Search Results - "HRABIE, Joseph A"

Chemistry of the Nitric Oxide-Releasing Diazeniumdiolate (“Nitrosohydroxylamine”) Functional Group and Its Oxygen-Substituted Derivatives by Hrabie, Joseph A, Keefer, Larry K

“…Hrabie and Keefer present a review of the chemistry of the atomic grouping of two nitrogens and two oxygens arranged as shown in resonance structures 1 and 2…”
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Nitric oxide and nanotechnology: A novel approach to inhibit neointimal hyperplasia by Kapadia, Muneera R., MD, Chow, Lesley W., BS, Tsihlis, Nick D., PhD, Ahanchi, Sadaf S., MD, Eng, Jason W, Murar, Jozef, BA, Martinez, Janet, AAS, Popowich, Daniel A., MD, Jiang, Qun, MD, Hrabie, Joseph A., PhD, Saavedra, Joseph E., PhD, Keefer, Larry K., PhD, Hulvat, James F., PhD, Stupp, Samuel I., PhD, Kibbe, Melina R., MD

“…Objective Nitric oxide (NO) has been shown to inhibit neointimal hyperplasia after arterial interventions in several animal models. To date, however, NO-based…”
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Nitric oxide delivery via a permeable balloon catheter inhibits neointimal growth after arterial injury by Havelka, George E., MD, Moreira, Edward S., PhD, Rodriguez, Monica P., MD, Tsihlis, Nick D., PhD, Wang, Zheng, Martínez, Janet, AAS, Hrabie, Joseph A., PhD, Kiefer, Larry K., PhD, Kibbe, Melina R., MD

“…Abstract Background Neointimal hyperplasia limits the longevity of vascular interventions. Nitric oxide (NO) is well known to inhibit neointimal hyperplasia…”
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Heightened efficacy of nitric oxide-based therapies in type II diabetes mellitus and metabolic syndrome by Ahanchi, Sadaf S, Varu, Vinit N, Tsihlis, Nick D, Martinez, Janet, Pearce, Charles G, Kapadia, Muneera R, Jiang, Qun, Saavedra, Joseph E, Keefer, Larry K, Hrabie, Joseph A, Kibbe, Melina R

“…Type II diabetes mellitus (DM) and metabolic syndrome are associated with accelerated restenosis following vascular interventions due to neointimal…”
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New nitric oxide-releasing zwitterions derived from polyamines by Hrabie, Joseph A, Klose, John R, Wink, David A, Keefer, Larry K

“…The reaction of nitric oxide (NO) with polyamines has been studied, resulting in the discovery of a new type of NO-releasing compound having the structure…”
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Augmentation of intrapericardial nitric oxide level by a prolonged-release nitric oxide donor reduces luminal narrowing after porcine coronary angioplasty by SANG HONG BAEK, HRABIE, Joseph A, KEEFER, Larry K, DONGMING HOU, FINEBERG, Naomi, RHOADES, Rodney, MARCH, Keith L

“…Nitric oxide (NO) is a potent vasodilator and antiplatelet agent that suppresses vascular smooth muscle cell proliferation. Hypothesizing that generating NO in…”
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Nitric Oxide-Releasing Polymers Containing the [N(O)NO]- Group by Smith, Daniel J, Chakravarthy, Debashish, Pulfer, Sharon, Simmons, Maia L, Hrabie, Joseph A, Citro, Michael L, Saavedra, Joseph E, Davies, Keith M, Hutsell, Thomas C, Mooradian, Daniel L, Hanson, Stephen R, Keefer, Larry K

“…Ions of structure X[N(O)NO]- display broad-spectrum pharmacological activity that correlates with the rate and extent of their spontaneous, first-order…”
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Beneficial effect of a short-acting NO donor for the prevention of neointimal hyperplasia by Pearce, Charles G., Najjar, Samer F., Kapadia, Muneera R., Murar, Jozef, Eng, Jason, Lyle, Brian, Aalami, Oliver O., Jiang, Qun, Hrabie, Joseph A., Saavedra, Joseph E., Keefer, Larry K., Kibbe, Melina R.

