Search Results - "HUAIYONG CHEN"

Macrophages in Lung Injury, Repair, and Fibrosis by Cheng, Peiyong, Li, Shuangyan, Chen, Huaiyong

“…Fibrosis progression in the lung commonly results in impaired functional gas exchange, respiratory failure, or even death. In addition to the aberrant…”
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SARS-CoV-2 Infection and Lung Regeneration by Zhao, Fuxiaonan, Ma, Qingwen, Yue, Qing, Chen, Huaiyong

“…The lung is the primary site of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced immunopathology whereby the virus enters the host cells by…”
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Role and mechanisms of autophagy in lung metabolism and repair by Li, Xue, Zhao, Fuxiaonan, Wang, An, Cheng, Peiyong, Chen, Huaiyong

“…Mammalian lungs are metabolically active organs that frequently encounter environmental insults. Stress responses elicit protective autophagy in epithelial…”
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Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection by Wu, Qi, Zhou, Lina, Sun, Xin, Yan, Zhongfang, Hu, Chunxiu, Wu, Junping, Xu, Long, Li, Xue, Liu, Huiling, Yin, Peiyuan, Li, Kuan, Zhao, Jieyu, Li, Yanli, Wang, Xiaolin, Li, Yu, Zhang, Qiuyang, Xu, Guowang, Chen, Huaiyong

“…Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term…”
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Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice by Liang, Jiurong, Zhang, Yanli, Xie, Ting, Liu, Ningshan, Chen, Huaiyong, Geng, Yan, Kurkciyan, Adrianne, Mena, Jessica Monterrosa, Stripp, Barry R, Jiang, Dianhua, Noble, Paul W

“…Reduced hyaluronan–TLR4 signaling in a stem cell population of the lung contributes to a lack of renewal of these cells and promotes fibrosis in patients with…”
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Organoids as a Powerful Model for Respiratory Diseases by Shen, Jun, Sun, Xin, Wu, Qi, Li, Yu, Chen, Huaiyong

“…Insults to the alveoli usually lead to inefficient gas exchange or even respiratory failure, which is difficult to model in animal studies. Over the past…”
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Plasma proteomic and metabolomic characterization of COVID-19 survivors 6 months after discharge by Li, Hongwei, Li, Xue, Wu, Qian, Wang, Xing, Qin, Zhonghua, Wang, Yaguo, He, Yanbin, Wu, Qi, Li, Li, Chen, Huaiyong

“…Coronavirus disease 2019 (COVID-19) has gained prominence as a global pandemic. Studies have suggested that systemic alterations persist in a considerable…”
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A single-cell transcriptomic landscape of the lungs of patients with COVID-19 by Wang, Si, Yao, Xiaohong, Ma, Shuai, Ping, Yifang, Fan, Yanling, Sun, Shuhui, He, Zhicheng, Shi, Yu, Sun, Liang, Xiao, Shiqi, Song, Moshi, Cai, Jun, Li, Jiaming, Tang, Rui, Zhao, Liyun, Wang, Chaofu, Wang, Qiaoran, Zhao, Lei, Hu, Huifang, Liu, Xindong, Sun, Guoqiang, Chen, Lu, Pan, Guoqing, Chen, Huaiyong, Li, Qingrui, Zhang, Peipei, Xu, Yuanyuan, Feng, Huyi, Zhao, Guo-Guang, Wen, Tianzi, Yang, Yungui, Huang, Xuequan, Li, Wei, Liu, Zhenhua, Wang, Hongmei, Wu, Haibo, Hu, Baoyang, Ren, Yong, Zhou, Qi, Qu, Jing, Zhang, Weiqi, Liu, Guang-Hui, Bian, Xiu-Wu

“…The lung is the primary organ targeted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), making respiratory failure a leading coronavirus…”
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Plasma metabolomic characterization of SARS-CoV-2 Omicron infection by Li, Xue, Liu, Yimeng, Xu, Guiying, Xie, Yi, Wang, Ximo, Wu, Junping, Chen, Huaiyong

“…Omicron variants of SARS-CoV-2 have spread rapidly worldwide; however, most infected patients have mild or no symptoms. This study aimed to understand the host…”
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Prdm1 positively regulates liver Group 1 ILCs cancer immune surveillance and preserves functional heterogeneity by He, Jitian, Gao, Le, Wang, Peiying, Chan, Wing Keung, Zheng, Yiran, Zhang, Yumo, Sun, Jiaman, Li, Xue, Wang, Jiming, Li, Xiao-Hong, Chen, Huaiyong, Yang, Zhouxin, Wang, Youwei

