Search Results - "HORSTKOTTE, Jan"

Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation by Desch, Steffen, Freund, Anne, Akin, Ibrahim, Behnes, Michael, Preusch, Michael R, Zelniker, Thomas A, Skurk, Carsten, Landmesser, Ulf, Graf, Tobias, Eitel, Ingo, Fuernau, Georg, Haake, Hendrik, Nordbeck, Peter, Hammer, Fabian, Felix, Stephan B, Hassager, Christian, Engstrøm, Thomas, Fichtlscherer, Stephan, Ledwoch, Jakob, Lenk, Karsten, Joner, Michael, Steiner, Stephan, Liebetrau, Christoph, Voigt, Ingo, Zeymer, Uwe, Brand, Michael, Schmitz, Roland, Horstkotte, Jan, Jacobshagen, Claudius, Pöss, Janine, Abdel-Wahab, Mohamed, Lurz, Philipp, Jobs, Alexander, de Waha-Thiele, Suzanne, Olbrich, Denise, Sandig, Frank, König, Inke R, Brett, Sabine, Vens, Maren, Klinge, Kathrin, Thiele, Holger

“…In this randomized trial involving patients with out-of-hospital cardiac arrest without ST-segment elevation on postresuscitation electrocardiography, no…”
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Randomized, Controlled Trial of Ultrasound-Assisted Catheter-Directed Thrombolysis for Acute Intermediate-Risk Pulmonary Embolism by Kucher, Nils, Boekstegers, Peter, Müller, Oliver J, Kupatt, Christian, Beyer-Westendorf, Jan, Heitzer, Thomas, Tebbe, Ulrich, Horstkotte, Jan, Müller, Ralf, Blessing, Erwin, Greif, Martin, Lange, Philipp, Hoffmann, Ralf-Thorsten, Werth, Sebastian, Barmeyer, Achim, Härtel, Dirk, Grünwald, Henriette, Empen, Klaus, Baumgartner, Iris

“…BACKGROUND—In patients with acute pulmonary embolism, systemic thrombolysis improves right ventricular (RV) dilatation, is associated with major bleeding, and…”
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Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis by Ziegler, Tilman, Horstkotte, Jan, Schwab, Claudia, Pfetsch, Vanessa, Weinmann, Karolina, Dietzel, Steffen, Rohwedder, Ina, Hinkel, Rabea, Gross, Lisa, Lee, Seungmin, Hu, Junhao, Soehnlein, Oliver, Franz, Wolfgang M, Sperandio, Markus, Pohl, Ulrich, Thomas, Markus, Weber, Christian, Augustin, Hellmut G, Fässler, Reinhard, Deutsch, Urban, Kupatt, Christian

“…Septic shock is characterized by increased vascular permeability and hypotension despite increased cardiac output. Numerous vasoactive cytokines are…”
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Thymosin β4 Is an Essential Paracrine Factor of Embryonic Endothelial Progenitor Cell-Mediated Cardioprotection by HINKEL, Rabea, EL-AOUNI, Chiraz, HANNAPPEL, Ewald, BOCK-MARQUETTE, Ildiko, DIMAIO, J. Michael, HATZOPOULOS, Antonis K, BOEKSTEGERS, Peter, KUPATT, Christian, OLSON, Tonia, HORSTKOTTE, Jan, MAYER, Stefan, MÜLLER, Sebastian, WILLHAUCK, Michael, SPITZWEG, Christine, GILDEHAUS, Franz-Josef, MÜNZING, Wolfgang

“…Background— Prolonged myocardial ischemia results in cardiomyocyte loss despite successful revascularization. We have reported that retrograde application of…”
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Percutaneous mitral valve repair as rescue procedure after post myocardial infarction papillary muscle rupture and acute cardiogenic shock by Horstkotte, Jan C., Horstkotte, M., Beucher, H., Felderhoff, T., Boekstegers, P.

