Search Results - "HOOGSTRATEN, Conny"

Generation and infusion of multi-antigen-specific T cells to prevent complications early after T-cell depleted allogeneic stem cell transplantation—a phase I/II study by Roex, Marthe C. J., van Balen, Peter, Germeroth, Lothar, Hageman, Lois, van Egmond, Esther, Veld, Sabrina A. J., Hoogstraten, Conny, van Liempt, Ellis, Zwaginga, Jaap J., de Wreede, Liesbeth C., Meij, Pauline, Vossen, Ann C. T. M., Danhof, Sophia, Einsele, Hermann, Schaafsma, M. Ron, Veelken, Hendrik, Halkes, Constantijn J. M., Jedema, Inge, Falkenburg, J. H. Frederik

“…Prophylactic infusion of selected donor T cells can be an effective method to restore specific immunity after T-cell-depleted allogeneic stem cell…”
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The allogeneic HLA-DP-restricted T-cell repertoire provoked by allogeneic dendritic cells contains T cells that show restricted recognition of hematopoietic cells including primary malignant cells by Laghmouchi, Aicha, Hoogstraten, Conny, van Balen, Peter, Falkenburg, J H Frederik, Jedema, Inge

“…Stem cell grafts from 10/10 HLA-matched unrelated donors are often mismatched for HLA-DP. In some patients, donor T-cell responses targeting the mismatched…”
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Promiscuity of Peptides Presented in HLA-DP Molecules from Different Immunogenicity Groups Is Associated With T-Cell Cross-Reactivity by Laghmouchi, Aicha, Kester, Michel G D, Hoogstraten, Conny, Hageman, Lois, de Klerk, Wendy, Huisman, Wesley, Koster, Eva A S, de Ru, Arnoud H, van Balen, Peter, Klobuch, Sebastian, van Veelen, Peter A, Falkenburg, J H Frederik, Jedema, Inge

“…In the context of HLA-DP-mismatched allogeneic stem cell transplantation, mismatched HLA-DP alleles can provoke profound allo-HLA-DP-specific immune responses…”
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Automated manufacture of ΔNPM1 TCR-engineered T cells for AML therapy by Yonezawa Ogusuku, Isabella Elias, Herbel, Vera, Lennartz, Simon, Brandes, Caroline, Argiro, Eva, Fabian, Caroline, Hauck, Carola, Hoogstraten, Conny, Veld, Sabrina, Hageman, Lois, Teppert, Karin, Koutsoumpli, Georgia, Griffioen, Marieke, Mockel-Tenbrinck, Nadine, Schaser, Thomas, de Groot, Rosa, Johnston, Ian C.D., Lock, Dominik

“…Acute myeloid leukemia (AML) is a heterogeneous malignancy that requires further therapeutic improvement, especially for the elderly and for subgroups with…”
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Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception? by van Bergen, Cornelis A M, Verdegaal, Elisabeth M E, Honders, M Wilhelmina, Hoogstraten, Conny, Steijn-van Tol, A Q M Jeanne, de Quartel, Linda, de Jong, Joan, Meyering, Maaike, Falkenburg, J H Frederik, Griffioen, Marieke, Osanto, Susanne

“…Allogeneic stem cell transplantation (alloSCT) followed by donor lymphocyte infusion (DLI) can be applied as immunotherapeutic intervention to treat malignant…”
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Long‐term in vitro persistence of magnetic properties after magnetic bead‐based cell separation of T cells by Laghmouchi, Aicha, Hoogstraten, Conny, Falkenburg, J. H. Frederik, Jedema, Inge

“…Magnetic‐activated cell sorting (MACS) using magnetic nanoparticles coated with specific antibodies is commonly used in immunology research. For in vitro…”
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A minority of T cells recognizing tumor-associated antigens presented in self-HLA can provoke antitumor reactivity by Roex, Marthe C.J., Hageman, Lois, Veld, Sabrina A.J., van Egmond, Esther, Hoogstraten, Conny, Stemberger, Christian, Germeroth, Lothar, Einsele, Hermann, Falkenburg, J. H. Frederik, Jedema, Inge

“…Tumor-associated antigens (TAAs) are monomorphic self-antigens that are proposed as targets for immunotherapeutic approaches to treat malignancies. We…”
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The Allo-HLA-DP Restricted T Cell Repertoire Contains a Variety of Tissue-Restricted Specificities with Therapeutic Value by Laghmouchi, Aicha, Hoogstraten, Conny, Balen, Peter Van, van de Water, Rick, Meent, Marian van de, Falkenburg, J.H. Frederik, Jedema, Inge

“…T cell-depleted allogeneic stem cell transplantation (alloSCT) is applied in patients with hematological malignancies to reduce the risk of graft versus host…”
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Prophylactic Infusion of Multi-Antigen Specific T-Cell Products to Prevent Complications after T Cell Depleted Allogeneic Stem Cell Transplantation — a Phase I/II Study by Roex, Marthe C.J., Balen, Peter van, Germeroth, Lothar, Hageman, Lois, van Egmond, Esther, Veld, Sabrina A.J., Hoogstraten, Conny, van Liempt, Ellis, Zwaginga, Jaap J., de Wreede, Liesbeth C., Einsele, Hermann, Veelken, Hendrik, Halkes, Constantijn J.M., Jedema, Inge, Falkenburg, J.H. Frederik

