Search Results - "HUICHUN XU"

Inherited causes of clonal haematopoiesis in 97,691 whole genomes by Weinstock, Joshua S., Nandakumar, Satish K., Bao, Erik L., Szeto, Mindy D., Liao, Xiaotian, Nasser, Joseph, Laurie, Cecelia, Burugula, Bala Bharathi, Gibson, Christopher J., Lin, Amy E., Aguet, Francois, Ardlie, Kristin, Mitchell, Braxton D., Barnes, Kathleen C., Moscati, Arden, Redline, Susan, Psaty, Bruce M., Silverman, Edwin K., Weiss, Scott T., Palmer, Nicholette D., Vasan, Ramachandran S., Burchard, Esteban G., He, Jiang, Kaplan, Robert C., Smith, Nicholas L., Arnett, Donna K., Schwartz, David A., Guo, Xiuqing, Konkle, Barbara A., Custer, Brian, Peralta, Juan M., Gui, Hongsheng, Meyers, Deborah A., McGarvey, Stephen T., Chen, Ida Yii-Der, Shoemaker, M. Benjamin, Peyser, Patricia A., Broome, Jai G., Wang, Fei Fei, North, Kari E., Launer, Lenore J., Cade, Brian E., Bis, Joshua C., Cho, Michael H., Lasky-Su, Jessica, Bowden, Donald W., Cupples, L. Adrienne, Mak, Angel C. Y., Smith, Jennifer A., Kelly, Tanika N., Aslibekyan, Stella, Heckbert, Susan R., Tiwari, Hemant K., Yang, Ivana V., Heit, John A., Johnsen, Jill M., Curran, Joanne E., Wenzel, Sally E., Rao, Dabeeru C., Darbar, Dawood, Moon, Jee-Young, Tracy, Russell P., Buth, Erin J., Rafaels, Nicholas, Loos, Ruth J. F., Liu, Yongmei, Hou, Lifang, Lee, Jiwon, Kachroo, Priyadarshini, Freedman, Barry I., Levy, Daniel, Bielak, Lawrence F., Hixson, James E., Floyd, James S., Whitsel, Eric A., Ellinor, Patrick T., Irvin, Marguerite R., Fingerlin, Tasha E., Armasu, Sebastian M., Wheeler, Marsha M., Blangero, John, Williams, L. Keoki, Levy, Bruce D., Sheu, Wayne Huey-Herng, Roden, Dan M., Taylor, Kent D., Johnson, Andrew D., Auer, Paul L., Kooperberg, Charles, Laurie, Cathy C., Blackwell, Thomas W., Smith, Albert V., Lange, Ethan, Rotter, Jerome I., Kitzman, Jacob O., Lander, Eric S., Ebert, Benjamin L., Reiner, Alexander P., Jaiswal, Siddhartha, Kathiresan, Sekar

“…Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown 1 . The…”
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Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data by Wainschtein, Pierrick, Jain, Deepti, Zheng, Zhili, Cupples, L. Adrienne, Shadyab, Aladdin H., McKnight, Barbara, Shoemaker, Benjamin M., Mitchell, Braxton D., Psaty, Bruce M., Kooperberg, Charles, Liu, Ching-Ti, Albert, Christine M., Roden, Dan, Chasman, Daniel I., Darbar, Dawood, Lloyd-Jones, Donald M., Arnett, Donna K., Regan, Elizabeth A., Boerwinkle, Eric, Rotter, Jerome I., O’Connell, Jeffrey R., Yanek, Lisa R., de Andrade, Mariza, Allison, Matthew A., McDonald, Merry-Lynn N., Chung, Mina K., Fornage, Myriam, Chami, Nathalie, Smith, Nicholas L., Ellinor, Patrick T., Vasan, Ramachandran S., Mathias, Rasika A., Loos, Ruth J. F., Rich, Stephen S., Lubitz, Steven A., Heckbert, Susan R., Redline, Susan, Guo, Xiuqing, Chen, Y. -D Ida, Laurie, Cecelia A., Hernandez, Ryan D., McGarvey, Stephen T., Goddard, Michael E., Laurie, Cathy C., North, Kari E., Lange, Leslie A., Weir, Bruce S., Yengo, Loic, Yang, Jian, Visscher, Peter M.