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Endothelial Nitric Oxide Synthase Overexpression Provides a Functionally Relevant Angiogenic Switch in Hibernating Pig Myocardium by Kupatt, Christian, MD, Hinkel, Rabea, DVM, von Brühl, Marie-Luise, DVM, Pohl, Tilmann, MD, Horstkotte, Jan, MD, Raake, Philip, MD, El Aouni, Chiraz, PhD, Thein, Eckehard, DVM, Dimmeler, Stefanie, PhD, Feron, Olivier, PhD, Boekstegers, Peter, MD

“…Endothelial Nitric Oxide Synthase Overexpression Provides a Functionally Relevant Angiogenic Switch in Hibernating Pig Myocardium Christian Kupatt, Rabea…”
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Cotransfection of Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Via Recombinant Adeno-Associated Virus Resolves Chronic Ischemic Malperfusion by Kupatt, Christian, MD, Hinkel, Rabea, DVM, Pfosser, Achim, MD, El-Aouni, Chiraz, PhD, Wuchrer, Alexander, MD, Fritz, Andrea, MD, Globisch, Franziska, MD, Thormann, Michael, DVM, Horstkotte, Jan, MD, Lebherz, Corinna, MD, Thein, Eckart, DVM, Banfi, Andrea, PhD, Boekstegers, Peter, MD

“…Objectives We set out to investigate the ability of cardiotropic adeno-associated viral vector (AAV2.9 = recombinant adeno-associated virus [rAAV]) to induce…”
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Molecular mechanisms of platelet-mediated leukocyte recruitment during myocardial reperfusion by Kupatt, Christian, Wichels, Reinhard, Horstkotte, Jan, Krombach, Fritz, Habazettl, Helmut, Boekstegers, Peter

“…Leukocyte interaction with platelets and endothelial cells as cause of myocardial stunning was investigated. Mice were anesthetized and, after thoracotomy, the…”
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Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation by Hinkel, Rabea, DVM, Lange, Philipp, MD, Petersen, Björn, DVM, Gottlieb, Elena, MD, Ng, Judy King Man, PhD, Finger, Stefanie, MSc, Horstkotte, Jan, MD, Lee, Seungmin, MSc, Thormann, Michael, DVM, Knorr, Maike, MD, El-Aouni, Chiraz, PhD, Boekstegers, Peter, MD, Reichart, Bruno, MD, Wenzel, Philip, MD, Niemann, Heiner, DVM, Kupatt, Christian, MD

“…Abstract Background Heme oxygenase-1 (HO-1) is an inducible stress-responsive enzyme converting heme to bilirubin, carbon monoxide, and free iron, which exerts…”
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Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial by Sibbing, Dirk, Aradi, Dániel, Gross, Lisa, Trenk, Dietmar, Geisler, Tobias, Orban, Martin, Hadamitzky, Martin, Merkely, Béla, Kiss, Róbert Gábor, Komócsi, András, Dézsi, Csaba A, Holdt, Lesca, Felix, Stephan B, Parma, Radoslaw, Schwinger, Robert H G, Rieber, Johannes, Huber, Kurt, Neumann, Franz-Josef, Koltowski, Lukasz, Mehilli, Julinda, Massberg, Steffen, Parma, Radoslaw, Parma, Zofia, Lesiak, Maciej, Komosa, Anna, Huczek, Zenon, Koltowski, Lukasz, Kowara, Michal, Rymuza, Bartosz, Klopotowski, Mariusz, Veress, Gábor, Dézsi, András Döme, Merkely, Béla, Lux, Árpád, Kiss, Róbert Gábor, Papp, Judit, Kovács, Andrea, Dézsi, Csaba András, Amer, Sayour, Róna, Szilárd, Komócsi, András, Ili, Renáta, Ungi, Imre, Zweiker, Robert, Tóth-Gayor, Gábor, Huber, Kurt, Haller, Paul, von Scheidt, Wolfgang, Blüthgen, Andreas, Neumann, Franz-Josef, Trenk, Dietmar, Leggewie, Stefan, Kreider-Stempfle, Hans Ulrich, Kara, Kaffer, Mügge, Andreas, Fichtlscherer, Stephan, Zeiher, Andreas M., Seeger, Florian, Hinterseer, Martin, König, Andreas, Lederle, Susanne, Jacobshagen, Claudius, Czepluch, Frauke, Maier, Lars, Schillinger, Wolfgang, Sossalla, Samuel, Hummel, Astrid, Felix, Stephan, Karakas, Mahir, Sydow, Karsten, Rudolph, Tanja, Halbach, Marcel, Gori, Tommaso, Münzel, Thomas, May, Andreas, Gerstenberg, Carsten-Manuel, Pilecky, David, Rieber, Johannes, Deichstetter, Markus, Sibbing, Dirk, Gross, Lisa, Kääb, Stefan, Löw, Anja, Orban, Martin, Sattler, Stefan, Teupser, Daniel, Holdt, Lesca, Räder, Thomas, Schütz, Torsten, Vahldiek, Felix, Divchev, Dimitar, Ince, Hüseyin, Nienaber, Christoph A, Radunski, Henning, Boekstegers, Peter, Horstkotte, Jan, Mueller, Ralf, Geisler, Tobias, Schwinger, Robert, Rasp, Oliver

