Search Results - "HUMPHRIES, Alexander C"

The Asymmetric Maitland−Japp Reaction and Its Application to the Construction of the C1−C19 Bis-pyran Unit of Phorboxazole B by Clarke, Paul A, Santos, Soraia, Mistry, Nimesh, Burroughs, Laurence, Humphries, Alexander C

“…The synthesis of the C1−C19 bis-pyran unit of phorboxazole B has been achieved. The key pyran rings were constructed by means of an asymmetric Maitland−Japp…”
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8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABAA receptor by Humphries, Alexander C., Gancia, Emanuela, Gilligan, Myra T., Goodacre, Simon, Hallett, David, Merchant, Kevin J., Thomas, Steve R.

“…8-Fluoroimidazo[1,2-a]pyridine has been established as a physicochemical mimic of imidazo[1,2-a]pyrimidine, using both in silico and traditional techniques…”
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A Brønsted Acid Mediated Cascade Enone Synthesis from Aldehydes Containing a Tethered Propargylsilane by Ramalho, Rui, Jervis, Peter J, Kariuki, Benson M, Humphries, Alexander C, Cox, Liam R

“…MeSO3H effects the intramolecular allenylation of a series of aldehydes 1 to provide allenyl alcohol product 3 as a single diastereoisomer. Cyclization…”
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4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia by Fish, L Rebecca, Gilligan, Myra T, Humphries, Alexander C, Ivarsson, Magnus, Ladduwahetty, Tammy, Merchant, Kevin J, O'Connor, Desmond, Patel, Smita, Philipps, Elisabeth, Vargas, Hugo M, Hutson, Peter H, MacLeod, Angus M

“…Incorporation of fluorine at the 4-position of an existing series of sulfonyl piperidine 5-HT2A antagonists gave compounds with increased selectivity over the…”
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Evidence for a Significant Role of α3-Containing GABAA Receptors in Mediating the Anxiolytic Effects of Benzodiazepines by Dias, Rebecca, Sheppard, Wayne F. A., Fradley, Rosa L., Garrett, Elizabeth M., Stanley, Joanna L., Tye, Spencer J., Goodacre, Simon, Lincoln, Rachael J., Cook, Susan M., Conley, Rachel, Hallett, David, Humphries, Alexander C., Thompson, Sally A., Wafford, Keith A., Street, Leslie J., Castro, J. Luis, Whiting, Paul J., Rosahl, Thomas W., Atack, John R., McKernan, Ruth M., Dawson, Gerard R., Reynolds, David S.

“…The GABA A receptor subtypes responsible for the anxiolytic effects of nonselective benzodiazepines (BZs) such as chlordiazepoxide (CDP) and diazepam remain…”
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8-Fluoroimidazo[1,2-a]pyridine: synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA A receptor by Humphries, Alexander C, Gancia, Emanuela, Gilligan, Myra T, Goodacre, Simon, Hallett, David, Merchant, Kevin J, Thomas, Steve R

“…8-Fluoroimidazo[1,2-a]pyridine has been established as a physicochemical mimic of imidazo[1,2-a]pyrimidine, using both in silico and traditional techniques…”
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8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA sub(A) receptor by Humphries, Alexander C, Gancia, Emanuela, Gilligan, Myra T, Goodacre, Simon, Hallett, David, Merchant, Kevin J, Thomas, Steve R

“…8-Fluoroimidazo[1,2-a]pyridine has been established as a physicochemical mimic of imidazo[1,2-a]pyrimidine, using both in silico and traditional techniques…”
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Evidence for a Significant Role of α3-Containing GABA A Receptors in Mediating the Anxiolytic Effects of Benzodiazepines by Dias, Rebecca, Sheppard, Wayne F. A., Fradley, Rosa L., Garrett, Elizabeth M., Stanley, Joanna L., Tye, Spencer J., Goodacre, Simon, Lincoln, Rachael J., Cook, Susan M., Conley, Rachel, Hallett, David, Humphries, Alexander C., Thompson, Sally A., Wafford, Keith A., Street, Leslie J., Castro, J. Luis, Whiting, Paul J., Rosahl, Thomas W., Atack, John R., McKernan, Ruth M., Dawson, Gerard R., Reynolds, David S.

