Search Results - "HUMAR, Bostjan"

Hereditary diffuse gastric cancer: A manifestation of lost cell polarity by Humar, Bostjan, Guilford, Parry

“…Hereditary diffuse gastric cancer is a cancer syndrome caused by germline mutations in the gene for the cell adhesion protein E‐cadherin (CDH1). E‐cadherin…”
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Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors by Schneider, Marcel A., Linecker, Michael, Fritsch, Ralph, Muehlematter, Urs J., Stocker, Daniel, Pestalozzi, Bernhard, Samaras, Panagiotis, Jetter, Alexander, Kron, Philipp, Petrowsky, Henrik, Nicolau, Claude, Lehn, Jean-Marie, Humar, Bostjan, Graf, Rolf, Clavien, Pierre-Alain, Limani, Perparim

“…Hypoxia is prominent in solid tumors and a recognized driver of malignancy. Thus far, targeting tumor hypoxia has remained unsuccessful. Myo-inositol…”
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Hereditary diffuse gastric cancer: translation of CDH1 germline mutations into clinical practice by Guilford, Parry, Humar, Bostjan, Blair, Vanessa

“…Hereditary diffuse gastric cancer (HDGC) is the only known cancer syndrome that is dominated by gastric adenocarcinoma. HDGC is caused by germline mutation of…”
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Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice by Rickenbacher, Andreas, Jang, Jae Hwi, Limani, Perparim, Ungethüm, Udo, Lehmann, Kuno, Oberkofler, Christian E, Weber, Achim, Graf, Rolf, Humar, Bostjan, Clavien, Pierre-Alain

“…Background & Aims Fasting and calorie restriction are associated with a prolonged life span and an increased resistance to stress. The protective effects of…”
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E-Cadherin Deficiency Initiates Gastric Signet-Ring Cell Carcinoma in Mice and Man by HUMAR, Bostjan, BLAIR, Vanessa, CHARLTON, Amanda, MORE, Helen, MARTIN, Iain, GUILFORD, Parry

“…The importance of loss of the cell-cell adhesion molecule E-cadherin (encoded by CDH1) to tumor progression is well established. However, CDH1 germ-line…”
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Liver Failure After Extended Hepatectomy in Mice Is Mediated by a p21-Dependent Barrier to Liver Regeneration by Lehmann, Kuno, Tschuor, Christoph, Rickenbacher, Andreas, Jang, Jae–Hwi, Oberkofler, Christian E, Tschopp, Oliver, Schultze, Simon M, Raptis, Dimitri A, Weber, Achim, Graf, Rolf, Humar, Bostjan, Clavien, Pierre–Alain

“…Background & Aims Extended liver resection leads to hepatic failure because of a small remnant liver volume. Excessive parenchymal damage has been proposed as…”
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Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss by Tschuor, Christoph, Kachaylo, Ekaterina, Limani, Përparim, Raptis, Dimitri A, Linecker, Michael, Tian, Yinghua, Herrmann, Uli, Grabliauskaite, Kamile, Weber, Achim, Columbano, Amedeo, Graf, Rolf, Humar, Bostjan, Clavien, Pierre-Alain

“…Graphical abstract…”
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Hypoxia‐driven Hif2a coordinates mouse liver regeneration by coupling parenchymal growth to vascular expansion by Kron, Philipp, Linecker, Michael, Limani, Perparim, Schlegel, Andrea, Kambakamba, Patryk, Lehn, Jean‐Marie, Nicolau, Claude, Graf, Rolf, Humar, Bostjan, Clavien, Pierre‐Alain

“…Interaction between sinusoidal endothelial cells and hepatocytes is a prerequisite for liver function. Upon tissue loss, both liver cell populations need to be…”
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Omega-3 Fatty Acids Protect Fatty and Lean Mouse Livers After Major Hepatectomy by Linecker, Michael, Limani, Perparim, Kambakamba, Patryk, Kron, Philipp, Tschuor, Christoph, Calo, Nicolas, Foti, Michelangelo, Dufour, Jean-François, Graf, Rolf, Humar, Bostjan, Clavien, Pierre-Alain

“…OBJECTIVE:The aim of this study was to assess the effect of Ω3 fatty acids (Ω3FA) on fatty and lean liver in hepatic surgery. BACKGROUND:The global spread of…”
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Systemic protection through remote ischemic preconditioning is spread by platelet‐dependent signaling in mice by Oberkofler, Christian E., Limani, Perparim, Jang, Jae‐Hwi, Rickenbacher, Andreas, Lehmann, Kuno, Raptis, Dimitri A., Ungethuem, Udo, Tian, Yinghua, Grabliauskaite, Kamile, Humar, Rok, Graf, Rolf, Humar, Bostjan, Clavien, Pierre‐Alain

“…Remote ischemic preconditioning (RIPC), the repetitive transient mechanical obstruction of vessels at a limb remote to the operative site, is a novel strategy…”
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Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway by Furrer, Katarzyna, Rickenbacher, Andreas, Tian, Yinghua, Jochum, Wolfram, Bittermann, Anne Greet, Käch, Andres, Humar, Bostjan, Graf, Rolf, Moritz, Wolfgang, Clavien, Pierre-Alain

