Search Results - "HOUNSLOW, Andrea M"

Two-site recognition of Staphylococcus aureus peptidoglycan by lysostaphin SH3b by Gonzalez-Delgado, Luz S., Walters-Morgan, Hannah, Salamaga, Bartłomiej, Robertson, Angus J., Hounslow, Andrea M., Jagielska, Elżbieta, Sabała, Izabela, Williamson, Mike P., Lovering, Andrew L., Mesnage, Stéphane

“…Lysostaphin is a bacteriolytic enzyme targeting peptidoglycan, the essential component of the bacterial cell envelope. It displays a very potent and specific…”
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Molecular basis for bacterial peptidoglycan recognition by LysM domains by Mesnage, Stéphane, Dellarole, Mariano, Baxter, Nicola J., Rouget, Jean-Baptiste, Dimitrov, Jordan D., Wang, Ning, Fujimoto, Yukari, Hounslow, Andrea M., Lacroix-Desmazes, Sébastien, Fukase, Koichi, Foster, Simon J., Williamson, Michael P.

“…Carbohydrate recognition is essential for growth, cell adhesion and signalling in all living organisms. A highly conserved carbohydrate binding module, LysM,…”
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Ferrous Iron Binding Key to Mms6 Magnetite Biomineralisation: A Mechanistic Study to Understand Magnetite Formation Using pH Titration and NMR Spectroscopy by Rawlings, Andrea E., Bramble, Jonathan P., Hounslow, Andrea M., Williamson, Michael P., Monnington, Amy E., Cooke, David J., Staniland, Sarah S.

“…Formation of magnetite nanocrystals by magnetotactic bacteria is controlled by specific proteins which regulate the particles’ nucleation and growth. One such…”
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Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system by Smith, Robert E, Salamaga, Bartłomiej, Szkuta, Piotr, Hajdamowicz, Natalia, Prajsnar, Tomasz K, Bulmer, Gregory S, Fontaine, Thierry, Kołodziejczyk, Justyna, Herry, Jean-Marie, Hounslow, Andrea M, Williamson, Mike P, Serror, Pascale, Mesnage, Stéphane

“…Enterococcus faecalis is an opportunistic pathogen with an intrinsically high resistance to lysozyme, a key effector of the innate immune system. This high…”
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Structure of a Wbl protein and implications for NO sensing by M. tuberculosis by Kudhair, Bassam K., Hounslow, Andrea M., Rolfe, Matthew D., Crack, Jason C., Hunt, Debbie M., Buxton, Roger S., Smith, Laura J., Le Brun, Nick E., Williamson, Michael P., Green, Jeffrey

“…Mycobacterium tuberculosis causes pulmonary tuberculosis (TB) and claims ~1.8 million human lives per annum. Host nitric oxide (NO) is important in controlling…”
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Allomorphy as a mechanism of post-translational control of enzyme activity by Wood, Henry P., Cruz-Navarrete, F. Aaron, Baxter, Nicola J., Trevitt, Clare R., Robertson, Angus J., Dix, Samuel R., Hounslow, Andrea M., Cliff, Matthew J., Waltho, Jonathan P.

“…Enzyme regulation is vital for metabolic adaptability in living systems. Fine control of enzyme activity is often delivered through post-translational…”
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Reprogramming of Escherichia coli K-12 metabolism during the initial phase of transition from an anaerobic to a micro-aerobic environment by Trotter, Eleanor W, Rolfe, Matthew D, Hounslow, Andrea M, Craven, C Jeremy, Williamson, Michael P, Sanguinetti, Guido, Poole, Robert K, Green, Jeffrey

“…Many bacteria undergo transitions between environments with differing O₂ availabilities as part of their natural lifestyles and during biotechnological…”
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Detection of salt bridges to lysines in solution in barnase by Williamson, Mike P, Hounslow, Andrea M, Ford, Joe, Fowler, Kyle, Hebditch, Max, Hansen, Poul Erik

“…We show that salt bridges involving lysines can be detected by deuterium isotope effects on NMR chemical shifts of the sidechain amine. Lys27 in the…”
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Near attack conformers dominate β-phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate by Griffin, Joanna L, Bowler, Matthew W, Baxter, Nicola J, Leigh, Katherine N, Dannatt, Hugh R. W, Hounslow, Andrea M, Blackburn, G. Michael, Webster, Charles Edwin, Cliff, Matthew J, Waltho, Jonathan P

“…Experimental observations of fluoromagnesate and fluoroaluminate complexes of β-phosphoglucomutase (β-PGM) have demonstrated the importance of charge balance…”
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Anionic Charge Is Prioritized over Geometry in Aluminum and Magnesium Fluoride Transition State Analogs of Phosphoryl Transfer Enzymes by Baxter, Nicola J, Blackburn, G. Michael, Marston, James P, Hounslow, Andrea M, Cliff, Matthew J, Bermel, Wolfgang, Williams, Nicholas H, Hollfelder, Florian, Wemmer, David E, Waltho, Jonathan P