“…The GABA A receptor subtypes responsible for the anxiolytic effects of nonselective benzodiazepines (BZs) such as chlordiazepoxide (CDP) and diazepam remain…”
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Evidence for a Significant Role of alpha 3-Containing GABA sub(A) Receptors in Mediating the Anxiolytic Effects of Benzodiazepines by Dias, Rebecca, Sheppard, Wayne FA, Fradley, Rosa L, Garrett, Elizabeth M, Stanley, Joanna L, Tye, Spencer J, Goodacre, Simon, Lincoln, Rachael J, Cook, Susan M, Conley, Rachel, Hallett, David, Humphries, Alexander C, Thompson, Sally A, Wafford, Keith A, Street, Leslie J, Castro, JLuis, Whiting, Paul J, Rosahl, Thomas W, Atack, John R, McKernan, Ruth M, Dawson, Gerard R, Reynolds, David S

“…The GABA sub(A) receptor subtypes responsible for the anxiolytic effects of nonselective benzodiazepines (BZs) such as chlordiazepoxide (CDP) and diazepam…”
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4-Fluorosulfonylpiperidines: Selective 5-HT 2A ligands for the treatment of insomnia by Fish, L. Rebecca, Gilligan, Myra T., Humphries, Alexander C., Ivarsson, Magnus, Ladduwahetty, Tammy, Merchant, Kevin J., O’Connor, Desmond, Patel, Smita, Philipps, Elisabeth, Vargas, Hugo M., Hutson, Peter H., MacLeod, Angus M.

“…α-Fluorosulfones, of general structure 3, were synthesized as an alternative approach to reduce the p K a of the piperidine ring in an existing series of…”
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4-Fluorosulfonylpiperidines : Selective 5-HT2A ligands for the treatment of insomnia: G-protein-coupled receptors in drug discovery by FISH, L. Rebecca, GILLIGAN, Myra T, HUTSON, Peter H, MACLEOD, Angus M, HUMPHRIES, Alexander C, IVARSSON, Magnus, LADDUWAHETTY, Tammy, MERCHANT, Kevin J, O'CONNOR, Desmond, PATEL, Smita, PHILIPPS, Elisabeth, VARGAS, Hugo M

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Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines by Dias, Rebecca, Sheppard, Wayne F A, Fradley, Rosa L, Garrett, Elizabeth M, Stanley, Joanna L, Tye, Spencer J, Goodacre, Simon, Lincoln, Rachael J, Cook, Susan M, Conley, Rachel, Hallett, David, Humphries, Alexander C, Thompson, Sally A, Wafford, Keith A, Street, Leslie J, Castro, J Luis, Whiting, Paul J, Rosahl, Thomas W, Atack, John R, McKernan, Ruth M, Dawson, Gerard R, Reynolds, David S

“…The GABA(A) receptor subtypes responsible for the anxiolytic effects of nonselective benzodiazepines (BZs) such as chlordiazepoxide (CDP) and diazepam remain…”
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Evidence for a Significant Role of {alpha}3-Containing GABAA Receptors in Mediating the Anxiolytic Effects of Benzodiazepines by Dias, Rebecca, Sheppard, Wayne F. A, Fradley, Rosa L, Garrett, Elizabeth M, Stanley, Joanna L, Tye, Spencer J, Goodacre, Simon, Lincoln, Rachael J, Cook, Susan M, Conley, Rachel, Hallett, David, Humphries, Alexander C, Thompson, Sally A, Wafford, Keith A, Street, Leslie J, Castro, J. Luis, Whiting, Paul J, Rosahl, Thomas W, Atack, John R, McKernan, Ruth M, Dawson, Gerard R, Reynolds, David S

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