Search Results - "HUANG, Kenneth H"

Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents by Huang, Kenneth H, Veal, James M, Fadden, R. Patrick, Rice, John W, Eaves, Jeron, Strachan, Jon-Paul, Barabasz, Amy F, Foley, Briana E, Barta, Thomas E, Ma, Wei, Silinski, Melanie A, Hu, Mei, Partridge, Jeffrey M, Scott, Anisa, DuBois, Laura G, Freed, Tiffany, Steed, Paul M, Ommen, Andy J, Smith, Emilie D, Hughes, Philip F, Woodward, Angela R, Hanson, Gunnar J, McCall, W. Stephen, Markworth, Christopher J, Hinkley, Lindsay, Jenks, Matthew, Geng, Lifeng, Lewis, Meredith, Otto, James, Pronk, Bert, Verleysen, Katleen, Hall, Steven E

“…A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library…”
Get full text

Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90 by BARTA, Thomas E, VEAL, James M, BARABASZ, Amy F, FOLEY, Briana E, OTTO, James, HALL, Steven E, RICE, John W, PARTRIDGE, Jeffrey M, FADDEN, R. Patrick, WEI MA, JENKS, Matthew, LIFENG GENG, HANSON, Gunnar J, HUANG, Kenneth H

“…Hsp90 maintains the conformational stability of multiple proteins implicated in oncogenesis and has emerged as a target for chemotherapy. We report here the…”
Get full text

Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption by Huang, Kenneth H, Loutfy, Mona R, Tsoukas, Christos M, Bernard, Nicole F

“…The advantage of treatment interruptions (TIs) in salvage therapy remains controversial. Regardless, characterizations of the correlates of CD4 count fall…”
Get full text

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis by Rice, John W., Veal, James M., Fadden, R. Patrick, Barabasz, Amy F., Partridge, Jeffrey M., Barta, Thomas E., Dubois, Laura G., Huang, Kenneth H., Mabbett, Sarah R., Silinski, Melanie A., Steed, Paul M., Hall, Steven E.

“…Objective To evaluate the ability of SNX‐7081, a novel small molecule inhibitor of Hsp90, to block components of inflammation, including cytokine production,…”
Get full text

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90 by Huang, Kenneth H., Barta, Thomas E., Rice, John W., Smith, Emilie D., Ommen, Andy J., Ma, Wei, Veal, James M., Fadden, R. Patrick, Barabasz, Amy F., Foley, Briana E., Hughes, Philip F., Hanson, Gunnar J., Markworth, Christopher J., Silinski, Melanie, Partridge, Jeffrey M., Steed, Paul M., Hall, Steven E.

“…Compound affinity to Hsp90 in Kd and cellular activities in IC50. A novel class of Hsp90 inhibitors, structurally distinct from previously reported scaffolds,…”
Get full text

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90 by Fadden, Patrick, Huang, Kenneth H., Veal, James M., Steed, Paul M., Barabasz, Amy F., Foley, Briana, Hu, Mei, Partridge, Jeffrey M., Rice, John, Scott, Anisa, Dubois, Laura G., Freed, Tiffany A., Silinski, Melanie A. Rehder, Barta, Thomas E., Hughes, Philip F., Ommen, Andy, Ma, Wei, Smith, Emilie D., Spangenberg, Angela Woodward, Eaves, Jeron, Hanson, Gunnar J., Hinkley, Lindsay, Jenks, Matthew, Lewis, Meredith, Otto, James, Pronk, Gijsbertus J., Verleysen, Katleen, Haystead, Timothy A., Hall, Steven E.

“…A chemoproteomics-based drug discovery strategy is presented that utilizes a highly parallel screening platform, encompassing more than 1000 targets, with a…”
Get full text

Predictive value of immune parameters before treatment interruption (TI) for CD4+ T―cell count change during TI in HIV infection by HUANG, Kenneth H, LOUTFY, Mona R, BOULET, Salix, TOMA, Emil, TSOUKAS, Christos M, BERNARD, Nicole F

“…Despite the contraindications, stopping treatment for HIV infection continues to be a common practice. Understanding whether T-cell proliferative capacity and…”
Get full text

Spontaneous resolution of hepatitis C virus infection is not due to a mutation at Cys-508 of MAVS/VISA/IPS-1/CARDIF by Huang, Kenneth H, Bruneau, Julie, Shoukry, Naglaa, Bernard, Nicole F

Get full text

Longitudinal changes in HIV-specific IFN-gamma secretion in subjects who received Remune vaccination prior to treatment interruption by Huang, Kenneth H, Boisvert, Marie-Pierre, Chung, Famane, Loignon, Maude, Zarowny, Don, Cyr, Lise, Toma, Emil, Bernard, Nicole F

“…Despite the benefits of highly active antiretroviral therapy (HAART) for suppressing viral replication in HIV infection, virus persists and rebounds during…”
Get full text

Discovery of benzamide tetrahydro-4 H-carbazol-4-ones as novel small molecule inhibitors of Hsp90 by Barta, Thomas E., Veal, James M., Rice, John W., Partridge, Jeffrey M., Fadden, R. Patrick, Ma, Wei, Jenks, Matthew, Geng, Lifeng, Hanson, Gunnar J., Huang, Kenneth H., Barabasz, Amy F., Foley, Briana E., Otto, James, Hall, Steven E.

“…Hsp90 maintains the conformational stability of multiple proteins implicated in oncogenesis and has emerged as a target for chemotherapy. We report here the…”
Get full text