Search Results - "HOON, SHAWN"

Kinetic Controlled Tag-Catcher Interactions for Directed Covalent Protein Assembly by Tan, Lee Ling, Hoon, Shawn S, Wong, Fong T

“…Over the last few years, a number of different protein assembly strategies have been developed, greatly expanding the toolbox for controlling macromolecular…”
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Preventing mussel adhesion using lubricant-infused materials by Amini, Shahrouz, Kolle, Stefan, Petrone, Luigi, Ahanotu, Onyemaechi, Sunny, Steffi, Sutanto, Clarinda N., Hoon, Shawn, Cohen, Lucas, Weaver, James C., Aizenberg, Joanna, Vogel, Nicolas, Miserez, Ali

“…Mussels are opportunistic macrofouling organisms that can attach to most immersed solid surfaces, leading to serious economic and ecological consequences for…”
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Skin Commensal Malassezia globosa Secreted Protease Attenuates Staphylococcus aureus Biofilm Formation by Li, Hao, Goh, Bee Na, Teh, Wooi Keong, Jiang, Zhenze, Goh, Joleen Pei Zhen, Goh, Amelia, Wu, Guangxi, Hoon, Shawn S., Raida, Manfred, Camattari, Andrea, Yang, Liang, O’Donoghue, Anthony J., Dawson, Thomas L.

“…Skin provides the first defense against pathogenic micro-organisms and is also colonized by a diverse microbiota. Phylogenetic analysis of whole skin…”
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Infiltration of chitin by protein coacervates defines the squid beak mechanical gradient by Tan, YerPeng, Hoon, Shawn, Guerette, Paul A, Wei, Wei, Ghadban, Ali, Hao, Cai, Miserez, Ali, Waite, J Herbert

“…The squid beak displays a 200-fold stiffness gradient across its length. A battery of experiments, including ‘omics analysis and rheological measurements, now…”
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Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges by Lovci, Michael T, Ghanem, Dana, Marr, Henry, Arnold, Justin, Gee, Sherry, Parra, Marilyn, Liang, Tiffany Y, Stark, Thomas J, Gehman, Lauren T, Hoon, Shawn, Massirer, Katlin B, Pratt, Gabriel A, Black, Douglas L, Gray, Joe W, Conboy, John G, Yeo, Gene W

“…The Rbfox family of developmentally important splicing factors controls alternative splicing in a tissue-specific manner. Genome-wide analyses now show that…”
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A fluid-supported 3D hydrogel bioprinting method by Beh, Cyrus W., Yew, Dionis S., Chai, Ruth J., Chin, Sau Yin, Seow, Yiqi, Hoon, Shawn S.

“…Hydrogels are used in many biomedical applications, including regenerative medicine and surgical training phantoms. However, the ability to shape these…”
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Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells by Low, Blaise Su Jun, Lim, Chang Siang, Ding, Shirley Suet Lee, Tan, Yaw Sing, Ng, Natasha Hui Jin, Krishnan, Vidhya Gomathi, Ang, Su Fen, Neo, Claire Wen Ying, Verma, Chandra S., Hoon, Shawn, Lim, Su Chi, Tai, E. Shyong, Teo, Adrian Kee Keong

“…Heterozygous HNF1A gene mutations can cause maturity onset diabetes of the young 3 (MODY3), characterized by insulin secretion defects. However, specific…”
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HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes by Ng, Natasha Hui Jin, Ghosh, Soumita, Bok, Chek Mei, Ching, Carmen, Low, Blaise Su Jun, Chen, Juin Ting, Lim, Euodia, Miserendino, María Clara, Tan, Yaw Sing, Hoon, Shawn, Teo, Adrian Kee Keong

“…HNF4A and HNF1A encode transcription factors that are important for the development and function of the pancreas and liver. Mutations in both genes have been…”
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MapCell: Learning a Comparative Cell Type Distance Metric With Siamese Neural Nets With Applications Toward Cell-Type Identification Across Experimental Datasets by Koh, Winston, Hoon, Shawn

“…Large collections of annotated single-cell RNA sequencing (scRNA-seq) experiments are being generated across different organs, conditions and organisms on…”
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Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses by Kapeli, Katannya, Pratt, Gabriel A., Vu, Anthony Q., Hutt, Kasey R., Martinez, Fernando J., Sundararaman, Balaji, Batra, Ranjan, Freese, Peter, Lambert, Nicole J., Huelga, Stephanie C., Chun, Seung J., Liang, Tiffany Y., Chang, Jeremy, Donohue, John P., Shiue, Lily, Zhang, Jiayu, Zhu, Haining, Cambi, Franca, Kasarskis, Edward, Hoon, Shawn, Ares Jr, Manuel, Burge, Christopher B., Ravits, John, Rigo, Frank, Yeo, Gene W.