“…Analyses of data from genome-wide association studies on unrelated individuals have shown that, for human traits and diseases, approximately one-third to…”
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Stroke genetics informs drug discovery and risk prediction across ancestries by Jürgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, He, Yunye, Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Parodi, Livia, Bae, Hee-Joon, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Cárcel-Márquez, Jara, Nygaard, Marianne, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Amouyel, Philippe, Bakker, Mark K., Bennett, David A., Bis, Joshua C., Bordes, Constance, Børte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., de Cid, Rafael, Ferreira, Leslie E., He, Jing, Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Konuma, Takahiro, Kumar, Amit, Launer, Lenore J., Lee, Keon-Joo, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Meitinger, Thomas, Mitchell, Braxton D., Morisaki, Takayuki, O’Donnell, Martin J., Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Schmidt, Carsten O., Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Tiwari, Hemant K., Wennberg, Patrik, Wilson, Peter W. F., Yang, Qiong, Yoon, Kyungheon, Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Ikram, Mohammad A., Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Kõrv, Janika, Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, Liman, Thomas, Ruigrok, Ynte M., Bastarache, Lisa, Damrauer, Scott M., Rotter, Jerome I., Niiranen, Teemu J., Walters, Robin G., Owolabi, Mayowa O., Huffman, Jennifer E., Kamatani, Yoichiro, Dichgans, Martin, Debette, Stephanie

“…Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of…”
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Genetic diversity fuels gene discovery for tobacco and alcohol use by Wang, Xingyan, Jang, Seon-Kyeong, Jiang, Yu, Khunsriraksakul, Chachrit, Addison, Clifton, Aliev, Fazil, Arnett, Donna K., Ashley-Koch, Allison E., Barr, R. Graham, Bielak, Lawrence F., Benjamin, Emelia J., Bis, Joshua C., Bjornsdottir, Gyda, Blangero, John, Chavan, Sameer, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Iona, Choquet, Hélène, Cole, John W., Cucca, Francesco, Dick, Danielle M., Fernandes Silva, Lilian, Fiorillo, Edoardo, Garrett, Melanie E., Glahn, David C., Gordon, Scott D., Gu, Dongfeng, Gudbjartsson, Daniel F., Hall, Michael E., Haller, Toomas, Harris, Kathleen Mullan, He, Jiang, Hewitt, John K., Hickie, Ian, Hidalgo, Bertha, Hokanson, John E., Hottenga, JoukeJan, Hwu, Chii-Min, Jee, Yon Ho, Joo, Yoonjung Y., Kamatani, Yoichiro, Kaplan, Robert C., Kelly, Tanika N., Kraft, Peter, Krauter, Kenneth, Laakso, Markku, Lasky-Su, Jessica, Li, Liming, Lloyd-Jones, Donald M., Mägi, Reedik, Manichaikul, Ani, Mathur, Ravi, Matoba, Nana, McArdle, Patrick F., Metspalu, Andres, Moll, Matthew, Montasser, May E., Nielsen, Jonas B., Oelsner, Elizabeth C., Orrù, Valeria, Palmer, Nicholette D., Park, S. Lani, Peters, Ulrike, Peters, Annette, Polderman, Tinca J. C., Rafaels, Nicholas, Reiner, Alex P., Roan, Carol, Rotter, Jerome I., Runarsdottir, Valgerdur, Saccone, Nancy L., Shadyab, Aladdin H., Shringarpure, Suyash S., Sicinski, Kamil, Smith, Jennifer A., Smith, Nicholas L., Sotoodehnia, Nona, Stallings, Michael C., Stefansson, Hreinn, Syed, Moin, Tal-Singer, Ruth, Telen, Marilyn J., Tiwari, Hemant, Wall, Tamara L., White, Wendy B., Whitfield, John B., Wiggins, Kerri L., Willemsen, Gonneke, Willer, Cristen J., Xu, Huichun, Yanek, Lisa R., Young, Kendra A., Yu, Bing, Zhao, Wei, Zöllner, Sebastian, Bierut, Laura J., Gagliano Taliun, Sarah A., Munafò, Marcus R., Liu, Dajiang J.