“…Current guidelines recommend potent platelet inhibition with prasugrel or ticagrelor for 12 months after an acute coronary syndrome managed with percutaneous…”
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Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model by Hinkel, Rabea, Lange, Philipp, Petersen, Björn, Gottlieb, Elena, Ng, Judy King Man, Finger, Stefanie, Horstkotte, Jan, Lee, Seungmin, Thormann, Michael, Knorr, Maike, El-Aouni, Chiraz, Boekstegers, Peter, Reichart, Bruno, Wenzel, Philip, Niemann, Heiner, Kupatt, Christian

“…Heme oxygenase-1 (HO-1) is an inducible stress-responsive enzyme converting heme to bilirubin, carbon monoxide, and free iron, which exerts anti-inflammatory…”
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Intraprocedural assessment of mitral regurgitation during the mitraclip procedure: Impact of continuous left atrial pressure monitoring by Horstkotte, Jan, Kloeser, C., Beucher, H., Schwarzlaender, E., von Bardeleben, R. S., Boekstegers, P.

“…Introduction Intraprocedural assessment of mitral regurgitation (MR) is a challenging issue during the MitraClip procedure, which might influence not only the…”
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Immediate unselected coronary angiography versus delayed triage in survivors of out-of-hospital cardiac arrest without ST-segment elevation: Design and rationale of the TOMAHAWK trial by Desch, Steffen, Freund, Anne, Graf, Tobias, Fichtlscherer, Stephan, Haake, Hendrik, Preusch, Michael, Hammer, Fabian, Akin, Ibrahim, Christ, Martin, Liebetrau, Christoph, Skurk, Carsten, Steiner, Stephan, Voigt, Ingo, Schmitz, Roland, Mudra, Harald, Ledwoch, Jakob, Menck, Niels, Horstkotte, Jan, Pels, Klaus, Lahmann, Anna-Lena, Otto, Sylvia, Lenk, Karsten, Ohlow, Marc-Alexander, Hassager, Christian, Nordbeck, Peter, Zeymer, Uwe, Jobs, Alexander, de Waha-Thiele, Suzanne, Olbrich, Denise, König, Inke, Klinge, Kathrin, Thiele, Holger

“…Patients experiencing out-of-hospital cardiac arrest (OHCA) without ST-segment elevation are a heterogenic group with a variety of underlying causes. Up to…”
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STEMI TREATMENT BY CRP REMOVAL PROMISES CLINICAL BENEFIT: FIRST RESULTS OF THE CAMI1 STUDY by Garlichs, Christoph D., Sheriff, Ahmed, Kelle, Sebastian, Torzewski, Jan, Lehrke, Stephanie, Horstkotte, Jan, Darius, Harald, Pflücke, Christian, Heigl, Franz, Ince, Hüseyin, Mitzner, Steffen, Ries, Wolfgang

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Cotransfection of Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Via Recombinant Adeno-Associated Virus Resolves Chronic Ischemic Malperfusion: Role of Vessel Maturation by KUPATT, Christian, HINKEL, Rabea, THEIN, Eckart, BANFI, Andrea, BOEKSTEGERS, Peter, PFOSSER, Achim, EL-AOUNI, Chiraz, WUCHRER, Alexander, FRITZ, Andrea, GLOBISCH, Franziska, THORMANN, Michael, HORSTKOTTE, Jan, LEBHERZ, Corinna

