Search Results - "HONKO, Anna"

Long-term sequelae after Ebola virus disease in Bundibugyo, Uganda: a retrospective cohort study by Clark, Danielle V, Dr, Kibuuka, Hannah, MD, Millard, Monica, MPH, Wakabi, Salim, MD, Lukwago, Luswa, MPH, Taylor, Alison, BS, Eller, Michael A, PhD, Eller, Leigh Anne, PhD, Michael, Nelson L, MD, Honko, Anna N, PhD, Olinger, Gene G, PhD, Schoepp, Randal J, PhD, Hepburn, Matthew J, MD, Hensley, Lisa E, PhD, Robb, Merlin L, MD

“…Summary Background The limited data available for long-term Ebola virus disease health outcomes suggest that sequelae persist for longer than 1 year after…”
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Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study by Geisbert, Thomas W, Prof, Lee, Amy CH, MSc, Robbins, Marjorie, PhD, Geisbert, Joan B, Honko, Anna N, PhD, Sood, Vandana, MSc, Johnson, Joshua C, BSc, de Jong, Susan, PhD, Tavakoli, Iran, BSc, Judge, Adam, PhD, Hensley, Lisa E, PhD, MacLachlan, Ian, PhD

“…Summary Background We previously showed that small interfering RNAs (siRNAs) targeting the Zaire Ebola virus (ZEBOV) RNA polymerase L protein formulated in…”
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Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike by Tong, Pei, Gautam, Avneesh, Windsor, Ian W., Travers, Meghan, Chen, Yuezhou, Garcia, Nicholas, Whiteman, Noah B., McKay, Lindsay G.A., Storm, Nadia, Malsick, Lauren E., Honko, Anna N., Lelis, Felipe J.N., Habibi, Shaghayegh, Jenni, Simon, Cai, Yongfei, Rennick, Linda J., Duprex, W. Paul, McCarthy, Kevin R., Lavine, Christy L., Zuo, Teng, Lin, Junrui, Zuiani, Adam, Feldman, Jared, MacDonald, Elizabeth A., Hauser, Blake M., Griffths, Anthony, Seaman, Michael S., Schmidt, Aaron G., Chen, Bing, Neuberg, Donna, Bajic, Goran, Harrison, Stephen C., Wesemann, Duane R.

“…Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2 infections, but with unknown reach from original infection to…”
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Optimized microRNA purification from TRIzol-treated plasma by Duy, Janice, Koehler, Jeffrey W, Honko, Anna N, Minogue, Timothy D

“…MicroRNAs (miRNAs) represent new and potentially informative diagnostic targets for disease detection and prognosis. However, little work exists documenting…”
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Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge by Stanley, Daphne A, Honko, Anna N, Asiedu, Clement, Trefry, John C, Lau-Kilby, Annie W, Johnson, Joshua C, Hensley, Lisa, Ammendola, Virginia, Abbate, Adele, Grazioli, Fabiana, Foulds, Kathryn E, Cheng, Cheng, Wang, Lingshu, Donaldson, Mitzi M, Colloca, Stefano, Folgori, Antonella, Roederer, Mario, Nabel, Gary J, Mascola, John, Nicosia, Alfredo, Cortese, Riccardo, Koup, Richard A, Sullivan, Nancy J

“…A chimpanzee adenovirus-based vaccination approach elicits acute and long-term protection against ebolavirus challenge in nonhuman primates. Ebolavirus disease…”
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Detailed analysis of the pathologic hallmarks of Nipah virus (Malaysia) disease in the African green monkey infected by the intratracheal route by Cline, Curtis, Bell, Todd M, Facemire, Paul, Zeng, Xiankun, Briese, Thomas, Lipkin, W Ian, Shamblin, Joshua D, Esham, Heather L, Donnelly, Ginger C, Johnson, Joshua C, Hensley, Lisa E, Honko, Anna N, Johnston, Sara C

“…Disease associated with Nipah virus infection causes a devastating and often fatal spectrum of syndromes predominated by both respiratory and neurologic…”
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Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs by Postnikova, Elena, Cong, Yu, DeWald, Lisa Evans, Dyall, Julie, Yu, Shuiqing, Hart, Brit J, Zhou, Huanying, Gross, Robin, Logue, James, Cai, Yingyun, Deiuliis, Nicole, Michelotti, Julia, Honko, Anna N, Bennett, Richard S, Holbrook, Michael R, Olinger, Gene G, Hensley, Lisa E, Jahrling, Peter B

