Search Results - "HUBERT, Philippe"

Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material by De Backer, Benjamin, Debrus, Benjamin, Lebrun, Pierre, Theunis, Laetitia, Dubois, Nathalie, Decock, Lies, Verstraete, Alain, Hubert, Philippe, Charlier, Corinne

“…GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms…”
Get full text

Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES) by Nabbout, Rima, Mazzuca, Michel, Hubert, Philippe, Peudennier, Sylviane, Allaire, Catherine, Flurin, Vincent, Aberastury, Marina, Silva, Walter, Dulac, Olivier

“…Summary Purpose:  Fever induced refractory epileptic encephalopathy in school age children (FIRES) is a devastating condition initiated by prolonged…”
Get full text

Raman chemical imaging, a new tool in kidney stone structure analysis: Case-study and comparison to Fourier Transform Infrared spectroscopy by Castiglione, Vincent, Sacré, Pierre-Yves, Cavalier, Etienne, Hubert, Philippe, Gadisseur, Romy, Ziemons, Eric

“…The kidney stone's structure might provide clinical information in addition to the stone composition. The Raman chemical imaging is a technology used for the…”
Get full text

Quantitative Structure Retention-Relationship Modeling: Towards an Innovative General-Purpose Strategy by Kumari, Priyanka, Van Laethem, Thomas, Hubert, Philippe, Fillet, Marianne, Sacré, Pierre-Yves, Hubert, Cédric

“…Reversed-Phase Liquid Chromatography (RPLC) is a common liquid chromatographic mode used for the control of pharmaceutical compounds during their drug life…”
Get full text

User-Driven Strategy for In Silico Screening of Reversed-Phase Liquid Chromatography Conditions for Known Pharmaceutical-Related Small Molecules by Van Laethem, Thomas, Kumari, Priyanka, Boulanger, Bruno, Hubert, Philippe, Fillet, Marianne, Sacré, Pierre-Yves, Hubert, Cédric

“…In the pharmaceutical field, and more precisely in quality control laboratories, robust liquid chromatographic methods are needed to separate and analyze…”
Get full text

Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatography by Dispas, Amandine, Desfontaine, Vincent, Andri, Bertyl, Lebrun, Pierre, Kotoni, Dorina, Clarke, Adrian, Guillarme, Davy, Hubert, Philippe

“…[Display omitted] •SFC is an alternative to European Pharmacopeia method LC method for salbutamol sulfate impurities determination.•Separation of salbutamol…”
Get full text

Optimisation of a Microwave Synthesis of Silver Nanoparticles by a Quality by Design Approach to Improve SERS Analytical Performances by Horne, Julie, Beckers, Pierre, Sacré, Pierre-Yves, De Bleye, Charlotte, Francotte, Pierre, Thelen, Nicolas, Hubert, Philippe, Ziemons, Eric, Hubert, Cédric

“…A major limitation preventing the use of surface-enhanced Raman scattering (SERS) in routine analyses is the signal variability due to the heterogeneity of…”
Get full text

Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration by Zgheib, Elias, Kim, Min Ji, Jornod, Florence, Bernal, Kévin, Tomkiewicz, Céline, Bortoli, Sylvie, Coumoul, Xavier, Barouki, Robert, De Jesus, Kelly, Grignard, Elise, Hubert, Philippe, Katsanou, Efrosini S., Busquet, Francois, Audouze, Karine

“…•Regulatory tests for EDC identification do not assess all the endocrine pathways.•We provide a state-of-the-art analysis of existing non-validated test…”
Get full text

ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors by Crouzet, Thibault, Grignard, Elise, Brion, François, Blanc, Etienne B., Podechard, Normand, Langouet, Sophie, Alonso-Magdalena, Paloma, Hubert, Philippe, Kim, Min Ji, Audouze, Karine

“…Growing evidence shows that endocrine disruptors (EDs), known to affect the reproductive system, may also disturb other hormone-regulated functions leading to…”
Get full text

A New Alternative Tool to Analyse Glycosylation in Monoclonal Antibodies Based on Drop-Coating Deposition Raman imaging: A Proof of Concept by Hamla, Sabrina, Sacré, Pierre-Yves, Derenne, Allison, Cowper, Ben, Goormaghtigh, Erik, Hubert, Philippe, Ziemons, Eric

