Search Results - "HRABETA, JAN"

Histone Deacetylase Inhibitors as Anticancer Drugs by Eckschlager, Tomas, Plch, Johana, Stiborova, Marie, Hrabeta, Jan

“…Carcinogenesis cannot be explained only by genetic alterations, but also involves epigenetic processes. Modification of histones by acetylation plays a key…”
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Drug Sequestration in Lysosomes as One of the Mechanisms of Chemoresistance of Cancer Cells and the Possibilities of Its Inhibition by Hraběta, Jan, Belhajová, Marie, Šubrtová, Hana, Merlos Rodrigo, Miguel Angel, Heger, Zbyněk, Eckschlager, Tomáš

“…Resistance to chemotherapeutics and targeted drugs is one of the main problems in successful cancer therapy. Various mechanisms have been identified to…”
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Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1 by Doktorova, Helena, Hrabeta, Jan, Khalil, Mohamed Ashraf, Eckschlager, Tomas

“…The aim of this review is to provide the information about molecular basis of hypoxia-induced chemoresistance, focusing on the possibility of diagnostic and…”
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Valproic Acid Increases CD133 Positive Cells that Show Low Sensitivity to Cytostatics in Neuroblastoma by Khalil, Mohamed Ashraf, Hraběta, Jan, Groh, Tomáš, Procházka, Pavel, Doktorová, Helena, Eckschlager, Tomáš

“…Valproic acid (VPA) is a well-known antiepileptic drug that exhibits antitumor activities through its action as a histone deacetylase inhibitor. CD133 is…”
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Anthracyclines and ellipticines as DNA-damaging anticancer drugs: recent advances by Kizek, Rene, Adam, Vojtech, Hrabeta, Jan, Eckschlager, Tomas, Smutny, Svatopluk, Burda, Jaroslav V, Frei, Eva, Stiborova, Marie

“…Over the past forty years, anthracyclines and ellipticines have attracted attention as promising cytostatics. In this review, we focus on their mechanisms of…”
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Nanodrugs used in cancer therapy by Kopeckova, Katerina, Eckschlager, Tomas, Sirc, Jakub, Hobzova, Radka, Plch, Johana, Hrabeta, Jan, Michalek, Jiri

“…Cancer despite the introduction of new targeted therapy remains for many patients a fatal disease. Nanotechnology in cancer medicine has emerged as a promising…”
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Apoferritin/Vandetanib Association Is Long-Term Stable But Does Not Improve Pharmacological Properties of Vandetanib by Jáklová, Kateřina, Feglarová, Tereza, Rex, Simona, Heger, Zbyněk, Eckschlager, Tomáš, Hraběta, Jan, Hodek, Petr, Kolárik, Matúš, Indra, Radek

“…A tyrosine kinase inhibitor, vandetanib (Van), is an anticancer drug affecting the signaling of VEGFR, EGFR and RET protooncogenes. Van is primarily used for…”
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MIAT Is an Upstream Regulator of NMYC and the Disruption of the MIAT/NMYC Axis Induces Cell Death in NMYC Amplified Neuroblastoma Cell Lines by Feriancikova, Barbara, Feglarova, Tereza, Krskova, Lenka, Eckschlager, Tomas, Vicha, Ales, Hrabeta, Jan

“…Neuroblastoma (NBL) is the most common extracranial childhood malignant tumor and represents a major cause of cancer-related deaths in infants. amplification…”
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Metallothioneins and cancer by Eckschlager, Tomas, Adam, Vojtech, Hrabeta, Jan, Figova, Katarina, Kizek, Rene

“…Metallothioneins (MTs) are low molecular, cysteine-rich proteins that have naturally-occurring Zn(2+) in both clusters. They may serve as a reservoir of metals…”
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Metallothioneins and zinc in cancer diagnosis and therapy by Krizkova, Sona, Ryvolova, Marketa, Hrabeta, Jan, Adam, Vojtech, Stiborova, Marie, Eckschlager, Tomas, Kizek, Rene

“…Metallothioneins (MTs) are involved in protection against oxidative stress (OS) and toxic metals and they participate in zinc metabolism and its homeostasis…”
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Overcoming multidrug resistance in Dox-resistant neuroblastoma cell lines via treatment with HPMA copolymer conjugates containing anthracyclines and P-gp inhibitors by Koziolová, Eva, Janoušková, Olga, Cuchalová, Lucie, Hvězdová, Zuzana, Hraběta, Jan, Eckschlager, Tomáš, Sivák, Ladislav, Ulbrich, Karel, Etrych, Tomáš, Šubr, Vladimír