“…Identifying effective antivirals for treating Ebola virus disease (EVD) and minimizing transmission of such disease is critical. A variety of cell-based assays…”
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Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies by Wirchnianski, Ariel S, Nyakatura, Elisabeth K, Herbert, Andrew S, Kuehne, Ana I, Abbasi, Shawn A, Florez, Catalina, Storm, Nadia, McKay, Lindsay G A, Dailey, Leandrew, Kuang, Erin, Abelson, Dafna M, Wec, Anna Z, Chakraborti, Srinjoy, Holtsberg, Frederick W, Shulenin, Sergey, Bornholdt, Zachary A, Aman, M Javad, Honko, Anna N, Griffiths, Anthony, Dye, John M, Chandran, Kartik, Lai, Jonathan R

“…Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as…”
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Detailed analysis of the African green monkey model of Nipah virus disease by Johnston, Sara C, Briese, Thomas, Bell, Todd M, Pratt, William D, Shamblin, Joshua D, Esham, Heather L, Donnelly, Ginger C, Johnson, Joshua C, Hensley, Lisa E, Lipkin, W Ian, Honko, Anna N

“…Henipaviruses are implicated in severe and frequently fatal pneumonia and encephalitis in humans. There are no approved vaccines or treatments available for…”
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Demonstration of cross-protective vaccine immunity against an emerging pathogenic Ebolavirus Species by Hensley, Lisa E, Mulangu, Sabue, Asiedu, Clement, Johnson, Joshua, Honko, Anna N, Stanley, Daphne, Fabozzi, Giulia, Nichol, Stuart T, Ksiazek, Thomas G, Rollin, Pierre E, Wahl-Jensen, Victoria, Bailey, Michael, Jahrling, Peter B, Roederer, Mario, Koup, Richard A, Sullivan, Nancy J

“…A major challenge in developing vaccines for emerging pathogens is their continued evolution and ability to escape human immunity. Therefore, an important goal…”
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In vivo Ebola virus infection leads to a strong innate response in circulating immune cells by Caballero, Ignacio S, Honko, Anna N, Gire, Stephen K, Winnicki, Sarah M, Melé, Marta, Gerhardinger, Chiara, Lin, Aaron E, Rinn, John L, Sabeti, Pardis C, Hensley, Lisa E, Connor, John H

“…Ebola virus is the causative agent of a severe syndrome in humans with a fatality rate that can approach 90 %. During infection, the host immune response is…”
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broad-spectrum antiviral targeting entry of enveloped viruses by Wolf, Mike C, Freiberg, Alexander N, Zhang, Tinghu, Akyol-Ataman, Zeynep, Grock, Andrew, Hong, Patrick W, Li, Jianrong, Watson, Natalya F, Fang, Angela Q, Aguilar, Hector C, Porotto, Matteo, Honko, Anna N, Damoiseaux, Robert, Miller, John P, Woodson, Sara E, Chantasirivisal, Steven, Fontanes, Vanessa, Negrete, Oscar A, Krogstad, Paul, Dasgupta, Asim, Moscona, Anne, Hensley, Lisa E, Whelan, Sean P, Faull, Kym F, Holbrook, Michael R, Jung, Michael E, Lee, Benhur

“…We describe an antiviral small molecule, LJ001, effective against numerous enveloped viruses including Influenza A, filoviruses, poxviruses, arenaviruses,…”
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Monoclonal antibody therapy for Junin virus infection by Zeitlin, Larry, Geisbert, Joan B., Deer, Daniel J., Fenton, Karla A., Bohorov, Ognian, Bohorova, Natasha, Goodman, Charles, Kim, Do, Hiatt, Andrew, Pauly, Michael H., Velasco, Jesus, Whaley, Kevin J., Altmann, Friedrich, Gruber, Clemens, Steinkellner, Herta, Honko, Anna N., Kuehne, Ana I., Aman, M. Javad, Sahandi, Sara, Enterlein, Sven, Zhan, Xiaoguo, Enria, Delia, Geisbert, Thomas W.