“…We set out to investigate the ability of cardiotropic adeno-associated viral vector (AAV2.9 = recombinant adeno-associated virus [rAAV]) to induce prolonged…”
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Surface Chemistry of Quantum Dots Determines Their Behavior in Postischemic Tissue by Rehberg, Markus, Leite, Camila F, Mildner, Karina, Horstkotte, Jan, Zeuschner, Dagmar, Krombach, Fritz

“…The behavior of quantum dots (QDs) in the microvasculature and their impact on inflammatory reactions under pathophysiological conditions are still largely…”
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Endothelial RAGE exacerbates acute postischaemic cardiac inflammation by Ziegler, Tilman, Horstkotte, Melanie, Lange, Philipp, Ng, Judy, Bongiovanni, Dario, Hinkel, Rabea, Laugwitz, Karl-Ludwig, Sperandio, Markus, Horstkotte, Jan, Kupatt, Christian

“…Advanced glycation end-products (AGEs) interact with their receptor RAGE, leading to an inflammatory state. We investigated the role of RAGE in postischaemic…”
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A randomised trial on platelet function-guided de-escalation of antiplatelet treatment in ACS patients undergoing PCI. Rationale and design of the Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment for Acute Coronary Syndromes (TROPICAL-ACS) Trial by Sibbing, Dirk, Aradi, Dániel, Jacobshagen, Claudius, Gross, Lisa, Trenk, Dietmar, Geisler, Tobias, Orban, Martin, Gori, Tommaso, Hadamitzky, Martin, Merkely, Béla, Kiss, Róbert Gábor, Komócsi, András, Dézsi, Csaba A, Thalmeier, Andreas, Löw, Anja, Holdt, Lesca, Teupser, Daniel, Ince, Hüseyin, Felix, Stephan B, Parma, Radoslaw, Malek, Lukasz, Horstkotte, Jan, Baylacher, Monika, Schwinger, Robert, Rieber, Johannes, Mudra, Harald, Hausleiter, Jörg, Huber, Kurt, Neumann, Franz-Josef, Koltowski, Lukasz, Huczek, Zenon, Mehilli, Julinda, Massberg, Steffen

“…Outcomes of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) have been significantly improved with the use of potent…”
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Mitochondrial Thioredoxin Reductase Is Essential for Early Postischemic Myocardial Protection by HORSTKOTTE, Jan, PERISIC, Tamara, SCHULZ, Sabine, SCHMITT, Sabine, WIDDER, Julian, SINOWATZ, Fred, BECKER, Bernhard F, BAUERSACHS, Johann, NAEBAUER, Michael, FRANZ, Wolfgang M, JEREMIAS, Irmela, BRIELMEIER, Markus, SCHNEIDER, Manuela, ZISCHKA, Hans, CONRAD, Marcus, KUPATT, Christian, LANGE, Philipp, SCHROEDER, Melanie, KIERMAYER, Claudia, HINKEL, Rabea, ZIEGLER, Tilman, MANDAL, Pankaj K, DAVID, Robert

“…Excessive formation of reactive oxygen species contributes to tissue injury and functional deterioration after myocardial ischemia/reperfusion. Especially,…”
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Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation: One-Year Outcomes of a Randomized Clinical Trial by Desch, Steffen, Freund, Anne, Akin, Ibrahim, Behnes, Michael, Preusch, Michael R, Zelniker, Thomas A, Skurk, Carsten, Landmesser, Ulf, Graf, Tobias, Eitel, Ingo, Fuernau, Georg, Haake, Hendrik, Nordbeck, Peter, Hammer, Fabian, Felix, Stephan B, Hassager, Christian, Kjærgaard, Jesper, Fichtlscherer, Stephan, Ledwoch, Jakob, Lenk, Karsten, Joner, Michael, Steiner, Stephan, Liebetrau, Christoph, Voigt, Ingo, Zeymer, Uwe, Brand, Michael, Schmitz, Roland, Horstkotte, Jan, Jacobshagen, Claudius, Pöss, Janine, Abdel-Wahab, Mohamed, Lurz, Philipp, Jobs, Alexander, de Waha, Suzanne, Olbrich, Denise, Sandig, Frank, König, Inke R, Brett, Sabine, Vens, Maren, Klinge, Kathrin, Thiele, Holger

“…Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest (OHCA). The long-term effect of early coronary angiography on patients with OHCA…”
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