Search Results - "HUANG, Ru Chih C"

Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01 by Kimura, Kotohiko, Huang, Ru Chih C

“…The ability of Tetra-O-methyl nordihydroguaiaretic acid (M4N) to induce rapid cell death in combination with Etoposide, Rapamycin, or UCN-01 was examined in…”
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Interaction and Collaboration of SP1, HIF-1, and MYC in Regulating the Expression of Cancer-Related Genes to Further Enhance Anticancer Drug Development by Kimura, Kotohiko, Jackson, Tiffany L. B., Huang, Ru Chih C.

“…Specificity protein 1 (SP1), hypoxia-inducible factor 1 (HIF-1), and MYC are important transcription factors (TFs). SP1, a constitutively expressed…”
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Tetra-O-methyl-nordihydroguaiaretic acid inhibits energy metabolism and synergistically induces anticancer effects with temozolomide on LN229 glioblastoma tumors implanted in mice while preventing obesity in normal mice that consume high-fat diets by Kimura, Kotohiko, Chun, Jong Ho, Lin, Yu-Ling, Liang, Yu-Chuan, Jackson, Tiffany L B, Huang, Ru Chih C

“…Tetra-O-methyl-nordihydroguaiaretic acid (terameprocol; M4N), a global transcription inhibitor, in combination with a second anticancer drug induces strong…”
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Immobilization of Growth Factors on Collagen Scaffolds Mediated by Polyanionic Collagen Mimetic Peptides and Its Effect on Endothelial Cell Morphogenesis by Wang, Allen Y, Leong, Shirley, Liang, Yu-Chuan, Huang, Ru Chih C, Chen, Christopher S, Yu, S. Michael

“…Angiogenesis, a morphogenic event endothelial cells (ECs) undergo in response to 3-D environmental triggers, is critical to the survival and ultimate…”
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Tetra-O-Methyl Nordihydroguaiaretic Acid Induces Growth Arrest and Cellular Apoptosis by Inhibiting Cdc2 and Survivin Expression by Chang, Chih-Chuan, Heller, Jonathan D., Kuo, Jennifer, Ru Chih C. Huang, Roseman, Saul

“…We previously reported that Sp1-dependent Cdc2 gene expression is inhibited by tetra-O-methyl nordihydroguaiaretic acid ( M4 N) and that M4 N is likely…”
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Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhiza by Abd-Elazem, Ibrahim S, Chen, Hong S, Bates, Robert B, Huang, Ru Chih C

“…Water soluble extracts of the herbal plant, Salvia miltiorrhiza (Danshen) exhibited potent effect against HIV-1 integrase activity in vitro and viral…”
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Systemic Treatment with Tetra-O-Methyl Nordihydroguaiaretic Acid Suppresses the Growth of Human Xenograft Tumors by PARK, Richard, CHANG, Chih-Chuan, LIANG, Yu-Chuan, CHUNG, Yousun, HENRY, Ryan A, LIN, Elaine, MOLD, David E, HUANG, Ru Chih C

“…Purpose: We have previously shown that the transcriptional inhibitor tetra- O -methyl nordihydroguaiaretic acid (M 4 N) induces growth arrest in tumor cells…”
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In vivo amelioration of endogenous antitumor autoantibodies via low-dose P₄N through the LTA4H/activin A/BAFF pathway by Lin, Yu-Ling, Tsai, Nu-Man, Hsieh, Cheng-Hao, Ho, Shu-Yi, Chang, Jung, Wu, Hsin-Yi, Hsu, Ming-Hua, Chang, Chia-Ching, Liao, Kuang-Wen, Jackson, Tiffany L. B., Mold, David E., Huang, Ru Chih C.

“…Cancer progression is associated with the development of antitumor autoantibodies in patients’ sera. Although passive treatment with antitumor antibodies has…”
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Cluster of genes encoding the major egg envelope protein of zebrafish by Mold, David E., Kim, Irene F., Tsai, Chuan-Mei, Lee, David, Chang, Chi-Yao, Huang, Ru Chih C.

“…The proteins of fish egg envelopes are encoded by genes that are closely related to the genes for human zona pellucida proteins. A cluster of three genes…”
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Inhibition of human immunodeficiency virus type 1 transcription and replication by DNA sequence-selective plant lignans by Gnabre, J N, Brady, J N, Clanton, D J, Ito, Y, Dittmer, J, Bates, R B, Huang, R C

“…A plant lignan, 3'-O-methyl nordihydroguaiaretic acid (3'-O-methyl NDGA, denoted Malachi 4:5-6 or Mal.4; molecular weight 316), was isolated from Larrea…”
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Glycosylated nordihydroguaiaretic acids as anti-cancer agents by Hwu, Jih Ru, Hsu, Chuan-I, Hsu, Ming-Hua, Liang, Yu-Chuan, Huang, Ru Chih C., Lee, Yuan C.

