Search Results - "HOVDA, D. A"

Essential protective roles of reactive astrocytes in traumatic brain injury by Myer, D. J., Gurkoff, G. G., Lee, S. M., Hovda, D. A., Sofroniew, M. V.

“…Astrocytes respond to traumatic brain injury (TBI) by altered gene expression, hypertrophy and proliferation that occur in a gradated fashion in relation to…”
Get full text

Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function by Griesbach, G.S, Hovda, D.A, Molteni, R, Wu, A, Gomez-Pinilla, F

“…Voluntary exercise leads to an upregulation of brain-derived neurotrophic factor (BDNF) and associated proteins involved in synaptic function. Activity-induced…”
Get full text

Heightening of the stress response during the first weeks after a mild traumatic brain injury by Griesbach, G.S, Hovda, D.A, Tio, D.L, Taylor, A.N

“…Abstract The effects of a mild traumatic brain injury range from white matter disruption to affective disorders. We set out to determine the response to…”
Get full text

Repeat traumatic brain injury in the juvenile rat is associated with increased axonal injury and cognitive impairments by Prins, M L, Hales, A, Reger, M, Giza, C C, Hovda, D A

“…Among the enormous population of head-injured children and young adults are a growing subpopulation who experience repeat traumatic brain injury (RTBI). The…”
Get more information

Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in rats by Griesbach, G.S, Hovda, D.A, Gomez-Pinilla, F, Sutton, R.L

“…Abstract Prior work has shown that d -amphetamine (AMPH) treatment or voluntary exercise improves cognitive functions after traumatic brain injury (TBI). In…”
Get full text

Effects of acute restraint-induced stress on glucocorticoid receptors and brain-derived neurotrophic factor after mild traumatic brain injury by Griesbach, G.S, Vincelli, J, Tio, D.L, Hovda, D.A

“…Abstract We have previously reported that experimental mild traumatic brain injury results in increased sensitivity to stressful events during the first…”
Get full text

Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury by Prins, M.L., Fujima, L.S., Hovda, D.A.

“…Although the adult brain primarily metabolizes glucose, the evidence from the starvation literature has demonstrated that the adult brain retains some…”
Get full text

Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat by Gurkoff, G.G, Giza, C.C, Shin, D, Auvin, S, Sankar, R, Hovda, D.A

“…Abstract Following CNS injury there is a period of vulnerability when cells will not easily tolerate a secondary insult. However recent studies have shown that…”
Get full text

Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring by VESPA, P. M, NUWER, M. R, NENOV, V, RONNE-ENGSTROM, E, HOVDA, D. A, BERGSNEIDER, M, KELLY, D. F, MARTIN, N. A, BECKER, D. P

“…The early pathophysiological features of traumatic brain injury observed in the intensive care unit (ICU) have been described in terms of altered cerebral…”
Get full text

Cerebral hyperglycolysis following severe traumatic brain injury in humans : a positron emission tomography study by BERGSNEIDER, M, HOVDA, D. A, BECKER, D. P, SHALMON, E, KELLY, D. F, VESPA, P. M, MARTIN, N. A, PHELPS, M. E, MCARTHUR, D. L, CARON, M. J, KRAUS, J. F

“…Experimental traumatic brain injury studies have shown that cerebral hyperglycolysis is a pathophysiological response to injury-induced ionic and neurochemical…”
Get full text

Increased cerebral uptake and oxidation of exogenous βHB improves ATP following traumatic brain injury in adult rats by Prins, M. L., Lee, S. M., Fujima, L. S., Hovda, D. A.

“…There is growing evidence of the brain's ability to increase its reliance on alternative metabolic substrates under conditions of energy stress such as…”
Get full text

Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury : a microdialysis study by VESPA, P, PRINS, M, RONNE-ENGSTROM, E, CARON, M, SHALMON, E, HOVDA, D. A, MARTIN, N. A, BECKER, D. P

“…To determine the extent and duration of change in extracellular glutamate levels after human traumatic brain injury (TBI), 17 severely brain injured adults…”
Get full text

Characterization of cerebral hemodynamic phases following severe head trauma : hypoperfusion, hyperemia, and vasospasm by MARTIN, N. A, PATWARDHAN, R. V, ALEXANDER, M. J, AFRICK, C. Z, LEE, J. H, SHALMON, E, HOVDA, D. A, BECKER, D. P

“…The extent and timing of posttraumatic cerebral hemodynamic disturbances have significant implications for the monitoring and treatment of patients with head…”
Get full text

The neurochemical and metabolic cascade following brain injury: moving from animal models to man by Hovda, D A, Lee, S M, Smith, M L, Von Stuck, S, Bergsneider, M, Kelly, D, Shalmon, E, Martin, N, Caron, M, Mazziotta, J

“…Experimental traumatic brain injury produces a series of cellular events contributing to a neurochemical and neurometabolic cascade. This cascade is defined by…”
Get more information

Cerebral blood flow as a predictor of outcome following traumatic brain injury by KELLY, D. F, MARTIN, N. A, KORDESTANI, R, COUNELIS, G, HOVDA, D. A, BERGSNEIDER, M, MCBRIDE, D. Q, SHALMON, E, HERMAN, D, BECKER, D. P

“…As part of a prospective study of the cerebrovascular effects of head injury, 54 moderate and severely injured patients underwent 184 133Xe-cerebral blood flow…”
Get full text

α-phenyl-tert-N-butyl nitrone (PHN) improves functional and morphological outcome after cortical contusion injury in the rat by MARKLUND, N, CLAUSEN, F, LEWEN, A, HOVDA, D. A, OLSSON, Y, HILLERED, L

“…alpha-Phenyl-tert-N-butyl nitrone (PBN), a potent reactive oxygen species (ROS) scavenger, has shown robust neuroprotective properties in several models of…”
Get full text

Developmental neuroplasticity in a model of cerebral hemispherectomy and stroke by VILLABLANCA, J. R, HOVDA, D. A

“…Cerebral hemispherectomy, a last resort treatment for childhood epilepsy, is a standard procedure which dramatically illustrates the resilience of the brain to…”
Get full text

Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury by Katayama, Y, Becker, D P, Tamura, T, Hovda, D A

“…An increase in extracellular K+ concentration ([K+]c) of the rat hippocampus following fluid-percussion concussive brain injury was demonstrated with…”
Get full text

Traumatic brain injury in the developing rat: effects of maturation on Morris water maze acquisition by Prins, M L, Hovda, D A

“…Previous work has demonstrated that postnatal and adult rats show different physiological responses to lateral fluid percussion (FP) brain injury. Compared to…”
Get more information

Cerebral metabolic response to traumatic brain injury sustained early in development: a 2-deoxy-D-glucose autoradiographic study by Thomas, S, Prins, M L, Samii, M, Hovda, D A

“…Following fluid percussion (FP) traumatic brain injury (TBI), adult rats exhibit dynamic regional changes in cerebral glucose metabolism characterized by an…”
Get more information