“…The function of the liver is well-preserved during the aging process, although some evidence suggests that liver regeneration might be impaired with advanced…”
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Exploration of the Transcriptional Landscape of ALPPS Reveals the Pathways of Accelerated Liver Regeneration by Borger, Pieter, Schneider, Marcel, Frick, Lukas, Langiewicz, Magda, Sorokin, Maksim, Buzdin, Anton, Kachaylo, Ekaterina, Graf, Rolf, Humar, Bostjan, Clavien, Pierre-Alain

“…ALPPS (associating liver partition and portal vein ligation for staged hepatectomy), a novel 2-staged hepatectomy, dramatically accelerates liver regeneration…”
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Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation by Jang, Jae-Hwi, Rickenbacher, Andreas, Humar, Bostjan, Weber, Achim, Raptis, Dimitri Aristotle, Lehmann, Kuno, Stieger, Bruno, Moritz, Wolfgang, Soll, Christopher, Georgiev, Panco, Fischer, David, Laczko, Endre, Graf, Rolf, Clavien, Pierre-Alain

“…Obstructive cholestasis induces liver injury, postoperative complications, and mortality after surgery. Adaptive control of cholestasis, including bile salt…”
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Pharmacogenetic Profiling for Cetuximab Plus Irinotecan Therapy in Patients With Refractory Advanced Colorectal Cancer by GRAZIANO, Francesco, RUZZO, Annamaria, ANDREONI, Francesca, MALTESE, Paolo, RULLI, Eliana, HUMAR, Bostjan, FALCONE, Alfredo, GIUSTINI, Lucio, TONINI, Giuseppe, FONTANA, Andrea, MASI, Gianluca, MAGNANI, Mauro, LOUPAKIS, Fotios, CANESTRARI, Emanuele, SANTINI, Daniele, CATALANO, Vincenzo, BISONNI, Renato, TORRESI, Umberto, FLORIANI, Irene, SCHIAVON, Gaia

“…Regulation of epidermal growth factor receptor (EGFR) signaling pathways may play a relevant role in determining the activity of cetuximab therapy in patients…”
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Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer by HUMAR, Bostjan, FUKUZAWA, Ryuji, GUILFORD, Parry, BLAIR, Vanessa, DUNBIER, Anita, MORE, Helen, CHARLTON, Amanda, HAN KWANG YANG, WOO HO KIM, REEVE, Anthony E, MARTIN, Iain

“…The initial development of diffuse gastric cancer (DGC) is poorly understood. The study of E-cadherin (CDH1) germ line mutation carriers predisposed to DGC…”
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Anti‐tumoral effects of exercise on hepatocellular carcinoma growth by Saran, Uttara, Guarino, Maria, Rodríguez, Sarai, Simillion, Cedric, Montani, Matteo, Foti, Michelangelo, Humar, Bostjan, St‐Pierre, Marie V., Dufour, Jean‐François

“…Regular physical exercise has many beneficial effects, including antitumor properties, and is associated with a reduced risk of developing hepatocellular…”
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Large-Scale Profiling of Signaling Pathways Reveals a Distinct Demarcation between Normal and Extended Liver Resection by Borger, Pieter, Buzdin, Anton, Sorokin, Maksim, Kachaylo, Ekaterina, Humar, Bostjan, Graf, Rolf, Clavien, Pierre-Alien

“…Despite numerous studies addressing normal liver regeneration, we still lack comprehensive understanding of the biological processes underlying failed liver…”
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"A randomized, double-blind study of the effects of omega-3 fatty acids (Omegaven) on outcome after major liver resection" by Linecker, Michael, Limani, Perparim, Botea, Florin, Popescu, Irinel, Alikhanov, Ruslan, Efanov, Michail, Kim, Pavel, Khatkov, Igor, Raptis, Dimitri Aristotele, Tschuor, Christoph, Beck-Schimmer, Beatrice, Bonvini, John, Wirsching, Andrea, Kron, Philipp, Slankamenac, Ksenija, Humar, Bostjan, Graf, Rolf, Petrowsky, Henrik, Clavien, Pierre-Alain

“…The body is dependent on the exogenous supply of omega-3 polyunsaturated fatty acids (n3-PUFA). These essential fatty acids are key players in regulating…”
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Sewed revascularization for arterialized liver transplantation in mice by Humar, Bostjan, PhD, Raptis, Dimitri Aristotle, MD, Weber, Achim, MD, Graf, Rolf, PhD, Clavien, Pierre Alain, MD, PhD, Tian, Yinghua, MD

“…Abstract Background Mouse models of liver transplantation are powerful tools for biomedical research. The cuff method is currently the most popular approach…”
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Prognostic Analysis of E-Cadherin Gene Promoter Hypermethylation in Patients with Surgically Resected, Node-Positive, Diffuse Gastric Cancer by GRAZIANO, Francesco, ARDUINI, Federica, MARI, Davide, MAGNANI, Mauro, CASCINU, Stefano, RUZZO, Annamaria, BEARZI, Italo, HUMAR, Bostjan, MORE, Helen, SILVA, Rosarita, MURETTO, Pietro, GUILFORD, Parry, TESTA, Enrica

“…Purpose: Recent investigations have demonstrated that hypermethylation is a frequent mechanism for silencing tumor suppressor genes. This is a potentially…”
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