Search Results - "HUANG, William"

A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS by Huang, William Y C, Alvarez, Steven, Kondo, Yasushi, Lee, Young Kwang, Chung, Jean K, Lam, Hiu Yue Monatrice, Biswas, Kabir H, Kuriyan, John, Groves, Jay T

“…The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) is a key Ras activator that is autoinhibited in the cytosol and activates upon membrane…”
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Relating cellular signaling timescales to single-molecule kinetics: A first-passage time analysis of Ras activation by SOS by Huang, William Y. C., Alvarez, Steven, Kondo, Yasushi, Kuriyan, John, Groves, Jay T.

“…Son of Sevenless (SOS) is a Ras guanine nucleotide exchange factor (GEF) that plays a central role in numerous cellular signaling pathways. Like many other…”
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Cytoplasmic organization promotes protein diffusion in Xenopus extracts by Huang, William Y. C., Cheng, Xianrui, Ferrell, James E.

“…The cytoplasm is highly organized. However, the extent to which this organization influences the dynamics of cytoplasmic proteins is not well understood. Here,…”
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Membrane localization accelerates association under conditions relevant to cellular signaling by Huang, William Y C, Boxer, Steven G, Ferrell, Jr, James E

“…Translocation of cytoplasmic molecules to the plasma membrane is commonplace in cell signaling. Membrane localization has been hypothesized to increase…”
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Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner by Lowe, Alan R, Tang, Jeffrey H, Yassif, Jaime, Graf, Michael, Huang, William Y C, Groves, Jay T, Weis, Karsten, Liphardt, Jan T

“…Soluble karyopherins of the importin-β (impβ) family use RanGTP to transport cargos directionally through the nuclear pore complex (NPC). Whether impβ or…”
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Rosacea Pathogenesis by Ahn, Christine S., Huang, William W.

“…Rosacea is a chronic inflammatory skin disorder that is not fully understood but involves the complex interplay of genetic factors, immune dysregulation,…”
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Prediction of a positive surgical margin and biochemical recurrence after robot-assisted radical prostatectomy by Yang, Ching-Wei, Wang, Hsiao-Hsien, Hassouna, Mohamed Fayez, Chand, Manish, Huang, William J. S., Chung, Hsiao-Jen

“…The positive surgical margin (PSM) and biochemical recurrence (BCR) are two main factors associated with poor oncotherapeutic outcomes after prostatectomy…”
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Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice by Tang, Moon-shong, Wu, Xue-Ru, Lee, Hyun-Wook, Xia, Yong, Deng, Fang-Ming, Moreira, Andre L., Chen, Lung-Chi, Huang, William C., Lepor, Herbert

“…Electronic-cigarettes (E-cigs) are marketed as a safe alternative to tobacco to deliver the stimulant nicotine, and their use is gaining in popularity,…”
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A Prospective, Blinded Comparison of Magnetic Resonance (MR) Imaging–Ultrasound Fusion and Visual Estimation in the Performance of MR-targeted Prostate Biopsy: The PROFUS Trial by Wysock, James S, Rosenkrantz, Andrew B, Huang, William C, Stifelman, Michael D, Lepor, Herbert, Deng, Fang-Ming, Melamed, Jonathan, Taneja, Samir S

“…Abstract Background Increasing evidence supports the use of magnetic resonance (MR)–targeted prostate biopsy. The optimal method for such biopsy remains…”
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Coupled membrane lipid miscibility and phosphotyrosine-driven protein condensation phase transitions by Chung, Jean K., Huang, William Y.C., Carbone, Catherine B., Nocka, Laura M., Parikh, Atul N., Vale, Ronald D., Groves, Jay T.