“…The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS). To compare TAF15 function to that of two ALS-associated RBPs, FUS and…”
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Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes by Hillenmeyer, Maureen E, Fung, Eula, Wildenhain, Jan, Pierce, Sarah E, Hoon, Shawn, Lee, William, Proctor, Michael, St.Onge, Robert P, Tyers, Mike, Koller, Daphne, Altman, Russ B, Davis, Ronald W, Nislow, Corey, Giaever, Guri

“…Genetics aims to understand the relation between genotype and phenotype. However, because complete deletion of most yeast genes (~80%) has no obvious…”
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Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins by Huelga, Stephanie C., Vu, Anthony Q., Arnold, Justin D., Liang, Tiffany Y., Liu, Patrick P., Yan, Bernice Y., Donohue, John Paul, Shiue, Lily, Hoon, Shawn, Brenner, Sydney, Ares, Manuel, Yeo, Gene W.

“…Understanding how RNA binding proteins control the splicing code is fundamental to human biology and disease. Here, we present a comprehensive study to…”
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The human pathobiont Malassezia furfur secreted protease Mfsap1 regulates cell dispersal and exacerbates skin inflammation by Goh, Joleen P Z, Ruchti, Fiorella, Poh, Si En, Koh, Winston L C, Tan, Kiat Yi, Lim, Yan Ting, Thng, Steven T G, Sobota, Radoslaw M, Hoon, Shawn S, Liu, Chenxi, O'Donoghue, Anthony J, LeibundGut-Landmann, Salomé, Oon, Hazel H, Li, Hao, Dawson, Jr, Thomas L

“…form the dominant eukaryotic microbial community on the human skin. The genus possesses a repertoire of secretory hydrolytic enzymes involved in protein and…”
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Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation by Fabrizio, Paola, Hoon, Shawn, Shamalnasab, Mehrnaz, Galbani, Abdulaye, Wei, Min, Giaever, Guri, Nislow, Corey, Longo, Valter D

“…The study of the chronological life span of Saccharomyces cerevisiae, which measures the survival of populations of non-dividing yeast, has resulted in the…”
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Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues In Vivo by Xue, Yuezhen, Barker, Nick, Hoon, Shawn, He, Pingping, Thakur, Teena, Abdeen, Shifana Raja, Maruthappan, Priadarsini, Ghadessy, Farid J, Lane, David P

“…p53 protein, activated and stabilized by posttranslational modifications, performs its major functions by inducing DNA repair, cell-cycle arrest, or apoptosis…”
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TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination by Ho, Wan Yun, Chang, Jer-Cherng, Lim, Kenneth, Cazenave-Gassiot, Amaury, Nguyen, Aivi T, Foo, Juat Chin, Muralidharan, Sneha, Viera-Ortiz, Ashley, Ong, Sarah J M, Hor, Jin Hui, Agrawal, Ira, Hoon, Shawn, Arogundade, Olubankole Aladesuyi, Rodriguez, Maria J, Lim, Su Min, Kim, Seung Hyun, Ravits, John, Ng, Shi-Yan, Wenk, Markus R, Lee, Edward B, Tucker-Kellogg, Greg, Ling, Shuo-Chien

“…Cholesterol metabolism operates autonomously within the central nervous system (CNS), where the majority of cholesterol resides in myelin. We demonstrate that…”
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Creation of stable and strictly regulated enzyme switch for signal-on immunodetection of various small antigens by Su, Jiulong, Beh, Cyrus, Ohmuro-Matsuyama, Yuki, Kitaguchi, Tetsuya, Hoon, Shawn, Ueda, Hiroshi

“…Recently, we reported a fusion-protein-based immunodetection system comprising the two domains of an antibody variable region as the detectors, each tethered…”
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TORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae by Alfatah, Mohammad, Wong, Jin Huei, Krishnan, Vidhya Gomathi, Lee, Yong Cheow, Sin, Quan Feng, Goh, Corinna Jie Hui, Kong, Kiat Whye, Lee, Wei Ting, Lewis, Jacqueline, Hoon, Shawn, Arumugam, Prakash

“…Target of Rapamycin Complex 1 (TORC1) is a highly conserved eukaryotic protein complex that couples the presence of growth factors and nutrients in the…”
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Aptamer selection by high-throughput sequencing and informatic analysis by Hoon, Shawn, Zhou, Bin, Janda, Kim D, Brenner, Sydney, Scolnick, Jonathan

“…Traditional methods for selecting aptamers require multiple rounds of selection and optimization in order to identify aptamers that bind with high affinity to…”
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SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes by Yeo, Chia Rou, Agrawal, Madhur, Hoon, Shawn, Shabbir, Asim, Shrivastava, Manu Kunaal, Huang, Shiqi, Khoo, Chin Meng, Chhay, Vanna, Yassin, M. Shabeer, Tai, E. Shyong, Vidal-Puig, Antonio, Toh, Sue-Anne

“…The Simpson Golabi Behmel Syndrome (SGBS) pre-adipocyte cell strain is widely considered to be a representative in vitro model of human white pre-adipocytes. A…”
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