“…Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for…”
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Prediction of Angina Pectoris Events in Middle-Aged and Elderly People Using RR Interval Time Series in the Resting State: A Cohort Study Based on SHHS by Zhang, Xiaoyan, Xu, Huichun

“…Angina pectoris is associated with adverse cardiovascular events. In this study, a Bi-directional Long Short-Term Memory (Bi-LSTM) prediction model with the…”
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A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response by Luo, Yang, Kanai, Masahiro, Choi, Wanson, Li, Xinyi, Sakaue, Saori, Yamamoto, Kenichi, Ogawa, Kotaro, Gutierrez-Arcelus, Maria, Gregersen, Peter K., Stuart, Philip E., Elder, James T., Forer, Lukas, Schönherr, Sebastian, Fuchsberger, Christian, Smith, Albert V., Fellay, Jacques, Carrington, Mary, Haas, David W., Guo, Xiuqing, Palmer, Nicholette D., Chen, Yii-Der Ida, Rotter, Jerome I., Taylor, Kent D., Rich, Stephen S., Correa, Adolfo, Wilson, James G., Kathiresan, Sekar, Cho, Michael H., Metspalu, Andres, Esko, Tonu, Okada, Yukinori, Han, Buhm, McLaren, Paul J., Raychaudhuri, Soumya

“…Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts, particularly in the MHC, which has population-specific structure…”
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Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish by Lynch, Megan T, Maloney, Kristin A, Xu, Huichun, Perry, James A, Center, Regeneron Genetics, Shuldiner, Alan R, Mitchell, Braxton D

“…Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting…”
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Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures by Liu, Da-Zhi, Tian, Yingfang, Ander, Bradley P, Xu, Huichun, Stamova, Boryana S, Zhan, Xinhua, Turner, Renee J, Jickling, Glen, Sharp, Frank R

“…MicroRNAs (miRNAs) regulate gene expression and have a critical role in many biologic and pathologic processes. We hypothesized that miRNA expression profiles…”
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A Deep Proteome Analysis Identifies the Complete Secretome as the Functional Unit of Human Cardiac Progenitor Cells by Sharma, Sudhish, Mishra, Rachana, Bigham, Grace E, Wehman, Brody, Khan, Mohd M, Xu, Huichun, Saha, Progyaparamita, Goo, Young Ah, Datla, Srinivasa Raju, Chen, Ling, Tulapurkar, Mohan E, Taylor, Bradley S, Yang, Peixin, Karathanasis, Sotirios, Goodlett, David R, Kaushal, Sunjay

“…RATIONALE:Cardiac progenitor cells are an attractive cell type for tissue regeneration but their mechanism for myocardial remodeling is still unclear…”
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Clinical and Genetic Atrial Fibrillation Risk and Discrimination of Cardioembolic From Noncardioembolic Stroke by Weng, Lu-Chen, Khurshid, Shaan, Gunn, Sophia, Trinquart, Ludovic, Lunetta, Kathryn L., Xu, Huichun, Benjamin, Emelia J., Ellinor, Patrick T., Anderson, Christopher D., Lubitz, Steven A.

“…Stroke is a leading cause of death and disability worldwide. Atrial fibrillation (AF) is a common cause of stroke but may not be detectable at the time of…”
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Exploring the associations of tobacco smoking and serum cotinine levels with selected inflammatory markers in adults with HIV in South Africa by Peer, Nasheeta, Nguyen, Kim Anh, Peprah, Emmanuel, Xu, Huichun, Matsha, Tandi E., Chegou, Novel N., Kengne, Andre-Pascal

“…This study examined the associations between tobacco smoking and serum cotinine levels, an objective biochemical measure of tobacco smoke exposure, with…”
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Improved Model Predictive Current Control of Single-Phase Five-Level PWM Rectifier by Zhu, Yifeng, Yue, Hao, Zhao, Hailong, Xu, Huichun

