Search Results - "HONKANEN, E"

Inhibitors of Serine/Threonine Protein Phosphatases: Biochemical and Structural Studies Provide Insight for Further Development by Swingle, Mark R, Honkanen, Richard E

“…The reversible phosphorylation of proteins regulates many key functions in eukaryotic cells. Phosphorylation is catalyzed by protein kinases, with the majority…”
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PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors by Choy, Meng S, Swingle, Mark, D’Arcy, Brandon, Abney, Kevin, Rusin, Scott F, Kettenbach, Arminja N, Page, Rebecca, Honkanen, Richard E, Peti, Wolfgang

“…Selective inhibitors for each serine/threonine phosphatase (PPP) are essential to investigate the biological actions of PPPs and to guide drug development…”
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The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer by Golden, Teresa, Swingle, Mark, Honkanen, Richard E.

“…Although the aberrant actions of protein kinases have long been known to contribute to tumor promotion and carcinogenesis, roles for protein phosphatases in…”
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Editorial: Deciphering the etiology of rare genetic disorders associated with protein phosphatases by Janssens, Veerle, Wadzinski, Brian E., Li, Chenchen, Honkanen, Richard E.

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Protein phosphatases in pancreatic islets by Ortsäter, Henrik, Grankvist, Nina, Honkanen, Richard E, Sjöholm, Åke

“…The prevalence of diabetes is increasing rapidly worldwide. A cardinal feature of most forms of diabetes is the lack of insulin-producing capability, due to…”
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Quantum-Based Modeling of Dephosphorylation in the Catalytic Site of Serine/Threonine Protein Phosphatase-5 (PPP5C) by E. Alan Salter, Andrzej Wierzbicki, Richard E. Honkanen

“…Serine/threonine protein phosphatase-5 (PP5; PPP5C) is a member of the phosphoprotein phosphatase (PPP) gene family. The PPP catalytic domains feature a…”
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Quantum-based modeling implies that bidentate Arg89-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation by Salter, E. Alan, Wierzbicki, Andrzej, Honkanen, Richard E., Swingle, Mark R.

“…PP2A-serine/threonine protein phosphatases function as heterotrimeric holoenzymes, composed of a common scaffold (A-subunit encoded by PPP2R1A/PPP2R1B), a…”
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IgA nephropathy recurs early in the graft when assessed by protocol biopsy by ORTIZ, Fernanda, GELPI, Rosana, KOSKINEN, Petri, MANONELLES, Anna, RÄISÄNEN-SOKOLOWSKI, Anne, CARRERA, Marta, HONKANEN, Eero, GRINYO, Josep M, CRUZADO, Josep M

“…The recurrence of IgA nephropathy (IgAN) in the allograft is common. Factors related to IgA recurrence are unclear. The aims of this study were to determine…”
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Disruption of Serine/Threonine Protein Phosphatase 5 (PP5:PPP5c) in Mice Reveals a Novel Role for PP5 in the Regulation of Ultraviolet Light-induced Phosphorylation of Serine/Threonine Protein Kinase Chk1 (CHEK1) by Amable, Lauren, Grankvist, Nina, Largen, Jason W., Ortsäter, Henrik, Sjöholm, Åke, Honkanen, Richard E.

“…PP5 is a ubiquitously expressed Ser/Thr protein phosphatase. High levels of PP5 have been observed in human cancers, and constitutive PP5 overexpression aids…”
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Small G Proteins Rac1 and Ras Regulate Serine/Threonine Protein Phosphatase 5 (PP5)·Extracellular Signal-Regulated Kinase (ERK) Complexes Involved in the Feedback Regulation of Raf1 by Mazalouskas, Matthew D., Godoy-Ruiz, Raquel, Weber, David J., Zimmer, Danna B., Honkanen, Richard E., Wadzinski, Brian E.