“…Countermeasures against potential biothreat agents remain important to US Homeland Security, and many of these pharmaceuticals could have dual use in the…”
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Pyridinyl imidazole inhibitors of p38 MAP kinase impair viral entry and reduce cytokine induction by Zaire ebolavirus in human dendritic cells by Johnson, Joshua C., Martinez, Osvaldo, Honko, Anna N., Hensley, Lisa E., Olinger, Gene G., Basler, Christopher F.

“…•Pyridinyl imidazole inhibitors of p38 MAP kinases inhibit ebolavirus replication in macrophages and dendritic cells.•Pyridinyl imidazole inhibitors of p38 MAP…”
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Low-Input, High-Resolution 5' Terminal Filovirus RNA Sequencing with ViBE-Seq by Ross, Stephen J, Hume, Adam J, Olejnik, Judith, Turcinovic, Jacquelyn, Honko, Anna N, McKay, Lindsay G A, Connor, John H, Griffiths, Anthony, Mühlberger, Elke, Cifuentes, Daniel

“…Although next-generation sequencing (NGS) has been instrumental in determining the genomic sequences of emerging RNA viruses, de novo sequence determination…”
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A single-shot ChAd3-MARV vaccine confers rapid and durable protection against Marburg virus in nonhuman primates by Hunegnaw, Ruth, Honko, Anna N, Wang, Lingshu, Carr, Derick, Murray, Tamar, Shi, Wei, Nguyen, Lam, Storm, Nadia, Dulan, Caitlyn N M, Foulds, Kathryn E, Agans, Krystle N, Cross, Robert W, Geisbert, Joan B, Cheng, Cheng, Ploquin, Aurélie, Stanley, Daphne A, Geisbert, Thomas W, Nabel, Gary J, Sullivan, Nancy J

“…Marburg virus (MARV) causes a severe hemorrhagic fever disease in primates with mortality rates in humans of up to 90%. MARV has been identified as a category…”
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Development and evaluation of a panel of filovirus sequence capture probes for pathogen detection by next-generation sequencing by Koehler, Jeffrey W, Hall, Adrienne T, Rolfe, P Alexander, Honko, Anna N, Palacios, Gustavo F, Fair, Joseph N, Muyembe, Jean-Jacques, Mulembekani, Prime, Schoepp, Randal J, Adesokan, Adeyemi, Minogue, Timothy D

“…A detailed understanding of the circulating pathogens in a particular geographic location aids in effectively utilizing targeted, rapid diagnostic assays, thus…”
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Flagellin Is an Effective Adjuvant for Immunization against Lethal Respiratory Challenge with Yersinia pestis by Honko, Anna N, Sriranganathan, Nammalwar, Lees, Cynthia J, Mizel, Steven B

“…Gram-negative flagellin, a Toll-like receptor 5 (TLR5) agonist, is a potent inducer of innate immune effectors such as cytokines and nitric oxide. In the lung,…”
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Fecal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) RNA Is Associated With Decreased Coronavirus Disease 2019 (COVID-19) Survival by Das Adhikari, Upasana, Eng, George, Farcasanu, Mara, Avena, Laura E, Choudhary, Manish C, Triant, Virginia A, Flagg, Meaghan, Schiff, Abigail E, Gomez, Isabella, Froehle, Leah M, Diefenbach, Thomas J, Ronsard, Larance, Lingwood, Daniel, Lee, Grace C, Rabi, Seyed Alireza, Erstad, Derek, Velmahos, George, Li, Jonathan Z, Hodin, Richard, Stone, James R, Honko, Anna N, Griffiths, Anthony, Yilmaz, Ömer H, Kwon, Douglas S

“…Abstract The clinical significance of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) RNA in stool remains uncertain. We found that extrapulmonary…”
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Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge by GEISBERT, Thomas W, BAILEY, Michael, CUSTERS, Jerome, VELLINGA, Jort, HENDRIKS, Jenny, JAHRLING, Peter, ROEDERER, Mario, GOUDSMIT, Jaap, KOUP, Richard, SULLIVAN, Nancy J, HENSLEY, Lisa, ASIEDU, Clement, GEISBERT, Joan, STANLEY, Daphne, HONKO, Anna, JOHNSON, Joshua, MULANGU, Sabue, GRAZIA PAU, Maria

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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