Search Results - "HOSTETLER, Karl Y"

Application of kinase bypass strategies to nucleoside antivirals by Ray, Adrian S., Hostetler, Karl Y.

“…► Nucleoside and nucleotides are the cornerstones of antiviral therapy. ► Requirement for activation and side-effects limit the efficacy of the current drugs…”
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Synthesis and Early Development of Hexadecyloxypropyl-cidofovir: An Oral Antipoxvirus Nucleoside Phosphonate by Hostetler, Karl Y.

“…Hexadecyloxypropyl-cidofovir (HDP-CDV) is a novel ether lipid conjugate of (S)-1-(3-hydroxy-2-phosphonoylmethoxypropyl)-cytosine (CDV) which exhibits a…”
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Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524) by Lo, Michael K, Shrivastava-Ranjan, Punya, Chatterjee, Payel, Flint, Mike, Beadle, James R, Valiaeva, Nadejda, Murphy, Joyce, Schooley, Robert T, Hostetler, Karl Y, Montgomery, Joel M, Spiropoulou, Christina F

“…The necessity for intravenous administration of remdesivir confines its utility for treatment of coronavirus disease 2019 (COVID-19) to hospitalized patients…”
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Cidofovir and (S)-9-[3-Hydroxy-(2-Phosphonomethoxy)Propyl]Adenine Are Highly Effective Inhibitors of Vaccinia Virus DNA Polymerase When Incorporated into the Template Strand by MAGEE, Wendy C, ALDERN, Kathy A, HOSTETLER, Karl Y, EVANS, David H

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Mechanism of Inhibition of Vaccinia Virus DNA Polymerase by Cidofovir Diphosphate by MAGEE, Wendy C, HOSTELLER, Karl Y, EVANS, David H

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Octadecyloxyethyl Adefovir Exhibits Potent in vitro and in vivo Cytotoxic Activity and Has Synergistic Effects with Ara-C in Acute Myeloid Leukemia by Khoury, Haytham, He, Ruijuan, Schimmer, Aaron, Beadle, James R, Hostetler, Karl Y, Minden, Mark D

“…Acute myeloid leukemia (AML) continues to be a deadly disease, with only 50-70% of patients achieving complete remission and less than 30% of adults having…”
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Ether Lipid-Ester Prodrugs of Acyclic Nucleoside Phosphonates: Activity against Adenovirus Replication In Vitro by Hartline, Caroll B., Gustin, Kortney M., Wan, William B., Ciesla, Stephanie L., Beadle, James R., Hostetler, Karl Y., Kern, Earl R

“…The acyclic nucleoside phosphonate cidofovir (CDV) and its closely related analogue (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-adenine ([S]-HPMPA) have been…”
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Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: Current state of the art by Hostetler, Karl Y.

“…Although the acyclic nucleoside phosphonates cidofovir, adefovir and tenofovir are approved for treating human cytomegalovirus, hepatitis B and HIV infections,…”
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Ether Lipid Ester Derivatives of Cidofovir Inhibit Polyomavirus BK Replication In Vitro by RANDHAWA, Parmjeet, FARASATI, Noush Afarin, SHAPIRO, Ron, HOSTETLER, Karl Y

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Enhanced Inhibition of Orthopoxvirus Replication In Vitro by Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir by KERN, Earl R, HARTLINE, Caroll, HARDEN, Emma, KEITH, Kathy, RODRIGUEZ, Natalie, BEADLE, James R, HOSTETLER, Karl Y

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Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections by PAINTER, George R, ALMOND, Merrick R, TROST, Lawrence C, LAMPERT, Bernhard M, NEYTS, Johan, DE CLERCQ, Erik, KORBA, Brent E, ALDERN, Kathy A, BEADLE, James R, HOSTETLER, Karl Y

“…ERRATUM ( vol. 51 , p. 4538 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg…”
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Solution Structure of a DNA Duplex Containing the Potent Anti-Poxvirus Agent Cidofovir by Julien, Olivier, Beadle, James R, Magee, Wendy C, Chatterjee, Subhrangsu, Hostetler, Karl Y, Evans, David H, Sykes, Brian D

“…Cidofovir (1(S)-[3-hydroxy-2-(phosphonome-thoxy)propyl]cytosine, CDV) is a potent inhibitor of orthopoxvirus DNA replication. Prior studies have shown that,…”
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Oral Treatment of Cowpox and Vaccinia Virus Infections in Mice with Ether Lipid Esters of Cidofovir by Quenelle, Debra C, Collins, Deborah J, Wan, W Brad, Beadle, James R, Hostetler, Karl Y, Kern, Earl R

“…AUTHOR'S CORRECTION ( vol. 48 , p. 1919 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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Comparative Activities of Lipid Esters of Cidofovir and Cyclic Cidofovir against Replication of Herpesviruses In Vitro by WILLIAMS-AZIZ, Stephanie L, HARTLINE, Caroll B, HARDEN, Emma A, DAILY, Shannon L, PRICHARD, Mark N, KUSHNER, Nicole L, BEADLE, James R, WAN, W. Brad, HOSTETLER, Karl Y, KERN, Earl R

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Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir Exhibit Multiple-Log Enhancement of Antiviral Activity against Cytomegalovirus and Herpesvirus Replication In Vitro by BEADLE, James R, HARTLINE, Caroll, ALDERN, Kathy A, RODRIGUEZ, Natalie, HARDEN, Emma, KERN, Earl R, HOSTETLER, Karl Y

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The Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A Replicons by WYLES, David L, KAIHARA, Kelly A, KORBA, Brent E, SCHOOLEY, Robert T, BEADLE, James R, HOSTETLER, Karl Y

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A novel lipid prodrug strategy for sustained delivery of hexadecyloxypropyl 9-[2-(phosphonomethoxy)ethyl]guanine (HDP-PMEG) on unwanted ocular proliferation by Chen, Mei, Hou, Jiangping, Tan, Guilin, Xie, Peng, Freeman, William R., Beadle, James R., Hostetler, Karl Y., Cheng, Lingyun

“…Proliferative vitreoretinopathy (PVR) is a blinding eye disease and there is no effective pharmacological measure to prevent PVR development. The difficulty…”
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Oral Hexadecyloxypropyl-Cidofovir Therapy in Pregnant Guinea Pigs Improves Outcome in the Congenital Model of Cytomegalovirus Infection by BRAVO, Fernando J, BERNSTEIN, David I, BEADLE, James R, HOSTETLER, Karl Y, CARDIN, Rhonda D

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Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-(14)C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism by Aldern, Kathy A, Ciesla, Stephanie L, Winegarden, Kristine L, Hostetler, Karl Y

“…Recently, there has been renewed interest in finding orally active drugs against smallpox. Cidofovir (CDV) given by parenteral injection has been shown to…”
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Inhibition of HIV-1 by Octadecyloxyethyl Esters of (S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl] Nucleosides and Evaluation of Their Mechanism of Action by Magee, Wendy C, Valiaeva, Nadejda, Beadle, James R, Richman, Douglas D, Hostetler, Karl Y, Evans, David H

“…(S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC [cidofovir]) and (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) are potent inhibitors…”
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