Search Results - "HUGHES, N. K"

The Alpha-fetoprotein Promoter Is the Target of Afr1-Mediated Postnatal Repression by Peyton, David K., Huang, Mei-Chuan, Giglia, Meredith A., Hughes, Nedda K., Spear, Brett T.

“…The α-fetoprotein (AFP) gene is transcribed at high levels in the fetal liver and is repressed at birth, leading to low but detectable levels of AFP mRNA in…”
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Modulation of the haematopoietic toxicity associated with zidovudine in vivo with lithium carbonate by Gallicchio, V S, Hughes, N K, Tse, K F

“…The drug zidovudine (AZT), a synthetic thymidine analogue, has been used in the treatment of acquired immunodeficiency syndrome (AIDS). Clinical use of…”
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Failure to establish long-term marrow cultures from immunodeficient mice (MAIDS): effect of zidovudine in vitro by Tse, K F, Hughes, N K, Gallicchio, V S

“…We report here the results of studies examining the ability of zidovudine (AZT) to influence the establishment and maintenance of long-term marrow cultures…”
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Effect of lithium in murine immunodeficiency virus infected animals by Gallicchio, V S, Cibull, M L, Hughes, N K, Tse, K F

“…Murine AIDS (MAIDS) is a disease that shows many similarities to human HIV infection. The etiological agent of MAIDS is a defective murine leukemia virus that…”
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Effective use of ribonucleotide reductase inhibitors (Didox and Trimidox) alone or in combination with didanosine (ddI) to suppress disease progression and increase survival in murine acquired immunodeficiency syndrome (MAIDS) by Mayhew, C, Oakley, O, Piper, J, Hughes, N K, Phillips, J, Birch, N J, Elford, H L, Gallicchio, V S

“…Ribonucleotide reductase inhibitors (RRIs) have been recently shown to inhibit retroviral replication. We examined a new series of RRIs,…”
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Effect of interleukin-1, GM-CSF, erythropoietin, and lithium on the toxicity associated with 3'-azido-3'-deoxythymidine (AZT) in vitro on hematopoietic progenitors (CFU-GM, CFU-MEG, and BFU-E) using murine retrovirus-infected hematopoietic cells by Gallicchio, V S, Hughes, N K, Hulette, B C, Noblitt, L

“…The drug 3'-azido-3'-deoxythymidine (AZT), a synthetic thymidine analogue, has been used clinically in the management of acquired immune deficiency syndrome…”
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In vitro modulation of the toxicity associated with the use of zidovudine on normal murine, human, and murine retrovirus-infected hematopoietic progenitor stem cells with basic fibroblast growth factor and synergistic activity with interleukin-1 by Gallicchio, V S, Hughes, N K, Hulette, B C

“…The antiviral drug used in the treatment of acquired immunodeficiency syndrome, zidovudine, has proved effective in ameliorating the morbidity and mortality…”
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Effect of lithium in immunodeficiency: improved blood cell formation in mice with decreased hematopoiesis as the result of LP-BM5 MuLV infection by Gallicchio, Vincent S., Hughes, Nedda K., Tse, Kam-Fai, Ling, Jean, Birch, Nicholas J.

“…Lithium salts have been demonstrated to induce the production of hematopoietic cells following administration in vivo and to minimize the reduction of these…”
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Stromal Cell Lines Derived From LP-BM5 Murine Leukemia Virus-Infected Long-Term Bone Marrow Cultures Impair Hematopoiesis In Vitro by Tse, Kam-Fai, Morrow, Jennifer K., Hughes, Nedda K., Gallicchio, Vincent S.

