Search Results - "HOSODA, HIROSHI"

Effect of Ghrelin on the Cardiovascular System by Hosoda, Hiroshi

“…Ghrelin, an n-octanoyl-modified 28-amino-acid-peptide, was first discovered in the human and rat stomach as an endogenous ligand for the growth hormone…”
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Glutamate in the medium of Lactiplantibacillus plantarum FL-664 affects the production of IL-12(p40) on murine spleen cells by Kawamoto-Miyamoto, Noriko, Hosoda, Hiroshi, Miyoshi, Kazuyuki, Nomoto, Koji

“…Lactic acid bacteria (LAB) have been attracting attention for their effects on innate immunity, and therefore, it is required to develop an efficient culturing…”
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Abnormal Microscopic Findings in the Placenta Correlate With the Severity of Fetal Heart Failure by Miyoshi, Takekazu, Matsuyama, Taka-aki, Nakai, Michikazu, Miyazato, Mikiya, Yoshimatsu, Jun, Hatakeyama, Kinta, Hosoda, Hiroshi

“…Background: This study investigated the association between placental pathology and fetal heart failure.Methods and Results: Singletons with a congenital heart…”
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Nationwide monitoring of selected antibiotics: Distribution and sources of sulfonamides, trimethoprim, and macrolides in Japanese rivers by Murata, Ayako, Takada, Hideshige, Mutoh, Kunihiro, Hosoda, Hiroshi, Harada, Arata, Nakada, Norihide

“…We report the results of a nationwide survey of commonly used human and veterinary antibiotics (7 sulfonamides, trimethoprim, and 4 macrolides) in 37 Japanese…”
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Significance of Atrial and Brain Natriuretic Peptide Measurements in Fetuses With Heart Failure by Miyoshi, Takekazu, Hosoda, Hiroshi, Minamino, Naoto

“…Fetal heart failure is mainly caused by congenital heart defect and arrhythmia. It is difficult to appropriately diagnose the severity of fetal heart failure…”
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Biological, Physiological, and Pharmacological Aspects of Ghrelin by Hosoda, Hiroshi, Kojima, Masayasu, Kangawa, Kenji

“…Ghrelin, identified as an endogenous ligand for the growth hormone secretagogue receptor, functions as a somatotrophic and orexigenic signal from the stomach…”
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Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation by Hasegawa, Shunsuke, Fukushima, Hotaka, Hosoda, Hiroshi, Serita, Tatsurou, Ishikawa, Rie, Rokukawa, Tomohiro, Kawahara-Miki, Ryouka, Zhang, Yue, Ohta, Miho, Okada, Shintaro, Tanimizu, Toshiyuki, Josselyn, Sheena A., Frankland, Paul W., Kida, Satoshi

“…Cognitive performance in people varies according to time-of-day, with memory retrieval declining in the late afternoon-early evening. However, functional roles…”
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The autonomic nervous system regulates gastric ghrelin secretion in rats by HOSODA, Hiroshi, KANGAWA, Kenji

“…Plasma ghrelin levels are responsive to short- and long-term nutrient fluctuation, but the mechanisms of its regulation are largely unknown. To explore the…”
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Decreased plasma ghrelin in male ALS patients is associated with poor prognosis by Nagaoka, Utako, Shimizu, Toshio, Uchihara, Toshiki, Komori, Takashi, Hosoda, Hiroshi, Takahashi, Kazushi

“…•Among ALS, male had lower plasma ghrelin levels than female, but disease specificity is unknown.•Low plasma ghrelin in male ALS was not associated with BMI,…”
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NSP-C contributes to the upregulation of CLOCK/BMAL1-mediated transcription by Hosoda, Hiroshi, Kida, Satoshi

“…The bHLH-PAS transcription factors clock circadian regulator (CLOCK) and brain and muscle ARNT-like protein 1 (BMAL1) play essential roles in the generation of…”
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C-type natriuretic peptide (CNP) in endothelial cells attenuates hepatic fibrosis and inflammation in non-alcoholic steatohepatitis by Bae, Cho-Rong, Hino, Jun, Hosoda, Hiroshi, Miyazato, Mikiya, Kangawa, Kenji

“…Our previous study revealed that mice transgenic for endothelial-cell–specific overexpression of CNP (E-CNP Tg mice) are protected against the increased fat…”
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Plasma Clearance of Intravenously Infused Adrenomedullin in Rats with Acute Renal Failure by Hosoda, Hiroshi, Nakamura, Tsutomu, Yoshihara, Fumiki