“…Viral infections and disease relapses are major complications between T cell depleted allogeneic stem cell transplantation (TCD alloSCT) and donor lymphocyte…”
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Prevention of Viral Infections after T Cell Depleted Allogeneic Stem Cell Transplantation By Infusion of Multi-Antigen Specific T Cell Products by Roex, Marthe C.J., Balen, Peter Van, Hageman, Lois, Van Egmond, Esther, Veld, Sabrina A.J., Hoogstraten, Conny, van Liempt, Ellis, Germeroth, Lothar, Einsele, Hermann, Halkes, Constantijn J.M., Jedema, Inge, Falkenburg, J.H. Frederik

“…Opportunistic viral infections and relapse are major complications in patients after T cell depleted allogeneic stem cell transplantation (TCD alloSCT). Since…”
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Effective Treatment of Refractory CMV Reactivation After Allogeneic Stem Cell Transplantation With In Vitro-generated CMV pp65-specific CD8+ T-cell Lines by MEIJ, Pauline, JEDEMA, Inge, MARIJT, Erik W. A, VON DEM BORNE, Peter A, LANKESTER, Arjan C, HALKES, Constantijn J. M, FALKENBURG, J. H. Frederik, ZANDVLIET, Maarten L, VAN DER HEIDEN, Pim L. J, VAN DE MEENT, Marian, VAN EGMOND, H. M. Esther, VAN LIEMPT, Ellis, HOOGSTRATEN, Conny, KRUITHOF, Simone, VELD, Sabrina

“…To treat patients with refractory cytomegalovirus (CMV) reactivation after allogeneic stem cell transplantation, a phase I/II clinical study on adoptive…”
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Durable Remission of Renal Cell Carcinoma After Donor Lymphocyte Infusion Is Unavoidably Linked with Graft Versus Host Disease As Illustrated by the Detection of Allo Reactive T Cells Recognizing a Novel Minor Histocompatibility Antigen Encoded by the FUCA2 Gene by van Bergen, Cornelis A.M., Verdegaal, Elizabeth M.E., Hoogstraten, Conny, van Steijn, A.Q.M. Jeanne, de Quartel, Linda, de Jong, Joan H., Meyering, Maaike, Griffioen, Marieke, Falkenburg, J.H.Frederik, Osanto, Susanne

“…Abstract 4467 Allogeneic stem cell transplantation (allo SCT) followed by donor lymphocyte infusion (DLI) can be applied as immunotherapeutic intervention to…”
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Priming of Allo-HLA-DP-Specific Reactivity from the Naïve T Cell Compartment Is Not Exclusively Mediated by Professional Antigen-Presenting Cells by Laghmouchi, Aicha, Hoogstraten, Conny, Falkenburg, J.H. Frederik, Jedema, Inge

“…•Allo-HLA-DP responses can be provoked from both the naïve and memory T cell compartments.•Professional hematopoietic antigen-presenting cells (dendritic cells…”
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Durable Remission of Renal Cell Carcinoma in Conjuncture with Graft versus Host Disease following Allogeneic Stem Cell Transplantation and Donor Lymphocyte Infusion: Rule or Exception?: e85198 by Bergen, A Mvan, Verdegaal, Elisabeth ME, Honders, M Wilhelmina, Hoogstraten, Conny, Tol, M JeanneSteijn-van, Quartel, Linda de, Jong, Joan de, Meyering, Maaike, Falkenburg, J HFrederik, Griffioen, Marieke

“…Allogeneic stem cell transplantation (alloSCT) followed by donor lymphocyte infusion (DLI) can be applied as immunotherapeutic intervention to treat malignant…”
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Functional CD8+ T cells infiltrate into nonsmall cell lung carcinoma by Verdegaal, Elizabeth M E, Hoogstraten, Conny, Sandel, Maro H, Kuppen, Peter J K, Brink, Antoinette A T P, Claas, Frans H J, Gorsira, Michael C B, Graadt van Roggen, J Frans, Osanto, Susanne

“…Infiltration of CD3(+)CD8(+) cytotoxic T cells was analyzed by multiparameter confocal laser microscopy in a panel of 16 randomly selected stage I nonsmall…”
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Preclinical evaluation of DISC-GMCSF for the treatment of breast carcinoma by Loudon, Peter T., McLean, Cornelia S., Martin, Gilly, Curry, Jayne, Leigh Shaw, M., Hoogstraten, Conny, Verdegaal, Els, Osanto, Susanne

“…Background DISC‐hGMCSF is a gH‐deleted HSV‐2 based vector expressing human GM‐CSF that has entered clinical trials for the therapy of metastatic melanoma. To…”
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Isolation of broadly reactive, tumor-specific, HLA class-I restricted CTL from blood lymphocytes of a breast cancer patient by Verdegaal, Els M.E, ten Bokkel Huinink, Daan, Hoogstraten, Conny, Marijnissen, Anne Karien, Gorsira, Michael B, Claas, F.H.J, Osanto, Susanne

“…Blood lymphocytes of a HLA-A2 positive breast cancer patient were stimulated with either MCF-7 or MDA-MB-231, i.e., HLA-A2-matched allogeneic breast carcinoma…”
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