Search Results - "HUBANK, M"

Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer by WANG, Q, WILLIAMSON, M, BOTT, S, BROOKMAN-AMISSAH, N, FREEMAN, A, NARICULAM, J, HUBANK, M. J. F, AHMED, A, MASTERS, J. R

“…Oligoarray analysis of a matched pair of prostate cancer and normal cell lines derived from the same radical prostatectomy specimen identified 113 candidate…”
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Results of the c-TRAK TN trial: a clinical trial utilising ctDNA mutation tracking to detect molecular residual disease and trigger intervention in patients with moderate- and high-risk early-stage triple-negative breast cancer by Turner, N.C., Swift, C., Jenkins, B., Kilburn, L., Coakley, M., Beaney, M., Fox, L., Goddard, K., Garcia-Murillas, I., Proszek, P., Hall, P., Harper-Wynne, C., Hickish, T., Kernaghan, S., Macpherson, I.R., Okines, A.F.C., Palmieri, C., Perry, S., Randle, K., Snowdon, C., Stobart, H., Wardley, A.M., Wheatley, D., Waters, S., Winter, M.C., Hubank, M., Allen, S.D., Bliss, J.M., S. Chan, Armstrong, A., Raja, F., Schmid, P., Tutt, A., Roux, R., Cleator, S.

“…Post-treatment detection of circulating tumour DNA (ctDNA) in early-stage triple-negative breast cancer (TNBC) patients predicts high risk of relapse. c-TRAK…”
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Targeting acute myeloid leukemia by drug-induced c-MYB degradation by Walf-Vorderwülbecke, V, Pearce, K, Brooks, T, Hubank, M, van den Heuvel-Eibrink, M M, Zwaan, C M, Adams, S, Edwards, D, Bartram, J, Samarasinghe, S, Ancliff, P, Khwaja, A, Goulden, N, Williams, G, de Boer, J, Williams, O

“…Despite advances in our understanding of the molecular basis for particular subtypes of acute myeloid leukemia (AML), effective therapy remains a challenge for…”
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Recommendations for a practical implementation of circulating tumor DNA mutation testing in metastatic non-small-cell lung cancer by Heitzer, E., van den Broek, D., Denis, M.G., Hofman, P., Hubank, M., Mouliere, F., Paz-Ares, L., Schuuring, E., Sültmann, H., Vainer, G., Verstraaten, E., de Visser, L., Cortinovis, D.

“…Liquid biopsy (LB) is a rapidly evolving diagnostic tool for precision oncology that has recently found its way into routine practice as an adjunct to tissue…”
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Effective Transplantation of Photoreceptor Precursor Cells Selected via Cell Surface Antigen Expression by Lakowski, J, Han, Y.‐T, Pearson, R.A, Gonzalez‐Cordero, A, West, E.L, Gualdoni, S, Barber, A.C, Hubank, M, Ali, R.R, Sowden, J.C

“…Retinal degenerative diseases are a major cause of untreatable blindness. Stem cell therapy to replace lost photoreceptors represents a feasible future…”
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Circulating tumour DNA is a potential biomarker for disease progression and response to targeted therapy in advanced thyroid cancer by Allin, D.M., Shaikh, R., Carter, P., Thway, K., Sharabiani, M.T.A., Gonzales-de-Castro, D., O'Leary, B., Garcia-Murillas, I., Bhide, S., Hubank, M., Harrington, K., Kim, D., Newbold, K.

“…Conventional biomarkers in thyroid cancer are not disease specific and fluctuate in advanced disease, making interpretation difficult. Circulating tumour DNA…”
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Eye on the B-ALL: B-cell receptor repertoires reveal persistence of numerous B-lymphoblastic leukemia subclones from diagnosis to relapse by Bashford-Rogers, R J M, Nicolaou, K A, Bartram, J, Goulden, N J, Loizou, L, Koumas, L, Chi, J, Hubank, M, Kellam, P, Costeas, P A, Vassiliou, G S

“…The strongest predictor of relapse in B-cell acute lymphoblastic leukemia (B-ALL) is the level of persistence of tumor cells after initial therapy. The high…”
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Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer by Harvey-Jones, E, Raghunandan, M, Robbez-Masson, L, Magraner-Pardo, L, Alaguthurai, T, Yablonovitch, A, Yen, J, Xiao, H, Brough, R, Frankum, J, Song, F, Yeung, J, Savy, T, Gulati, A, Alexander, J, Kemp, H, Starling, C, Konde, A, Marlow, R, Cheang, M, Proszek, P, Hubank, M, Cai, M, Trendell, J, Lu, R, Liccardo, R, Ravindran, N, Llop-Guevara, A, Rodriguez, O, Balmana, J, Lukashchuk, N, Dorschner, M, Drusbosky, L, Roxanis, I, Serra, V, Haider, S, Pettitt, S J, Lord, C J, Tutt, A N J

