Search Results - "HONGYU ZHAO"

Next-generation sequencing in liquid biopsy: cancer screening and early detection by Chen, Ming, Zhao, Hongyu

“…In recent years, the rapid development of next-generation sequencing (NGS) technologies has led to a significant reduction in sequencing cost with improved…”
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A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics by Zhou, Geyu, Zhao, Hongyu

“…Genetic prediction of complex traits has great promise for disease prevention, monitoring, and treatment. The development of accurate risk prediction models is…”
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Scaffold selection and scaffold hopping in lead generation: a medicinal chemistry perspective by Zhao, Hongyu

“…Hit selection and lead generation are crucial for the success of the resource-demanding lead-optimization phase in drug discovery, and represent a major…”
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CCLasso: correlation inference for compositional data through Lasso by Fang, Huaying, Huang, Chengcheng, Zhao, Hongyu, Deng, Minghua

“…Direct analysis of microbial communities in the environment and human body has become more convenient and reliable owing to the advancements of high-throughput…”
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Multi-sensor information fusion based on machine learning for real applications in human activity recognition: State-of-the-art and research challenges by Qiu, Sen, Zhao, Hongkai, Jiang, Nan, Wang, Zhelong, Liu, Long, An, Yi, Zhao, Hongyu, Miao, Xin, Liu, Ruichen, Fortino, Giancarlo

“…This paper firstly introduces common wearable sensors, smart wearable devices and the key application areas. Since multi-sensor is defined by the presence of…”
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ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation by Miao, Guangyan, Zhao, Hongyu, Li, Yan, Ji, Mingming, Chen, Yong, Shi, Yi, Bi, Yuhai, Wang, Peihui, Zhang, Hong

“…Autophagy acts as a cellular surveillance mechanism to combat invading pathogens. Viruses have evolved various strategies to block autophagy and even subvert…”
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Stance-Phase Detection for ZUPT-Aided Foot-Mounted Pedestrian Navigation System by Wang, Zhelong, Zhao, Hongyu, Qiu, Sen, Gao, Qin

“…Zero velocity updates (ZUPT) is an effective way for the foot-mounted inertial pedestrian navigation systems. For the ZUPT technique to work properly, it is…”
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Automated feature extraction from population wearable device data identified novel loci associated with sleep and circadian rhythms by Li, Xinyue, Zhao, Hongyu

“…Wearable devices have been increasingly used in research to provide continuous physical activity monitoring, but how to effectively extract features remains…”
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Study on catalytic co-pyrolysis of physical mixture/staged pyrolysis characteristics of lignite and straw over an catalytic beds of char and its mechanism by Zhao, Hongyu, Song, Qiang, Liu, Shucheng, Li, Yuhuan, Wang, Xiaohua, Shu, Xinqian

“…[Display omitted] •Effect of the arrangement of raw materials on pyrolysis product distribution was studied.•Tar from staged catalytic pyrolysis and…”
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GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation by Chung, Dongjun, Yang, Can, Li, Cong, Gelernter, Joel, Zhao, Hongyu

“…Results from Genome-Wide Association Studies (GWAS) have shown that complex diseases are often affected by many genetic variants with small or moderate…”
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Non-linear archetypal analysis of single-cell RNA-seq data by deep autoencoders by Wang, Yuge, Zhao, Hongyu

“…Advances in single-cell RNA sequencing (scRNA-seq) have led to successes in discovering novel cell types and understanding cellular heterogeneity among complex…”
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A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits by Cai, Mingxuan, Xiao, Jiashun, Zhang, Shunkang, Wan, Xiang, Zhao, Hongyu, Chen, Gang, Yang, Can

“…The development of polygenic risk scores (PRSs) has proved useful to stratify the general European population into different risk groups. However, PRSs are…”
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Using Distributed Wearable Sensors to Measure and Evaluate Human Lower Limb Motions by Qiu, Sen, Wang, Zhelong, Zhao, Hongyu, Hu, Huosheng

“…This paper presents a wearable sensor approach to motion measurements of human lower limbs, in which subjects perform specified walking trials at…”
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Prevalence, awareness, treatment, and control of hypertension in China: data from 1·7 million adults in a population-based screening study (China PEACE Million Persons Project) by Lu, Jiapeng, Lu, Yuan, Wang, Xiaochen, Li, Xinyue, Linderman, George C, Wu, Chaoqun, Cheng, Xiuyuan, Mu, Lin, Zhang, Haibo, Liu, Jiamin, Su, Meng, Zhao, Hongyu, Spatz, Erica S, Spertus, John A, Masoudi, Frederick A, Krumholz, Harlan M, Jiang, Lixin

“…Hypertension is common in China and its prevalence is rising, yet it remains inadequately controlled. Few studies have the capacity to characterise the…”
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Integration of expression QTLs with fine mapping via SuSiE by Zhang, Xiangyu, Jiang, Wei, Zhao, Hongyu

“…Genome-wide association studies (GWASs) have achieved remarkable success in associating thousands of genetic variants with complex traits. However, the…”
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Leveraging effect size distributions to improve polygenic risk scores derived from summary statistics of genome-wide association studies by Song, Shuang, Jiang, Wei, Hou, Lin, Zhao, Hongyu

“…Genetic risk prediction is an important problem in human genetics, and accurate prediction can facilitate disease prevention and treatment. Calculating…”
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Lead optimization in the nondrug-like space by Zhao, Hongyu

“…Drug-like space might be more densely populated with orally available compounds than the remaining chemical space, but lead optimization can still occur…”
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Magnetic Microrobots with Folate Targeting for Drug Delivery by Ye, Min, Zhou, Yan, Zhao, Hongyu, Wang, Xiaopu

“…Untethered microrobots can be used for cargo delivery (e.g., drug molecules, stem cells, and genes) targeting designated areas. However, it is not enough to…”
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TIMM17A overexpression in lung adenocarcinoma and its association with prognosis by Miao, Lili, Wu, Dejun, Zhao, Hongyu, Xie, Aiwei

“…Lung adenocarcinoma (LUAD), a leading cause of cancer-related mortality worldwide, demands a deeper understanding of its molecular mechanisms and the…”
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SCADIE: simultaneous estimation of cell type proportions and cell type-specific gene expressions using SCAD-based iterative estimating procedure by Tang, Daiwei, Park, Seyoung, Zhao, Hongyu

“…A challenge in bulk gene differential expression analysis is to differentiate changes due to cell type-specific gene expression and cell type proportions…”
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