“…Group 1 innate lymphoid cells (ILCs) comprise conventional natural killer (cNK) cells and type 1 innate lymphoid cells (ILC1s). The main functions of liver cNK…”
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Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea by Hou, Zhili, Wu, Qi, Sun, Xin, Chen, Huaiyong, Li, Yu, Zhang, Yongchun, Mori, Munemasa, Yang, Ying, Que, Jianwen, Jiang, Ming

“…Basal progenitor cells are crucial for the establishment and maintenance of the tracheal epithelium. However, it remains unclear how these progenitor cells are…”
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LKB1 deficiency upregulates RELM-α to drive airway goblet cell metaplasia by Li, Yu, Zhang, Qiuyang, Li, Li, Hao, De, Cheng, Peiyong, Li, Kuan, Li, Xue, Wang, Jianhai, Wang, Qi, Du, Zhongchao, Ji, Hongbin, Chen, Huaiyong

“…Targeting airway goblet cell metaplasia is a novel strategy that can potentially reduce the chronic obstructive pulmonary disease (COPD) symptoms. Tumor…”
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Particulate matter induces depression-like behavior through systemic inflammation and brain-derived neurotrophic factors by Li, Hui, Guo, Xiaoyu, Li, Pengxiang, Gao, Xinyu, Song, Xizi, Chen, Xinrui, Liang, Rong, Yang, Jiajia, Li, Yu, Chen, Huaiyong, Huang, Yongzhi, Zhang, Weiran, Sun, Quan, Chen, Liqun

“…framework of PM2.5 exposure induced depression in mice. [Display omitted] Particulate matter (PM) has always received widespread attention, PM2.5 pollution is…”
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Airway Epithelial Progenitors Are Region Specific and Show Differential Responses to Bleomycin-Induced Lung Injury by Chen, Huaiyong, Matsumoto, Keitaro, Brockway, Brian L., Rackley, Craig R., Liang, Jiurong, Lee, Joo-Hyeon, Jiang, Dianhua, Noble, Paul W., Randell, Scott H., Kim, Carla F., Stripp, Barry R.

“…Mechanisms that regulate regional epithelial cell diversity and pathologic remodeling in airways are poorly understood. We hypothesized that regional…”
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Airway epithelial regeneration requires autophagy and glucose metabolism by Li, Kuan, Li, Minmin, Li, Wenli, Yu, Hongzhi, Sun, Xin, Zhang, Qiuyang, Li, Yu, Li, Xue, Li, Yue, Abel, E. Dale, Wu, Qi, Chen, Huaiyong

“…Efficient repair of injured epithelium by airway progenitor cells could prevent acute inflammation from progressing into chronic phase in lung. Here, we used…”
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Niche-Dependent Regulation of Lkb1 in the Proliferation of Lung Epithelial Progenitor Cells by Ma, Qingwen, Li, Xue, Wang, Sisi, Wang, Qi, Li, Yu, Li, Kuan, Wang, Jianhai, Zhang, Qiuyang, Wu, Junping, Chen, Huaiyong

“…Lung homeostasis and regeneration depend on lung epithelial progenitor cells. (Liver Kinase B1) has known roles in the differentiation of airway epithelial…”
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Cellular metabolic basis of altered immunity in the lungs of patients with COVID-19 by Li, Shuangyan, Zhao, Fuxiaonan, Ye, Jing, Li, Kuan, Wang, Qi, Du, Zhongchao, Yue, Qing, Wang, Sisi, Wu, Qi, Chen, Huaiyong

“…Metabolic pathways drive cellular behavior. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes lung tissue damage directly by…”
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Survival Analysis of Risk Factors for Mortality in a Cohort of Patients with Tuberculosis by Li, Xue, Wu, Junping, Yu, Weili, Han, Jing, Xie, Yi, Chen, Huaiyong

“…Identify the treatment effects and risk factors for mortality in patients with pulmonary tuberculosis receiving antituberculosis treatment under the Directly…”
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Organoid technology and lung injury mouse models evaluating effects of hydroxychloroquine on lung epithelial regeneration by Zhao, Fuxiaonan, Wang, Jianhai, Wang, Qi, Hou, Zhili, Zhang, Yingchao, Li, Xue, Wu, Qi, Chen, Huaiyong

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) damages lung epithelial stem/progenitor cells. Ideal anti-SARS-CoV-2 drug candidates should be…”
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Effects of Acute and Chronic Inflammation on B-Cell Development and Differentiation by Cain, Derek, Kondo, Motonari, Chen, Huaiyong, Kelsoe, Garnett

“…Recently, our understanding of hematopoiesis and the development of the immune system has fundamentally changed, leading to significant discoveries with…”
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