Search Results - "HORGAN, P. G"

A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer by Proctor, M J, McMillan, D C, Morrison, D S, Fletcher, C D, Horgan, P G, Clarke, S J

“…Background: The neutrophil lymphocyte ratio (NLR) has prognostic value in patients with a variety of cancers. Many chemotherapeutic trial databases hold…”
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An inflammation-based prognostic score (mGPS) predicts cancer survival independent of tumour site: a Glasgow Inflammation Outcome Study by Proctor, M J, Morrison, D S, Talwar, D, Balmer, S M, O'Reilly, D S J, Foulis, A K, Horgan, P G, McMillan, D C

“…Introduction: A selective combination of C-reactive protein and albumin (termed the modified Glasgow Prognostic Score, mGPS) has been shown to have prognostic…”
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The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer by Park, J.H., Richards, C.H., McMillan, D.C., Horgan, P.G., Roxburgh, C.S.D.

“…Tumour stroma percentage (TSP) has previously been reported to predict survival in patients with colorectal cancer (CRC); however, whether this is independent…”
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Comparison of the prognostic value of longitudinal measurements of systemic inflammation in patients undergoing curative resection of colorectal cancer by Guthrie, G J K, Roxburgh, C S D, Farhan-Alanie, O M, Horgan, P G, McMillan, D C

“…Background: The systemic inflammation-based prognostic scores, modified Glasgow Prognostic Score (mGPS) and the neutrophil-lymphocyte ratio (NLR) are now…”
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The relationship between the presence and site of cancer, an inflammation-based prognostic score and biochemical parameters. Initial results of the Glasgow Inflammation Outcome Study by Proctor, M J, Talwar, D, Balmar, S M, O'Reilly, D S J, Foulis, A K, Horgan, P G, Morrison, D S, McMillan, D C

“…Background: Cancer incidence is increasing in the United Kingdom, as well as on a global basis. Biochemical parameters, such as C-reactive protein and albumin…”
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Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer by Moyes, L H, Leitch, E F, McKee, R F, Anderson, J H, Horgan, P G, McMillan, D C

“…The presence of systemic inflammation before surgery, as evidenced by the glasgow prognostic score (mGPS), predicts poor long-term survival in colorectal…”
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Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer by LEITCH, E. F, CHAKRABARTI, M, CROZIER, J. E. M, MCKEE, R. F, ANDERSON, J. H, HORGAN, P. G, MCMILLAN, D. C

“…There is increasing evidence that the presence of a systemic inflammatory response plays an important role in predicting survival in patients with colorectal…”
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Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer by Guthrie, G J K, Roxburgh, C S D, Richards, C H, Horgan, P G, McMillan, D C

“…Background: Cancer-associated inflammation, in the form of local and systemic inflammatory responses, appear to be linked to tumour necrosis and have…”
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The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer by Alexander, P. G., van Wyk, H. C., Pennel, K. A. F., Hay, J., McMillan, D. C., Horgan, P. G., Roxburgh, C. S. D., Edwards, J., Park, J. H.

“…Background Glasgow Microenvironment Score (GMS) stratifies long-term survival into three groups based on tumour phenotype: peritumoural inflammation…”
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The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer by Little, C. H., Combet, E., McMillan, D. C., Horgan, P. G., Roxburgh, C. S. D.

“…Current focus in colorectal cancer (CRC) management is on reducing overall mortality by increasing the number of early-stage cancers diagnosed and treated with…”
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The impact of anti-inflammatory agents on the outcome of patients with colorectal cancer by Park, J.H, McMillan, D.C, Horgan, P.G, Roxburgh, C.S

“…Summary Although there is increasing appreciation of the role of the host inflammatory response in determining outcome in patients in colorectal cancer, there…”
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Prognostic value of tumour necrosis and host inflammatory responses in colorectal cancer by Richards, C. H., Roxburgh, C. S. D., Anderson, J. H., McKee, R. F., Foulis, A. K., Horgan, P. G., McMillan, D. C.

“…Background: Tumour necrosis is a marker of poor prognosis in some tumours but the mechanism is unclear. This study examined the prognostic value of tumour…”
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Contribution of surgical specialization to improved colorectal cancer survival by Oliphant, R., Nicholson, G. A., Horgan, P. G., Molloy, R. G., McMillan, D. C., Morrison, D. S.

“…Background Reorganization of colorectal cancer services has led to surgery being increasingly, but not exclusively, delivered by specialist surgeons. Outcomes…”
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The relationship between patient physiology, the systemic inflammatory response and survival in patients undergoing curative resection of colorectal cancer by Richards, C H, Leitch, E F, Horgan, P G, Anderson, J H, McKee, R F, McMillan, D C

“…Background: It is increasingly recognised that host-related factors may be important in determining cancer outcome. The aim was to examine the relationship…”
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The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer by Richards, C H, Flegg, K M, SD Roxburgh, C, Going, J J, Mohammed, Z, Horgan, P G, McMillan, D C

“…Background: The host inflammatory response is an important determinant of cancer outcome. We examined different methods of assessing the local inflammatory…”
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Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients by Willder, J M, Heng, S J, McCall, P, Adams, C E, Tannahill, C, Fyffe, G, Seywright, M, Horgan, P G, Leung, H Y, Underwood, M A, Edwards, J

“…Background: Prostate cancer cell growth is dependent upon androgen receptor (AR) activation, which is regulated by specific kinases. The aim of the current…”
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The relationship between tumour necrosis, tumour proliferation, local and systemic inflammation, microvessel density and survival in patients undergoing potentially curative resection of oesophageal adenocarcinoma by Dutta, S, Going, J J, Crumley, A B C, Mohammed, Z, Orange, C, Edwards, J, Fullarton, G M, Horgan, P G, McMillan, D C

“…Background: There is increasing evidence that the local and systemic inflammatory responses are associated with survival in oesophageal cancer. The aim of this…”
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Surgeons and selection of adjuvant therapy for node-negative colonic cancer by Horgan, P. G., McMillan, D. C.

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The impact of aspirin, statins and ACE-inhibitors on the presentation of colorectal neoplasia in a colorectal cancer screening programme by Mansouri, D, McMillan, D C, Roxburgh, C S D, Crighton, E M, Horgan, P G

“…Background: There is increasing evidence that aspirin, statins and ACE-inhibitors can reduce the incidence of colorectal cancer. The aim of the present study…”
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Preoperative indicators of the systemic inflammatory response in the treatment of patients with gastrointestinal cancer by McMillan, D. C., Horgan, P. G.

“…Measuring this response in patients with cancer is worthwhile…”
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