Search Results - "HOWARD, L."

Microglial signatures and their role in health and disease by Butovsky, Oleg, Weiner, Howard L.

“…Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a unique molecular homeostatic ‘signature’, consisting of a…”
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CNS inflammation and neurodegeneration by Chitnis, Tanuja, Weiner, Howard L

“…There is an increasing recognition that inflammation plays a critical role in neurodegenerative diseases of the CNS, including Alzheimer's disease, amyotrophic…”
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How expectations influence pain by Fields, Howard L.

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Integrating oncolytic viruses in combination cancer immunotherapy by Bommareddy, Praveen K., Shettigar, Megha, Kaufman, Howard L.

“…Oncolytic viruses can be usefully integrated into tumour immunotherapies, as they target multiple steps within the cancer–immunity cycle. Oncolytic viruses…”
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Multiple Sclerosis: Mechanisms and Immunotherapy by Baecher-Allan, Clare, Kaskow, Belinda J., Weiner, Howard L.

“…Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act on a genetically susceptible host. It features three clinical…”
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Oncolytic viruses: a new class of immunotherapy drugs by Kaufman, Howard L., Kohlhapp, Frederick J., Zloza, Andrew

“…Key Points Oncolytic viruses mediate anti-tumour responses through a dual mechanism involving viral oncolysis of cancer cells and induction of host anti-tumour…”
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Cancer Pharmacogenomics: Early Promise, But Concerted Effort Needed by McLeod, Howard L.

“…The past decade has brought together substantial advances in human genome analysis and a maturation of understanding of tumor biology. Although there is much…”
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Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis by Zrzavy, Tobias, Hametner, Simon, Wimmer, Isabella, Butovsky, Oleg, Weiner, Howard L, Lassmann, Hans

“…Microglia and macrophages accumulate at the sites of active demyelination and neurodegeneration in the multiple sclerosis brain and are thought to play a…”
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The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease? by Weiner, Howard L.

“…Multiple sclerosis is (MS) a T‐cell autoimmune disease characterized by a relapsing‐remitting followed by a progressive phase. Relapses are driven by the…”
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Molecular Pathways: Mechanism of Action for Talimogene Laherparepvec, a New Oncolytic Virus Immunotherapy by Kohlhapp, Frederick J, Kaufman, Howard L

“…Oncolytic viruses are native or engineered viruses that preferentially replicate in and lyse cancer cells. Selective tumor cell replication is thought to…”
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The Doctor's Dilemma: Opiate Analgesics and Chronic Pain by Fields, Howard L.

“…Opiates are utilized routinely and effectively as a short-term analgesic treatment for a variety of acute pain conditions such as occur following trauma, and…”
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The Host Shapes the Gut Microbiota via Fecal MicroRNA by Liu, Shirong, da Cunha, Andre Pires, Rezende, Rafael M., Cialic, Ron, Wei, Zhiyun, Bry, Lynn, Comstock, Laurie E., Gandhi, Roopali, Weiner, Howard L.

“…The host gut microbiota varies across species and individuals but is relatively stable over time within an individual. How the host selectively shapes the…”
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Mechanochemistry as an emerging tool for molecular synthesis: what can it offer? by Howard, Joseph L, Cao, Qun, Browne, Duncan L

“…Mechanochemistry is becoming more widespread as a technique for molecular synthesis with new mechanochemical reactions being discovered at increasing…”
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Can Biomarkers Guide Oncolytic Virus Immunotherapy? by Kaufman, Howard L

“…Defects in tumor cell IFNγ signaling is associated with resistance to immune checkpoint inhibitors. Recently, these defects were found to confer increased…”
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Blood neurofilament light: a critical review of its application to neurologic disease by Barro, Christian, Chitnis, Tanuja, Weiner, Howard L.

“…Neuronal injury is a universal event that occurs in disease processes that affect both the central and peripheral nervous systems. A blood biomarker linked to…”
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The therapeutic monoclonal antibody market by Ecker, Dawn M, Jones, Susan Dana, Levine, Howard L

“…Since the commercialization of the first therapeutic monoclonal antibody product in 1986, this class of biopharmaceutical products has grown significantly so…”
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Clinical landscape of oncolytic virus research in 2020 by Macedo, Nicholas, Miller, David M, Haq, Rizwan, Kaufman, Howard L

“…Oncolytic viruses (OVs) are a new class of cancer therapeutics. This review was undertaken to provide insight into the current landscape of OV clinical trials…”
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Understanding opioid reward by Fields, Howard L, Margolis, Elyssa B

“…Opioids are the most potent analgesics in clinical use; however, their powerful rewarding properties can lead to addiction. The scientific challenge is to…”
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A deeper dive into top-down control of pain and itch by Fields, Howard L

“…This scientific commentary refers to ‘Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit’ by Nguyen et al…”
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Testing a Continuum Structure of Self-Determined Motivation: A Meta-Analysis by Howard, Joshua L., Gagné, Marylène, Bureau, Julien S.

“…Self-determination theory proposes a multidimensional representation of motivation comprised of several factors said to fall along a continuum of relative…”
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