“…Serine/threonine protein phosphatase 5 (PP5, PPP5C) is known to interact with the chaperonin heat shock protein 90 (HSP90) and is involved in the regulation of…”
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Abdominal aortic calcification in dialysis patients: results of the CORD study by Honkanen, Eero, Kauppila, Leena, Wikström, Björn, Rensma, Pieter L., Krzesinski, Jean-Marie, Aasarod, Knut, Verbeke, Francis, Jensen, Per Bruno, Mattelaer, Pierre, Volck, Birgitte

“…Background. Patients with chronic kidney disease stage 5 have a high prevalence of vascular calcification, but the specific anatomical distribution and…”
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Ser/Thr Protein Phosphatase 5 Inactivates Hypoxia-induced Activation of an Apoptosis Signal-regulating Kinase 1/MKK-4/JNK Signaling Cascade by Zhou, Guofei, Golden, Teresa, Aragon, Ileana V, Honkanen, Richard E

“…Mitogen-activated protein kinase (MAPK) signaling cascades are multifunctional signaling networks that influence cell growth, differentiation, apoptosis, and…”
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Structural Basis for the Catalytic Activity of Human Serine/Threonine Protein Phosphatase-5 by Swingle, Mark R., Honkanen, Richard E., Ciszak, Ewa M.

“…Serine/threonine protein phosphatase-5 (PP5) affects many signaling networks that regulate cell growth and cellular responses to stress. Here we report the…”
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Serine/threonine protein phosphatase 5 regulates glucose homeostasis in vivo and apoptosis signalling in mouse pancreatic islets and clonal MIN6 cells by Grankvist, N., Amable, L., Honkanen, R. E., Sjöholm, Å., Ortsäter, H.

“…Aims/hypothesis During the development of type 2 diabetes mellitus, beta cells are often exposed to a high glucose/hyperlipidaemic environment, in which the…”
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Regulators of serine/threonine protein phosphatases at the dawn of a clinical era? by Honkanen, R E, Golden, T

“…Reversible phosphorylation is a key mechanism for regulating the biological activity of many human proteins that affect a diverse array of cellular processes,…”
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Human DNA polymerase η activity and translocation is regulated by phosphorylation by Chen, Yih-wen, Cleaver, James E, Hatahet, Zafer, Honkanen, Richard E, Chang, Jang-Yang, Yen, Yun, Chou, Kai-ming

“…Human DNA polymerase η (pol η) can replicate across UV-induced pyrimidine dimers, and defects in the gene encoding pol η result in a syndrome called xeroderma…”
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Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases by Bouazza, Belaid, Krytska, Kateryna, Debba-Pavard, Manel, Amrani, Yassine, Honkanen, Richard E, Tran, Jennifer, Tliba, Omar

“…Corticosteroid insensitivity (CSI) represents a profound challenge in managing patients with asthma. We recently demonstrated that short exposure of airway…”
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Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity by Yang, Xiulan, Liu, Yanping, Yang, Xi-Ming, Hu, Fangdi, Cui, Lin, Swingle, Mark R., Honkanen, Richard E., Soltani, Peyman, Tissier, Renaud, Cohen, Michael V., Downey, James M.

“…Cooling the ischemic heart by just a few degrees protects it from infarction without affecting its mechanical function, but the mechanism of this protection is…”
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Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors by Swingle, Mark R, Amable, Lauren, Lawhorn, Brian G, Buck, Suzanne B, Burke, Christopher P, Ratti, Pukar, Fischer, Kimberly L, Boger, Dale L, Honkanen, Richard E

“…Fostriecin and cytostatin are structurally related natural inhibitors of serine/threonine phosphatases, with promising antitumor activity. The total synthesis…”
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Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth by Shuhaibar, Leia C, Kaci, Nabil, Egbert, Jeremy R, Horville, Thibault, Loisay, Léa, Vigone, Giulia, Uliasz, Tracy F, Dambroise, Emilie, Swingle, Mark R, Honkanen, Richard E, Biosse Duplan, Martin, Jaffe, Laurinda A, Legeai-Mallet, Laurence

“…Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating mutations in the natriuretic peptide receptor 2 (NPR2) guanylyl cyclase…”
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