Search Results - "HUMPHRIES, Martin J."

Signal transduction via integrin adhesion complexes by Humphries, Jonathan D, Chastney, Megan R, Askari, Janet A, Humphries, Martin J

“…Integrin adhesion complexes (IACs) have evolved over millions of years to integrate metazoan cells physically with their microenvironment. It is presumed that…”
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Connections between the cell cycle, cell adhesion and the cytoskeleton by Jones, Matthew C, Zha, Junzhe, Humphries, Martin J

“…Cell division, the purpose of which is to enable cell replication, and in particular to distribute complete, accurate copies of genetic material to daughter…”
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Cell adhesion is regulated by CDK1 during the cell cycle by Jones, Matthew C, Askari, Janet A, Humphries, Jonathan D, Humphries, Martin J

“…In most tissues, anchorage-dependent growth and cell cycle progression are dependent on cells engaging extracellular matrices (ECMs) via integrin-receptor…”
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Proteomic definitions of basement membrane composition in health and disease by Randles, Michael J., Humphries, Martin J., Lennon, Rachel

“…Basement membranes are formed from condensed networks of extracellular matrix (ECM) proteins. These structures underlie all epithelial, mesothelial and…”
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The integrin adhesome network at a glance by Horton, Edward R, Humphries, Jonathan D, James, Jenny, Jones, Matthew C, Askari, Janet A, Humphries, Martin J

“…The adhesion nexus is the site at which integrin receptors bridge intracellular cytoskeletal and extracellular matrix networks. The connection between…”
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Demonstration of catch bonds between an integrin and its ligand by Kong, Fang, García, Andrés J, Mould, A. Paul, Humphries, Martin J, Zhu, Cheng

“…Binding of integrins to ligands provides anchorage and signals for the cell, making them prime candidates for mechanosensing molecules. How force regulates…”
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Cyclic Mechanical Reinforcement of Integrin–Ligand Interactions by Kong, Fang, Li, Zhenhai, Parks, William M., Dumbauld, David W., García, Andrés J., Mould, A. Paul, Humphries, Martin J., Zhu, Cheng

“…Cells regulate adhesion in response to internally generated and externally applied forces. Integrins connect the extracellular matrix to the cytoskeleton and…”
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Conformational equilibria and intrinsic affinities define integrin activation by Li, Jing, Su, Yang, Xia, Wei, Qin, Yan, Humphries, Martin J, Vestweber, Dietmar, Cabañas, Carlos, Lu, Chafen, Springer, Timothy A

“…We show that the three conformational states of integrin α 5 β 1 have discrete free energies and define activation by measuring intrinsic affinities for ligand…”
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Flexible Blade‐Coated Multicolor Polymer Light‐Emitting Diodes for Optoelectronic Sensors by Han, Donggeon, Khan, Yasser, Ting, Jonathan, King, Simon M., Yaacobi‐Gross, Nir, Humphries, Martin J., Newsome, Christopher J., Arias, Ana C.

“…A method to print two materials of different functionality during the same printing step is presented. In printed electronics, devices are built layer by layer…”
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Synergistic control of cell adhesion by integrins and syndecans by Humphries, Martin J, Morgan, Mark R, Bass, Mark D

“…The ability of cells to adhere to each other and to their surrounding extracellular matrices is essential for a multicellular existence. Adhesion provides…”
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Syndecan-4 Phosphorylation Is a Control Point for Integrin Recycling by Morgan, Mark R., Hamidi, Hellyeh, Bass, Mark D., Warwood, Stacey, Ballestrem, Christoph, Humphries, Martin J.

“…Precise spatiotemporal coordination of integrin adhesion complex dynamics is essential for efficient cell migration. For cells adherent to fibronectin,…”
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Global Analysis Reveals the Complexity of the Human Glomerular Extracellular Matrix by LENNON, Rachel, BYRON, Adam, HUMPHRIES, Jonathan D, RANDLES, Michael J, CARISEY, Alex, MURPHY, Stephanie, KNIGHT, David, BRENCHLEY, Paul E, ZENT, Roy, HUMPHRIES, Martin J

“…The glomerulus contains unique cellular and extracellular matrix (ECM) components, which are required for intact barrier function. Studies of the cellular…”
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Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking by Linscheid, Nora, Logantha, Sunil Jit R. J., Poulsen, Pi Camilla, Zhang, Shanzhuo, Schrölkamp, Maren, Egerod, Kristoffer Lihme, Thompson, Jonatan James, Kitmitto, Ashraf, Galli, Gina, Humphries, Martin J., Zhang, Henggui, Pers, Tune H., Olsen, Jesper Velgaard, Boyett, Mark, Lundby, Alicia

“…The sinus node is a collection of highly specialised cells constituting the heart’s pacemaker. The molecular underpinnings of its pacemaking abilities are…”
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Linking integrin conformation to function by Askari, Janet A, Buckley, Patrick A, Mould, A. Paul, Humphries, Martin J

“…Integrins are αβ heterodimeric adhesion receptors that relay signals bidirectionally across the plasma membrane between the extracellular matrix and…”
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Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins by Seong, Jihye, Tajik, Arash, Sun, Jie, Guan, Jun-Lin, Humphries, Martin J., Craig, Susan E., Shekaran, Asha, García, Andrés J., Lu, Shaoying, Lin, Michael Z., Wang, Ning, Wang, Yingxiao

“…Matrix mechanics controls cell fate by modulating the bonds between integrins and extracellular matrix (ECM) proteins. However, it remains unclear how…”
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Defining the extracellular matrix using proteomics by Byron, Adam, Humphries, Jonathan D., Humphries, Martin J.

“…Summary The cell microenvironment has a profound influence on the behaviour, growth and survival of cells. The extracellular matrix (ECM) provides not only…”
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Clathrin-containing adhesion complexes by Lock, John G, Baschieri, Francesco, Jones, Matthew C, Humphries, Jonathan D, Montagnac, Guillaume, Strömblad, Staffan, Humphries, Martin J

“…An understanding of the mechanisms whereby cell adhesion complexes (ACs) relay signals bidirectionally across the plasma membrane is necessary to interpret the…”
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Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition by Horton, Edward R, Humphries, Jonathan D, Stutchbury, Ben, Jacquemet, Guillaume, Ballestrem, Christoph, Barry, Simon T, Humphries, Martin J

“…Integrin adhesion complexes (IACs) form mechanochemical connections between the extracellular matrix and actin cytoskeleton and mediate phenotypic responses…”
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RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex by Jacquemet, Guillaume, Green, David M, Bridgewater, Rebecca E, von Kriegsheim, Alexander, Humphries, Martin J, Norman, Jim C, Caswell, Patrick T

“…Inhibition of αvβ3 or expression of mutant p53 promotes invasion into fibronectin (FN)-containing extracellular matrix (ECM) by enhancing Rab-coupling protein…”
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The importance of podocyte adhesion for a healthy glomerulus by Lennon, Rachel, Randles, Michael J, Humphries, Martin J

“…Podocytes are specialized epithelial cells that cover the outer surfaces of glomerular capillaries. Unique cell junctions, known as slit diaphragms, which…”
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