Search Results - "HOXIE, James"

Toward an antibody-based HIV-1 vaccine by Hoxie, James A

“…Developing an HIV-1 vaccine that can elicit antibodies to prevent infection has been a formidable challenge. Although no single immunogen has generated…”
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Tetherin downmodulation by SIVmac Nef lost with the H196Q escape variant is restored by an upstream variant by Schouest, Blake, Leslie, George J, Hoxie, James A, Maness, Nicholas J

“…The H.sub.196 residue in SIVmac239 Nef is conserved across the majority of HIV and SIV isolates, lies immediately adjacent to the AP-2 (adaptor protein 2)…”
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Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure by White, Tommi A, Bartesaghi, Alberto, Borgnia, Mario J, Meyerson, Joel R, de la Cruz, M Jason V, Bess, Julian W, Nandwani, Rachna, Hoxie, James A, Lifson, Jeffrey D, Milne, Jacqueline L S, Subramaniam, Sriram

“…The initial step in target cell infection by human, and the closely related simian immunodeficiency viruses (HIV and SIV, respectively) occurs with the binding…”
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Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy–treated macaques by Santangelo, Philip J, Rogers, Kenneth A, Zurla, Chiara, Blanchard, Emmeline L, Gumber, Sanjeev, Strait, Karen, Connor-Stroud, Fawn, Schuster, David M, Amancha, Praveen K, Hong, Jung Joo, Byrareddy, Siddappa N, Hoxie, James A, Vidakovic, Brani, Ansari, Aftab A, Hunter, Eric, Villinger, Francois

“…ImmunoPET/CT imaging using a labeled SIV-specific antibody can identify sites of viralinfection in SIV-infected macaques without the need for tissue biopsies,…”
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Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor by Pegu, Amarendra, Yang, Zhi-yong, Boyington, Jeffrey C, Wu, Lan, Ko, Sung-Youl, Schmidt, Stephen D, McKee, Krisha, Kong, Wing-Pui, Shi, Wei, Chen, Xuejun, Todd, John-Paul, Letvin, Norman L, Huang, Jinghe, Nason, Martha C, Hoxie, James A, Kwong, Peter D, Connors, Mark, Rao, Srinivas S, Mascola, John R, Nabel, Gary J

“…HIV-1 infection depends on effective viral entry mediated by the interaction of its envelope (Env) glycoprotein with specific cell surface receptors…”
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Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo by Maldini, Colby R., Claiborne, Daniel T., Okawa, Ken, Chen, Tao, Dopkin, Derrick L., Shan, Xiaochuan, Power, Karen A., Trifonova, Radiana T., Krupp, Katharine, Phelps, Meredith, Vrbanac, Vladimir D., Tanno, Serah, Bateson, Timothy, Leslie, George J., Hoxie, James A., Boutwell, Christian L., Riley, James L., Allen, Todd M.

“…An effective strategy to cure HIV will likely require a potent and sustained antiviral T cell response. Here we explored the utility of chimeric antigen…”
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Mechanisms of reactivation of latent tuberculosis infection due to SIV coinfection by Bucşan, Allison N, Chatterjee, Ayan, Singh, Dhiraj K, Foreman, Taylor W, Lee, Tae-Hyung, Threeton, Breanna, Kirkpatrick, Melanie G, Ahmed, Mushtaq, Golden, Nadia, Alvarez, Xavier, Hoxie, James A, Mehra, Smriti, Rengarajan, Jyothi, Khader, Shabaana A, Kaushal, Deepak

“…HIV is a major driver of tuberculosis (TB) reactivation. Depletion of CD4+ T cells is assumed to be the basis behind TB reactivation in individuals with latent…”
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Quantification of Entry Phenotypes of Macrophage-Tropic HIV-1 across a Wide Range of CD4 Densities by Joseph, Sarah B, Arrildt, Kathryn T, Swanstrom, Adrienne E, Schnell, Gretja, Lee, Benhur, Hoxie, James A, Swanstrom, Ronald

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Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease by Reshef, Ran, Luger, Selina M, Hexner, Elizabeth O, Loren, Alison W, Frey, Noelle V, Nasta, Sunita D, Goldstein, Steven C, Stadtmauer, Edward A, Smith, Jacqueline, Bailey, Sarah, Mick, Rosemarie, Heitjan, Daniel F, Emerson, Stephen G, Hoxie, James A, Vonderheide, Robert H, Porter, David L

“…Blocking lymphocyte chemotaxis with an oral inhibitor of the CCR5 receptor was associated with reduced incidence of visceral graft-versus-host disease (GVHD)…”
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An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum by FERRARI, Guido, POLLARA, Justin, KAPPES, John C, SHAW, George M, HOXIE, James A, ROBINSON, James E, HAYNES, Barton F, KOZINK, Daniel, HARMS, Tiara, DRINKER, Mark, FREEL, Stephanie, MOODY, M. Anthony, MUNIR ALAM, S, TOMARAS, Georgia D, OCHSENBAUER, Christina