“…Phosphoryl transfer reactions are ubiquitous in biology and metal fluoride complexes have played a central role in structural approaches to understanding how…”
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Why the Energy Landscape of Barnase Is Hierarchical by Pandya, Maya J, Schiffers, Stefanie, Hounslow, Andrea M, Baxter, Nicola J, Williamson, Mike P

“…We have used NMR and computational methods to characterize the dynamics of the ribonuclease barnase over a wide range of timescales in free and inhibitor-bound…”
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Molecular Mechanism for the Hofmeister Effect Derived from NMR and DSC Measurements on Barnase by Bye, Jordan W, Baxter, Nicola J, Hounslow, Andrea M, Falconer, Robert J, Williamson, Mike P

“…The effects of sodium thiocyanate, sodium chloride, and sodium sulfate on the ribonuclease barnase were studied using differential scanning calorimetry (DSC)…”
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High-affinity tamoxifen analogues retain extensive positional disorder when bound to calmodulin by Milanesi, Lilia, Trevitt, Clare R, Whitehead, Brian, Hounslow, Andrea M, Tomas, Salvador, Hosszu, Laszlo L P, Hunter, Christopher A, Waltho, Jonathan P

“…Using a combination of NMR and fluorescence measurements, we have investigated the structure and dynamics of the complexes formed between calcium-loaded…”
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A Trojan horse transition state analogue generated by MgF3− formation in an enzyme active site by Baxter, Nicola J, Olguin, Luis F, Golicnik, Marko, Feng, Guoqiang, Hounslow, Andrea M, Bermel, Wolfgang, Blackburn, G Michael, Hollfelder, Florian, Waltho, Jonathan P, Williams, Nicholas H

“…Identifying how enzymes stabilize high-energy species along the reaction pathway is central to explaining their enormous rate acceleration…”
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Structural and functional analysis of RNA and TAP binding to SF2/ASF by Tintaru, Aura M, Hautbergue, Guillaume M, Hounslow, Andrea M, Hung, Ming-Lung, Lian, Lu-Yun, Craven, C Jeremy, Wilson, Stuart A

“…The serine/arginine‐rich (SR) protein splicing factor 2/alternative splicing factor (SF2/ASF) has a role in splicing, stability, export and translation of…”
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Improved methodology for protein NMR structure calculation using hydrogen bond restraints and ANSURR validation: The SH2 domain of SH2B1 by Fowler, Nicholas J., Albalwi, Marym F., Lee, Subin, Hounslow, Andrea M., Williamson, Mike P.

“…Protein structures calculated using NMR data are less accurate and less well-defined than they could be. Here we use the program ANSURR to show that this…”
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Cystatin forms a Tetramer through Structural Rearrangement of Domain-swapped Dimers prior to Amyloidogenesis by Sanders, Anna, Jeremy Craven, C., Higgins, Lee D., Giannini, Silva, Conroy, Matthew J., Hounslow, Andrea M., Waltho, Jonathan P., Staniforth, Rosemary A.

“…The cystatins were the first amyloidogenic proteins to be shown to oligomerize through a 3D domain swapping mechanism. Here we show that, under conditions…”
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Catalysis by Glomerella cingulata Cutinase Requires Conformational Cycling between the Active and Inactive States of Its Catalytic Triad by Nyon, Mun Peak, Rice, David W., Berrisford, John M., Hounslow, Andrea M., Moir, Arthur J.G., Huang, Huazhang, Nathan, Sheila, Mahadi, Nor Muhammad, Bakar, Farah Diba Abu, Craven, C. Jeremy

“…Cutinase belongs to a group of enzymes that catalyze the hydrolysis of esters and triglycerides. Structural studies on the enzyme from Fusarium solani have…”
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Loss of Residues 119–136, Including the First β-strand of Human Prion Protein, Generates an Aggregation-competent Partially “Open” Form by Hosszu, Laszlo L.P., Sangar, Daljit, Batchelor, Mark, Risse, Emmanuel, Hounslow, Andrea M., Collinge, John, Waltho, Jonathan P., Bieschke, Jan

“…[Display omitted] •A distinct “open” form of human PrP, in equilibrium with its native state was identified.•This native-like conformer has increased solvent…”
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Structure and Dynamics of Coxsackievirus B4 2A Proteinase, an Enyzme Involved in the Etiology of Heart Disease by BAXTER, Nicola J, ROETZER, Andreas, LIEBIG, Hans-Dieter, SEDELNIKOVA, Svetlana E, HOUNSLOW, Andrea M, SKERN, Tim, WALTHO, Jonathan P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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