“…Nitric oxide (NO)-based therapies effectively inhibit neointimal hyperplasia in animal models of arterial injury and bypass grafting, but are not available…”
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Aminolysis of an N‑Diazeniumdiolated Amidine as an Approach to Diazeniumdiolated Ammonia by Biswas, Debanjan, Hrabie, Joseph A, Saavedra, Joseph E, Cao, Zhao, Keefer, Larry K, Ivanic, Joseph, Holland, Ryan J

“…Recent theoretical studies have suggested that the parent diazeniumdiolate ion, H2N–N­(O)NO– (“diazeniumdiolated ammonia”), might be stable enough to be…”
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Nitrogen-bound diazeniumdiolated amidines by Biswas, Debanjan, Deschamps, Jeffrey R, Keefer, Larry K, Hrabie, Joseph A

“…In contrast to amidines bearing ionizable alpha-CH bonds, which react with nitric oxide (NO) to add diazeniumdiolate groups at their alpha-carbons, benzamidine…”
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Nitric Oxide Reacts with Methoxide by DeRosa, Frank, Keefer, Larry K, Hrabie, Joseph A

“…Despite over a century of reports to the contrary, sodium methoxide has been found to react with nitric oxide (NO). The reaction, whose final organic product…”
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Nitric Oxide-Releasing Fabrics and Other Acrylonitrile-Based Diazeniumdiolates by DeRosa, Frank, Kibbe, Melina R, Najjar, Samer F, Citro, Michael L, Keefer, Larry K, Hrabie, Joseph A

“…Attachment of the diazeniumdiolate [−N(O)N−O−] functional group to polymers is of increasing interest pharmacologically for their ability to generate up to…”
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Nitric Oxide Releasing Polyurethanes with Covalently Linked Diazeniumdiolated Secondary Amines by Reynolds, Melissa M, Hrabie, Joseph A, Oh, Bong K, Politis, Jeffrey K, Citro, Michael L, Keefer, Larry K, Meyerhoff, Mark E

“…Two novel strategies for synthesizing stable polyurethanes (PUs) capable of generating bioactive nitric oxide (NO) are described. The methods rely on…”
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Conversion of Proteins to Diazeniumdiolate-Based Nitric Oxide Donors by Hrabie, Joseph A, Saavedra, Joseph E, Roller, Peter P, Southan, Garry J, Keefer, Larry K

“…Michael reaction of the methoxymethyl-protected monodiazeniumdiolate of piperazine (MOM-PIPERAZI/NO) with 4-maleimidobutyric acid followed by its conversion to…”
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Insulin enhances the effect of nitric oxide at inhibiting neointimal hyperplasia in a rat model of type 1 diabetes by Varu, Vinit N, Ahanchi, Sadie S, Hogg, Melissa E, Bhikhapurwala, Hussein A, Chen, Amy, Popowich, Daniel A, Vavra, Ashley K, Martinez, Janet, Jiang, Qun, Saavedra, Joseph E, Hrabie, Joseph A, Keefer, Larry K, Kibbe, Melina R

“…Diabetes confers greater restenosis from neointimal hyperplasia following vascular interventions. While localized administration of nitric oxide (NO) is known…”
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Diazeniumdiolate reactivity in model membrane systems by Dinh, Bach T., Price, Stacy E., Majul, Amr, El-Hajj, Mazen, Morozov, Victor, Hrabie, Joseph A., Davies, Keith M.

“…The effect of small unilamellar phospholipid vesicles on the acid-catalyzed dissociation of nitric oxide from diazeniumdiolate ions, R 1R 2N[N(O)NO] −, [ 1: R…”
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Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects by Maragos, Chris M, Morley, Deborah, Wink, David A, Dunams, Tambra M, Saavedra, Joseph E, Hoffman, Aaron, Bove, Alfred A, Isaac, Lawrence, Hrabie, Joseph A, Keefer, Larry K

“…Selected nucleophile/nitric oxide adducts [compounds which contain the anionic moiety, XN(O-)N = O] were studied for their ability to release nitric oxide…”
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Carbon-Bound Diazeniumdiolates from the Reaction of Nitric Oxide with Amidines by Hrabie, Joseph A, Citro, Michael L, Chmurny, Gwendolyn N, Keefer, Larry K

“…The enediamine tautomer of a variety of substituted amidine free bases reacts with nitric oxide (NO) to produce compounds containing a carbon-bound…”
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Piperazine as a Linker for Incorporating the Nitric Oxide-Releasing Diazeniumdiolate Group into Other Biomedically Relevant Functional Molecules by Saavedra, Joseph E, Booth, Melissa N, Hrabie, Joseph A, Davies, Keith M, Keefer, Larry K

“…Synthetic procedures have been devised to exploit the bifunctional amine piperazine (pip) as a linker capable of attaching the nitric oxide (NO)-releasing…”
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Effect of hydrophobic structure on the catalysis of nitric oxide release from zwitterionic diazeniumdiolates in surfactant and liposome media by Dinh, Bach, Dove, Kevin, Jappar, Dilara, Hrabie, Joseph A., Davies, Keith M.

“…The effect of phospholipid liposomes and surfactant micelles on the rate of nitric oxide release from zwitterionic diazeniumdiolates, R 1R 2N[N(O)NO] −, with…”
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