Search Results - "HOYLAERTS, M.F."

Passage of inhaled particles into the blood circulation in humans by NEMMAR, A, HOET, P. H. M, VANQUICKENBORNE, B, DINSDALE, D, THOMEER, M, HOYLAERTS, M. F, VANBILLOEN, H, MORTELMANS, L, NEMERY, B

“…Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these…”
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Effect of the presence of cholesterol in the interfacial microenvironment on the modulation of the alkaline phosphatase activity during in vitro mineralization by Favarin, B.Z., Andrade, M.A.R., Bolean, M., Simão, A.M.S., Ramos, A.P., Hoylaerts, M.F., Millán, J.L., Ciancaglini, P.

“…[Display omitted] •The composition of the lipid interface affects the kinetic behavior of the enzyme.•The presence of cholesterol increased the penetration of…”
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Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization by COSEMANS, J. M. E. M., VAN KRUCHTEN, R., OLIESLAGERS, S., SCHURGERS, L. J., VERHEYEN, F. K., MUNNIX, I. C. A., WALTENBERGER, J., ANGELILLO‐SCHERRER, A., HOYLAERTS, M. F., CARMELIET, P., HEEMSKERK, J. W. M.

“…Background: Interaction of murine Gas6 with the platelet Gas6 receptors Tyro3, Axl and Mer (TAM) plays an important role in arterial thrombus formation…”
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Ambient air pollution and acute myocardial infarction by VERMYLEN, J., NEMMAR, A., NEMERY, B., HOYLAERTS, M. F.

“…This review summarizes the nature of ambient air pollutants, which are either gaseous or particulate of various sizes, the latter determining their penetration…”
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Enhanced peripheral thrombogenicity after lung inflammation is mediated by platelet–leukocyte activation: role of P‐selectin by NEMMAR, A., HOET, P. H. M., VANDERVOORT, P., DINSDALE, D., NEMERY, B., HOYLAERTS, M. F.

“…Background: Inhaled ultrafine particles trigger peripheral thrombotic complications. Methods: We have analyzed the systemic prothrombotic risk following lung…”
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Matrix vesicles' biomimetic systems: Effect of pH on the regulation of phosphate production by physiological substrates hydrolysis by Simão, A.M.S, Bolean, M, Hoylaerts, M.F, Millán, J.L, Ciancaglini, P

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Partial versus complete factor VIII inhibition in a mouse model of venous thrombosis by Emmerechts, J, Vanassche, T, Loyen, S, Van Linthout, I, Cludts, K, Kauskot, A, Long, C, Jacquemin, M, Hoylaerts, M.F, Verhamme, P

“…Abstract Introduction Partial inhibition of Factor VIII (FVIII) may provide antithrombotic efficacy whilst avoiding excessive anticoagulation. Materials and…”
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Microparticle number or procoagulant activity are not upregulated in healthy elderly persons by Emmerechts, J, Loyen, S, Hoylaerts, M.F

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von Willebrand factor A1 domain can adequately substitute for A3 domain in recruitment of flowing platelets to collagen by BONNEFOY, A., ROMIJN, R. A., VANDERVOORT, P. A. H., VAN ROMPAEY, I., VERMYLEN, J., HOYLAERTS, M. F.

“…Background: Binding of von Willebrand factor (VWF) to platelet GPIbα and to collagen is attributed to VWF A1 and A3 domains, respectively. Objectives: Using…”
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ERK2 activation in arteriolar and venular murine thrombosis: platelet receptor GPIb vs. P2X1 by OURY, C., DAENENS, K., HU, H., TOTH‐ZSAMBOKI, E., BRYCKAERT, M., HOYLAERTS, M. F.

“…The functional significance of extracellular signal‐regulated kinase 2 (ERK2) activation was investigated during shear induced human platelet aggregation…”
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Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: A key to study an angiogenic marker in vivo? by Wynendaele, W., Derua, R., Hoylaerts, M. F., Pawinski, A., Waelkens, E., de Bruijn, E. A., Paridaens, R., Merlevede, W., van Oosterom, A. T.

