids, such as palmitate, promote accumulation of ceramide, which impairs activation and signalling of PKB (protein kinase B; also known as…”
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GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling by Stretton, Clare, Hoffmann, Thorsten M, Munson, Michael J, Prescott, Alan, Taylor, Peter M, Ganley, Ian G, Hundal, Harinder S

“…The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates…”
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Mono- and Polyunsaturated Fatty Acids Counter Palmitate-Induced Mitochondrial Dysfunction in Rat Skeletal Muscle Cells by Nisr, Raid B, Shah, Dinesh S, Hundal, Harinder S

“…Sustained increases in the circulating concentration of saturated fatty acids (SFAs, e.g. palmitate (PA), as seen during obesity, induces a chronic low grade…”
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The endocannabinoid system： ＇NO＇ longer anonymous in the control of nitrergic signalling by Lipina, Christopher, Hundal, Harinder S

“…The endocannabinoid system （ECS） is a key cellular signalling system that has been implicated in the regulation of diverse cellular functions. Importantly,…”
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Proteasomal Modulation of Cellular SNAT2 (SLC38A2) Abundance and Function by Unsaturated Fatty Acid Availability by Nardi, Francesca, Hoffmann, Thorsten M., Stretton, Clare, Cwiklinski, Emma, Taylor, Peter M., Hundal, Harinder S.

“…Expression and activity of the System A/SNAT2 (SLC38A2) amino acid transporter is up-regulated by amino acid starvation and hypertonicity by a mechanism…”
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Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system? by Lipina, Christopher, Irving, Andrew J, Hundal, Harinder S

“…The endocannabinoid system (ECS) regulates numerous cellular and physiological processes through the activation of receptors targeted by endogenously produced…”
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Caveolin‐3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function by Shah, Dinesh S., Nisr, Raid B., Stretton, Clare, Krasteva‐Christ, Gabriela, Hundal, Harinder S.

“…Background Caveolin‐3 (Cav3) is the principal structural component of caveolae in skeletal muscle. Dominant pathogenic mutations in the Cav3 gene, such as the…”
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Caveolin‐3 loss linked with the P104L LGMD‐1C mutation modulates skeletal muscle mTORC1 signalling and cholesterol homeostasis by Shah, Dinesh S., Nisr, Raid B., Krasteva‐Christ, Gabriela, Hundal, Harinder S.

“…Abstract Background Caveolins are the principal structural components of plasma membrane caveolae. Dominant pathogenic mutations in the muscle‐specific…”
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Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight by Mahfouz, Rana, Khoury, Rhéa, Blachnio-Zabielska, Agnieszka, Turban, Sophie, Loiseau, Nicolas, Lipina, Christopher, Stretton, Clare, Bourron, Olivier, Ferré, Pascal, Foufelle, Fabienne, Hundal, Harinder S, Hajduch, Eric

“…Ceramides are known to promote insulin resistance in a number of metabolically important tissues including skeletal muscle, the predominant site of…”
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Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells by Turban, Sophie, Stretton, Clare, Drouin, Olivier, Green, Charlotte J., Watson, Maria L., Gray, Alexander, Ross, Fiona, Lantier, Louise, Viollet, Benoit, Hardie, D. Grahame, Marette, Andre, Hundal, Harinder S.

“…The importance of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) as effectors of metformin (Met) action on glucose uptake (GU) in skeletal…”
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Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase by Green, Charlotte J, Macrae, Katherine, Fogarty, Sarah, Hardie, D Grahame, Sakamoto, Kei, Hundal, Harinder S

“…Sustained over-supply of saturated non-esterified 'free' fatty acids has been shown to promote skeletal muscle insulin resistance, which may be driven, in…”
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Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate by Macrae, Katherine, Stretton, Clare, Lipina, Christopher, Blachnio-Zabielska, Agnieszka, Baranowski, Marcin, Gorski, Jan, Marley, Anna, Hundal, Harinder S.

“…Chronic exposure of skeletal muscle to saturated fatty acids, such as palmitate (C16:0), enhances proinflammatory IKK-NFκB signaling by a mechanism involving…”
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Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A by Nardi, Francesca, Lipina, Christopher, Magill, David, Hage Hassan, Rima, Hajduch, Eric, Gray, Alexander, Hundal, Harinder S

“…Reduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and…”
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Distinct Sensor Pathways in the Hierarchical Control of SNAT2, a Putative Amino Acid Transceptor, by Amino Acid Availability by Hyde, Russell, Cwiklinski, Emma L., MacAulay, Katrina, Taylor, Peter M., Hundal, Harinder S.

“…Mammalian nutrient sensors are novel targets for therapeutic intervention in disease states such as insulin resistance and muscle wasting; however, the…”
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ABC50 Promotes Translation Initiation in Mammalian Cells by Paytubi, Sonia, Wang, Xuemin, Lam, Yun W., Izquierdo, Luis, Hunter, Mairi J., Jan, Eric, Hundal, Harinder S., Proud, Christopher G.

“…ABC50 is an ATP-binding cassette (ABC) protein, which, unlike most ABC proteins, does not possess membrane-spanning domains. ABC50 interacts with eukaryotic…”
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