Search Results - "HOULBROOK, S"

Isolation of a small molecule inhibitor of DNA base excision repair by Madhusudan, Srinivasan, Smart, Fiona, Shrimpton, Paul, Parsons, Jason L., Gardiner, Laurence, Houlbrook, Sue, Talbot, Denis C., Hammonds, Timothy, Freemont, Paul A., Sternberg, Michael J. E., Dianov, Grigory L., Hickson, Ian D.

“…The base excision repair (BER) pathway is essential for the removal of DNA bases damaged by alkylation or oxidation. A key step in BER is the processing of an…”
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The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues by TURLEY, H, COMLEY, M, HOULBROOK, S, NOZAKI, N, KIKUCHI, A, HICKSON, I. D, GATTER, K, HARRIS, A. L

“…In mammalian cells, there are two isoforms of DNA topoisomerase II, designated alpha (170-kDa form) and beta (180-kDa form). Previous studies using cell lines…”
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Topoisomerase II alpha co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity by Smith, K, Houlbrook, S, Greenall, M, Carmichael, J, Harris, A L

“…Topoisomerase II alpha (topo II alpha) is a key enzyme in DNA replication and a target for many anti-cancer drugs. High levels are associated with sensitivity…”
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8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs by ROBBINS, Susan K, HOULBROOK, Susan, PRIDDLE, John D, HARRIS, Adrian L

“…8-Cl-cAMP has been undergoing clinical trials as a potential chemotherapy agent, but there is much discussion in the literature as to whether the active agent…”
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Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines by HOULBROOK, S, ADDISON, C. M, DAVIES, S. L, CARMICHAEL, J, STRATFORD, I. J, HARRIS, A. L, HICKSON, I. D

“…Topoisomerase II is a key target for many anti-cancer drugs used to treat breast cancer. In human cells there are two closely related, but differentially…”
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Human cultured dendritic cells show differential sensitivity to chemotherapy agents as assessed by the MTS assay by CHAO, D, BAHL, P, HOULBROOK, S, HOY, L, HARRIS, A. L, AUSTYN, J. M

“…Assessment of the chemosensitivity of dendritic cells (DC) may allow more rational development of combined chemotherapy and immunotherapy protocols. Human…”
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The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase? by Robertson, N, Stratford, I J, Houlbrook, S, Carmichael, J, Adams, G E

“…15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin,…”
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Induction of thymidine phosphorylase as a pharmacodynamic end-point in patients with advanced carcinoma treated with 5-fluorouracil, folinic acid and interferon alpha by BRAYBROOKE, J. P, PROPPER, D. J, TALBOT, D. C, HARRIS, A. L, O'BYRNE, K. J, KOUKOURAKIS, M. I, PATTERSON, A. V, HOULBROOK, S, LOVE, S. D, VARCOE, S, TAYLOR, M, GANESAN, T. S

“…Thymidine phosphorylase (TP) is an essential enzyme for the biochemical activation of 5-fluorouracil (5-FU). Interferon upregulates TP in vivo, although the…”
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High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines by STUART, N. S. A, PHILIP, P, HARRIS, A. L, TONKIN, K, HOULBROOK, S, KIRK, J, LIEN, E. A, CARMICHAEL, J

“…Twenty-six patients with relapsed or drug-resistant cancer were treated with a combination of oral etoposide (300 mg day-1 for 3 days) and high-dose oral…”
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Differential modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites by KIRK, J, HOULBROOK, S, STUART, N. S. A, STRATFORD, I. J, HARRIS, A. L, CARMICHAEL, J

“…The ability of the anti-oestrogens tamoxifen, toremifene and their 4-hydroxy and N-desmethyl metabolites to modify doxorubicin (dox) toxicity to intrinsically…”
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Relationship between topoisomerase II levels and resistance to topoisomerase II inhibitors in lung cancer cell lines by Houlbrook, S, Harris, A L, Carmichael, J, Stratford, I J

“…Topoisomerase II is a key target of many anticancer drugs used to treat lung cancer. We measured the expression of topoisomerase II alpha and beta mRNA's and…”
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Selective reversal of vinblastine resistance in multidrug-resistant cell lines by tamoxifen, toremifene and their metabolites by Kirk, J, Houlbrook, S, Stuart, N S, Stratford, I J, Harris, A L, Carmichael, J

“…In this study we describe the effects of tamoxifen, toremifene and their 4-hydroxy and N-desmethyl metabolites on the toxicity of a range of drugs to human…”
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Relationship of hypoxia-inducible factor (HIF)-1α and HIF-2α expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines by BLANCHER, Christine, MOORE, John W, TALKS, Kate L, HOULBROOK, Sue, HARRIS, Adrian L

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Tissue plasminogen activators in breast cancer by Layer, G T, Burnand, K G, Gaffney, P J, Cederholm-Williams, S A, Mahmoud, M, Houlbrook, S, Pattison, M

“…Increased levels of tissue fibrinolytic activity have been detected in some malignant tumours and they have been implicated in metastatic spread. We have…”
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Overexpression of DNA polymerase   results in an increased rate of frameshift mutations during base excision repair by Chan, K., Houlbrook, S., Zhang, Q.-M., Harrison, M., Hickson, I. D., Dianov, G. L.

“…DNA polymerase β (Pol β) is important for the base excision repair (BER) pathway. Overexpression of Pol β is frequently found in cancer cells and is thought to…”
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Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines by Blancher, C, Moore, J W, Talks, K L, Houlbrook, S, Harris, A L

“…Hypoxia-inducible factors (HIF-1 and HIF-2) are two closely related protein complexes that activate transcription of target genes in response to hypoxia…”
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Evaluation of toremifene for reversal of multidrug resistance in renal cell cancer patients treated with vinblastine by BRAYBROOKE, J. P, VALLIS, K. A, HOULBROOK, S, ROCKETT, H, ELLMEN, J, ANTTILA, M, GANESAN, T. S, HARRIS, A. L, TALBOT, D. C

“…Expression of P-glycoprotein (Pgp), which confers the multidrug resistance (MDR) phenotype, is thought to contribute to the insensitivity of renal cell cancer…”
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Evaluation of the alkaline comet assay and urinary 3-methyladenine excretion for monitoring DNA damage in melanoma patients treated with dacarbazine and tamoxifen by BRAYBROOKE, J. P, HOULBROOK, S, CRAWLEY, J. E, PROPPER, D. J, O'BYRNE, K. J, STRATFORD, I. J, HARRIS, A. L, SHUKER, D. E. G, TALBOT, D. C

“…To develop, using dacarbazine as a model, reliable techniques for measuring DNA damage and repair as pharmacodynamic endpoints for patients receiving…”
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Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines

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Synthesis and Biological Activity of Thiazolylindolequinones, Analogs of the Natural Product BE 10988 by Moody, Christopher J, Swann, Elizabeth, Houlbrook, Susan, Stephens, Miriam A, Stratford, Ian J

“…A number of analogues of the naturally occurring thiazolylindolequinone BE 10988, a reported potent inhibitor of topoisomerase II, have been prepared and…”
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