Search Results - "HULME, E. C"

ERKI/II Regulation by the Muscarinic Acetylcholine Receptors in Neurons by Rosenblum, Kobi, Futter, Marie, Jones, Matthew, Hulme, E. C, Bliss, T. V. P

“…Muscarinic acetylcholine receptors (mAChRs) are known to be involved in learning and memory, but the molecular basis of their involvement is not well…”
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A self-administered questionnaire for basal osteoarthritis of the thumb by Citron, N., Hulme, C.E., Wardle, N.

“…Basal osteoarthritis of the thumb is a common condition for which numerous operations have been proposed without any particular one having been shown to be…”
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Structure and activation of muscarinic acetylcholine receptors by Hulme, E C, Lu, Z L, Saldanha, J W, Bee, M S

“…A homology model of the M(1) muscarinic acetylcholine receptor, based on the X-ray structure of bovine rhodopsin, has been used to interpret the results of…”
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Muscarinic receptor subtypes by Hulme, E C, Birdsall, N J, Buckley, N J

“…The aim of this review is to discuss the structure, function, and binding properties of the different muscarinic receptor species, attempting where possible to…”
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Propylbenzilylcholine Mustard Labels an Acidic Residue in Transmembrane Helix 3 of the Muscarinic Receptor by Curtis, C A M, Wheatley, M, Bansal, S, Birdsall, N J M, Eveleigh, P, Pedder, E K, Poyner, D, Hulme, E C

“…Muscarinic acetylcholine receptors were purified from rat forebrain and labeled with [3H]N-(2-chloroethyl)N- (2′,3′ - [3H2]propyl) - 2 - aminoethylbenzilate…”
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Acetylcholine mustard labels the binding site aspartate in muscarinic acetylcholine receptors by SPALDING, T. A, BIRDSALL, N. J. M, CURTIS, C. A. M, HULME, E. C

“…Acetylcholine mustard (AChM) is an analogue of acetylcholine (ACh) in which the onium headgroup is replaced by a chemically reactive aziridinium moiety. AChM…”
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The Hydration of the Neurotransmitter Acetylcholine in Aqueous Solution by Hulme, E.C., Soper, A.K., McLain, S.E., Finney, J.L.

“…Neutron diffraction augmented with hydrogen isotope substitution has been used to examine the water structure around the acetylcholine molecular ion in aqueous…”
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Pirenzepine distinguishes between different subclasses of muscarinic receptors by Hammer, R, Berrie, C. P, Birdsall, N. J. M, Burgen, A. S. V, Hulme, E. C

“…Some antagonists exhibit tissue selectivity in their pharmacological antagonism of muscarinic responses. However, the affinity constants for equilibrium…”
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The conformational switch in 7-transmembrane receptors: the muscarinic receptor paradigm by Hulme, Edward C, Lu, Zhi-Liang, Ward, Stuart D.C, Allman, Karen, Curtis, Carol A.M

“…The rhodopsin-like superfamily of 7-transmembrane receptors is the largest class of signalling molecules in the mammalian genome. Recently, a combination of…”
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Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation by KUTERNBACH, E, CURTIS, C. A. M, PEDDER, E. K, AITKEN, A, HARRIS, A. C. M, HULME, E. C

“…Muscarinic acetylcholine receptors (mAChR) were purified from rat brain and labeled either with the site-directed affinity label [3H]propylbenzilylcholine…”
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The conformational switch in muscarinic acetylcholine receptors by Hulme, E.C., Lu, Z-L., Bee, M., Curtis, C.A.M., Saldanha, J.

“…The recently-determined structure of rhodopsin has provided a suitable basis for modeling the three-dimensional structure of the M 1 muscarinic acetylcholine…”
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Modification of the binding properties of muscarinic receptors by gallamine by Stockton, J M, Birdsall, N J, Burgen, A S, Hulme, E C

“…The interaction of gallamine with muscarinic receptors from different tissues has been investigated. Gallamine binds to a site distinct from the conventional…”
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Seven-transmembrane receptors: crystals clarify by Lu, Zhi-Liang, Saldanha, Jose W, Hulme, Edward C

“…The X-ray structure of the photoreceptor rhodopsin has provided the first atomic-resolution structure of a seven-transmembrane (7-TM) G-protein-coupled…”
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The binding of agonists to brain muscarinic receptors by Birdsall, N J, Burgen, A S, Hulme, E C

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Modulation of the structure‐binding relationships of antagonists for muscarinic acetylcholine receptor subtypes by Pedder, E. Kristina, Eveleigh, Phike, Poyner, David, Hulme, Edward C., Birdsall, Nigel J.M.

“…1 Membranes from rat cerebral cortex, myocardium and extraorbital lacrimal gland were used as sources of M1 M2 and M3 muscarinic acetylcholine receptors…”
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The existence of stable enantiomers of telenzepine and their stereoselective interaction with muscarinic receptor subtypes by Eveleigh, P, Hulme, E C, Schudt, C, Birdsall, N J

“…[3H]Telenzepine has been shown to bind with high affinity (3 x 10(9) M-1) to a subpopulation of muscarinic binding sites in rat cerebral cortex, which have a…”
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The functional role of the binding site aspartate in muscarinic acetylcholine receptors, probed by site-directed mutagenesis by Page, Karen M., Curtis, Carol A.M., Jones, Philip G., Hulme, Edward C.

“…Mutation of the Asp in transmembrane domain three of the muscarinic receptors to Asn (M 1) or Glu (M 1 and M 2) strongly reduced the high-affinity component of…”
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Phenotypic classification of mutants: a tool for understanding ligand binding and activation of muscarinic acetylcholine receptors by Hulme, E C, Bee, M S, Goodwin, J A

“…GPCRs (G-protein-coupled receptors) such as the M(1) muscarinic receptor have so far proved recalcitrant to direct structure determination. Nevertheless…”
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The character of the muscarinic receptors in different regions of the rat brain by Birdsall, N. J. M., Hulme, E. C., Burgen, Arnold Stanley Vincent

“…The binding characteristics of muscarinic receptors have been critically examined in six regions of the rat brain. The binding curves of antagonists are…”
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The binding of antagonists to brain muscarinic receptors by Hulme, E C, Birdsall, N J, Burgen, A S, Mehta, P

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