“…Water-soluble N-(2-hydroxypropyl)methacrylamide copolymer conjugates bearing the anticancer drugs doxorubicin (Dox) or pirarubicin (THP), P-gp inhibitors…”
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Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells by Indra, Radek, Černá, Tereza, Heger, Zbyněk, Hraběta, Jan, Wilhelm, Marek, Dostálová, Simona, Lengálová, Alžběta, Martínková, Markéta, Adam, Vojtěch, Eckschlager, Tomáš, Schmeiser, Heinz H., Arlt, Volker M., Stiborová, Marie

“…Although ellipticine (Elli) is an efficient anticancer agent, it exerts several adverse effects. One approach to decrease the adverse effects of drugs is their…”
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Histone deacetylase inhibitors in cancer therapy. A review by Hrabeta, Jan, Stiborova, Marie, Adam, Vojtech, Kizek, Rene, Eckschlager, Tomas

“…Despite recent success toward discovery of more effective anticancer drugs, chemoresistance remains a major cause of treatment failure. There is emerging…”
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The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells by Cerna, Tereza, Hrabeta, Jan, Eckschlager, Tomas, Frei, Eva, Schmeiser, Heinz H, Arlt, Volker M, Stiborová, Marie

“…Neuroblastoma (NBL) originates from undifferentiated cells of the sympathetic nervous system. Chemotherapy is judged to be suitable for successful treatment of…”
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Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance by Hrabeta, Jan, Adam, Vojtech, Eckschlager, Tomas, Frei, Eva, Stiborova, Marie, Kizek, Rene

“…The history of metal based cytostatics began in the 1970s by discovering the effects of cisplatin. Since then several generations of platinum based cytostatics…”
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Multilayered Polyurethane/Poly(vinyl alcohol) Nanofibrous Mats for Local Topotecan Delivery as a Potential Retinoblastoma Treatment by Hobzova, Radka, Sirc, Jakub, Shrestha, Kusum, Mudrova, Barbora, Bosakova, Zuzana, Slouf, Miroslav, Munzarova, Marcela, Hrabeta, Jan, Feglarova, Tereza, Cocarta, Ana-Irina

“…Local chemotherapy using polymer drug delivery systems has the potential to treat some cancers, including intraocular retinoblastoma, which is difficult to…”
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The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells by Poljaková, Jitka, Eckschlager, Tomáš, Hraběta, Jan, Hřebačková, Jana, Smutný, Svatopluk, Frei, Eva, Martínek, Václav, Kizek, René, Stiborová, Marie

“…The plant constituent ellipticine forms DNA adducts detectable by 32P-postlabeling in the neuroblastoma cell line IMR-32. Adduct levels correlate with…”
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Hypoxia-mediated histone acetylation and expression of N-myc transcription factor dictate aggressiveness of neuroblastoma cells by POLJAKOVÁ, JITKA, GROH, TOMÁŠ, GUDINO, ŽANETA OMANA, HRABĚTA, JAN, BOŘEK-DOHALSKÁ, LUCIE, KIZEK, RENÉ, DOKTOROVÁ, HELENA, ECKSCHLAGER, TOMÁŠ, STIBOROVÁ, MARIE

“…Cells of solid malignancies generally adapt to entire lack of oxygen. Hypoxia induces the expression of several genes, which allows the cells to survive. For…”
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VPA does not enhance platinum binding to DNA in cisplatin-resistant neuroblastoma cancer cells by Raudenska, Martina, Krejcova, Ludmila, Richtera, Lukas, Heger, Zbynek, Hrabeta, Jan, Eckschlager, Tomas, Stiborova, Marie, Adam, Vojtech, Kratochvilova, Monika, Masarik, Michal, Gumulec, Jaromir

“…Neuroblastoma represents a malignancy of the sympathetic nervous system characteristic by biological heterogeneity. Thus, chemotherapy exhibits only low…”
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Valproic acid overcomes hypoxia-induced resistance to apoptosis by CIPRO, ŠIMON, HŘEBAČKOVÁ, JANA, HRABĚTA, JAN, POLJAKOVÁ, JITKA, ECKSCHLAGER, TOMÁŠ

“…Valproic acid (VPA), a histone deacetylase inhibitor (HDACi), has been shown to be an effective tool in cancer treatment. Although its ability to induce…”
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