Search Results - "HOOK, Lauren"

An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection by Egan, Kevin P, Hook, Lauren M, Naughton, Alexis, Pardi, Norbert, Awasthi, Sita, Cohen, Gary H, Weissman, Drew, Friedman, Harvey M

“…HSV-1 causes 50% of first-time genital herpes infections in resource-rich countries and affects 190 million people worldwide. A prophylactic herpes vaccine is…”
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Cytomegalovirus miRNAs Target Secretory Pathway Genes to Facilitate Formation of the Virion Assembly Compartment and Reduce Cytokine Secretion by Hook, Lauren M., Grey, Finn, Grabski, Robert, Tirabassi, Rebecca, Doyle, Tracy, Hancock, Meaghan, Landais, Igor, Jeng, Sophia, McWeeney, Shannon, Britt, William, Nelson, Jay A.

“…Herpesviruses, including human cytomegalovirus (HCMV), encode multiple microRNAs (miRNA) whose targets are just being uncovered. Moreover, miRNA function…”
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An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs by Awasthi, Sita, Hook, Lauren M, Shaw, Carolyn E, Pahar, Bapi, Stagray, Jacob A, Liu, David, Veazey, Ronald S, Friedman, Harvey M

“…A genital herpes vaccine is urgently needed to prevent pain and suffering, reduce the incidence of neonatal herpes, and decrease the risk of HIV acquisition…”
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Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs by Hook, Lauren M, Cairns, Tina M, Awasthi, Sita, Brooks, Benjamin D, Ditto, Noah T, Eisenberg, Roselyn J, Cohen, Gary H, Friedman, Harvey M

“…Herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) subunit antigen is included in many preclinical candidate vaccines. The rationale for including gD2 is…”
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A trivalent gC2/gD2/gE2 vaccine for herpes simplex virus generates antibody responses that block immune evasion domains on gC2 better than natural infection by Hook, Lauren M, Awasthi, Sita, Dubin, Jonathan, Flechtner, Jessica, Long, Deborah, Friedman, Harvey M

“…Highlights•Our goal is to produce antibodies to immune evasion domains through immunization. •Antibodies produced by HSV infection bind gC2 yet do not block…”
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Vaccines to prevent genital herpes by Egan, Kevin, Hook, Lauren M., LaTourette, Philip, Desmond, Angela, Awasthi, Sita, Friedman, Harvey M.

“…Genital herpes increases the risk of acquiring and transmitting Human Immunodeficiency Virus (HIV), is a source of anxiety for many about transmitting…”
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Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-κB-Activating Factors through Direct Downregulation of IKKα and IKKβ by Hancock, Meaghan H, Hook, Lauren M, Mitchell, Jennifer, Nelson, Jay A

“…Emerging evidence indicates that human cytomegalovirus (HCMV) manipulates host cell signaling pathways using both proteins and noncoding RNAs. Several studies…”
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A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1 by Egan, Kevin P, Awasthi, Sita, Tebaldi, Giulia, Hook, Lauren M, Naughton, Alexis M, Fowler, Bernard T, Beattie, Mitchell, Alameh, Mohamad-Gabriel, Weissman, Drew, Cohen, Gary H, Friedman, Harvey M

“…HSV-1 disease is a significant public health burden causing orofacial, genital, cornea, and brain infection. We previously reported that a trivalent HSV-2 gC2,…”
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Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models by Awasthi, Sita, Knox, James J, Desmond, Angela, Alameh, Mohamad-Gabriel, Gaudette, Brian T, Lubinski, John M, Naughton, Alexis, Hook, Lauren M, Egan, Kevin P, Tam, Ying K, Pardi, Norbert, Allman, David, Luning Prak, Eline T, Cancro, Michael P, Weissman, Drew, Cohen, Gary H, Friedman, Harvey M

“…Nucleoside-modified mRNA vaccines have gained global attention because of COVID-19. We evaluated a similar vaccine approach for preventing a chronic, latent…”
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Guinea Pig and Mouse Models for Genital Herpes Infection by Hook, Lauren M, Friedman, Harvey M, Awasthi, Sita

