Search Results - "HOWELL, GARETH"

Asymmetric and Diastereoselective Conjugate Addition Reactions: C–C Bond Formation at Large Scale by Howell, Gareth P

“…Asymmetric and diastereoselective conjugate addition reactions are discussed from an industrial perspective including examples of (1) Lewis acid/Brønsted base…”
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APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction by Soto, Ileana, Graham, Leah C, Richter, Hannah J, Simeone, Stephen N, Radell, Jake E, Grabowska, Weronika, Funkhouser, W Keith, Howell, Megan C, Howell, Gareth R

“…Aging is the major risk factor for neurodegenerative diseases such as Alzheimer's disease, but little is known about the processes that lead to age-related…”
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The complex role of neuroinflammation in glaucoma by Soto, Ileana, Howell, Gareth R

“…Glaucoma is a multifactorial neurodegenerative disorder affecting 80 million people worldwide. Loss of retinal ganglion cells and degeneration of their axons…”
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Enhancing face validity of mouse models of Alzheimer's disease with natural genetic variation by Onos, Kristen D, Uyar, Asli, Keezer, Kelly J, Jackson, Harriet M, Preuss, Christoph, Acklin, Casey J, O'Rourke, Rita, Buchanan, Rebecca, Cossette, Travis L, Sukoff Rizzo, Stacey J, Soto, Ileana, Carter, Gregory W, Howell, Gareth R

“…Classical laboratory strains show limited genetic diversity and do not harness natural genetic variation. Mouse models relevant to Alzheimer's disease (AD)…”
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Neuroinflammation in glaucoma: A new opportunity by Williams, Pete A., Marsh-Armstrong, Nick, Howell, Gareth R., Bosco, Alejandra, Danias, John, Simon, John, Di Polo, Adriana, Kuehn, Markus H., Przedborski, Serge, Raff, Martin, Trounce, Ian

“…Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding these complex processes, which…”
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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models by Jay, Taylor R, Miller, Crystal M, Cheng, Paul J, Graham, Leah C, Bemiller, Shane, Broihier, Margaret L, Xu, Guixiang, Margevicius, Daniel, Karlo, J Colleen, Sousa, Gregory L, Cotleur, Anne C, Butovsky, Oleg, Bekris, Lynn, Staugaitis, Susan M, Leverenz, James B, Pimplikar, Sanjay W, Landreth, Gary E, Howell, Gareth R, Ransohoff, Richard M, Lamb, Bruce T

“…Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for Alzheimer's disease (AD) and other neurodegenerative diseases…”
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Toward more predictive genetic mouse models of Alzheimer's disease by Onos, Kristen D, Sukoff Rizzo, Stacey J, Howell, Gareth R, Sasner, Michael

“…Highlights • Mouse models have improved our understanding of early-onset Alzheimer's disease. • The field lacks useful models of the more common late-onset…”
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Single-Cell Analysis of Fungal Uptake in Cultured Airway Epithelial Cells Using Differential Fluorescent Staining and Imaging Flow Cytometry by Bertuzzi, Margherita, Howell, Gareth J

“…The respiratory epithelium is the initial point of host contact for inhaled particles, leading to orchestrated, but highly heterogeneous, responses. Human…”
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Strategies to dissect microglia-synaptic interactions during aging and in Alzheimer's disease by Heuer, Sarah E., Bloss, Erik B., Howell, Gareth R.

“…Age is the largest risk factor for developing Alzheimer's disease (AD), a neurodegenerative disorder that causes a progressive and severe dementia. The…”
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Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma by Williams, Pete A, Howell, Gareth R, Barbay, Jessica M, Braine, Catherine E, Sousa, Gregory L, John, Simon W M, Morgan, James E

“…Glaucoma is a complex disease affecting an estimated 70 million people worldwide, characterised by the progressive degeneration of retinal ganglion cells and…”
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Intrinsic axonal degeneration pathways are critical for glaucomatous damage by Howell, Gareth R., Soto, Ileana, Libby, Richard T., John, Simon W.M.

