Search Results - "HORCHLER, Carey L"

Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: a late-stage diversification approach to potent 5HT1B antagonists by Horchler, Carey L, McCauley, Jr, John P, Hall, James E, Snyder, Dean H, Craig Moore, W, Hudzik, Thomas J, Chapdelaine, Marc J

“…Multiparallel amenable syntheses of 6-methoxy-8-amino-4-oxo-1,4-dihydroquinoline-2-carboxylic acid-(4-morpholin-4-yl-phenyl)amides (I) and…”
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Facile Route to 2-Fluoropyridines via 2-Pyridyltrialkylammonium Salts Prepared from Pyridine N-Oxides and Application to (18)F-Labeling by Xiong, Hui, Hoye, Adam T, Fan, Kuo-Hsien, Li, Ximin, Clemens, Jennifer, Horchler, Carey L, Lim, Nathaniel C, Attardo, Giorgio

“…Among known precursors for 2-[(18)F]fluoropyridines, pyridyltrialkylammonium salts have shown excellent reactivity; however, their broader utility has been…”
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Development and SAR of functionally selective allosteric modulators of GABAA receptors by Alhambra, Cristobal, Becker, Chris, Blake, Timothy, Chang, Amy (Hui-Fang), Damewood, James R., Jr, Daniels, Thalia, Dembofsky, Bruce T, Gurley, David A, Hall, James E, Herzog, Keith J, Horchler, Carey L, Ohnmacht, Cyrus J, Schmiesing, Richard Jon, Dudley, Adam, Ribadeneira, Maria D, Knappenberger, Katherine S, Maciag, Carla, Stein, Mark M, Chopra, Maninder, Liu, Xiaodong F, Christian, Edward P, Arriza, Jeffrey L, Chapdelaine, Marc J

“…Positive modulators at the benzodiazepine site of α2- and α3-containing GABAA receptors are believed to be anxiolytic. Through oocyte voltage clamp studies, we…”
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Pyridazinoquinolinetriones as NMDA Glycine-Site Antagonists with Oral Antinociceptive Activity in a Model of Neuropathic Pain by Bare, Thomas M, Brown, Dean G, Horchler, Carey L, Murphy, Megan, Urbanek, Rebecca A, Alford, Vernon, Barlaam, Christine, Dyroff, Martin C, Empfield, James B, Forst, Janet M, Herzog, Keith J, Keith, Richard A, Kirschner, Alan S, Lee, Chi-Ming C, Lewis, Joseph, McLaren, Frances M, Neilson, Kathy L, Steelman, Gary B, Trivedi, Shephali, Vacek, Edward P, Xiao, Wenhua

“…A series of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones were synthesized and found to have potent activity at the…”
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Facile Route to 2‑Fluoropyridines via 2‑Pyridyltrialkylammonium Salts Prepared from Pyridine N‑Oxides and Application to 18F‑Labeling by Xiong, Hui, Hoye, Adam T, Fan, Kuo-Hsien, Li, Ximin, Clemens, Jennifer, Horchler, Carey L, Lim, Nathaniel C, Attardo, Giorgio

“…Among known precursors for 2-[18F]­fluoropyridines, pyridyltrialkylammonium salts have shown excellent reactivity; however, their broader utility has been…”
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Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5h )-triones as NMDA glycine-site antagonists by BROWN, Dean G, URBANEK, Rebecca A, XIAO, Wenhua, DYROFF, Martin C, LEE, Chi-Ming C, TRIVEDI, Shephali, NEILSON, Kathy L, KEITH, Richard A, BARE, Thomas M, MCLAREN, Frances M, HORCHLER, Carey L, MURPHY, Megan, STEELMAN, Gary B, EMPFIELD, James R, FORST, Janet M, HERZOG, Keith J

“…Several members of the 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones (2) have been identified as being potent and…”
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Facile Route to 2-Fluoropyridines via 2-Pyridyltrialkylammonium Salts Prepared from Pyridine N -Oxides and Application to 18 F-Labeling by Xiong, Hui, Hoye, Adam T., Fan, Kuo-Hsien, Li, Ximin, Clemens, Jennifer, Horchler, Carey L., Lim, Nathaniel C., Attardo, Giorgio

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Development and SAR of functionally selective allosteric modulators of GABA A receptors by Alhambra, Cristobal, Becker, Chris, Blake, Timothy, Chang, Amy (Hui-Fang), Damewood, James R., Daniels, Thalia, Dembofsky, Bruce T., Gurley, David A., Hall, James E., Herzog, Keith J., Horchler, Carey L., Ohnmacht, Cyrus J., Schmiesing, Richard Jon, Dudley, Adam, Ribadeneira, Maria D., Knappenberger, Katherine S., Maciag, Carla, Stein, Mark M., Chopra, Maninder, Liu, Xiaodong F., Christian, Edward P., Arriza, Jeffrey L., Chapdelaine, Marc J.

“…New structural classes of functionally selective benzodiazepine-site allosteric modulators of GABA A receptors are reported. Positive modulators at the…”
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Development and SAR of functionally selective allosteric modulators of GABA sub(A receptors) by Alhambra, Cristobal, Becker, Chris, Blake, Timothy, Chang, Amy, Damewood, James R, Daniels, Thalia, Dembofsky, Bruce T, Gurley, David A, Hall, James E, Herzog, Keith J, Horchler, Carey L, Ohnmacht, Cyrus J, Schmiesing, Richard Jon, Dudley, Adam, Ribadeneira, Maria D, Knappenberger, Katherine S, Maciag, Carla, Stein, Mark M, Chopra, Maninder, Liu, Xiaodong F, Christian, Edward P, Arriza, Jeffrey L, Chapdelaine, Marc J

“…Positive modulators at the benzodiazepine site of alpha 2- and alpha 3-containing GABA sub(A receptors are believed to be anxiolytic. Through oocyte voltage…”
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Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4- yl-phenyl)amides: A late-stage diversification approach to potent 5HT sub(1B) antagonists by Horchler, Carey L, McCauley, John P, Hall, James E, Snyder, Dean H, Moore, WCraig, Hudzik, Thomas J, Chapdelaine, Marc J

“…Multiparallel amenable syntheses of 6-methoxy-8-amino-4-oxo-1,4- dihydroquinoline-2-carboxylic acid-(4-morpholin-4-yl-phenyl)amides (I) and 4-…”
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Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: A late-stage diversification approach to potent 5HT 1B antagonists by Horchler, Carey L., McCauley, John P., Hall, James E., Snyder, Dean H., Craig Moore, W., Hudzik, Thomas J., Chapdelaine, Marc J.

“…MPS amenable syntheses of novel potent 5HT1b antagonists, 6-methoxy-8-amino-4-oxo-1,4-dihydroquinoline-2-carboxylic acid-(4-morpholin-4-yl-phenyl)amides ( I)…”
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