“…This article describes procedures for two preclinical animal models for genital herpes infection. The guinea pig model shares many features of genital herpes…”
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Herpes simplex virus type 2 trivalent protein vaccine containing glycoproteins C, D and E protects guinea pigs against HSV-1 genital infection by Egan, Kevin, Hook, Lauren M, Naughton, Alexis, Friedman, Harvey M, Awasthi, Sita

“…A vaccine to prevent genital herpes is an unmet public health need. We previously reported that a trivalent vaccine containing herpes simplex virus type 2…”
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Antibody responses to crucial functional epitopes as a novel approach to assess immunogenicity of vaccine adjuvants by Awasthi, Sita, Hook, Lauren M., Swaminathan, Gokul, Cairns, Tina M., Brooks, Benjamin, Smith, Jeffrey S., Ditto, Noah T., Gindy, Marian E., Bett, Andrew J., Espeseth, Amy S., Cohen, Gary H., Friedman, Harvey M.

“…We are interested in developing a vaccine that prevents genital herpes. Adjuvants have a major impact on vaccine immunogenicity. We compared two adjuvants, an…”
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Techniques for Characterizing Cytomegalovirus-Encoded miRNAs by Diggins, Nicole L, Crawford, Lindsey B, Struthers, Hillary M, Hook, Lauren M, Landais, Igor, Skalsky, Rebecca L, Hancock, Meaghan H

“…microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level by binding to sites within the 3' untranslated…”
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Novel Adjuvant S-540956 Targets Lymph Nodes and Reduces Genital Recurrences and Vaginal Shedding of HSV-2 DNA When Administered with HSV-2 Glycoprotein D as a Therapeutic Vaccine in Guinea Pigs by Awasthi, Sita, Onishi, Motoyasu, Lubinski, John M, Fowler, Bernard T, Naughton, Alexis M, Hook, Lauren M, Egan, Kevin P, Hagiwara, Masaki, Shirai, Seiki, Sakai, Akiho, Nakagawa, Takayuki, Goto, Kumiko, Yoshida, Osamu, Stephens, Alisa J, Choi, Grace, Cohen, Gary H, Katayama, Kazufumi, Friedman, Harvey M

“…Herpes simplex virus type 2 (HSV-2) is a leading cause of genital ulcer disease and a major risk factor for acquisition and transmission of HIV. Frequent…”
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Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine by Hook, Lauren M, Awasthi, Sita, Cairns, Tina M, Alameh, Mohamad-Gabriel, Fowler, Bernard T, Egan, Kevin P, Sung, Molly M H, Weissman, Drew, Cohen, Gary H, Friedman, Harvey M

“…The toxicity of mRNA-lipid nanoparticle (LNP) vaccines depends on the total mRNA-LNP dose. We established that the maximum tolerated dose of our trivalent…”
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A trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model by Awasthi, Sita, Hook, Lauren M., Shaw, Carolyn E., Friedman, Harvey M.

“…An estimated 417 million people worldwide ages 15 to 49 are infected with herpes simplex virus type 2 (HSV-2), the most common cause of genital ulcer disease…”
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Human Cytomegalovirus US7 Is Regulated Synergistically by Two Virally Encoded MicroRNAs and by Two Distinct Mechanisms by TIRABASSI, Rebecca, HOOK, Lauren, LANDAIS, Igor, GREY, Finn, MEYERS, Heather, HEWITT, Helen, NELSON, Jay

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Techniques for characterizing cytomegalovirus-encoded miRNAs by Hook, Lauren M, Landais, Igor, Hancock, Meaghan H, Nelson, Jay A

“…microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, by binding to sites within the 3' untranslated…”
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Blocking Antibody Access to Neutralizing Domains on Glycoproteins Involved in Entry as a Novel Mechanism of Immune Evasion by Herpes Simplex Virus Type 1 Glycoproteins C and E by HOOK, Lauren M, JIALING HUANG, MING JIANG, HODINKA, Richard, FRIEDMAN, Harvey M

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Herpes Simplex Virus Type 1 and 2 Glycoprotein C Prevents Complement-Mediated Neutralization Induced by Natural Immunoglobulin M Antibody by HOOK, Lauren M, LUBINSKI, John M, MING JIANG, PANGBURN, Michael K, FRIEDMAN, Harvey M

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