Search Results - "HUFFNAGLE, Gary B"

The role of the microbiome in exacerbations of chronic lung diseases by Dickson, Robert P, MD, Martinez, Fernando J, Prof, Huffnagle, Gary B, Prof

“…Summary Culture-independent microbiological techniques have shown a previously unappreciated complexity to the bacterial microbiome of the respiratory tract…”
Get full text

The Lung Microbiome: New Principles for Respiratory Bacteriology in Health and Disease by Dickson, Robert P, Huffnagle, Gary B

“…  Numerous studies, dating back nearly a century, have demonstrated that microaspiration is common in healthy, asymptomatic subjects [2-5], and knowledge of…”
Get full text

The Microbiome and the Respiratory Tract by Dickson, Robert P, Erb-Downward, John R, Martinez, Fernando J, Huffnagle, Gary B

“…Although the notion that "the normal lung is free from bacteria" remains common in textbooks, it is virtually always stated without citation or argument. The…”
Get full text

The microbiome and regulation of mucosal immunity by McDermott, Andrew J., Huffnagle, Gary B.

“…Summary The gastrointestinal tract is a mucosal surface constantly exposed to foreign antigens and microbes, and is protected by a vast array of…”
Get full text

The Lung Microbiome during Health and Disease by Yagi, Kazuma, Huffnagle, Gary B., Lukacs, Nicholas W., Asai, Nobuhiro

“…Healthy human lungs have traditionally been considered to be a sterile organ. However, culture-independent molecular techniques have reported that large…”
Get full text

Interplay between Candida albicans and Lactic Acid Bacteria in the Gastrointestinal Tract: Impact on Colonization Resistance, Microbial Carriage, Opportunistic Infection, and Host Immunity by Zeise, Karen D, Woods, Robert J, Huffnagle, Gary B

“…Emerging studies have highlighted the disproportionate role of Candida albicans in influencing both early community assembly of the bacterial microbiome and…”
Get full text

The Lung Microbiota of Healthy Mice Are Highly Variable, Cluster by Environment, and Reflect Variation in Baseline Lung Innate Immunity by Dickson, Robert P, Erb-Downward, John R, Falkowski, Nicole R, Hunter, Ellen M, Ashley, Shanna L, Huffnagle, Gary B

“…The "gut-lung axis" is commonly invoked to explain the microbiome's influence on lung inflammation. Yet the lungs harbor their own microbiome, which is altered…”
Get full text

Bacterial Topography of the Healthy Human Lower Respiratory Tract by Dickson, Robert P, Erb-Downward, John R, Freeman, Christine M, McCloskey, Lisa, Falkowski, Nicole R, Huffnagle, Gary B, Curtis, Jeffrey L

“…Although culture-independent techniques have refuted lung sterility in health, controversy about contamination during bronchoscope passage through the upper…”
Get full text

Microbiology, genomics, and clinical significance of the Pseudomonas fluorescens species complex, an unappreciated colonizer of humans by Scales, Brittan S, Dickson, Robert P, LiPuma, John J, Huffnagle, Gary B

“…Pseudomonas fluorescens is not generally considered a bacterial pathogen in humans; however, multiple culture-based and culture-independent studies have…”
Get full text

The microbiome in wound repair and tissue fibrosis by Scales, Brittan S, Huffnagle, Gary B

“…Bacterial colonization occurs in all wounds, chronic or acute, and the break in epithelium integrity that defines a wound impairs the forces that shape and…”
Get full text

Analysis of the lung microbiome in the "healthy" smoker and in COPD by Erb-Downward, John R, Thompson, Deborah L, Han, Meilan K, Freeman, Christine M, McCloskey, Lisa, Schmidt, Lindsay A, Young, Vincent B, Toews, Galen B, Curtis, Jeffrey L, Sundaram, Baskaran, Martinez, Fernando J, Huffnagle, Gary B

“…Although culture-independent techniques have shown that the lungs are not sterile, little is known about the lung microbiome in chronic obstructive pulmonary…”
Get full text

Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection by Theriot, Casey M., Koenigsknecht, Mark J., Carlson, Paul E., Hatton, Gabrielle E., Nelson, Adam M., Li, Bo, Huffnagle, Gary B., Z. Li, Jun, Young, Vincent B.

