Search Results - "HOUGH, David W."

Catalytic efficiency and kcat / KM : a useful comparator? by Eisenthal, Robert, Danson, Michael J, Hough, David W

“…The ratio kcat / KM – often referred to as the ‘specificity constant’ – is a useful index for comparing the relative rates of an enzyme acting on alternative,…”
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Metabolism of Pentose Sugars in the Hyperthermophilic Archaea Sulfolobus solfataricus and Sulfolobus acidocaldarius by Nunn, Charlotte E.M., Johnsen, Ulrike, Schönheit, Peter, Fuhrer, Tobias, Sauer, Uwe, Hough, David W., Danson, Michael J.

“…We have previously shown that the hyperthermophilic archaeon, Sulfolobus solfataricus, catabolizes d-glucose and d-galactose to pyruvate and glyceraldehyde via…”
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Paliperidone extended-release as adjunctive therapy to lithium or valproate in the treatment of acute mania: A randomized, placebo-controlled study by Berwaerts, Joris, Lane, Rosanne, Nuamah, Isaac F, Lim, Pilar, Remmerie, Bart, Hough, David W

“…Abstract Background Combination treatment with atypical antipsychotics and a mood stabilizer is often recommended for treatment of manic or mixed episodes…”
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A randomized, placebo- and active-controlled study of paliperidone extended release for the treatment of acute manic and mixed episodes of bipolar I disorder by Vieta, Eduard, Nuamah, Isaac F, Lim, Pilar, Yuen, Eric C, Palumbo, Joseph M, Hough, David W, Berwaerts, Joris

“…Vieta E, Nuamah IF, Lim P, Yuen EC, Palumbo JM, Hough DW, Berwaerts J. A randomized, placebo‐ and active‐controlled study of paliperidone extended release for…”
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A one-year prospective study of the safety, tolerability and pharmacokinetics of the highest available dose of paliperidone palmitate in patients with schizophrenia by Coppola, Danielle, Liu, Yanning, Gopal, Srihari, Remmerie, Bart, Samtani, Mahesh N, Hough, David W, Nuamah, Isaac, Sulaiman, Ahmad, Pandina, Gahan

“…There are no previous reports of paliperidone palmitate's (PP) long term tolerability or pharmacokinetics of the highest dose in patients with schizophrenia…”
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Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex by Marrott, Nia L, Marshall, Jacqueline J T, Svergun, Dmitri I, Crennell, Susan J, Hough, David W, van den Elsen, Jean M H, Danson, Michael J

“…The four-component polypeptides of the 2-oxoacid dehydrogenase complex from the thermophilic archaeon Thermoplasma acidophilum assemble to give an active…”
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Structurally Informed Site-Directed Mutagenesis of a Stereochemically Promiscuous Aldolase To Afford Stereochemically Complementary Biocatalysts by Royer, Sylvain F., Haslett, Luke, Crennell, Susan J., Hough, David W., Danson, Michael J., Bull, Steven D.

“…2-Keto-3-deoxygluconate aldolase from the hyperthermophile Sulfolobus solfataricus is a highly thermostable type I aldolase that can catalyze carbon−carbon…”
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Efficacy and Safety of the 3-Month Formulation of Paliperidone Palmitate vs Placebo for Relapse Prevention of Schizophrenia: A Randomized Clinical Trial by Berwaerts, Joris, Liu, Yanning, Gopal, Srihari, Nuamah, Isaac, Xu, Haiyan, Savitz, Adam, Coppola, Danielle, Schotte, Alain, Remmerie, Bart, Maruta, Nataliya, Hough, David W

“…Treatment nonadherence and relapse are common problems in patients with schizophrenia. The long-acting 3-month formulation of paliperidone palmitate, owing to…”
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Metabolic Pathway Promiscuity in the Archaeon Sulfolobus solfataricus Revealed by Studies on Glucose Dehydrogenase and 2-Keto-3-deoxygluconate Aldolase by Lamble, Henry J., Heyer, Narinder I., Bull, Steven D., Hough, David W., Danson, Michael J.

“…The hyperthermophilic Archaeon Sulfolobus solfataricus metabolizes glucose by a non-phosphorylative variant of the Entner-Doudoroff pathway. In this pathway…”
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The Structural Basis of Substrate Promiscuity in Glucose Dehydrogenase from the Hyperthermophilic Archaeon Sulfolobus solfataricus by Milburn, Christine C., Lamble, Henry J., Theodossis, Alex, Bull, Steven D., Hough, David W., Danson, Michael J., Taylor, Garry L.

