Search Results - "HOTFILDER, M"

The ganglioside antigen G(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting by Kailayangiri, S, Altvater, B, Meltzer, J, Pscherer, S, Luecke, A, Dierkes, C, Titze, U, Leuchte, K, Landmeier, S, Hotfilder, M, Dirksen, U, Hardes, J, Gosheger, G, Juergens, H, Rossig, C

“…Novel treatment strategies are needed to cure disseminated Ewing sarcoma. Primitive neuroectodermal features and a mesenchymal stem cell origin are both…”
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Identification of novel therapeutic targets in Ewing sarcoma using a pooled shRNA screening approach in a tumor cell-specific environment by Potratz, J, Schaefer, C, Clemens, D, Hotfilder, M, Dirksen, U

“…An abstract of a study by Dirksen et al aiming identification of novel therapeutic targets in Ewing sarcoma using a pooled shRNA screening approach in a tumor…”
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Ewing sarcoma dissemination and response to T-cell therapy in mice assessed by whole-body magnetic resonance imaging by Liebsch, L, Kailayangiri, S, Beck, L, Altvater, B, Koch, R, Dierkes, C, Hotfilder, M, Nagelmann, N, Faber, C, Kooijman, H, Ring, J, Vieth, V, Rossig, C

“…Background: Novel treatment strategies in Ewing sarcoma include targeted cellular therapies. Preclinical in vivo models are needed that reflect their activity…”
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Cytotoxic T cells transduced with chimeric anti-CD19 receptors prevent engraftment of primary lymphoblastic leukemia in vivo by Landmeier, S, Altvater, B, Pscherer, S, Meltzer, J, Sebire, N, Pule, M, Vera, J, Hotfilder, M, Juergens, H, Vormoor, J, Rossig, C

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PI3K AKT is involved in mediating survival signals that rescue Ewing tumour cells from fibroblast growth factor 2-induced cell death by Hotfilder, M, Sondermann, P, Senss, A, van Valen, F, Jürgens, H, Vormoor, J

“…While in vitro studies had shown that fibroblast growth factor 2 (FGF2) can induce cell death in Ewing tumours, it remained unclear how Ewing tumour cells…”
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Lack of expression of the chondroitin sulphate proteoglycan neuron‐glial antigen 2 on candidate stem cell populations in paediatric acute myeloid leukaemia/abn(11q23) and acute lymphoblastic leukaemia/t(4;11) by Neudenberger, J., Hotfilder, M., Rosemann, A., Langebrake, C., Reinhardt, D., Pieters, R., Schrauder, A., Schrappe, M., Röttgers, S., Harbott, J., Vormoor, J.

“…Summary It has increasingly been acknowledged that only a few leukaemic cells possess the capability to renew themselves and that only these self‐renewing…”
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CD44 expression and hyaluronic acid binding of malignant glioma cells by Knüpfer, M M, Poppenborg, H, Hotfilder, M, Kühnel, K, Wolff, J E, Domula, M

“…The mechanisms leading to rapid invasive growth of malignant gliomas are poorly understood. Expression of the hyaluronic acid (HA) receptor CD44 and adhesion…”
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136 - Identification of novel therapeutic targets in Ewing sarcoma using a pooled shRNA screening approach in a tumor cell-specific environment by Potratz, J., Schaefer, C., Clemens, D., Hotfilder, M., Dirksen, U.

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071 - FUNCTIONAL CHARACTERIZATION OF POTENTIAL DIAGNOSTIC TARGETS IN BURKITT-NHL by te Vrugt, M., Bartels, A., Kosch, L., Feldmeyer, L., Hollfoth, V., Tölle, I., Randau, G., Michgehl, U., Hotfilder, M., Lanvers-Kaminsky, C., Burkhardt, B.

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FUNCTIONAL CHARACTERIZATION OF POTENTIAL DIAGNOSTIC TARGETS IN BURKITT-NHL by te Vrugt, M., Bartels, A., Kosch, L., Feldmeyer, L., Hollfoth, V., Tölle, I., Randau, G., Michgehl, U., Hotfilder, M., Lanvers-Kaminsky, C., Burkhardt, B.