“…Antibiotics can have significant and long-lasting effects on the gastrointestinal tract microbiota, reducing colonization resistance against pathogens…”
Get full text

Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis by O'Dwyer, David N, Ashley, Shanna L, Gurczynski, Stephen J, Xia, Meng, Wilke, Carol, Falkowski, Nicole R, Norman, Katy C, Arnold, Kelly B, Huffnagle, Gary B, Salisbury, Margaret L, Han, MeiLan K, Flaherty, Kevin R, White, Eric S, Martinez, Fernando J, Erb-Downward, John R, Murray, Susan, Moore, Bethany B, Dickson, Robert P

“…Idiopathic pulmonary fibrosis (IPF) causes considerable global morbidity and mortality, and its mechanisms of disease progression are poorly understood. Recent…”
Get full text

Mathematical modeling of primary succession of murine intestinal microbiota by Marino, Simeone, Baxter, Nielson T., Huffnagle, Gary B., Petrosino, Joseph F., Schloss, Patrick D.

“…Understanding the nature of interpopulation interactions in host-associated microbial communities is critical to understanding gut colonization, responses to…”
Get full text

Towards an ecology of the lung: new conceptual models of pulmonary microbiology and pneumonia pathogenesis by Dickson, Robert P, Dr, Erb-Downward, John R, PhD, Huffnagle, Gary B, PhD

“…Summary Pneumonia is a major cause of morbidity and mortality for which no new methods of treatment have entered clinical practice since the discovery of…”
Get full text

Lung Microbiota Predict Clinical Outcomes in Critically Ill Patients by Dickson, Robert P, Schultz, Marcus J, van der Poll, Tom, Schouten, Laura R, Falkowski, Nicole R, Luth, Jenna E, Sjoding, Michael W, Brown, Christopher A, Chanderraj, Rishi, Huffnagle, Gary B, Bos, Lieuwe D J

“…Recent studies have revealed that, in critically ill patients, lung microbiota are altered and correlate with alveolar inflammation. The clinical significance…”
Get full text

Application of a neutral community model to assess structuring of the human lung microbiome by Venkataraman, Arvind, Bassis, Christine M, Beck, James M, Young, Vincent B, Curtis, Jeffrey L, Huffnagle, Gary B, Schmidt, Thomas M

“…DNA from phylogenetically diverse microbes is routinely recovered from healthy human lungs and used to define the lung microbiome. The proportion of this DNA…”
Get full text

Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals by Bassis, Christine M, Erb-Downward, John R, Dickson, Robert P, Freeman, Christine M, Schmidt, Thomas M, Young, Vincent B, Beck, James M, Curtis, Jeffrey L, Huffnagle, Gary B

“…No studies have examined the relationships between bacterial communities along sites of the upper aerodigestive tract of an individual subject. Our objective…”
Get full text

Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET study by Han, MeiLan K, Dr, Zhou, Yueren, MS, Murray, Susan, ScD, Tayob, Nabihah, PhD, Noth, Imre, Prof, Lama, Vibha N, MD, Moore, Bethany B, Prof, White, Eric S, MD, Flaherty, Kevin R, MD, Huffnagle, Gary B, Prof, Martinez, Fernando J, Prof

“…Summary Background The role of the lung microbiome in the pathogenesis of idiopathic pulmonary fibrosis is unknown. We investigated whether unique microbial…”
Get full text

Macrophage M1/M2 polarization dynamically adapts to changes in cytokine microenvironments in Cryptococcus neoformans infection by Davis, Michael J, Tsang, Tiffany M, Qiu, Yafeng, Dayrit, Jeremy K, Freij, Joudeh B, Huffnagle, Gary B, Olszewski, Michal A

“…The outcome of cryptococcal pneumonia correlates with local macrophage polarization status, as M1 and M2 polarization marks protective and nonprotective…”
Get full text