Search Results - "HOULSTON, R"

Collateral damage: the impact on outcomes from cancer surgery of the COVID-19 pandemic by Sud, A., Jones, M.E., Broggio, J., Loveday, C., Torr, B., Garrett, A., Nicol, D.L., Jhanji, S., Boyce, S.A., Gronthoud, F., Ward, P., Handy, J.M., Yousaf, N., Larkin, J., Suh, Y-E., Scott, S., Pharoah, P.D.P., Swanton, C., Abbosh, C., Williams, M., Lyratzopoulos, G., Houlston, R., Turnbull, C.

“…Cancer diagnostics and surgery have been disrupted by the response of health care services to the coronavirus disease 2019 (COVID-19) pandemic. Progression of…”
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Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis by Walther, A, Houlston, R, Tomlinson, I

“…Several studies have suggested that microsatellite instability (MSI) resulting from defective DNA mismatch repair confers a better prognosis in colorectal…”
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Systematic Review of Microsatellite Instability and Colorectal Cancer Prognosis by POPAT, S, HUBNER, R, HOULSTON, R. S

“…A number of studies have investigated the relationship between microsatellite instability (MSI) and colorectal cancer (CRC) prognosis. Although many have…”
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Systematic review of the relationship between family history and lung cancer risk by MATAKIDOU, A, EISEN, T, HOULSTON, R. S

“…We performed a systematic review of 28 case-control, 17 cohort and seven twin studies of the relationship between family history and risk of lung cancer and a…”
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TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations by Labussière, M, Di Stefano, A L, Gleize, V, Boisselier, B, Giry, M, Mangesius, S, Bruno, A, Paterra, R, Marie, Y, Rahimian, A, Finocchiaro, G, Houlston, R S, Hoang-Xuan, K, Idbaih, A, Delattre, J-Y, Mokhtari, K, Sanson, M

“…Background: The role of telomerase reverse transcriptase ( TERT ) in gliomagenesis has been recently further strengthened by the frequent occurrence of TERT…”
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Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients by Shah, V, Sherborne, A L, Walker, B A, Johnson, D C, Boyle, E M, Ellis, S, Begum, D B, Proszek, P Z, Jones, J R, Pawlyn, C, Savola, S, Jenner, M W, Drayson, M T, Owen, R G, Houlston, R S, Cairns, D A, Gregory, W M, Cook, G, Davies, F E, Jackson, G H, Morgan, G J, Kaiser, M F

“…Robust establishment of survival in multiple myeloma (MM) and its relationship to recurrent genetic aberrations is required as outcomes are variable despite…”
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Meeting report from the joint IARC–NCI international cancer seminar series: a focus on colorectal cancer by Gunter, M.J., Alhomoud, S., Arnold, M., Brenner, H., Burn, J., Casey, G., Chan, A.T., Cross, A.J., Giovannucci, E., Hoover, R., Houlston, R., Jenkins, M., Laurent-Puig, P., Peters, U., Ransohoff, D., Riboli, E., Sinha, R., Stadler, Z.K., Brennan, P., Chanock, S.J.

“…Despite significant progress in our understanding of the etiology, biology and genetics of colorectal cancer, as well as important clinical advances, it…”
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Implications of polygenic risk for personalised colorectal cancer screening by Frampton, M.J.E., Law, P., Litchfield, K., Morris, E.J., Kerr, D., Turnbull, C., Tomlinson, I.P., Houlston, R.S.

“…We modelled the utility of applying a personalised screening approach for colorectal cancer (CRC) when compared with standard age-based screening. In this…”
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Interobserver agreement in grading of colorectal cancers-findings from a nationwide web-based survey of histopathologists by Chandler, I, Houlston, R S

“…Aims:  Tumour grade represents a gestalt of all molecular changes in malignancy, reflecting aggressiveness and has been shown to add prognostic information…”
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Folate and colorectal cancer prevention by Hubner, R A, Houlston, R S

“…Anti-folate chemotherapy agents such as methotrexate and fluorouracil reduce proliferation of neoplastic cells by inhibiting DNA synthesis. Paradoxically…”
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A systematic review and meta‐analysis of familial prostate cancer risk by Johns, L.E., Houlston, R.S.

