Search Results - "HUGHES, Christopher"

Applications of tumor chip technology by Hachey, Stephanie J, Hughes, Christopher C W

“…Over the past six decades the inflation-adjusted cost to bring a new drug to market has been increasing constantly and doubles every 9 years - now reaching in…”
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Engineering Vascularized Organoid-on-a-Chip Models by Shirure, Venktesh S, Hughes, Christopher C.W, George, Steven C

“…Recreating human organ-level function in vitro is a rapidly evolving field that integrates tissue engineering, stem cell biology, and microfluidic technology…”
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Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels by Wang, Xiaolin, Phan, Duc T T, Sobrino, Agua, George, Steven C, Hughes, Christopher C W, Lee, Abraham P

“…This paper reports a method for generating an intact and perfusable microvascular network that connects to microfluidic channels without appreciable leakage…”
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A Role for Partial Endothelial–Mesenchymal Transitions in Angiogenesis? by Welch-Reardon, Katrina M, Wu, Nan, Hughes, Christopher C.W

“…The contribution of epithelial-to-mesenchymal transitions (EMT) in both developmental and pathological conditions has been widely recognized and studied. In a…”
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A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications by Phan, Duc T T, Wang, Xiaolin, Craver, Brianna M, Sobrino, Agua, Zhao, Da, Chen, Jerry C, Lee, Lilian Y N, George, Steven C, Lee, Abraham P, Hughes, Christopher C W

“…There is a growing awareness that complex 3-dimensional (3D) organs are not well represented by monolayers of a single cell type - the standard format for many…”
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Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth by Romero-López, Mónica, Trinh, Andrew L, Sobrino, Agua, Hatch, Michaela M.S, Keating, Mark T, Fimbres, Cristhian, Lewis, David E, Gershon, Paul D, Botvinick, Elliot L, Digman, Michelle, Lowengrub, John S, Hughes, Christopher C.W

“…Abstract Extracellular matrix (ECM) is an essential and dynamic component of all tissues and directly affects cellular behavior by providing both mechanical…”
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Crosstalk Between Vascular Endothelial Growth Factor, Notch, and Transforming Growth Factor-β in Vascular Morphogenesis by Holderfield, Matthew T, Hughes, Christopher C.W

“…Vascular morphogenesis encompasses a temporally regulated set of morphological changes that endothelial cells undergo to generate a network of interconnected…”
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Single-pot, solid-phase-enhanced sample preparation for proteomics experiments by Hughes, Christopher S., Moggridge, Sophie, Müller, Torsten, Sorensen, Poul H., Morin, Gregg B., Krijgsveld, Jeroen

“…A critical step in proteomics analysis is the optimal extraction and processing of protein material to ensure the highest sensitivity in downstream detection…”
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Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering by Arulmoli, Janahan, Wright, Heather J., Phan, Duc T.T., Sheth, Urmi, Que, Richard A., Botten, Giovanni A., Keating, Mark, Botvinick, Elliot L., Pathak, Medha M., Zarembinski, Thomas I., Yanni, Daniel S., Razorenova, Olga V., Hughes, Christopher C.W., Flanagan, Lisa A.

“…[Display omitted] Human neural stem/progenitor cells (hNSPCs) are good candidates for treating central nervous system (CNS) trauma since they secrete…”
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A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays by Hsu, Yu-Hsiang, Moya, Monica L, Hughes, Christopher C W, George, Steven C, Lee, Abraham P

“…This paper reports a polydimethylsiloxane microfluidic model system that can develop an array of nearly identical human microtissues with interconnected…”
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Of Mice and Not Men: Differences between Mouse and Human Immunology by Mestas, Javier, Hughes, Christopher C. W

“…Mice are the experimental tool of choice for the majority of immunologists and the study of their immune responses has yielded tremendous insight into the…”
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3D microtumors in vitro supported by perfused vascular networks by Sobrino, Agua, Phan, Duc T. T., Datta, Rupsa, Wang, Xiaolin, Hachey, Stephanie J., Romero-López, Mónica, Gratton, Enrico, Lee, Abraham P., George, Steven C., Hughes, Christopher C. W.

“…There is a growing interest in developing microphysiological systems that can be used to model both normal and pathological human organs in vitro . This…”
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Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis by Hultgren, Nan W., Fang, Jennifer S., Ziegler, Mary E., Ramirez, Ricardo N., Phan, Duc T. T., Hatch, Michaela M. S., Welch-Reardon, Katrina M., Paniagua, Antonio E., Kim, Lin S., Shon, Nathan N., Williams, David S., Mortazavi, Ali, Hughes, Christopher C. W.

“…Slug ( SNAI2 ), a member of the well-conserved Snail family of transcription factors, has multiple developmental roles, including in epithelial-to-mesenchymal…”
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The vascular niche in next generation microphysiological systems by Ewald, Makena L, Chen, Yu-Hsi, Lee, Abraham P, Hughes, Christopher C W

“…In recent years, microphysiological system (MPS, also known as, organ-on-a-chip or tissue chip) platforms have emerged with great promise to improve the…”
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Extending the Compatibility of the SP3 Paramagnetic Bead Processing Approach for Proteomics by Moggridge, Sophie, Sorensen, Poul H, Morin, Gregg B, Hughes, Christopher S

“…The diversity in protein and peptide biochemistry necessitates robust protocols and reagents for efficiently handling and enriching these molecules prior to…”
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An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy by Hachey, Stephanie J, Movsesyan, Silva, Nguyen, Quy H, Burton-Sojo, Giselle, Tankazyan, Ani, Wu, Jie, Hoang, Tuyen, Zhao, Da, Wang, Shuxiong, Hatch, Michaela M, Celaya, Elizabeth, Gomez, Samantha, Chen, George T, Davis, Ryan T, Nee, Kevin, Pervolarakis, Nicholas, Lawson, Devon A, Kessenbrock, Kai, Lee, Abraham P, Lowengrub, John, Waterman, Marian L, Hughes, Christopher C W

“…Around 95% of anti-cancer drugs that show promise during preclinical study fail to gain FDA-approval for clinical use. This failure of the preclinical pipeline…”
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Organotypic stromal cells impact endothelial cell transcriptome in 3D microvessel networks by Curtis, Matthew B., Kelly, Natalie, Hughes, Christopher C. W., George, Steven C.

“…Endothelial cells line all major blood vessels and serve as integral regulators of many functions including vessel diameter, cellular trafficking, and…”
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Co-Occurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness by Marra, Annachiara, Pandharipande, Pratik P., Girard, Timothy D., Patel, Mayur B., Hughes, Christopher G., Jackson, James C., Thompson, Jennifer L., Chandrasekhar, Rameela, Ely, Eugene Wesley, Brummel, Nathan E.

“…To describe the frequency of co-occurring newly acquired cognitive impairment, disability in activities of daily livings, and depression among survivors of a…”
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Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients by McNeil, J Brennan, Hughes, Christopher G, Girard, Timothy, Ware, Lorraine B, Ely, E Wesley, Chandrasekhar, Rameela, Han, Jin H

“…Delirium's pathophysiology is poorly understood. We sought to determine if plasma biomarkers of inflammation, coagulation, endothelial activation, and blood…”
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In vitro perfused human capillary networks by Moya, Monica L, Hsu, Yu-Hsiang, Lee, Abraham P, Hughes, Christopher C W, George, Steven C

“…Replicating in vitro the complex in vivo tissue microenvironment has the potential to transform our approach to medicine and also our understanding of biology…”
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