“…Plasma adrenomedullin concentrations are reportedly elevated in patients with renal failure; however, the underlying mechanism is unclear. In this study, we…”
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Angiotensin II promotes pulmonary metastasis of melanoma through the activation of adhesion molecules in vascular endothelial cells by Ishikane, Shin, Hosoda, Hiroshi, Nojiri, Takashi, Tokudome, Takeshi, Mizutani, Tetsuya, Miura, Koichi, Akitake, Yoshiharu, Kimura, Toru, Imamichi, Yoshitaka, Kawabe, Shinya, Toyohira, Yumiko, Yanagihara, Nobuyuki, Takahashi-Yanaga, Fumi, Miyazato, Mikiya, Miyamoto, Kaoru, Kangawa, Kenji

“…[Display omitted] Hypertension is considered as one of the cancer progressive factors, and often found comorbidity in cancer patients. Renin-angiotensin system…”
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Ghrelin and Des-acyl Ghrelin: Two Major Forms of Rat Ghrelin Peptide in Gastrointestinal Tissue by Hosoda, Hiroshi, Kojima, Masayasu, Matsuo, Hisayuki, Kangawa, Kenji

“…Ghrelin, a novel peptide purified from stomach, is the endogenous ligand for the growth hormone secretagogue receptor and has potent growth hormone-releasing…”
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Blockade of Pancreatic Islet–Derived Ghrelin Enhances Insulin Secretion to Prevent High-Fat Diet–Induced Glucose Intolerance by DEZAKI, Katsuya, SONE, Hideyuki, KOIZUMI, Masaru, NAKATA, Masanori, KAKEI, Masafumi, NAGAI, Hideo, HOSODA, Hiroshi, KANGAWA, Kenji, YADA, Toshihiko

“…Blockade of Pancreatic Islet–Derived Ghrelin Enhances Insulin Secretion to Prevent High-Fat Diet–Induced Glucose Intolerance Katsuya Dezaki 1 , Hideyuki Sone 1…”
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Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells by Nojiri, Takashi, Hosoda, Hiroshi, Tokudome, Takeshi, Miura, Koichi, Ishikane, Shin, Otani, Kentaro, Kishimoto, Ichiro, Shintani, Yasushi, Inoue, Masayoshi, Kimura, Toru, Sawabata, Noriyoshi, Minami, Masato, Nakagiri, Tomoyuki, Funaki, Soichiro, Takeuchi, Yukiyasu, Maeda, Hajime, Kidoya, Hiroyasu, Kiyonari, Hiroshi, Shioi, Go, Arai, Yuji, Hasegawa, Takeshi, Takakura, Nobuyuki, Hori, Megumi, Ohno, Yuko, Miyazato, Mikiya, Mochizuki, Naoki, Okumura, Meinoshin, Kangawa, Kenji

“…Significance Postoperative cancer recurrence is a major problem following curative cancer surgery. Perioperative systemic inflammation induces the adhesion of…”
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Moderate maternal food restriction in mice impairs physical growth, behavior, and neurodevelopment of offspring by Akitake, Yoshiharu, Katsuragi, Shinji, Hosokawa, Masato, Mishima, Kenichi, Ikeda, Tomoaki, Miyazato, Mikiya, Hosoda, Hiroshi

“…Abstract Intrauterine growth retardation (IUGR) occurs in 3% to 7% of all pregnancies. Recent human studies have indicated that neurodevelopmental…”
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Ghrelin is a growth-hormone-releasing acylated peptide from stomach by Kojima, Masayasu, Hosoda, Hiroshi, Date, Yukari, Nakazato, Masamitsu, Matsuo, Hisayuki, Kangawa, Kenji

“…Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary. They act through GHS-R, a…”
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Local Action of Neprilysin Exacerbates Pressure Overload Induced Cardiac Remodeling by Nakagawa, Hitoshi, Kumazawa, Takuya, Onoue, Kenji, Nakada, Yasuki, Nakano, Tomoya, Ishihara, Satomi, Minamino, Naoto, Hosoda, Hiroshi, Iwata, Nobuhisa, Ueda, Tomoya, Seno, Ayako, Nishida, Taku, Soeda, Tsunenari, Okayama, Satoshi, Watanabe, Makoto, Kawakami, Rika, Saito, Yoshihiko

“…NEP (Neprilysin) degrades natriuretic peptides, and its inhibition is a clinically accepted target for heart failure treatment. NEP is widely expressed in…”
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Comprehensive Profiling of GPCR Expression in Ghrelin-Producing Cells by Koyama, Hiroyuki, Iwakura, Hiroshi, Dote, Katsuko, Bando, Mika, Hosoda, Hiroshi, Ariyasu, Hiroyuki, Kusakabe, Toru, Son, Choel, Hosoda, Kiminori, Akamizu, Takashi, Kangawa, Kenji, Nakao, Kazuwa

“…To determine the comprehensive G protein-coupled receptor (GPCR) expression profile in ghrelin-producing cells and to elucidate the role of GPCR-mediated…”
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