“…In this paper, a single-phase five-level rectifier with coupled inductors is studied. First, a discrete mathematical model of a single-phase five-level…”
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Big Data Approaches to Phenotyping Acute Ischemic Stroke Using Automated Lesion Segmentation of Multi-Center Magnetic Resonance Imaging Data by Wu, Ona, Winzeck, Stefan, Giese, Anne-Katrin, Hancock, Brandon L, Etherton, Mark R, Bouts, Mark J.R.J, Donahue, Kathleen, Schirmer, Markus D, Irie, Robert E, Mocking, Steven J.T, McIntosh, Elissa C, Bezerra, Raquel, Kamnitsas, Konstantinos, Frid, Petrea, Wasselius, Johan, Cole, John W, Xu, Huichun, Holmegaard, Lukas, Jiménez-Conde, Jordi, Lemmens, Robin, Lorentzen, Eric, McArdle, Patrick F, Meschia, James F, Roquer, Jaume, Rundek, Tatjana, Sacco, Ralph L, Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Stanne, Tara M, Thijs, Vincent, Vagal, Achala, Woo, Daniel, Bevan, Stephen, Kittner, Steven J, Mitchell, Braxton D, Rosand, Jonathan, Worrall, Bradford B, Jern, Christina, Lindgren, Arne G, Maguire, Jane, Rost, Natalia S

“…BACKGROUND AND PURPOSE—We evaluated deep learning algorithms’ segmentation of acute ischemic lesions on heterogeneous multi-center clinical diffusion-weighted…”
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Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease by Peprah, Emmanuel, Xu, Huichun, Tekola-Ayele, Fasil, Royal, Charmaine D

“…Genomic research is one of the tools for elucidating the pathogenesis of diseases of global health relevance and paving the research dimension to clinical and…”
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Gene Expression Profiling of Blood for the Prediction of Ischemic Stroke by STAMOVA, Boryana, HUICHUN XU, KHOURY, Jane C, PANCIOLI, Arthur, JAUCH, Edward, BRODERICK, Joseph P, SHARP, Frank R, JICKLING, Glen, BUSHNELL, Cheryl, YINGFANG TIAN, ANDER, Bradley P, XINHUA ZHAN, DAZHI LIU, TURNER, Renee, ADAMCZYK, Peter

“…A blood-based biomarker of acute ischemic stroke would be of significant value in clinical practice. This study aimed to (1) replicate in a larger cohort our…”
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Blood-brain barrier breakdown and repair by Src after thrombin-induced injury by Liu, Da-Zhi, Ander, Bradley P., Xu, Huichun, Shen, Yan, Kaur, Pali, Deng, Wenbin, Sharp, Frank R.

“…Objective Thrombin mediates the life‐threatening cerebral edema that occurs after intracerebral hemorrhage. Therefore, we examined the mechanisms of…”
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Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program by Sarnowski, Chloé, Leong, Aaron, Raffield, Laura M., Wu, Peitao, de Vries, Paul S., DiCorpo, Daniel, Guo, Xiuqing, Xu, Huichun, Liu, Yongmei, Zheng, Xiuwen, Hu, Yao, Brody, Jennifer A., Goodarzi, Mark O., Hidalgo, Bertha A., Highland, Heather M., Jain, Deepti, Liu, Ching-Ti, Naik, Rakhi P., O’Connell, Jeffrey R., Perry, James A., Porneala, Bianca C., Selvin, Elizabeth, Wessel, Jennifer, Psaty, Bruce M., Curran, Joanne E., Peralta, Juan M., Blangero, John, Kooperberg, Charles, Mathias, Rasika, Johnson, Andrew D., Reiner, Alexander P., Mitchell, Braxton D., Cupples, L. Adrienne, Vasan, Ramachandran S., Correa, Adolfo, Morrison, Alanna C., Boerwinkle, Eric, Rotter, Jerome I., Rich, Stephen S., Manning, Alisa K., Dupuis, Josée, Meigs, James B.

