Search Results - "HONMA, KIMI"

Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models by Suetsugu, Atsushi, Honma, Kimi, Saji, Shigetoyo, Moriwaki, Hisataka, Ochiya, Takahiro, Hoffman, Robert M.

“…Exosomes play an important role in cell-to-cell communication to promote tumor metastasis. In order to image the fate of cancer-cell-derived exosomes in…”
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RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy by Tominaga, Naoomi, Hagiwara, Keitaro, Kosaka, Nobuyoshi, Honma, Kimi, Nakagama, Hitoshi, Ochiya, Takahiro

“…The tetraspanin CD63 is a highly N-glycosylated protein that is known to regulate cancer malignancy. However, the contribution of glycosylation of CD63 to…”
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Efficient Delivery of Small Interfering RNA to Bone-Metastatic Tumors by Using Atelocollagen in vivo by Takeshita, Fumitaka, Minakuchi, Yoshiko, Nagahara, Shunji, Honma, Kimi, Sasaki, Hideo, Hirai, Kotaro, Teratani, Takumi, Namatame, Nachi, Yamamoto, Yusuke, Hanai, Koji, Kato, Takashi, Sano, Akihiko, Ochiya, Takahiro

“…Silencing of gene expression by small interfering RNAs (siRNAs) is rapidly becoming a powerful tool for genetic analysis and represents a potential strategy…”
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Atelocollagen-Mediated Systemic DDS for Nucleic Acid Medicines by HANAI, KOJI, TAKESHITA, FUMITAKA, HONMA, KIMI, NAGAHARA, SHUNJI, MAEDA, MIHO, MINAKUCHI, YOSHIKO, SANO, AKIHIKO, OCHIYA, TAKAHIRO

“…:  The goal of our research is to provide a practical platform for drug delivery in oligonucleotide therapy. We report here the efficacy of an…”
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Type I collagen gene suppresses tumor growth and invasion of malignant human glioma cells by Honma, Kimi, Miyata, Teruo, Ochiya, Takahiro

“…Invasion is a hallmark of a malignant tumor, such as a glioma, and the progression is followed by the interaction of tumor cells with an extracellular matrix…”
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Atelocollagen-Based Gene Transfer in Cells Allows High-Throughput Screening of Gene Functions by Honma, Kimi, Ochiya, Takahiro, Nagahara, Shunji, Sano, Akihiko, Yamamoto, Hanako, Hirai, Kotaro, Aso, Yu, Terada, Masaaki

“…We have previously demonstrated that Atelocollagen, used clinically for wound healing, is a reliable safe carrier for gene delivery. To obtain phenotypic…”
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Screening of potential molecular targets for colorectal cancer therapy by Honma, Kimi, Takemasa, Ichiro, Matoba, Ryo, Yamamoto, Yusuke, Takeshita, Fumitaka, Mori, Masaki, Monden, Morito, Matsubara, Kenichi, Ochiya, Takahiro

“…Colorectal cancer is a leading cause of cancer death worldwide. To identify molecular targets for colorectal cancer therapy, we tested small interfering RNAs…”
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The role of atelocollagen-based cell transfection array in high-throughput screening of gene functions and in drug discovery by Honma, Kimi, Miyata, Teruo, Ochiya, Takahiro

“…The human genome project has been completed, but the function of many genes is unknown. It is, therefore, necessary to elucidate the function of a large number…”
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RPN2 gene confers docetaxel resistance in breast cancer by Ochiya, Takahiro, Honma, Kimi, Iwao-Koizumi, Kyoko, Takeshita, Fumitaka, Yamamoto, Yusuke, Yoshida, Teruhiko, Nishio, Kazuto, Nagahara, Shunji, Kato, Kikuya

“…Resistance to drugs is a clinical problem. Downregulating the gene RPN2 , which encodes part of an N -oligosaccharyl transferase complex, sensitized breast…”
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Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β by Takahashi, Ryou-u, Takeshita, Fumitaka, Honma, Kimi, Ono, Masaya, Kato, Kikuya, Ochiya, Takahiro