“…Resistance to therapies that target homologous recombination deficiency (HRD) in breast cancer limits their overall effectiveness. Multiple, preclinically…”
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Familial rare EGFR-mutant lung cancer syndrome: Review of literature and description of R776H family by Gabriel, L., McVeigh, T., Macmahon, S., Avila, Z., Donovan, L., Hunt, I., Draper, A., Minchom, A., Popat, S., Davidson, M., Bhosle, J., Milner Watts, C., Hubank, M., Yuan, L., O'Brien, MER

“…Interest in hereditary lung cancer is increasing, in particular germline mutations in the Epidermal Growth Factor Receptor (EGFR) gene. We review the current…”
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Circulating tumour DNA (ctDNA) as a tool to assess response and guide therapy adaptation in rectal cancer by Khakoo, S., Carter, P., Valeri, N., Shaikh, R., Jones, T., Begum, R., Rana, I., Picchia, S., Bali, M., Brown, G., Wotherspoon, A., Terlizzo, M., von Loga, K., Ahmed, I., Watkins, D., Chau, I., Starling, N., Tait, D., Hubank, M., Cunningham, D.

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The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors by de Boer, J, Yeung, J, Ellu, J, Ramanujachar, R, Bornhauser, B, Solarska, O, Hubank, M, Williams, O, Brady, H J M

“…The oncogenic fusion protein E2A–HLF is a chimeric transcription factor that arises from the t(17;19) translocation in childhood B-cell acute lymphoblastic…”
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Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes by Woodward, M J, de Boer, J, Heidorn, S, Hubank, M, Kioussis, D, Williams, O, Brady, H J M

“…Glucocorticoids have significant immunoregulatory actions on thymocytes and T cells and act by binding and activating cytosolic glucocorticoid receptors, which…”
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Identifying differences in mRNA expression by representational difference analysis of cDNA by Hubank, M., Schatz, D.G.

“…Detection of differentially regulated genes has been severely hampered by technical limitations. In an effort to overcome these problems, the PCR-coupled…”
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DNMT3A‐2 EXPRESSION LEVELS CHARACTERISE DIFFUSE LARGE B‐CELL LYMPHOMA WITH DISTINCT METHYLATION PATTERNS AND OUTCOME by Kuhnl, A., Shaikh, R., Cunningham, D., Counsell, N., Barrans, S., Burton, C., Bentley, M., Gleeson, M., Edwards, L., Ulrich, L., Smith, P., Clifton‐Hadley, L., Schofield, O., Lawrie, A., Linch, D., Hubank, M., Kaiser, M.

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rHVDM: an R package to predict the activity and targets of a transcription factor by Barenco, M., Papouli, E., Shah, S., Brewer, D., Miller, C.J., Hubank, M.

“…Highly parallel genomic platforms like microarrays often present researchers with long lists of differentially expressed genes but contain little or no…”
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KATP channel gene expression is induced by urocortin and mediates its cardioprotective effect by LAWRENCE, K. M, CHANALARIS, A, KNIGHT, R. A, LATCHMAN, D. S, SCARABELLI, T, HUBANK, M, PASINI, E, TOWNSEND, P. A, COMINI, L, FERRARI, R, TINKER, A, STEPHANOU, A

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Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium insensitive phospholipase A2 gene expression by Lawrence, Kevin M., Scarabelli, Tiziano M., Turtle, Lance, Chanalaris, Anastasios, Townsend, Paul A., Carroll, Christopher J., Hubank, Mike, Stephanou, Anastasis, Knight, Richard A., Latchman, David S.

“…ABSTRACT We have used Affymetrix gene chip technology to look for changes in gene expression caused by a 24 h exposure of rat primary neonatal cardiac myocytes…”
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Isolation and functional assessment of common, polymorphic variants of the B-MYB proto-oncogene associated with a reduced cancer risk by Schwab, R, Bussolari, R, Corvetta, D, Chayka, O, Santilli, G, Kwok, J M-M, Amorotti, G F, Tonini, G P, Iacoviello, L, Bertorelle, R, Menin, C, Hubank, M, Calabretta, B, Sala, A

“…The B-MYB proto-oncogene is a transcription factor belonging to the MYB family that is frequently overexpressed or amplified in different types of human…”
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Isolation and functional assessment of common, polymorphic variants of the B-MYB proto-oncogene associated with a reduced cancer risk by Schwab, R, Bussolari, R, Corvetta, D, Chayka, O, Santilli, G, Kwok, J M-M, Ferrari-Amorotti, G, Tonini, G P, Iacoviello, L, Bertorelle, R, Menin, C, Hubank, M, Calabretta, B, Sala, A

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Reconstructing gene networks: what are the limits? by Stark, J, Brewer, D, Barenco, M, Tomescu, D, Callard, R, Hubank, M

“…To fully realize the benefits of high-throughput post-genomic technologies it is necessary to reconstruct and analyse the complicated network of interactions…”
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