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Interferon-gamma increases IL-6 production in human glioblastoma cell lines by Hotfilder, M, Knupfer, H, Mohlenkamp, G, Pennekamp, P, Knupfers, M, Van Gool, S, Wolff, J E

“…Various immunotherapeutical approaches are presently evaluated for their efficacy to eradicate glioma cells. Complicating the concepts, these tumors secrete…”
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In Childhood Acute Lymphoblastic Leukemia, Blasts at Different Stages of Immunophenotypic Maturation Have Stem Cell Properties by le Viseur, Christoph, Hotfilder, Marc, Bomken, Simon, Wilson, Kerrie, Röttgers, Silja, Schrauder, André, Rosemann, Annegret, Irving, Julie, Stam, Ronald W., Shultz, Leonard D., Harbott, Jochen, Jürgens, Heribert, Schrappe, Martin, Pieters, Rob, Vormoor, Josef

“…We examined the leukemic stem cell potential of blasts at different stages of maturation in childhood acute lymphoblastic leukemia (ALL). Human leukemic bone…”
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Leukemic stem cells in childhood high-risk ALL/t(9;22) and t(4;11) are present in primitive lymphoid-restricted CD34+CD19-cells by HOTFILDER, Marc, RÖTTGERS, Silja, ROSEMANN, Annegret, SCHRAUDER, André, SCHRAPPE, Martin, PIETERS, Rob, JÜRGENS, Heribert, HARBOTT, Jochen, VORMOOR, Josef

“…Open questions in the pathogenesis of childhood acute lymphoblastic leukemia (ALL) are which hematopoietic cell is target of the malignant transformation and…”
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The ganglioside antigen G sub(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting by Kailayangiri, S, Altvater, B, Meltzer, J, Pscherer, S, Luecke, A, Dierkes, C, Titze, U, Leuchte, K, Landmeier, S, Hotfilder, M, Dirksen, U, Hardes, J, Gosheger, G, Juergens, H, Rossig, C

“…Background: Novel treatment strategies are needed to cure disseminated Ewing sarcoma. Primitive neuroectodermal features and a mesenchymal stem cell origin are…”
Get full text

The ganglioside antigen GD2 is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting by Kailayangiri, S, Altvater, B, Meltzer, J, Pscherer, S, Luecke, A, Dierkes, C, Titze, U, Leuchte, K, Landmeier, S, Hotfilder, M, Dirksen, U, Hardes, J, Gosheger, G, Juergens, H, Rossig, C

“…Background: Novel treatment strategies are needed to cure disseminated Ewing sarcoma. Primitive neuroectodermal features and a mesenchymal stem cell origin are…”
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RNAi-based adjuvant therapy in a NSCLC mouse model prevents the development of distant metastasis by Müller-Tidow, C., Bulk, E., Hascher, A., Sargin, B., Vormoor, J., Hotfilder, M., Berdel, W. E., Serve, H.

“…Abstract only 18089 Background: Surgery cures about 50% of the patients with early stage NSCLC. Although adjuvant chemotherapy improves outcome, a considerably…”
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Immature CD34+CD19− progenitor/stem cells in TEL/AML1-positive acute lymphoblastic leukemia are genetically and functionally normal by Hotfilder, Marc, Röttgers, Silja, Rosemann, Annegret, Jürgens, Heribert, Harbott, Jochen, Vormoor, Josef

“…One important question in stem cell biology of childhood acute lymphoblastic leukemia (ALL) is whether immature CD34+CD19− cells are part of the leukemic cell…”
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Selective and nonselective toxicity of TRAIL/Apo2L combined with chemotherapy in human bone tumour cells vs. normal human cells by Van Valen, Frans, Fulda, Simone, Schäfer, Karl‐Ludwig, Truckenbrod, Borna, Hotfilder, Marc, Poremba, Christopher, Debatin, Klaus‐Michael, Winkelmann, Winfried

“…Although TRAIL/Apo2L preferably induces apoptosis in tumour cells without toxicity in normal cells, many tumour cell types display TRAIL/Apo2L resistance…”
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c-KIT-expressing Ewing tumour cells are insensitive to imatinib mesylate (STI571) by HOTFILDER, Marc, LANVERS, Claudia, JÜRGENS, Heribert, BOOS, Joachim, VORMOOR, Josef

“…In order to determine whether Ewing tumour patients may be potential candidates for imatinib mesylate therapy, we analysed the expression of the currently…”
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P13K/AKT is involved in mediating survival signals that rescue Ewing tumour cells from fibroblast growth factor 2-induced cell death by HOTFILDER, M, SONDERMANN, P, SENSS, A, VAN VALEN, F, JÜRGENS, H, VORMOOR, J

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