Search Results - "HUABAO XIONG"

Regulation of iNOS on Immune Cells and Its Role in Diseases by Xue, Qingjie, Yan, Yingchun, Zhang, Ruihua, Xiong, Huabao

“…In recent years, there have been many studies on the function of nitric oxide synthase (NOS) in experimental animals and humans. This review analyzes and…”
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Roles of BTLA in Immunity and Immune Disorders by Ning, Zhaochen, Liu, Keyan, Xiong, Huabao

“…B and T lymphocyte attenuator (BTLA) is one of the most important cosignaling molecules. It belongs to the CD28 superfamily and is similar to programmed cell…”
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Implications of NKG2A in immunity and immune-mediated diseases by Wang, Xiaotong, Xiong, Huabao, Ning, Zhaochen

“…In recent studies, NKG2A is revealed to be a key immune checkpoint for both natural killer (NK) cells and CD8 + T cells. It form heterodimer receptors with…”
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The implications of FASN in immune cell biology and related diseases by Xiao, Yucai, Yang, Yonghong, Xiong, Huabao, Dong, Guanjun

“…Fatty acid metabolism, particularly fatty acid synthesis, is a very important cellular physiological process in which nutrients are used for energy storage and…”
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Transcriptional regulation on effector T cells in the pathogenesis of psoriasis by Qu, Yuying, Li, Dongmei, Xiong, Huabao, Shi, Dongmei

“…Psoriasis is one of the most common inflammatory diseases, characterized by scaly erythematous plaques on the skin. The accumulated evidence on immunopathology…”
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The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis by Geng, Shuo, Chen, Keqiang, Yuan, Ruoxi, Peng, Liang, Maitra, Urmila, Diao, Na, Chen, Chun, Zhang, Yao, Hu, Yuan, Qi, Chen-Feng, Pierce, Susan, Ling, Wenhua, Xiong, Huabao, Li, Liwu

“…Sustained low-grade inflammation mediated by non-resolving inflammatory monocytes has long been suspected in the pathogenesis of atherosclerosis; however, the…”
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Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals by Shan, Meimei, Gentile, Maurizio, Yeiser, John R., Walland, A. Cooper, Bornstein, Victor U., Chen, Kang, He, Bing, Cassis, Linda, Bigas, Anna, Cois, Montserrat, Comerma, Laura, Huang, Bihui, Blander, Magarian, Xiong, Huabao, Mayer, Lloyd, Berin, Cecilia, Augenlicht, Leonard H., Velcich, Anna, Cerutti, Andrea

“…A dense mucus layer in the large intestine prevents inflammation by shielding the underlying epithelium from luminal bacteria and food antigens. This mucus…”
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IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination by Bie, Qingli, Song, Hui, Chen, Xinke, Yang, Xiao, Shi, Shuo, Zhang, Lihua, Zhao, Rou, Wei, Li, Zhang, Baogui, Xiong, Huabao, Zhang, Bin

“…Cancer stem cells (CSCs) are characterized by robust self-renewal and tumorigenesis and are responsible for metastasis, drug resistance, and angiogenesis…”
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Link of sorafenib resistance with the tumor microenvironment in hepatocellular carcinoma: Mechanistic insights by Tian, Xinchen, Yan, Tinghao, Liu, Fen, Liu, Qingbin, Zhao, Jing, Xiong, Huabao, Jiang, Shulong

“…Sorafenib, a multi-kinase inhibitor with antiangiogenic, antiproliferative, and proapoptotic properties, is the first-line treatment for patients with…”
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Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization by Lu, Geming, Zhang, Ruihua, Geng, Shuo, Peng, Liang, Jayaraman, Padmini, Chen, Chun, Xu, Feifong, Yang, Jianjun, Li, Qin, Zheng, Hao, Shen, Kimberly, Wang, Juan, Liu, Xiyu, Wang, Weidong, Zheng, Zihan, Qi, Chen-Feng, Si, Chuanping, He, John Cijiang, Liu, Kebin, Lira, Sergio A., Sikora, Andrew G., Li, Liwu, Xiong, Huabao

“…Here we show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2…”
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Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation by Cheung, Ka Lung, Zhang, Fan, Jaganathan, Anbalagan, Sharma, Rajal, Zhang, Qiang, Konuma, Tsuyoshi, Shen, Tong, Lee, June-Yong, Ren, Chunyan, Chen, Chih-Hung, Lu, Geming, Olson, Matthew R., Zhang, Weijia, Kaplan, Mark H., Littman, Dan R., Walsh, Martin J., Xiong, Huabao, Zeng, Lei, Zhou, Ming-Ming

