Search Results - "HOSTOMSKY, Z"

Correction to: NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699 by Hunter, J. E., Willmore, E., Irving, J. A. E., Hostomsky, Z., Veuger, S. J., Durkacz, B. W.

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Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules by Murray, J, Thomas, H, Berry, P, Kyle, S, Patterson, M, Jones, C, Los, G, Hostomsky, Z, Plummer, E R, Boddy, A V, Curtin, N J

“…Background: Poly(ADP-ribose) polymerase-1 (PARP) inhibitors (PARPi) exploit tumour-specific defects in homologous recombination DNA repair and continuous…”
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NF-[kappa]B mediates radio-sensitization by the PARP-1 inhibitor, AG-014699 by Hunter, J E, Willmore, E, Irving, J A E, Hostomsky, Z, Veuger, S J, Durkacz, B W

“…The stress-inducible transcription factor, nuclear factor (NF)-κB induces genes involved in proliferation and apoptosis. Aberrant NF-κB activity is common in…”
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NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699 by Hunter, J E, Willmore, E, Irving, J A E, Hostomsky, Z, Veuger, S J, Durkacz, B W

“…The stress-inducible transcription factor, nuclear factor (NF)-κB induces genes involved in proliferation and apoptosis. Aberrant NF-κB activity is common in…”
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Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699 by Daniel, R A, Rozanska, A L, Mulligan, E A, Drew, Y, Thomas, H D, Castelbuono, D J, Hostomsky, Z, Plummer, E R, Tweddle, D A, Boddy, A V, Clifford, S C, Curtin, N J

“…Background: Temozolomide shows activity against medulloblastoma, the most common malignant paediatric brain tumour. Poly(ADP-ribose) polymerase (PARP)…”
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Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase by White, Alex W, Almassy, Robert, Calvert, A. Hilary, Curtin, Nicola J, Griffin, Roger J, Hostomsky, Zdenek, Maegley, Karen, Newell, David R, Srinivasan, Sheila, Golding, Bernard T

“…The nuclear enzyme poly(ADP-ribose) polymerase (PARP) facilitates the repair of DNA strand breaks and is implicated in the resistance of cancer cells to…”
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The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme by Stempniak, M, Hostomska, Z, Nodes, B R, Hostomsky, Z

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Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis by GRIMSLEY, J. K, TJALKENS, R. B, STRAUCH, M. A, BIRD, T. H, SPIEGELMAN, G. B, HOSTOMSKY, Z, WHITELEY, J. M, HOCH, J. A

“…The Spo0A transcription factor is responsible for the initiation of sporulation and is active in transcription only after phosphorylation by a specific signal…”
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Reconstitution in vitro of RNase H Activity by Using Purified N-Terminal and C-Terminal Domains of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by Hostomsky, Zdenek, Hostomska, Zuzana, Hudson, Geoffrey O., Moomaw, Ellen W., Nodes, Beverly R.

“…Two constituent protein domains of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase were expressed separately and purified to homogeneity. The…”
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Reverse transcriptase of human immunodeficiency virus type 1: functionality of subunits of the heterodimer in DNA synthesis by Hostomsky, Z, Hostomska, Z, Fu, T B, Taylor, J

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Development of a Nonradioactive Ribonuclease H Assay by Rychetsky, P., Hostomska, Z., Hostomsky, Z., Strop, P.

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Redesignation of the RNase D activity associated with retroviral reverse transcriptase as RNase H by HOSTOMSKY, Z, HUGHES, S. H, GOFF, S. P, LE GRICE, S. F. J

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Proteolytic release and crystallization of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase by Z Hostomska, D A Matthews, J F Davies, 2nd, B R Nodes, Z Hostomsky

“…The RNase H domain of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase was released from recombinant DHFR-RNase H fusion protein by the action…”
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Base Excision Repair Is Impaired in Mammalian Cells Lacking Poly(ADP-ribose) Polymerase-1 by Dantzer, Françoise, de la Rubia, Guadelupe, Ménissier-de Murcia, Josiane, Hostomsky, Zdenek, de Murcia, Gilbert, Schreiber, Valérie

“…In mammalian cells, damaged bases in DNA are corrected by the base excision repair pathway which is divided into two distinct pathways depending on the length…”
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Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells by CURTIN, Nicola J, WANG, Lan-Zhen, NEWELL, David R, YIAKOUVAKI, Anthie, KYLE, Suzanne, ARRIS, Christine A, CANAN-KOCH, Stacie, WEBBER, Stephen E, DURKACZ, Barbara W, CALVERT, Hilary A, HOSTOMSKY, Zdenek

“…Purpose: Mismatch repair (MMR) deficiency confers resistance to temozolomide, a clinically active DNA-methylating agent. The purpose of the current study was…”
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Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors by Skalitzky, Donald J, Marakovits, Joseph T, Maegley, Karen A, Ekker, Anne, Yu, Xiao-Hong, Hostomsky, Zdenek, Webber, Stephen E, Eastman, Brian W, Almassy, Robert, Li, Jianke, Curtin, Nicola J, Newell, David R, Calvert, A. Hilary, Griffin, Roger J, Golding, Bernard T

“…Novel tricyclic benzimidazole carboxamide poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized. Several compounds were found to be powerful…”
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The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site by Love, Robert A, Parge, Hans E, Wickersham, John A, Hostomsky, Zdenek, Habuka, Noriyuki, Moomaw, Ellen W, Adachi, Tsuyoshi, Hostomska, Zuzana

“…During replication of hepatitis C virus (HCV), the final steps of polyprotein processing are performed by a viral proteinase located in the N-terminal…”
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Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines by DELANEY, C. A, WANG, L.-Z, KYLE, S, WHITE, A. W, CALVERT, A. H, CURTIN, N. J, DURKACZ, B. W, HOSTOMSKY, Z, NEWELL, D. R

“…Potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The…”
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Identification of potent nontoxic poly(ADP-ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies by CALABRESE, Christopher R, BATEY, Michael A, MAEGLEY, Karen, CALVERT, Alan H, HOSTOMSKY, Zdenek, NEWELL, David R, CURTIN, Nicola J, THOMAS, Huw D, DURKACZ, Barbara W, WANG, Lan-Zhen, KYLE, Suzanne, SKALITZKY, Donald, LI, Janke, ZHANG, Catherine, BORITZKI, Theodore

“…The nuclear enzyme poly(ADP-ribose) polymerase (PARP-1) facilitates DNA repair, and is, therefore, an attractive target for anticancer chemo- and…”
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Affinity chromatography with biotinylated RNAs by Ruby, S W, Goelz, S E, Hostomsky, Z, Abelson, J N

“…Small, reversibly biotinylated RNAs as described here are versatile ligands for affinity chromatography of RNA-binding components. These RNAs can be attached…”
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