“…OBJECTIVE To identify published studies quantifying familial prostate cancer risks in relatives of prostate cancer cases and, by meta‐analysis, obtain more…”
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Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV mut and IgHV unmut subgroups by Burns, A, Alsolami, R, Becq, J, Stamatopoulos, B, Timbs, A, Bruce, D, Robbe, P, Vavoulis, D, Clifford, R, Cabes, M, Dreau, H, Taylor, J, Knight, S J L, Mansson, R, Bentley, D, Beekman, R, Martín-Subero, J I, Campo, E, Houlston, R S, Ridout, K E, Schuh, A

“…Chronic lymphocytic leukaemia (CLL) consists of two biologically and clinically distinct subtypes defined by the abundance of somatic hypermutation (SHM)…”
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The TERT variant rs2736100 is associated with colorectal cancer risk by Kinnersley, B, Migliorini, G, Broderick, P, Whiffin, N, Dobbins, S E, Casey, G, Hopper, J, Sieber, O, Lipton, L, Kerr, D J, Dunlop, M G, Tomlinson, I PM, Houlston, R S

“…Background: Polymorphic variation at the 5p15.33 ( TERT–CLPTM1L ) locus is associated with the risk of many cancers but a relationship with colorectal cancer…”
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BRCA1 testing should be offered to individuals with triple-negative breast cancer diagnosed below 50 years by Robertson, L, Hanson, H, Seal, S, Warren-Perry, M, Hughes, D, Howell, I, Turnbull, C, Houlston, R, Shanley, S, Butler, S, Evans, D G, Ross, G, Eccles, D, Tutt, A, Rahman, N

“…Background: Triple-negative (TN) tumours are the predominant breast cancer subtype in BRCA1 mutation carriers. Recently, it was proposed that all individuals…”
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Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta‐Analysis of Three Genome‐Wide Association Studies by Tamm, R, Mägi, R, Tremmel, R, Winter, S, Mihailov, E, Smid, A, Möricke, A, Klein, K, Schrappe, M, Stanulla, M, Houlston, R, Weinshilboum, R, Mlinarič Raščan, Irena, Metspalu, A, Milani, L, Schwab, M, Schaeffeler, E

“…Thiopurine‐related hematotoxicity in pediatric acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases has been linked to genetically defined…”
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Inherited genetic susceptibility to multiple myeloma by Morgan, G J, Johnson, D C, Weinhold, N, Goldschmidt, H, Landgren, O, Lynch, H T, Hemminki, K, Houlston, R S

“…Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic…”
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A retrospective observational study of the relationship between family history and survival from colorectal cancer by Morris, E J A, Penegar, S, Whitehouse, L E, Quirke, P, Finan, P, Bishop, D T, Wilkinson, J, Houlston, R S

“…Background: Although family history is well established to be a risk factor for developing colorectal cancer (CRC), much less is known about its impact on…”
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Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma by da Silva Filho, M I, Försti, A, Weinhold, N, Meziane, I, Campo, C, Huhn, S, Nickel, J, Hoffmann, P, Nöthen, M M, Jöckel, K-H, Landi, S, Mitchell, J S, Johnson, D, Morgan, G J, Houlston, R, Goldschmidt, H, Jauch, A, Milani, P, Merlini, G, Rowcieno, D, Hawkins, P, Hegenbart, U, Palladini, G, Wechalekar, A, Schönland, S O, Hemminki, K

“…Immunoglobulin light chain (AL) amyloidosis is characterized by tissue deposition of amyloid fibers derived from immunoglobulin light chain. AL amyloidosis and…”
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Glutathione S-transferase M1 status and lung cancer risk : A meta-analysis by HOULSTON, R. S

“…Interindividual differences in lung cancer susceptibility may be mediated in part through polymorphic variability in the bioactivation of procarcinogens. GSTM1…”
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TP53 polymorphisms and lung cancer risk: a systematic review and meta‐analysis by Matakidou, A., Eisen, T., Houlston, R.S.

“…To examine the risk of lung cancer associated with the codon 72, intron 6 and intron 3 TP53 polymorphisms a meta‐analysis of published case–control studies was…”
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