“…Background: Serum VEGF levels are elevated in cancer patients and are used as a tumor marker in different malignancies. We have measured VEGF levels in…”
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Antithrombotic effect of clopidogrel in a vena cava thrombosis model in obese mice by Lijnen, H.R, Helsen, S, Hoylaerts, M.F

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Bacterial killing by platelets: making sense of (H)IT by Hoylaerts, M. F., Vanassche, T., Verhamme, P.

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Clumping factor A, von Willebrand factor‐binding protein and von Willebrand factor anchor Staphylococcus aureus to the vessel wall by Claes, J., Liesenborghs, L., Peetermans, M., Veloso, T. R., Missiakas, D., Schneewind, O., Mancini, S., Entenza, J. M., Hoylaerts, M. F., Heying, R., Verhamme, P., Vanassche, T.

“…Essentials Staphylococcus aureus (S. aureus) binds to endothelium via von Willebrand factor (VWF). Secreted VWF‐binding protein (vWbp) mediates S. aureus…”
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Platelet rescue by macrophage depletion in obese ADAMTS‐13‐deficient mice at risk of thrombotic thrombocytopenic purpura by Geys, L., Roose, E., Scroyen, I., Rottensteiner, H., Tersteeg, C., Hoylaerts, M. F., Vanhoorelbeke, K., Lijnen, H. R.

“…Essentials Obesity is a potential risk factor for development of thrombotic thrombocytopenic purpura (TTP). Obese ADAMTS‐13‐deficient mice were triggered with…”
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Air pollution‐associated procoagulant changes: the role of circulating microvesicles by EMMERECHTS, J., JACOBS, L., VAN KERCKHOVEN, S., LOYEN, S., MATHIEU, C., FIERENS, F., NEMERY, B., NAWROT, T.S., HOYLAERTS, M.F.

“…Background: Epidemiological studies suggest an association between exposure to particulate matter (PM) in air pollution and the risk of venous thromboembolism…”
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Inhibition of staphylothrombin by dabigatran reduces Staphylococcus aureus virulence by VANASSCHE, T., VERHAEGEN, J., PEETERMANS, W. E., VAN RYN, J., CHENG, A., SCHNEEWIND, O., HOYLAERTS, M. F., VERHAMME, P.

“…Background: Staphylocoagulase and von Willebrand binding protein (VWbp) bind to prothrombin to form the staphylothrombin complex that converts fibrinogen into…”
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Neuromedin U potentiates ADP- and epinephrine-induced human platelet activation by Grippi, C., Izzi, B., Gianfagna, F., Noro, F., Falcinelli, E., Di Pardo, A., Amico, E., Donati, M.B., de Gaetano, G., Iacoviello, L., Hoylaerts, M.F., Cerletti, C.

“…Neuromedin U (NmU) is a pleiotropic hypothalamic neuropeptide involved in the gut–brain axis. It acts via both a Gαq/11-coupled receptor (NMUR1) and a…”
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[PP.07.05] PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1 IS NOT A SUSCEPTIBILITY GENE FOR CARDIOVASCULAR DISEASE IN THE GENERAL POPULATION by Yang, W., Petit, T., Cauwenberghs, N., Zhang, Z., Thijs, L., Salvi, E., Izizi, B., Vandenbriele, C., Wei, F., Gu, Y., Jacobs, L., Citterio, L., Carpini, S. Delli, Barlassina, C., Cusi, D., Hoylaerts, M.F., Verhamme, P., Kuznetsova, T., Staessen, J.A.

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Short‐term exposure to particulate matter induces arterial but not venous thrombosis in healthy mice by EMMERECHTS, J., ALFARO‐MORENO, E., VANAUDENAERDE, B. M., NEMERY, B., HOYLAERTS, M. F.

“…Background:  Epidemiological findings suggest an association between exposure to particulate matter (PM) and venous thrombo‐embolism. Objectives:  To…”
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