“…Lipid miscibility phase separation has long been considered to be a central element of cell membrane organization. More recently, protein condensation phase…”
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The roles of aromatase inhibitors in treating hypogonadism and male infertility by Huang, William

“…Testis is an organ with both endocrine and exocrine functions. The former stands for testosterone release, and the latter represents sperm production…”
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E-cadherin junction formation involves an active kinetic nucleation process by Biswas, Kabir H., Hartman, Kevin L., Yu, Cheng-han, Harrison, Oliver J., Song, Hang, Smith, Adam W., Huang, William Y. C., Lin, Wan-Chen, Guo, Zhenhuan, Padmanabhan, Anup, Troyanovsky, Sergey M., Dustin, Michael L., Shapiro, Lawrence, Honig, Barry, Zaidel-Bar, Ronen, Groves, Jay T.

“…Epithelial (E)-cadherin-mediated cell−cell junctions play important roles in the development and maintenance of tissue structure in multicellular organisms…”
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Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS by Huang, William Y. C., Yan, Qingrong, Lin, Wan-Chen, Chung, Jean K., Hansen, Scott D., Christensen, Sune M., Tu, Hsiung-Lin, Kuriyan, John, Groves, Jay T.

“…The assembly of cell surface receptors with downstream signaling molecules is a commonly occurring theme in multiple signaling systems. However, little is…”
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Capturing the swelling of solid-electrolyte interphase in lithium metal batteries by Zhang, Zewen, Li, Yuzhang, Xu, Rong, Zhou, Weijiang, Li, Yanbin, Oyakhire, Solomon T, Wu, Yecun, Xu, Jinwei, Wang, Hansen, Yu, Zhiao, Boyle, David T, Huang, William, Ye, Yusheng, Chen, Hao, Wan, Jiayu, Bao, Zhenan, Chiu, Wah, Cui, Yi

“…Although liquid-solid interfaces are foundational in broad areas of science, characterizing this delicate interface remains inherently difficult because of…”
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Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation by Huang, William Y. C, Ditlev, Jonathon A, Chiang, Han-Kuei, Rosen, Michael K, Groves, Jay T

“…Tyrosine phosphorylation of membrane receptors and scaffold proteins followed by recruitment of SH2 domain-containing adaptor proteins constitutes a central…”
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E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells by Lee, Hyun-Wook, Park, Sung-Hyun, Weng, Mao-wen, Wang, Hsiang-Tsui, Huang, William C., Lepor, Herbert, Wu, Xue-Ru, Chen, Lung-Chi, Tang, Moon-shong

“…E-cigarette smoke delivers stimulant nicotine as aerosol without tobacco or the burning process. It contains neither carcinogenic incomplete combustion…”
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Stochastic geometry sensing and polarization in a lipid kinase–phosphatase competitive reaction by Hansen, Scott D., Huang, William Y. C., Lee, Young Kwang, Bieling, Peter, Christensen, Sune M., Groves, Jay T.

“…Phosphorylation reactions, driven by competing kinases and phosphatases, are central elements of cellular signal transduction. We reconstituted a native…”
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Improving cyclability of Li metal batteries at elevated temperatures and its origin revealed by cryo-electron microscopy by Wang, Jiangyan, Huang, William, Pei, Allen, Li, Yuzhang, Shi, Feifei, Yu, Xiaoyun, Cui, Yi

“…Operations of lithium-ion batteries have long been limited to a narrow temperature range close to room temperature. At elevated temperatures, cycling…”
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Three-dimensional Printing and Augmented Reality: Enhanced Precision for Robotic Assisted Partial Nephrectomy by Wake, Nicole, Bjurlin, Marc A., Rostami, Pooya, Chandarana, Hersh, Huang, William C.

“…To describe novel 3-dimensional (3D) printing and augmented reality (AR) methods of image data visualization to facilitate anatomic understanding and to assist…”
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H-Ras forms dimers on membrane surfaces via a protein—protein interface by Lin, Wan-Chen, Iversen, Lars, Tu, Hsiung-Lin, Rhodes, Christopher, Christensen, Sune M., Iwig, Jeffrey S., Hansen, Scott D., Huang, William Y. C., Groves, Jay T.

“…The lipid-anchored small GTPase Ras is an important signaling node in mammalian cells. A number of observations suggest that Ras is laterally organized within…”
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