“…The hyperthermophilic archaeon Sulfolobus solfataricus grows optimally above 80 °C and utilizes an unusual, promiscuous, non-phosphorylative Entner-Doudoroff…”
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The Structural Basis for Substrate Promiscuity in 2-Keto-3-deoxygluconate Aldolase from the Entner-Doudoroff Pathway in Sulfolobus solfataricus by Theodossis, Alex, Walden, Helen, Westwick, Elaine J, Connaris, Helen, Lamble, Henry J, Hough, David W, Danson, Michael J, Taylor, Garry L

“…The hyperthermophilic Archaea Sulfolobus solfataricus grows optimally above 80 °C and metabolizes glucose by a non-phosphorylative variant of the…”
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Gluconate dehydratase from the promiscuous Entner–Doudoroff pathway in Sulfolobus solfataricus by Lamble, Henry J., Milburn, Christine C., Taylor, Garry L., Hough, David W., Danson, Michael J.

“…An investigation has been carried out into gluconate dehydratase from the hyperthermophilic Archaeon Sulfolobus solfataricus. The enzyme has been purified from…”
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Promiscuity in the part-phosphorylative Entner–Doudoroff pathway of the archaeon Sulfolobus solfataricus by Lamble, Henry J., Theodossis, Alex, Milburn, Christine C., Taylor, Garry L., Bull, Steven D., Hough, David W., Danson, Michael J.

“…The hyperthermophilic archaeon Sulfolobus solfataricus metabolises glucose and galactose by a ‘promiscuous’ non-phosphorylative variant of the Entner–Doudoroff…”
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Structural adaptations of the cold-active citrate synthase from an Antarctic bacterium by Russell, Rupert JM, Gerike, Ursula, Danson, Michael J, Hough, David W, Taylor, Garry L

“…Background: The structural basis of adaptation of enzymes to low temperature is poorly understood. Dimeric citrate synthase has been used as a model enzyme to…”
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The Crystal Structure of Citrate Synthase from the Hyperthermophilic Archaeon Pyrococcus furiosus at 1.9 Å Resolution by Russell, Rupert J. M, Ferguson, Jacqueline M. C, Hough, David W, Danson, Michael J, Taylor, Garry L

“…The crystal structure of the closed form of citrate synthase, with citrate and CoA bound, from the hyperthermophilic Archaeon Pyrococcus furiosus has been…”
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A Thermostable Aldolase for the Synthesis of 3-Deoxy-2-ulosonic Acids by Lamble, Henry J., Royer, Sylvain F., Hough, David W., Danson, Michael J., Taylor, Garry L., Bull, Steven D.

“…A stereochemically promiscuous 2‐keto‐3‐deoxygluconate aldolase has been used as an efficient biocatalyst to catalyse the aldol reaction of pyruvate with C3‐…”
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Structure, function and stability of enzymes from the Archaea by Danson, Michael J, Hough, David W

“…The Archaea include microorganisms growing in some of the most extreme environments on earth. Consequently, their cellular components are remarkably stable…”
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Use of a Packed-Column Bioreactor for Isolation of Diverse Protease-Producing Bacteria from Antarctic Soil by WERY, Nathalie, GERIKE, Ursula, SHARMAN, Ajay, CHAUDHURI, Julian B, HOUGH, David W, DANSON, Michael J

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Efficacy and safety of paliperidone palmitate in adult patients with acutely symptomatic schizophrenia: a randomized, double-blind, placebo-controlled, dose-response study by Gopal, Srihari, Hough, David W, Xu, Haiyan, Lull, Julia M, Gassmann-Mayer, Cristiana, Remmerie, Bart M, Eerdekens, Marielle H, Brown, David W

“…This 13-week, double-blind study evaluated the efficacy and safety of the atypical antipsychotic paliperidone palmitate (recently approved in the United…”
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Structure of a bifunctional alcohol dehydrogenase involved in bioethanol generation in Geobacillus thermoglucosidasius by Extance, Jonathan, Crennell, Susan J., Eley, Kirstin, Cripps, Roger, Hough, David W., Danson, Michael J.

“…Bifunctional alcohol/aldehyde dehydrogenase (ADHE) enzymes are found within many fermentative microorganisms. They catalyse the conversion of an acyl‐coenzyme…”
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