Search Results - "HUBMAYR, Rolf D"

Transpulmonary Pressure: The Importance of Precise Definitions and Limiting Assumptions by Loring, Stephen H, Topulos, George P, Hubmayr, Rolf D

“…Recent studies applying the principles of respiratory mechanics to respiratory disease have used inconsistent and mutually exclusive definitions of the term…”
Get full text

Validation of an electronic surveillance system for acute lung injury by Herasevich, Vitaly, Yilmaz, Murat, Khan, Hasrat, Hubmayr, Rolf D., Gajic, Ognjen

“…Objective Early detection of acute lung injury (ALI) is essential for timely implementation of evidence-based therapies and enrollment into clinical trials. We…”
Get full text

Risk Factors and Outcomes in Transfusion-associated Circulatory Overload by Murphy, Edward L., MD, MPH, Kwaan, Nicholas, MPH, MD, Looney, Mark R., MD, Gajic, Ognjen, MD, Hubmayr, Rolf D., MD, Gropper, Michael A., MD, PhD, Koenigsberg, Monique, RN, Wilson, Greg, CCRP, Matthay, Michael, MD, Bacchetti, Peter, PhD, Toy, Pearl, MD

“…Abstract Background Transfusion-associated circulatory overload is characterized by new respiratory distress and hydrostatic pulmonary edema within 6 hours…”
Get full text

Intraoperative tidal volume as a risk factor for respiratory failure after pneumonectomy by FERNANDEZ-PEREZ, Evans R, KEEGAN, Mark T, BROWN, Daniel R, HUBMAYR, Rolf D, GAJIC, Ognjen

“…Respiratory failure is a leading cause of postoperative morbidity and mortality in patients undergoing pneumonectomy. The authors hypothesized that…”
Get full text

Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients by Khan, Hasrat, Belsher, Jon, Yilmaz, Murat, Afessa, Bekele, Winters, Jeffrey L, Moore, S Breanndan, Hubmayr, Rolf D, Gajic, Ognjen

“…Transfusion has long been identified as a risk factor for acute lung injury (ALI)/ARDS. No study has formally evaluated the transfusion of specific blood…”
Get more information

TRIM72 promotes alveolar epithelial cell membrane repair and ameliorates lung fibrosis by Cong, Xiaofei, Nagre, Nagaraja, Herrera, Jeremy, Pearson, Andrew C, Pepper, Ian, Morehouse, Robell, Ji, Hong-Long, Jiang, Dianhua, Hubmayr, Rolf D, Zhao, Xiaoli

“…Chronic tissue injury was shown to induce progressive scarring in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF), while an array of…”
Get full text

Ventilator settings as a risk factor for acute respiratory distress syndrome in mechanically ventilated patients by GAJIC, Ognjen, FRUTOS-VIVAR, Fernando, ESTEBAN, André, HUBMAYR, Rolf D, ANZUETO, Antonio

“…A single-center retrospective study initial recently identified ventilator settings as a major risk factor for the development of acute respiratory distress…”
Get full text

Pulmonary edema after transfusion: How to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury by Gajic, Ognjen, Gropper, Michael A, Hubmayr, Rolf D

“…OBJECTIVE:Pulmonary edema is an underrecognized and potentially serious complication of blood transfusion. Distinct mechanisms include adverse immune reactions…”
Get full text

Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions by Roubinian, Nareg H., Looney, Mark R., Kor, Daryl J., Lowell, Clifford A., Gajic, Ognjen, Hubmayr, Rolf D., Gropper, Michael A., Koenigsberg, Monique, Wilson, Gregory A., Matthay, Michael A., Toy, Pearl, Murphy, Edward L.

“…BACKGROUND Pulmonary transfusion reactions are important complications of blood transfusion, yet differentiating these clinical syndromes is diagnostically…”
Get full text

Point: Is Low Tidal Volume Mechanical Ventilation Preferred for All Patients on Ventilation? Yes by Hubmayr, Rolf D., MD, FCCP

Get full text

The physical basis of ventilator-induced lung injury by Plataki, Maria, Hubmayr, Rolf D

“…Although mechanical ventilation (MV) is a life-saving intervention for patients with acute respiratory distress syndrome (ARDS), it can aggravate or cause lung…”
Get more information

Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation by Gajic, Ognjen, Dara, Saqib I, Mendez, Jose L, Adesanya, Adebola O, Festic, Emir, Caples, Sean M, Rana, Rimki, St. Sauver, Jennifer L, Lymp, James F, Afessa, Bekele, Hubmayr, Rolf D

“…OBJECTIVE:Although ventilation with small tidal volumes is recommended in patients with established acute lung injury, most others receive highly variable…”
Get full text

The role of purinergic signaling on deformation induced injury and repair responses of alveolar epithelial cells by Belete, Hewan A, Hubmayr, Rolf D, Wang, Shaohua, Singh, Raman-Deep

“…Cell wounding is an important driver of the innate immune response of ventilator-injured lungs. We had previously shown that the majority of wounded alveolus…”
Get full text

Effect of 24-hour mandatory versus on-demand critical care specialist presence on quality of care and family and provider satisfaction in the intensive care unit of a teaching hospital by Gajic, Ognjen, Afessa, Bekele, Hanson, Andrew C, Krpata, Tami, Yilmaz, Murat, Mohamed, Shehab F, Rabatin, Jeffrey T, Evenson, Laura K, Aksamit, Timothy R, Peters, Steve G, Hubmayr, Rolf D, Wylam, Mark E

“…OBJECTIVE:The benefit of continuous on-site presence by a staff academic critical care specialist in the intensive care unit of a teaching hospital is not…”
Get full text

The Stability and Workload Index for Transfer score predicts unplanned intensive care unit patient readmission: Initial development and validation by Gajic, Ognjen, Malinchoc, Michael, Comfere, Thomas B, Harris, Marcelline R, Achouiti, Ahmed, Yilmaz, Murat, Schultz, Marcus J, Hubmayr, Rolf D, Afessa, Bekele, Farmer, J Christopher

“…OBJECTIVE:Unplanned readmission of hospitalized patients to an intensive care unit (ICU) is associated with a worse outcome, but our ability to identify who is…”
Get full text

TRIM72 is required for effective repair of alveolar epithelial cell wounding by Kim, Seong Chul, Kellett, Thomas, Wang, Shaohua, Nishi, Miyuki, Nagre, Nagaraja, Zhou, Beiyun, Flodby, Per, Shilo, Konstantin, Ghadiali, Samir N, Takeshima, Hiroshi, Hubmayr, Rolf D, Zhao, Xiaoli

“…The molecular mechanisms for lung cell repair are largely unknown. Previous studies identified tripartite motif protein 72 (TRIM72) from striated muscle and…”
Get more information

Spatiotemporal dynamics of actin remodeling and endomembrane trafficking in alveolar epithelial type I cell wound healing by Godin, Lindsay M, Vergen, Jorge, Prakash, Y S, Pagano, Richard E, Hubmayr, Rolf D

“…Alveolar epithelial type I cell (ATI) wounding is prevalent in ventilator-injured lungs and likely contributes to pathogenesis of "barotrauma" and "biotrauma."…”
Get more information

Ventilator settings and outcome of respiratory failure in chronic interstitial lung disease by Fernández-Pérez, Evans R, Yilmaz, Murat, Jenad, Hussam, Daniels, Craig E, Ryu, Jay H, Hubmayr, Rolf D, Gajic, Ognjen

“…While patients with interstitial lung disease (ILD) may be particularly susceptible to ventilator-induced lung injury, ventilator strategies have not been…”
Get more information

TRIM72 modulates caveolar endocytosis in repair of lung cells by Nagre, Nagaraja, Wang, Shaohua, Kellett, Thomas, Kanagasabai, Ragu, Deng, Jing, Nishi, Miyuki, Shilo, Konstantin, Oeckler, Richard A, Yalowich, Jack C, Takeshima, Hiroshi, Christman, John, Hubmayr, Rolf D, Zhao, Xiaoli

“…Alveolar epithelial and endothelial cell injury is a major feature of the acute respiratory distress syndrome, in particular when in conjunction with…”
Get more information

Endocytic response of type I alveolar epithelial cells to hypertonic stress by Wang, Shaohua, Singh, Raman Deep, Godin, Lindsay, Pagano, Richard E, Hubmayr, Rolf D

“…We present plasma membrane (PM) internalization responses of type I alveolar epithelial cells to a 50 mosmol/l increase in tonicity. Our research is motivated…”
Get more information