“…Mutant p53 (mtp53) gain of function (GOF) contributes to various aspects of tumor progression including cancer stem cell (CSC) property acquisition. A key…”
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Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo by Minakuchi, Yoshiko, Takeshita, Fumitaka, Kosaka, Nobuyoshi, Sasaki, Hideo, Yamamoto, Yusuke, Kouno, Makiko, Honma, Kimi, Nagahara, Shunji, Hanai, Koji, Sano, Akihiko, Kato, Takashi, Terada, Masaaki, Ochiya, Takahiro

“…Silencing gene expression by siRNAs is rapidly becoming a powerful tool for the genetic analysis of mammalian cells. However, the rapid degradation of siRNA…”
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Atelocollagen for protein and gene delivery by Sano, Akihiko, Maeda, Miho, Nagahara, Shunji, Ochiya, Takahiro, Honma, Kimi, Itoh, Hiroshi, Miyata, Teruo, Fujioka, Keiji

“…Recent progress in recombinant gene technology and cell culture technology has made it possible to use protein and polynucleotides as effective drugs. However,…”
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アテロコラーゲンsiRNA導入技術のRNAi医薬への応用 by 本間, 紀美, 竹下, 文隆, 落谷, 孝広

“…1.はじめに RNA干渉(RNAi)は,植物でみつかった転写後遺伝子サイレンシング(post-transcriptional genesilencing;PTGS)あるいは,ウイルス誘発性遺伝子サイレンシング(viral-induced gene…”
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Local and systemic delivery of siRNAs for oligonucleotide therapy by Takeshita, Fumitaka, Hokaiwado, Naomi, Honma, Kimi, Banas, Agnieszka, Ochiya, Takahiro

“…RNA interference (RNAi) is a relatively new found phenomenon of posttranscriptional gene silencing to regulate the expression of multiple genes involved in a…”
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Application of Atelocollagen-mediated siRNA Delivery for RNAi Therapies by HONMA, Kimi, TAKESHITA, Fumitaka, OCHIYA, Takahiro

“…RNAi has rapidly become a powerful tool for drug target discovery and validation in an in vitro culture system and, consequently, interest is rapidly growing…”
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RPN2 gene confers docetaxel resistance in breast cancer by Honma, Kimi, Iwao-Koizumi, Kyoko, Takeshita, Fumitaka, Yamamoto, Yusuke, Yoshida, Teruhiko, Nishio, Kazuto, Nagahara, Shunji, Kato, Kikuya, Ochiya, Takahiro

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Correction: Corrigendum: RPN2 gene confers docetaxel resistance in breast cancer by Honma, Kimi, Iwao-Koizumi, Kyoko, Takeshita, Fumitaka, Yamamoto, Yusuke, Yoshida, Teruhiko, Nishio, Kazuto, Nagahara, Shunji, Kato, Kikuya, Ochiya, Takahiro

“…Nat. Med. 14, 939–948 (2008); published online 17 August 2008; corrected after print 7 October 2008 In the version of this article initially published, the…”
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Corrigendum: RPN2 gene confers docetaxel resistance in breast cancer by Honma, Kimi, Iwao-Koizumi, Kyoko, Takeshita, Fumitaka, Yamamoto, Yusuke, Yoshida, Teruhiko, Nishio, Kazuto, Nagahara, Shunji, Kato, Kikuya, Ochiya, Takahiro

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Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3[beta] by Takahashi, Ryou-u, Takeshita, Fumitaka, Honma, Kimi, Ono, Masaya, Kato, Kikuya, Ochiya, Takahiro

“…Mutant p53 (mtp53) gain of function (GOF) contributes to various aspects of tumor progression including cancer stem cell (CSC) property acquisition. A key…”
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304. Atelocollagen-Based Cell Transfection Array Allows High-Throughput Screening of Gene Functions by Honma, Kimi, Ito, Hiroshi, Nagahara, Syunji, Miyata, Teruo, Ochiya, Takahiro

“…The human genome project has been completed, and it is urgently required that genome information has been implicated in drug discovery, gene therapy and…”
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