“…The BET proteins are major transcriptional regulators and have emerged as new drug targets, but their functional distinction has remained elusive. In this…”
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Pyruvate dehydrogenase kinase regulates macrophage polarization in metabolic and inflammatory diseases by Li, Chenyu, Liu, Chuanbin, Zhang, Junfeng, Lu, Yanyu, Jiang, Bingtong, Xiong, Huabao, Li, Chunxia

“…Macrophages are highly heterogeneous and plastic, and have two main polarized phenotypes that are determined by their microenvironment, namely pro- and…”
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D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF) by Merk, Melanie, Zierow, Swen, Leng, Lin, Das, Rituparna, Du, Xin, Schulte, Wibke, Fan, Juan, Lue, Hongqi, Chen, Yibang, Xiong, Huabao, Chagnon, Frederic, Bernhagen, Jürgen, Lolis, Elias, Mor, Gil, Lesur, Olivier, Bucala, Richard

“…Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the immune response. Neutralization or genetic deletion of MIF does not completely…”
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Human bone marrow-derived mesenchymal stem cells promote the growth and drug-resistance of diffuse large B-cell lymphoma by secreting IL-6 and elevating IL-17A levels by Zhong, Weijie, Zhu, Zhigang, Xu, Xin, Zhang, Hui, Xiong, Huabao, Li, Qingshan, Wei, Yaming

“…The drug-resistance and relapse of diffuse large B-cell lymphoma (DLBCL), which are related to mesenchymal stem cells (MSCs), have become increasingly common…”
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Vincristine upregulates PD-L1 and increases the efficacy of PD-L1 blockade therapy in diffuse large B-cell lymphoma by Wei, Ting, Li, Manjun, Zhu, Zhigang, Xiong, Huabao, Shen, Han, Zhang, Hui, Du, Qinghua, Li, Qingshan

“…Background Some chemotherapy drugs have immunomodulatory effects on specific tumors. The potential of vincristine (VCR) in the R-CHOP regimen to act as both a…”
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BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice by Cheung, Kalung, Lu, Geming, Sharma, Rajal, Vincek, Adam, Zhang, Ruihua, Plotnikov, Alexander N., Zhang, Fan, Zhang, Qiang, Ju, Ying, Hu, Yuan, Zhao, Li, Han, Xinye, Meslamani, Jamel, Xu, Feihong, Jaganathan, Anbalagan, Shen, Tong, Zhu, Hongfa, Rusinova, Elena, Zeng, Lei, Zhou, Jiachi, Yang, Jianjun, Peng, Liang, Ohlmeyer, Michael, Walsh, Martin J., Zhang, David Y., Xiong, Huabao, Zhou, Ming-Ming

“…T-helper 17 (Th17) cells have important functions in adaptor immunity and have also been implicated in inflammatory disorders. The bromodomain and…”
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Corilagin Ameliorates Con A-Induced Hepatic Injury by Restricting M1 Macrophage Polarization by Yan, Fenglian, Cheng, Dalei, Wang, Haiyan, Gao, Min, Zhang, Junfeng, Cheng, Hongyan, Wang, Changying, Zhang, Hui, Xiong, Huabao

“…Immune-mediated hepatic injury plays a key role in the initiation and pathogenesis of diverse liver diseases. However, treatment choice for immune-mediated…”
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A systems approach identifies HIPK2 as a key regulator of kidney fibrosis by Jin, Yuanmeng, Ratnam, Krishna, Chuang, Peter Y, Fan, Ying, Zhong, Yifei, Dai, Yan, Mazloom, Amin R, Chen, Edward Y, D'Agati, Vivette, Xiong, Huabao, Ross, Michael J, Chen, Nan, Ma'ayan, Avi, He, John Cijiang

“…HIV infection is often associated with severe nephropathy, including renal fibrosis. John He and his colleagues have used a systems biology approach in a mouse…”
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ACK1 Contributes to the Pathogenesis of Inflammation and Autoimmunity by Promoting the Activation of TLR Signaling Pathways by Jing, Lina, Zhang, Xin, Liu, Dong, Yang, Yonghong, Xiong, Huabao, Dong, Guanjun

“…Toll-like receptors (TLRs) are the first line of defense in the immune system, whose activation plays a key role in the pathogenesis of inflammation and…”
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SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment by Huang, Bo, Lei, Zhang, Zhang, Gui-Mei, Li, Dong, Song, Chuanwang, Li, Bo, Liu, Yanyan, Yuan, Ye, Unkeless, Jay, Xiong, Huabao, Feng, Zuo-Hua

“…Despite the evidence for the role of inflammation in cancer initiation, promotion, and progression, the precise mechanism by which the inflammation within…”
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