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Clinical and immunologic impact of CCR5 blockade in graft-versus-host disease prophylaxis by Moy, Ryan H., Huffman, Austin P., Richman, Lee P., Crisalli, Lisa, Wang, Ximi K., Hoxie, James A., Mick, Rosemarie, Emerson, Stephen G., Zhang, Yi, Vonderheide, Robert H., Porter, David L., Reshef, Ran

“…Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Lymphocyte…”
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Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8 + T cells by Nguyen, Son, Deleage, Claire, Darko, Samuel, Ransier, Amy, Truong, Duc P, Agarwal, Divyansh, Japp, Alberto Sada, Wu, Vincent H, Kuri-Cervantes, Leticia, Abdel-Mohsen, Mohamed, Del Rio Estrada, Perla M, Ablanedo-Terrazas, Yuria, Gostick, Emma, Hoxie, James A, Zhang, Nancy R, Naji, Ali, Reyes-Terán, Gustavo, Estes, Jacob D, Price, David A, Douek, Daniel C, Deeks, Steven G, Buggert, Marcus, Betts, Michael R

“…The functional properties of circulating CD8 T cells have been associated with immune control of HIV. However, viral replication occurs predominantly in…”
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Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus by Leslie, George J, Wang, Jianbin, Richardson, Max W, Haggarty, Beth S, Hua, Kevin L, Duong, Jennifer, Secreto, Anthony J, Jordon, Andrea P O, Romano, Josephine, Kumar, Kritika E, DeClercq, Joshua J, Gregory, Philip D, June, Carl H, Root, Michael J, Riley, James L, Holmes, Michael C, Hoxie, James A

“…HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion…”
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HIV-1-Infected CD4 + T Cells Present MHC Class II-Restricted Epitope via Endogenous Processing by Addison, Mary M, Ellis, Gavin I, Leslie, George J, Zawadzky, Noah B, Riley, James L, Hoxie, James A, Eisenlohr, Laurence C

“…HIV-1-specific CD4 T cells (T s) play a critical role in controlling HIV-1 infection. Canonically, T s are activated by peptides derived from extracellular…”
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HIV Vaccine Research: The Way Forward by Fauci, Anthony S, Johnston, Margaret I, Dieffenbach, Carl W, Burton, Dennis R, Hammer, Scott M, Hoxie, James A, Martin, Malcolm, Overbaugh, Julie, Watkins, David I, Mahmoud, Adel, Greene, Warner C

“…The need to broaden research directed at answering fundamental questions in HIV vaccine discovery through laboratory, nonhuman primate (NHP), and clinical…”
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Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4 by Welles, Hugh C, King, Hannah A D, Nettey, Leonard, Cavett, Nicole, Gorman, Jason, Zhou, Tongqing, Tsybovsky, Yaroslav, Du, Renguang, Song, Kaimei, Nguyen, Richard, Ambrozak, David, Ransier, Amy, Schramm, Chaim A, Doria-Rose, Nicole A, Swanstrom, Adrienne E, Hoxie, James A, LaBranche, Celia, Montefiori, David C, Douek, Daniel C, Kwong, Peter D, Mascola, John R, Roederer, Mario, Mason, Rosemarie D

“…Both SIV and SHIV are powerful tools for evaluating antibody-mediated prevention and treatment of HIV-1. However, owing to a lack of rhesus-derived SIV broadly…”
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A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein by Byland, Rahel, Vance, Patricia J, Hoxie, James A, Marsh, Mark

“…During the assembly of enveloped viruses viral and cellular components essential for infectious particles must colocalize at specific membrane locations. For…”
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High‐throughput quantitative analysis of HIV‐1 and SIV‐specific ADCC‐mediating antibody responses by Pollara, Justin, Hart, Lydia, Brewer, Faraha, Pickeral, Joy, Packard, Beverly Z., Hoxie, James A., Komoriya, Akira, Ochsenbauer, Christina, Kappes, John C., Roederer, Mario, Huang, Ying, Weinhold, Kent J., Tomaras, Georgia D., Haynes, Barton F., Montefiori, David C., Ferrari, Guido

“…We have developed a high‐throughput platform to detect the presence of HIV‐1 and SIV‐specific ADCC‐mediating antibody responses. The assay is based on the…”
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Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site by XUELING WU, WANG, Charlene, SHAW, George M, WYATT, Richard T, MASCOLA, John R, O'DELL, Sijy, YUXING LI, KEELE, Brandon F, ZHONGJIA YANG, IMAMICHI, Hiromi, DORIA-ROSE, Nicole, HOXIE, James A, CONNORS, Mark

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Analysis of Neutralization Specificities in Polyclonal Sera Derived from Human Immunodeficiency Virus Type 1-Infected Individuals by YUXING LI, SVEHLA, Krisha, CONNORS, Mark, HOXIE, James, MASCOLA, John R, WYATT, Richard, LOUDER, Mark K, WYCUFF, Diane, PHOGAT, Sanjay, MIN TANG, MIGUELES, Stephen A, XUELING WU, PHOGAT, Adhuna, SHAW, George M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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