“…Perglycosylated nordihydroguaiaretic acids were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction, which possessed good water solubility and…”
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New nordihydroguaiaretic acid derivatives as anti-HIV agents by Hwu, Jih Ru, Hsu, Ming-Hua, Huang, Ru Chih C.

“…A series of new nordihydroguaiaretic acid derivatives were prepared and screened, which exhibited inhibitory activity against HIV. Reaction of…”
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First Total Syntheses of Oresbiusins A and B, Their Antipodes, and Racemates: Configuration Revision and Anti-HIV Activity by Hwu, Jih Ru, Varadaraju, Tirumala G., Abd-Elazem, Ibrahim S., Huang, Ru Chih C.

“…The first total syntheses of oresbiusin A in the (+)‐, (–)‐, and (±)‐forms were accomplished in five steps with overall yields of ca. 70 %. The key…”
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Hepatocellular Carcinoma Targeting Agents: Conjugates of Nitroimidazoles with Trimethyl Nordihydroguaiaretic Acid by Hsu, Ming-Hua, Wu, Szu-Chun, Pao, Kuan-Chuan, Unlu, Irem, Gnabre, John N., Mold, David E., Huang, Ru Chih C., Hwu, Jih Ru

“…Cancer has been a primary global health issue for decades, with hepatocellular carcinoma (HCC) resulting in more than half a million new cases annually. With…”
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Survivin-Dependent and -Independent Pathways and the Induction of Cancer Cell Death by Tetra- O-methyl Nordihydroguaiaretic Acid by Huang, Ru Chih C., Chang, Chih Chuan, Mold, David

“…The inhibitor of apoptosis protein (IAP) family encodes a group of Baculovirus IAP repeat domain (BIR)-containing proteins that suppress apoptosis. Some of the…”
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microfluidic-FCS platform for investigation on the dissociation of Sp1-DNA complex by doxorubicin by Yeh, Hsin-Chih, Puleo, Christopher M, Lim, Teck Chuan, Ho, Yi-Ping, Giza, Paul E, Huang, Ru Chih C, Wang, Tza-Huei

“…The transcription factor (TF) Sp1 is a well-known RNA polymerase II transcription activator that binds to GC-rich recognition sites in a number of essential…”
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Reversal of multidrug resistance by two nordihydroguaiaretic acid derivatives, M4N and maltose-M3N, and their use in combination with doxorubicin or paclitaxel by CHANG, Chih-Chuan, LIANG, Yu-Chuan, KLUTZ, Athena, HSU, Chuan-I, LIN, Chien-Fu, MOLD, David E, CHOU, Ting-Chao, YUAN CHUAN LEE, HUANG, Ru Chih C

“…Multidrug resistance (MDR) continues to be a major obstacle for successful anticancer therapy. One of the principal factors implicated in MDR is the over…”
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Tetra-o-methyl nordihydroguaiaretic acid induces G2 arrest in mammalian cells and exhibits tumoricidal activity in vivo by HELLER, Jonathan D, KUO, Jennifer, WU, T. C, KAST, W. Martin, HUANG, Ru Chih C

“…The transcription inhibitor tetra-O-methyl nordihydroguaiaretic acid (M4N) was found to arrest the proliferation of C3, C33a, CEM-T4, and TC-1 cells in culture…”
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Inhibition of human papillomavirus type 16 gene expression by nordihydroguaiaretic acid plant lignan derivatives by Craigo, Jodi, Callahan, Michelle, Huang, Ru Chih C, DeLucia, Angelo L

“…Several methylated derivatives of a plant lignan, nordihydroguaiaretic acid (NDGA) were found to be potent anti-viral agents by suppressing Sp1 regulated…”
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Antiviral Saponins from Tieghemella heckelii by GOSSE, Benjamin, GNABRE, John, BATES, Robert B., DICUS, Christopher W., NAKKIEW, Pichaya, HUANG, Ru Chih C.

“…Arganine C (1) and a new saponin, tieghemelin (2), were isolated from Tieghemella heckelii fruits. Arganine C (1) strongly inhibited HIV entry into cells in a…”
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