“…Glaucoma is a neurodegenerative disease affecting 70million people worldwide. For some time, analysis of human glaucoma and animal models suggested that RGC…”
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Under Pressure: Cellular and Molecular Responses During Glaucoma, a Common Neurodegeneration with Axonopathy by NICKELLS, Robert W, HOWELL, Gareth R, SOTO, Ileana, JOHN, Simon W. M

“…Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million people by the end of this decade. Retinal ganglion cells (RGCs) are the…”
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Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease by Yang, Hongtian Stanley, Onos, Kristen D., Choi, Kwangbom, Keezer, Kelly J., Skelly, Daniel A., Carter, Gregory W., Howell, Gareth R.

“…Genetic and genome-wide association studies suggest a central role for microglia in Alzheimer’s disease (AD). However, single-cell RNA sequencing (scRNA-seq)…”
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Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer’s Disease Mouse Models by Muraoka, Satoshi, Jedrychowski, Mark P, Iwahara, Naotoshi, Abdullah, Mohammad, Onos, Kristen D, Keezer, Kelly J, Hu, Jianqiao, Ikezu, Seiko, Howell, Gareth R, Gygi, Steven P, Ikezu, Tsuneya

“…Extracellular vesicles (EVs) are secreted by any neural cells in the central nervous system for molecular clearance, cellular communications, and disease…”
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The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation by Svedberg, Freya R., Brown, Sheila L., Krauss, Maria Z., Campbell, Laura, Sharpe, Catherine, Clausen, Maryam, Howell, Gareth J., Clark, Howard, Madsen, Jens, Evans, Christopher M., Sutherland, Tara E., Ivens, Alasdair C., Thornton, David J., Grencis, Richard K., Hussell, Tracy, Cunoosamy, Danen M., Cook, Peter C., MacDonald, Andrew S.

“…Fine control of macrophage activation is needed to prevent inflammatory disease, particularly at barrier sites such as the lungs. However, the dominant…”
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Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma by Berry, Ryan H, Qu, Juan, John, Simon W M, Howell, Gareth R, Jakobs, Tatjana C

“…It has been hypothesized that synaptic pruning precedes retinal ganglion cell degeneration in glaucoma, causing early dysfunction to retinal ganglion cells. To…”
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Differential splicing of neuronal genes in a Trem2R47H mouse model mimics alterations associated with Alzheimer's disease by Pandey, Ravi S, Kotredes, Kevin P, Sasner, Michael, Howell, Gareth R, Carter, Gregory W

“…Molecular characterization of late-onset Alzheimer's disease (LOAD), the leading cause of age-related dementia, has revealed transcripts, proteins, and pathway…”
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Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma by Williams, Pete A, Tribble, James R, Pepper, Keating W, Cross, Stephen D, Morgan, B Paul, Morgan, James E, John, Simon W M, Howell, Gareth R

“…Glaucoma is a complex, multifactorial disease characterised by the loss of retinal ganglion cells and their axons leading to a decrease in visual function. The…”
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Copper‐Catalyzed Borylative Couplings with C−N Electrophiles by Talbot, Fabien J. T., Dherbassy, Quentin, Manna, Srimanta, Shi, Chunling, Zhang, Shibo, Howell, Gareth P., Perry, Gregory J. P., Procter, David J.

“…Copper‐catalyzed borylative multicomponent reactions (MCRs) involving olefins and C−N electrophiles are a powerful tool to rapidly build up molecular…”
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Genetic context drives age‐related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits by Heuer, Sarah E., Nickerson, Emily W., Howell, Gareth R., Bloss, Erik B.

“…The disconnection of neuronal circuitry through synaptic loss is presumed to be a major driver of age‐related cognitive decline. Age‐related cognitive decline…”
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