“…Murine acquired immunodeficiency syndrome (MAIDS) induced by defective LP-BM5 murine leukemia virus is a disease with many similarities to human AIDS. Previous…”
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Protection of 3'-azido-3'-deoxythymidine induced toxicity to murine hematopoietic progenitors (CFU-GM, BFU-E and CFU-MEG) with interleukin-1 by Gallicchio, V S, Doukas, M A, Hulette, B C, Hughes, N K, Gass, C

“…3'-Azido-3'-deoxythymidine (AZT) has attained wide clinical utility in the treatment of acquired immunodeficiency syndrome (AIDS). Unfortunately, associated…”
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Effect of combination interleukin-1 and erythropoietin in ameliorating the hematopoietic toxicity associated with the use of zidovudine administered to normal mice by Gallicchio, V S, Hughes, N K, Tse, K F, Gaines, H

“…Use of the anti-viral drug zidovudine in the treatment of acquired immunodeficiency syndrome (AIDS) has been associated with the development of hematopoietic…”
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Prevention of the hematopoietic toxicity associated with zidovudine in vivo with IL-1 alone or in combination with GM-CSF administered to normal mice by Gallicchio, V S, Hughes, N K, Tse, K F, Gaines, H

“…We studied the effect of interleukin-1 (IL-1 alpha) either alone or administered with GM-CSF on the induction of hematopoietic toxicity associated with…”
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Reconstitution of erythroid, megakaryocyte and myeloid hematopoietic support function with neutralizing antibodies against IL-4 and TGF beta 1 in long-term bone marrow cultures infected with LP-BM5 murine leukemia virus by Tse, K F, Inayat, MS, Morrow, J K, Hughes, N K, Oakley, O R, Gallicchio, V S

“…Murine acquired immunodeficiency syndrome (MAIDS) induced by a defective LP-BM5 murine leukemia virus (MuLV) produces hematopoietic cytopenias similar to HIV…”
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Lithium and hematopoiesis: effective experimental use of lithium as an agent to improve bone marrow transplantation by Gallicchio, V S, Messino, M J, Hulette, B C, Hughes, N K

“…Bone marrow transplantation (BMT) has become a widely used procedure in the treatment of numerous hematological and non-hematological clinical disorders. The…”
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Effect of combination interleukin-3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF) on hematopoiesis administered to retrovirus-infected immunodeficient mice receiving dose-escalation zidovudine (AZT) by GALLICCHIO, V. S, HUGHES, N. K, KAM-FAI TSE, LING, J, GAINES, H, BOWEN, T. E, ULUITU, M

“…We have previously demonstrated that continuous administration of dose-escalation zidovudine (AZT) in either normal or LP-BM5 MuLV immunodeficient…”
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Basic fibroblast growth factor (bFGF) and its receptor expression ( bek and flg) In bone marrow stroma of murine AIDS by Tse, Kam-Fai, Inayat, Mohammed S, Morrow, Jennifer K, DellaPuca, Richard, Hughes, Nedda K, Gallicchio, Vincent S

“…Murine acquired immunodeficiency disease (MAIDS) induced by LPBM5 MuLV is characterized by a late-stage lymphoma and hematopoietic cytopenias similar to those…”
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Sustained zidovudine treatment on hematopoiesis in immunodeficient mice by Gallicchio, V S, Hughes, N K, Tse, K F

“…Zidovudine (AZT) has been the drug of choice in the treatment of human AIDS; however, associated with the use of zidovudine has been the development of…”
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Effective modulation of the haematopoietic toxicity associated with zidovudine exposure to murine and human haematopoietic progenitor stem cells in vitro with lithium chloride by Gallicchio, V S, Hughes, N K

“…The drug zidovudine (AZT), a synthetic thymidine analogue, has been used in the treatment of acquired immunodeficiency syndrome (AIDS). Clinical use of…”
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Suppression of murine hematopoiesis in vivo after chronic administration of zidovudine: evidence that zidovudine-induced anemia is the result of decreased bone marrow-derived, erythropoietin-responsive progenitor cells by Gallicchio, V S, Hughes, N K

“…We studied the long-term effect of continued zidovudine exposure in mice on hematopoiesis, as determined by peripheral blood indices, assays of erythroid…”
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Prevention of hematopoietic myeloid and megakaryocyte toxicity associated with zidovudine in vivo in mice with recombinant GM-CSF by Gallicchio, V S, Hughes, N K, Tse, K F

“…We studied the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on the suppression of hematopoiesis associated with the use of the antiviral…”
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