“…Glycosylation is considered a critical quality attribute of therapeutic proteins as it affects their stability, bioactivity, and safety. Hence, the development…”
Get full text

A probabilistic class-modelling method based on prediction bands for functional spectral data: Methodological approach and application to near-infrared spectroscopy by Hermane, Avohou T., Pierre-Yves, Sacré, Pierre, Lebrun, Philippe, Hubert, Eric, Ziemons

“…Class-modelling methods aim to predict the conformity of new unknown samples with a single target class, using statistical decision rules built exclusively…”
Get full text

Analysis of recent pharmaceutical regulatory documents on analytical method validation by Rozet, Eric, Ceccato, Attilio, Hubert, Cédric, Ziemons, Eric, Oprean, Radu, Rudaz, Serge, Boulanger, Bruno, Hubert, Philippe

“…All analysts face the same situations as method validation is the process of proving that an analytical method is acceptable for its intended purpose. In order…”
Get full text

Kawasaki disease: an unexpected etiology of shock and multiple organ dysfunction syndrome by Gatterre, Pauline, Oualha, Mehdi, Dupic, Laurent, Iserin, Franck, Bodemer, Christine, Lesage, Fabrice, Hubert, Philippe

“…Objective Severe forms of Kawasaki disease (KD) associated with shock have recently been reported in which a greater number of coronary artery abnormalities…”
Get full text

Design space approach in the optimization of the spray-drying process by Lebrun, Pierre, Krier, Fabrice, Mantanus, Jérôme, Grohganz, Holger, Yang, Mingshi, Rozet, Eric, Boulanger, Bruno, Evrard, Brigitte, Rantanen, Jukka, Hubert, Philippe

“…Design Space representation of the spray-drying process under study. [Display omitted] ► The aim was to identify the Design Space of a spray-drying process. ►…”
Get full text

Posttraumatic Stress Reactions in Parents of Children Esophageal Atresia by Le Gouëz, Morgane, Alvarez, Luis, Rousseau, Véronique, Hubert, Philippe, Abadie, Véronique, Lapillonne, Alexandre, Kermorvant-Duchemin, Elsa

“…The aim of this study was to investigate psychological stress in parents of children with esophageal atresia and to explore factors associated with the…”
Get full text

Supercritical fluid chromatography: a promising alternative to current bioanalytical techniques by Dispas, Amandine, Jambo, Hugues, André, Sébastien, Tyteca, Eva, Hubert, Philippe

“…During the last years, chemistry was involved in the worldwide effort toward environmental problems leading to the birth of green chemistry. In this context,…”
Get full text

Comparison of Vibrational Spectroscopic Techniques for Quantification of Water in Natural Deep Eutectic Solvents by Elderderi, Suha, Sacré, Pierre-Yves, Wils, Laura, Chourpa, Igor, Elbashir, Abdalla A, Hubert, Philippe, Byrne, Hugh J, Boudesocque-Delaye, Leslie, Ziemons, Eric, Bonnier, Franck

“…Vibrational spectroscopic techniques, i.e., attenuated total reflectance infrared (ATR-IR), near infrared spectroscopy (NIRS) and Raman spectroscopy (RS),…”
Get full text

Regulatory Testing for Endocrine Disruptors; Need for Validated Methods and Integrated Approaches by Grignard, Elise, de Jesus, Kelly, Hubert, Philippe

Get full text

Perspective: What constitutes a quality paper in drug analysis? by Dispas, Amandine, Hubert, Cédric, Hubert, Philippe

“…[Display omitted]…”
Get full text

A new criterion to assess distributional homogeneity in hyperspectral images of solid pharmaceutical dosage forms by Sacré, Pierre-Yves, Lebrun, Pierre, Chavez, Pierre-François, Bleye, Charlotte De, Netchacovitch, Lauranne, Rozet, Eric, Klinkenberg, Régis, Streel, Bruno, Hubert, Philippe, Ziemons, Eric

“…[Display omitted] •DHI has been developed to assess distributional homogeneity in hyperspectral maps.•This criterion has been tested with simulated maps of…”
Get full text