Search Results - "HUGHES, O."

A clinically applicable approach to continuous prediction of future acute kidney injury by Tomašev, Nenad, Glorot, Xavier, Rae, Jack W., Zielinski, Michal, Askham, Harry, Saraiva, Andre, Mottram, Anne, Meyer, Clemens, Ravuri, Suman, Protsyuk, Ivan, Connell, Alistair, Hughes, Cían O., Karthikesalingam, Alan, Cornebise, Julien, Montgomery, Hugh, Rees, Geraint, Laing, Chris, Baker, Clifton R., Peterson, Kelly, Reeves, Ruth, Hassabis, Demis, King, Dominic, Suleyman, Mustafa, Back, Trevor, Nielson, Christopher, Ledsam, Joseph R., Mohamed, Shakir

“…The early prediction of deterioration could have an important role in supporting healthcare professionals, as an estimated 11% of deaths in hospital follow a…”
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Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration by Krauss, Raul, Bosanac, Todd, Devraj, Rajesh, Engber, Thomas, Hughes, Robert O.

“…Attempts to develop neuroprotective treatments for neurodegenerative disorders have not yet been clinically successful. Axonal degeneration has been recognized…”
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Clinically applicable deep learning for diagnosis and referral in retinal disease by De Fauw, Jeffrey, Ledsam, Joseph R., Romera-Paredes, Bernardino, Nikolov, Stanislav, Tomasev, Nenad, Blackwell, Sam, Askham, Harry, Glorot, Xavier, O’Donoghue, Brendan, Visentin, Daniel, van den Driessche, George, Lakshminarayanan, Balaji, Meyer, Clemens, Mackinder, Faith, Bouton, Simon, Ayoub, Kareem, Chopra, Reena, King, Dominic, Karthikesalingam, Alan, Hughes, Cían O., Raine, Rosalind, Hughes, Julian, Sim, Dawn A., Egan, Catherine, Tufail, Adnan, Montgomery, Hugh, Hassabis, Demis, Rees, Geraint, Back, Trevor, Khaw, Peng T., Suleyman, Mustafa, Cornebise, Julien, Keane, Pearse A., Ronneberger, Olaf

“…The volume and complexity of diagnostic imaging is increasing at a pace faster than the availability of human expertise to interpret it. Artificial…”
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Randomized Trial of Preventive Angioplasty in Myocardial Infarction by Wald, David S, Morris, Joan K, Wald, Nicholas J, Chase, Alexander J, Edwards, Richard J, Hughes, Liam O, Berry, Colin, Oldroyd, Keith G

“…Patients with acute STEMI were randomly assigned to undergo infarct-vessel-only PCI or preventive PCI (PCI to noninfarct arteries with stenoses). The rate of…”
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The Trojan hives: pollinator pathogens, imported and distributed in bumblebee colonies by Graystock, Peter, Yates, Kathryn, Evison, Sophie E. F., Darvill, Ben, Goulson, Dave, Hughes, William O. H.

“…1. Over a million commercially produced bumblebee colonies are imported annually on a global scale for the pollination of greenhouse crops. After importation,…”
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SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration by Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron, Ve, Thomas

“…Axon degeneration is a central pathological feature of many neurodegenerative diseases. Sterile alpha and Toll/interleukin-1 receptor motif-containing 1…”
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Parasites in bloom: flowers aid dispersal and transmission of pollinator parasites within and between bee species by Graystock, Peter, Goulson, Dave, Hughes, William O. H.

“…The dispersal of parasites is critical for epidemiology, and the interspecific vectoring of parasites when species share resources may play an underappreciated…”
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NAD + cleavage activity by animal and plant TIR domains in cell death pathways by Horsefield, Shane, Burdett, Hayden, Zhang, Xiaoxiao, Manik, Mohammad K, Shi, Yun, Chen, Jian, Qi, Tiancong, Gilley, Jonathan, Lai, Jhih-Siang, Rank, Maxwell X, Casey, Lachlan W, Gu, Weixi, Ericsson, Daniel J, Foley, Gabriel, Hughes, Robert O, Bosanac, Todd, von Itzstein, Mark, Rathjen, John P, Nanson, Jeffrey D, Boden, Mikael, Dry, Ian B, Williams, Simon J, Staskawicz, Brian J, Coleman, Michael P, Ve, Thomas, Dodds, Peter N, Kobe, Bostjan

“…SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD ) during Wallerian…”
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Thyroid hormone receptors mediate two distinct mechanisms of long-wavelength vision by Volkov, Leo I., Kim-Han, Jeong Sook, Saunders, Lauren M., Poria, Deepak, Hughes, Andrew E. O., Kefalov, Vladimir J., Parichy, David M., Corbo, Joseph C.

“…Thyroid hormone (TH) signaling plays an important role in the regulation of long-wavelength vision in vertebrates. In the retina, thyroid hormone receptor β…”
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Comparing second-line tests to assess fetal wellbeing in Labor: a feasibility study and pilot randomized controlled trial by Hughes, O., Murphy, D. J.

