Search Results - "HORNICK, Jason"

The 2020 WHO Classification: What’s New in Soft Tissue Tumor Pathology? by Kallen, Michael E., Hornick, Jason L.

“…The fifth edition of the World Health Organization Classification of Tumors of Soft Tissue and Bone was published in early 2020. The revisions reflect a…”
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Limited biopsies of soft tissue tumors: the contemporary role of immunohistochemistry and molecular diagnostics by Hornick, Jason L.

“…Diagnosing soft tissue tumors is challenging, even on ample incisional biopsies or resection specimens. There are more than 100 distinct types of soft tissue…”
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Replacing Molecular Genetic Testing With Immunohistochemistry Using Antibodies That Recognize the Protein Products of Gene Rearrangements: “Next-generation” Immunohistochemistry by Hornick, Jason L.

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Cutaneous soft tissue tumors: how do we make sense of fibrous and “fibrohistiocytic” tumors with confusing names and similar appearances? by Hornick, Jason L.

“…In the 2018 World Health Organization Classification of Skin Tumors, a wide range of predominantly benign mesenchymal neoplasms are included in the…”
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Comparative analysis of ACE2 protein expression in rodent, non-human primate, and human respiratory tract at baseline and after injury: A conundrum for COVID-19 pathogenesis by Soni, Sourabh, Jiang, Yujie, Tesfaigzi, Yohannes, Hornick, Jason L, Çataltepe, Sule

“…Angiotensin converting enzyme 2 (ACE2) is the putative functional receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current literature…”
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Update on immunohistochemistry in bone and soft tissue tumors: Cost-effectively replacing molecular testing with immunohistochemistry by Wakefield, Craig, Hornick, Jason L

“…Soft tissue tumors form part of a challenging domain in diagnostic pathology owing to their comparative rarity, astonishing histologic diversity, and overlap…”
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“Malignant Mesenchymoma” Revisited: A Clinicopathologic Study of Leiomyosarcomas With Osteosarcomatous Differentiation by Yu, Sanhong, Hornick, Jason L.

“…Leiomyosarcoma (LMS) is the most common sarcoma in adults. Rarely, LMS dedifferentiates into an undifferentiated sarcoma. Very few cases of LMS with…”
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A worldwide journey of thyroid cancer incidence centred on tumour histology by Rossi, Esther Diana, Pantanowitz, Liron, Hornick, Jason L

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Neuropathological Features of Covid-19 by Solomon, Isaac H, Normandin, Erica, Bhattacharyya, Shamik, Mukerji, Shibani S, Keller, Kiana, Ali, Ahya S, Adams, Gordon, Hornick, Jason L, Padera, Robert F, Sabeti, Pardis

“…Eighteen brains of patients who died 0 to 32 days after the onset of symptoms of SARS-CoV-2 infection showed hypoxic–ischemic changes but no encephalitis,…”
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INI1-deficient tumors: diagnostic features and molecular genetics by Hollmann, Travis J, Hornick, Jason L

“…Significant progress has been made in understanding the molecular genetic alterations involved in sarcomagenesis. Cytogenetic and molecular studies have…”
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Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics by Schaefer, Inga-Marie, Fletcher, Christopher DM, Hornick, Jason L

“…The diagnosis of malignant peripheral nerve sheath tumor is challenging, particularly in the sporadic setting. Inactivation of the polycomb repressive complex…”
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Subclassification of pleomorphic sarcomas: How and why should we care? by Hornick, Jason L.

“…Pleomorphic sarcomas are a heterogeneous group of mesenchymal neoplasms with widely varied clinical behavior but overlapping histologic appearances. The…”
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Contemporary Sarcoma Diagnosis, Genetics, and Genomics by Schaefer, Inga-Marie, Cote, Gregory M, Hornick, Jason L

“…Sarcomas include diverse mesenchymal neoplasms with widely varied prognosis, clinical behavior, and treatment. Owing to their rarity and histologic overlap,…”
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A Novel SS18-SSX Fusion-specific Antibody for the Diagnosis of Synovial Sarcoma by Baranov, Esther, McBride, Matthew J., Bellizzi, Andrew M., Ligon, Azra H., Fletcher, Christopher D.M., Kadoch, Cigall, Hornick, Jason L.

“…Synovial sarcoma (SS), an aggressive soft tissue sarcoma with a predilection for the extremities of young adults, harbors the pathognomonic t(X;18)(p11;q11)…”
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Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics by Doyle, Leona A, Vivero, Marina, Fletcher, Christopher DM, Mertens, Fredrik, Hornick, Jason L

“…Solitary fibrous tumor (SFT) is composed of spindled to ovoid cells in a patternless architecture with prominent stromal collagen and hemangiopericytoma-like…”
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SWI/SNF complex-deficient soft tissue neoplasms: An update by Schaefer, Inga-Marie, Hornick, Jason L.

“…•Mutations of the SWI/SNF chromatin remodeling complex are found in >20% of cancers.•SMARCB1 is most frequently inactivated in SWI/SNF-deficient soft tissue…”
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FOSB is a Useful Diagnostic Marker for Pseudomyogenic Hemangioendothelioma by Hung, Yin P, Fletcher, Christopher D.M, Hornick, Jason L

“…Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma is a distinctive vascular neoplasm of intermediate biological potential with a predilection for…”
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Nuclear Expression of CAMTA1 Distinguishes Epithelioid Hemangioendothelioma From Histologic Mimics by Doyle, Leona A, Fletcher, Christopher D.M, Hornick, Jason L

“…Epithelioid hemangioendothelioma (EHE) is a malignant endothelial neoplasm characterized by recurrent translocations involving chromosomal regions 1p36.3 and…”
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Novel uses of immunohistochemistry in the diagnosis and classification of soft tissue tumors by Hornick, Jason L

“…Immunohistochemistry plays a key role in the diagnosis of soft tissue tumors. Until recently, however, the primary purpose of immunohistochemistry in this…”
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In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19 by Schaefer, Inga-Marie, Padera, Robert F., Solomon, Isaac H., Kanjilal, Sanjat, Hammer, Mark M., Hornick, Jason L., Sholl, Lynette M.

“…Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has led to a global public health crisis. In elderly individuals and those with comorbidities,…”
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