Search Results - "HORNKOHL, A"

Platelets Generated In Vitro From Proplatelet-Displaying Human Megakaryocytes Are Functional by Choi, Esther S., Nichol, Janet L., Hokom, Martha M., Hornkohl, Alex C., Hunt, Pamela

“…An in vitro culture system demonstrating the transitions from megakaryocyte progenitors to functional platelets is described. CD34-selected cells from normal…”
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Serum thrombopoietin levels in patients with aplastic anaemia by Marsh, J C, Gibson, F M, Prue, R L, Bowen, A, Dunn, V T, Hornkohl, A C, Nichol, J L, Gordon-Smith, E C

“…Endogenous serum thrombopoietin (TPO) levels were measured in 31 patients with aplastic anaemia (AA) using an enzyme immunoassay with a sensitivity of 20 pg/…”
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Purification and Biologic Characterization of Plasma-Derived Megakaryocyte Growth and Development Factor by Hunt, Pamela, Li, Yue-Sheng, Nichol, Janet L., Hokom, Martha M., Bogenberger, Jakob M., Swift, Susan E., Skrine, James D., Hornkohl, Alex C., Lu, Hsieng, Clogston, Chris, Merewether, Lee Anne, Johnson, Merrie Jo, Parker, Vann, Knudten, Andrew, Farese, Ann, Hsu, Rou Yin, Garcia, Andrew, Stead, Richard, Bosselman, Robert A., Bartley, Timothy D.

“…The isolation and cloning of the ligand for the cytokine receptor, Mpl, have been recently described. In this report we present details of the purification of…”
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High levels of thrombopoietin in sera of patients with essential thrombocythemia : Cause or consequence of abnormal platelet production? by GRIESSHAMMER, M, HORNKOHL, A, NICHOL, J. L, HECHT, T, RAGHAVACHAR, A, HEIMPEL, H, SCHREZENMEIER, H

“…Thrombopoietin (TPO) is the most important regulator of megakaryocyte development and platelet production. Platelet production is thought to be regulated by a…”
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Thrombopoietin level in young Patients is related to megakaryocyte frequency and platelet count by KUEFER, M. U, WANG, W. C, HEAD, D. R, WILIMAS, J. A, FURMAN, W. L, QING LIU, HORNKOHL, A. C, BEST, D. M, JACKSON, C. W

“…To examine the relationships among platelet counts, bone marrow megakaryocyte frequency, and circulating thrombopoietin (TPO) levels. TPO levels in 17 children…”
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The effect of the platelet-derived glycosaminoglycan serglycin on in vitro proplatelet-like process formation by Hunt, P, Hokom, M M, Hornkohl, A, Wiemann, B, Rohde, M F, Arakawa, T

“…The formation of proplatelet-like processes on megakaryocytes cultured in vitro has been shown to be inhibited by prothrombin, found residually in human serum,…”
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Enrichment and characterization of peripheral blood-derived megakaryocyte progenitors that mature in short-term liquid culture by Nichol, J L, Hornkohl, A C, Choi, E S, Hokom, M M, Ponting, I, Schuening, F W, Hunt, P

“…A population of peripheral blood-derived cells that mature into megakaryocytes within four to eight days of liquid culture is described. This population was…”
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Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl by Bartley, T D, Bogenberger, J, Hunt, P, Li, Y S, Lu, H S, Martin, F, Chang, M S, Samal, B, Nichol, J L, Swift, S

“…A novel megakaryocyte growth and development factor (MGDF) has been identified in aplastic canine plasma, and its cDNAs have been cloned from canine, murine,…”
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Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia by Nichol, J L, Hokom, M M, Hornkohl, A, Sheridan, W P, Ohashi, H, Kato, T, Li, Y S, Bartley, T D, Choi, E, Bogenberger, J

“…The present study shows that recombinant human megakaryocyte growth and development factor (r-HuMGDF) behaves both as a megakaryocyte colony stimulating factor…”
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Functional human platelet generation in vitro and regulation of cytoplasmic process formation by Choi, E S, Hokom, M M, Nichol, J L, Hornkohl, A, Hunt, P

“…A recent report from this laboratory described an in vitro system in which CD34+ cells are stimulated to form mature megakaryocytes and, subsequently,…”
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Recombinant human megakaryocyte growth and development factor (rHuMGDF), a ligand for c-Mpl, produces functional human platelets in vitro by Choi, E S, Hokom, M, Bartley, T, Li, Y S, Ohashi, H, Kato, T, Nichol, J L, Skrine, J, Knudten, A, Chen, J

“…Platelet formation, occurring from bone marrow or lung megakaryocytes, has been difficult to study mechanistically. Recombinant human megakaryocyte growth and…”
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Thrombopoietin serum levels in patients with aplastic anaemia: correlation with platelet count and persistent elevation in remission by Schrezenmeier, Hubert, Griesshammer, Martin, Hornkohl, Alex, Nichol, Janet L., Hecht, Thomas, Heimpel, Herrmann, Kubanek, Bernhard, Raghavachar, Aruna

“…In an attempt to evaluate the role of thrombopoietin (TPO) in the pathobiology of aplastic anaemia (AA), we have examined TPO levels in sera from 54 AA…”
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Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional by Choi, ES, Nichol, JL, Hokom, MM, Hornkohl, AC, Hunt, P

“…An in vitro culture system demonstrating the transitions from megakaryocyte progenitors to functional platelets is described. CD34- selected cells from normal…”
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Evidence That Stem Cell Factor Is Involved in the Rebound Thrombocytosis That Follows 5-Fluorouracil Treatment by Hunt, Pamela, Zsebo, Krisztina M., Hokom, Martha M., Hornkohl, Alex, Birkett, Neal C., del Castillo, Juan C., Martin, Francis

“…The mechanisms responsible for 5-fluorouracil (5FU)-induced rebound thrombocytosis are not completely understood. SI/SIdmice, which do not undergo rebound…”
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Evidence that stem cell factor is involved in the rebound thrombocytosis that follows 5-fluorouracil treatment by Hunt, P, Zsebo, KM, Hokom, MM, Hornkohl, A, Birkett, NC, del Castillo, JC, Martin, F

“…The mechanisms responsible for 5-fluorouracil (5FU)-induced rebound thrombocytosis are not completely understood. SI/SI(d) mice, which do not undergo rebound…”
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