“…To explore the feasibility of conducting a randomized controlled trial (RCT) designed to compare the performance of digital fetal scalp stimulation (dFSS) and…”
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Ancestral Monogamy Shows Kin Selection Is Key to the Evolution of Eusociality by Hughes, William O. H., Oldroyd, Benjamin P., Beekman, Madeleine, Ratnieks, Francis L. W.

“…Close relatedness has long been considered crucial to the evolution of eusociality. However, it has recently been suggested that close relatedness may be a…”
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Validation and Clinical Applicability of Whole-Volume Automated Segmentation of Optical Coherence Tomography in Retinal Disease Using Deep Learning by Wilson, Marc, Chopra, Reena, Wilson, Megan Z, Cooper, Charlotte, MacWilliams, Patricia, Liu, Yun, Wulczyn, Ellery, Florea, Daniela, Hughes, Cían O, Karthikesalingam, Alan, Khalid, Hagar, Vermeirsch, Sandra, Nicholson, Luke, Keane, Pearse A, Balaskas, Konstantinos, Kelly, Christopher J

“…Quantitative volumetric measures of retinal disease in optical coherence tomography (OCT) scans are infeasible to perform owing to the time required for manual…”
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Molecular signatures of plastic phenotypes in two eusocial insect species with simple societies by Patalano, Solenn, Vlasova, Anna, Wyatt, Chris, Ewels, Philip, Camara, Francisco, Ferreira, Pedro G., Asher, Claire L., Jurkowski, Tomasz P., Segonds-Pichon, Anne, Bachman, Martin, González-Navarrete, Irene, Minoche, André E., Krueger, Felix, Lowy, Ernesto, Marcet-Houben, Marina, Rodriguez-Ales, Jose Luis, Nascimento, Fabio S., Balasubramanian, Shankar, Gabaldon, Toni, Tarver, James E., Andrews, Simon, Himmelbauer, Heinz, Hughes, William O. H., Guigó, Roderic, Reik, Wolf, Sumner, Seirian

“…Phenotypic plasticity is important in adaptation and shapes the evolution of organisms. However, we understand little about what aspects of the genome are…”
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Targeted agri-environment schemes significantly improve the population size of common farmland bumblebee species by Wood, Thomas J., Holland, John M., Hughes, William O. H., Goulson, Dave

“…Changes in agricultural practice across Europe and North America have been associated with range contractions and local extinction of bumblebees (Bombus spp.)…”
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The top 100 most cited manuscripts in bladder cancer: A bibliometric analysis (review article) by Mainwaring, A., Bullock, N., Ellul, T., Hughes, O., Featherstone, J.

“…Bladder cancer is one of the top 10 frequently occurring neoplasms worldwide and is responsible for over 150,000 deaths per annum. Bibliometric analysis helps…”
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Potential acetylcholine-based communication in honeybee haemocytes and its modulation by a neonicotinoid insecticide by Pamminger, Tobias, Basley, Kate, Goulson, Dave, Hughes, William O H

“…There is growing concern that some managed and wild insect pollinator populations are in decline, potentially threatening biodiversity and sustainable food…”
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Use of deep learning to develop continuous-risk models for adverse event prediction from electronic health records by Tomašev, Nenad, Harris, Natalie, Baur, Sebastien, Mottram, Anne, Glorot, Xavier, Rae, Jack W., Zielinski, Michal, Askham, Harry, Saraiva, Andre, Magliulo, Valerio, Meyer, Clemens, Ravuri, Suman, Protsyuk, Ivan, Connell, Alistair, Hughes, Cían O., Karthikesalingam, Alan, Cornebise, Julien, Montgomery, Hugh, Rees, Geraint, Laing, Chris, Baker, Clifton R., Osborne, Thomas F., Reeves, Ruth, Hassabis, Demis, King, Dominic, Suleyman, Mustafa, Back, Trevor, Nielson, Christopher, Seneviratne, Martin G., Ledsam, Joseph R., Mohamed, Shakir

“…Early prediction of patient outcomes is important for targeting preventive care. This protocol describes a practical workflow for developing deep-learning risk…”
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Emerging dangers: Deadly effects of an emergent parasite in a new pollinator host by Graystock, Peter, Yates, Kathryn, Darvill, Ben, Goulson, Dave, Hughes, William O.H.

“…[Display omitted] . •We investigate the status of the emergent honeybee parasite, Nosema ceranae, in bumblebees.•We molecularly identify the presence of N…”
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Maternal depression, stress and feeding styles: towards a framework for theory and research in child obesity by El-Behadli, Ana F., Sharp, Carla, Hughes, Sheryl O., Obasi, Ezemenari M., Nicklas, Theresa A.

“…Against the background of rising rates of obesity in children and adults in the USA, and modest effect sizes for obesity interventions, the aim of the present…”
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Horizontal Convection by HUGHES, Graham O, GRIFFITHS, Ross W

“…Differential heating along one horizontal boundary of a fluid-filled volume establishes an overturning circulation (horizontal convection) in the volume. The…”
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