“…Hemoglobin A1c (HbA1c) is widely used to diagnose diabetes and assess glycemic control in individuals with diabetes. However, nonglycemic determinants,…”
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Plasmodium falciparum gametocyte development 1 (Pfgdv1) and gametocytogenesis early gene identification and commitment to sexual development by Eksi, Saliha, Morahan, Belinda J, Haile, Yoseph, Furuya, Tetsuya, Jiang, Hongying, Ali, Omar, Xu, Huichun, Kiattibutr, Kirakorn, Suri, Amreena, Czesny, Beata, Adeyemo, Adebowale, Myers, Timothy G, Sattabongkot, Jetsumon, Su, Xin-zhuan, Williamson, Kim C

“…Malaria transmission requires the production of male and female gametocytes in the human host followed by fertilization and sporogonic development in the…”
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Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting by Bis, Joshua C, Smith, Albert Vernon, Saba, Yasaman, Luciano, Michelle, Bastin, Mark E, Lemmens, Robin, Ames, David, Chong, Elizabeth, van der Lugt, Aad, Jimenez-Conde, Jordi, Rundek, Tatjana, Arnett, Donna K, Jern, Christina, Johnson, Julie A, Benavente, Oscar R, Geerlings, Mirjam I, Tzourio, Christophe, Sachdev, Perminder S, Markus, Hugh S, Seshadri, Sudha, Anderson, Christopher D, de Bakker, Paul IW, Engström, Gunnar, Kissela, Brett M, Pera, Joanna, Soriano-Tárraga, Carolina, Stanne, Tara, Nyquist, Paul, Drazyk, Anna, Markus, Hugh, Chasman, Daniel, Elkind, Mitchell, Bijlenga, Philippe, Yue, Suo, Mateen, Farrah, Meschia, James, Pare, Guillaume, Klijn, Karin, Kamatani, Yoichiro, Tregouet, David, Carrera, Caty, Ruigrok, Ynte, Sargurupremraj, Murali, Liebeskind, David, Tan, Rhea, Broderick, Joseph, Sale, Michele, Konrad, Jan, Nordestgaard, Børge G, Psaty, Bruce M, Benn, Marianne, Farrall, Martin, Nalls, Mike, Oliveira, Sofia A, Becker, James T, Carlsson, Cynthia M, Carney, Regina M, Crocco, Elizabeth A, Faber, Kelley M, Farlow, Martin R, Farrer, Lindsay A, Gearing, Marla, Gilbert, John R, Hamilton-Nelson, Kara L, Haroutunian, Vahram, Huebinger, Ryan M, Kukull, Walter A, Lah, James J, Li, Ge, Lunetta, Kathryn L, Mack, Wendy J, Manly, Jennifer J, Masliah, Eliezer, Miller, Carol A, Pierce, Aimee, Potter, Huntington, Raj, Ashok, Sano, Mary, Spina, Salvatore, Tanzi, Rudolph E, Vinters, Harry V, Yu, Chang-En, Yu, Lei, Liu, Yongmei, Johnson, Andrew D, deStefano, Anita L, van Buchem, Mark A, Boerwinkle, Eric, de Craen, Anton J.M, Ibrahim-Verbaas, Carla A, Oostra, Ben A, Cupples, L Adrienne, Meisinger, Christa, Nambi, Vijay, Halperin, Eran, Orru, Marco, Ernst, Florian, Chilukoti, Ravi Kumar, Wilson, James F, Gudnason, Vilmundur

“…OBJECTIVETo explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts. METHODSWe performed meta-analyses…”
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Signatures of cardioembolic and large-vessel ischemic stroke by Jickling, Glen C., Xu, Huichun, Stamova, Boryana, Ander, Bradley P., Zhan, Xinhua, Tian, Yingfang, Liu, Dazhi, Turner, Renée J., Mesias, Matthew, Verro, Piero, Khoury, Jane, Jauch, Edward C., Pancioli, Arthur, Broderick, Joseph P., Sharp, Frank R.

“…Objective: The cause of stroke remains unknown or cryptogenic in many patients. We sought to determine whether gene expression signatures in blood can…”
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