Search Results - "HSUEH, Eddy"

TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy by Li, Lingyun, Liu, Xia, Sanders, Katherine L., Edwards, James L., Ye, Jian, Si, Fusheng, Gao, Aiqin, Huang, Lan, Hsueh, Eddy C., Ford, David A., Hoft, Daniel F., Peng, Guangyong

“…Regulatory T (Treg) cells induce an immunosuppressive microenvironment that is a major obstacle for successful tumor immunotherapy. Dissecting the regulatory…”
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Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition by Liu, Xia, Mo, Wei, Ye, Jian, Li, Lingyun, Zhang, Yanping, Hsueh, Eddy C., Hoft, Daniel F., Peng, Guangyong

“…Defining the suppressive mechanisms used by regulatory T (Treg) cells is critical for the development of effective strategies for treating tumors and chronic…”
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Utility of PD-L1 immunohistochemistry assays for predicting PD-1/PD-L1 inhibitor response by Diggs, Laurence P, Hsueh, Eddy C

“…We have seen a notable increase in the application of PD-1/PD-L1 inhibitors for the treatment of several solid and hematogenous malignancies including…”
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Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy by Liu, Xia, Hartman, Celine L, Li, Lingyun, Albert, Carolyn J, Si, Fusheng, Gao, Aiqin, Huang, Lan, Zhao, Yangjing, Lin, Wenli, Hsueh, Eddy C, Shen, Lizong, Shao, Qixiang, Hoft, Daniel F, Ford, David A, Peng, Guangyong

“…The functional state of T cells is a key determinant for effective antitumor immunity and immunotherapy. Cellular metabolism, including lipid metabolism,…”
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Tumor Microenvironments Direct the Recruitment and Expansion of Human Th17 Cells by Su, Xinming, Ye, Jian, Hsueh, Eddy C, Zhang, Yanping, Hoft, Daniel F, Peng, Guangyong

“…Although Th17 cells play critical roles in the pathogenesis of many inflammatory and autoimmune diseases, their prevalence among tumor-infiltrating lymphocytes…”
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CD4+ and CD8+ T cells have opposing roles in breast cancer progression and outcome by Huang, Yi, Ma, Chunling, Zhang, Qunyuan, Ye, Jian, Wang, Fang, Zhang, Yanping, Hunborg, Pamela, Varvares, Mark A, Hoft, Daniel F, Hsueh, Eddy C, Peng, Guangyong

“…The Cancer Immunoediting concept has provided critical insights suggesting dual functions of immune system during the cancer initiation and development…”
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Tumor-infiltrating γδ T lymphocytes predict clinical outcome in human breast cancer by Ma, Chunling, Zhang, Qunyuan, Ye, Jian, Wang, Fang, Zhang, Yanping, Wevers, Eric, Schwartz, Theresa, Hunborg, Pamela, Varvares, Mark A, Hoft, Daniel F, Hsueh, Eddy C, Peng, Guangyong

“…Understanding and dissecting the role of different subsets of regulatory tumor-infiltrating lymphocytes (TILs) in the immunopathogenesis of individual cancer…”
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Tumor-Infiltrating gamma delta T Lymphocytes Predict Clinical Outcome in Human Breast Cancer by Ma, Chunling, Zhang, Qunyuan, Ye, Jian, Wang, Fang, Zhang, Yanping, Wevers, Eric, Schwartz, Theresa, Hunborg, Pamela, Varvares, Mark A, Hoft, Daniel F, Hsueh, Eddy C, Peng, Guangyong

“…Understanding and dissecting the role of different subsets of regulatory tumor-infiltrating lymphocytes (TILs) in the immunopathogenesis of individual cancer…”
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Tumor-Derived gamma delta Regulatory T Cells Suppress Innate and Adaptive Immunity through the Induction of Immunosenescence by Ye, Jian, Ma, Chunling, Hsueh, Eddy C, Eickhoff, Christopher S, Zhang, Yanping, Varvares, Mark A, Hoft, Daniel F, Peng, Guangyong

“…Fundamentally understanding the suppressive mechanisms used by different subsets of tumor-infiltrating regulatory T (Treg) cells is critical for the…”
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Tumor-derived γδ regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence by Ye, Jian, Ma, Chunling, Hsueh, Eddy C, Eickhoff, Christopher S, Zhang, Yanping, Varvares, Mark A, Hoft, Daniel F, Peng, Guangyong

“…Fundamentally understanding the suppressive mechanisms used by different subsets of tumor-infiltrating regulatory T (Treg) cells is critical for the…”
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Molecular risk prediction in cutaneous melanoma: A meta-analysis of the 31-gene expression profile prognostic test in 1,479 patients by Greenhaw, Bradley N., Covington, Kyle R., Kurley, Sarah J., Yeniay, Yildiray, Cao, Nhat Anh, Plasseraud, Kristen M., Cook, Robert W., Hsueh, Eddy C., Gastman, Brian R., Wei, Maria L.

“…Multiple studies have reported on the accuracy of the prognostic 31-gene expression profile test for cutaneous melanoma. Consistency of the test results across…”
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TLR8 signaling enhances tumor immunity by preventing tumor‐induced T‐cell senescence by Ye, Jian, Ma, Chunling, Hsueh, Eddy C, Dou, Jie, Mo, Wei, Liu, Shuai, Han, Bing, Huang, Yi, Zhang, Yanping, Varvares, Mark A, Hoft, Daniel F, Peng, Guangyong

“…Accumulating evidence suggests the immunosuppressive microenvironments created by malignant tumors represent a major obstacle for effective anti‐tumor…”
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Optimizing treatment approaches for patients with cutaneous melanoma by integrating clinical and pathologic features with the 31-gene expression profile test by Jarell, Abel, Gastman, Brian R., Dillon, Larry D., Hsueh, Eddy C., Podlipnik, Sebastian, Covington, Kyle R., Cook, Robert W., Bailey, Christine N., Quick, Ann P., Martin, Brian J., Kurley, Sarah J., Goldberg, Matthew S., Puig, Susana

“…Many patients with low-stage cutaneous melanoma will experience tumor recurrence, metastasis, or death, and many higher staged patients will not. To develop an…”
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Specific Recruitment of gamma delta Regulatory T Cells in Human Breast Cancer by Ye, Jian, Ma, Chunling, Wang, Fang, Hsueh, Eddy C, Toth, Karoly, Huang, Yi, Mo, Wei, Liu, Shuai, Han, Bing, Varvares, Mark A, Hoft, Daniel F, Peng, Guangyong

“…These findings rationalize the use of IL-10 antibodies to block migration of a class of T-regulatory cells into the breast cancer microenvironment, thereby…”
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SALL1 functions as a tumor suppressor in breast cancer by regulating cancer cell senescence and metastasis through the NuRD complex by Ma, Chunling, Wang, Fang, Han, Bing, Zhong, Xiaoli, Si, Fusheng, Ye, Jian, Hsueh, Eddy C, Robbins, Lynn, Kiefer, Susan M, Zhang, Yanping, Hunborg, Pamela, Varvares, Mark A, Rauchman, Michael, Peng, Guangyong

“…SALL1 is a multi-zinc finger transcription factor that regulates organogenesis and stem cell development, but the role of SALL1 in tumor biology and…”
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Deprivation of arginine by recombinant human arginase in prostate cancer cells by Hsueh, Eddy C, Knebel, Stephanie M, Lo, Wai-Hung, Leung, Yun-Chung, Cheng, Paul Ning-Man, Hsueh, Chung-Tsen

“…Recombinant human arginase (rhArg) has been developed for arginine deprivation therapy in cancer, and is currently under clinical investigation. During…”
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Increased Th17 cells in the tumor microenvironment is mediated by IL-23 via tumor-secreted prostaglandin E2 by Qian, Xuesong, Gu, Ling, Ning, Huan, Zhang, Yanping, Hsueh, Eddy C, Fu, Mingui, Hu, Xiaoyu, Wei, Lin, Hoft, Daniel F, Liu, Jianguo

“…Tumor cell-derived molecules such as cytokines and lipid mediators play a critical role in inducing chronic inflammation in the tumor microenvironment. We…”
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Interim analysis of survival in a prospective, multi-center registry cohort of cutaneous melanoma tested with a prognostic 31-gene expression profile test by Hsueh, Eddy C, DeBloom, James R, Lee, Jonathan, Sussman, Jeffrey J, Covington, Kyle R, Middlebrook, Brooke, Johnson, Clare, Cook, Robert W, Slingluff, Jr, Craig L, McMasters, Kelly M

“…A 31-gene expression profile (GEP) test that provides risk classification of cutaneous melanoma (CM) patients has been validated in several retrospective…”
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Human regulatory T cells induce T-lymphocyte senescence by Ye, Jian, Huang, Xingxu, Hsueh, Eddy C., Zhang, Qunyuan, Ma, Chunling, Zhang, Yanping, Varvares, Mark A., Hoft, Daniel F., Peng, Guangyong

“…Regulatory T (Treg) cells have broad suppressive activity on host immunity, but the fate and function of suppressed responder T cells remains largely unknown…”
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TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy by Ye, Jian, Wang, Yadan, Liu, Xia, Li, Lingyun, Opejin, Adeleye, Hsueh, Eddy C, Luo, Huanle, Wang, Tian, Hawiger, Daniel, Peng, Guangyong

“…Innate regulation through TLR signaling has been shown to be important for promoting T cell subset development and function. However, limited information is…”
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