Search Results - "HONGSHENG XIE"

Improved Efficacy in a Fabry Disease Model Using a Systemic mRNA Liver Depot System as Compared to Enzyme Replacement Therapy by DeRosa, Frank, Smith, Lianne, Shen, Yinghua, Huang, Yan, Pan, Jing, Xie, Hongsheng, Yahalom, Barak, Heartlein, Michael W.

“…Fabry disease is a lysosomal storage disorder caused by the deficiency of α-galactosidase A. Enzyme deficiency results in a progressive decline in renal and…”
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The effect of spread through air spaces on postoperative recurrence-free survival in patients with multiple primary lung cancers by Xie, Hongsheng, Dou, Shihua, Huang, Xiaoxiang, Wen, Yuxin, Yang, Lin

“…The purpose of the study was to investigate the effect of spread through air spaces (STAS) on the postoperative prognosis of patients with multiple primary…”
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Molecular imaging biomarkers in familial frontotemporal lobar degeneration: Progress and prospects by Wang, Ruihan, Gao, Hui, Xie, Hongsheng, Jia, Zhiyun, Chen, Qin

“…Familial frontotemporal lobar degeneration (FTLD) is a pathologically heterogeneous group of neurodegenerative diseases with diverse genotypes and clinical…”
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A Comprehensive Assessment of the Refrigerant Charging Amount on the Global Performance of a Transcritical CO2-Based Bus Air Conditioning and Heat Pump System by Song, Yulong, Xie, Hongsheng, Yang, Mengying, Wei, Xiangyu, Cao, Feng, Yin, Xiang

“…To mitigate the contemporary environmental challenges and to respect the regulations on the progressive ban of hydrofluorocarbons (HFC), natural fluid CO2 was…”
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Altered brain activation during reward anticipation in bipolar disorder by Long, Xipeng, Wang, Xiuli, Tian, Fangfang, Cao, Yuan, Xie, Hongsheng, Jia, Zhiyun

“…Although altered reward sensitivity has been observed in individuals with bipolar disorder (BD), the brain function findings related to reward processing…”
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Disulfide-Linked Antibody−Maytansinoid Conjugates: Optimization of In Vivo Activity by Varying the Steric Hindrance at Carbon Atoms Adjacent to the Disulfide Linkage by Kellogg, Brenda A, Garrett, Lisa, Kovtun, Yelena, Lai, Katharine C, Leece, Barbara, Miller, Michael, Payne, Gillian, Steeves, Rita, Whiteman, Kathleen R, Widdison, Wayne, Xie, Hongsheng, Singh, Rajeeva, Chari, Ravi V. J, Lambert, John M, Lutz, Robert J

“…In this report, we describe the synthesis of a panel of disulfide-linked huC242 (anti-CanAg) antibody maytansinoid conjugates (AMCs), which have varying levels…”
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Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen by KOVTUN, Yelena V, AUDETTE, Charlene A, YUMEI YE, HONGSHENG XIE, RUBERTI, Mary F, PHINNEY, Sara J, LEECE, Barbara A, CHITTENDEN, Thomas, BLÄTTLER, Walter A, GOLDMACHER, Victor S

“…Conjugates of the anti-CanAg humanized monoclonal antibody huC242 with the microtubule-formation inhibitor DM1 (a maytansinoid), or with the DNA alkylator DC1…”
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Disorganized thalamic subregional functional connectivity in bipolar I disorder by Long, Xipeng, Wang, Xiuli, Cao, Yuan, Kong, Di, Wu, Baolin, Xie, Hongsheng, Zhao, Ziru, Roberts, Neil, Gong, Qiyong, Jia, Zhiyun

“…Thalamus plays a pivotal role in the pathophysiology of neuropsychiatric conditions due to its strategic position and intricate connectivity with the cerebral…”
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On the Much‐Improved High‐Voltage Cycling Performance of LiCoO2 by Phase Alteration from O3 to O2 Structure by Zan, Mingwei, Xie, Hongsheng, Jiao, Sichen, Jiang, Kai, Wang, Xuelong, Xiao, Ruijuan, Yu, Xiqian, Li, Hong, Huang, Xuejie

“…Lithium cobalt oxide (LiCoO2) is an irreplaceable cathode material for lithium‐ion batteries with high volumetric energy density. The prevailing O3 phase…”
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Semisynthetic Maytansine Analogues for the Targeted Treatment of Cancer by Widdison, Wayne C, Wilhelm, Sharon D, Cavanagh, Emily E, Whiteman, Kathleen R, Leece, Barbara A, Kovtun, Yelena, Goldmacher, Victor S, Xie, Hongsheng, Steeves, Rita M, Lutz, Robert J, Zhao, Robert, Wang, Lintao, Blättler, Walter A, Chari, Ravi V. J

“…Maytansine, a highly cytotoxic natural product, failed as an anticancer agent in human clinical trials because of unacceptable systemic toxicity. The potent…”
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Pharmacokinetics and bioavailability of a therapeutic enzyme (idursulfase) in cynomolgus monkeys after intrathecal and intravenous administration by Xie, Hongsheng, Chung, Jou-Ku, Mascelli, Mary Ann, McCauley, Thomas G

“…Intravenous enzyme replacement therapy with iduronate-2-sulfatase is an approved treatment for Hunter syndrome, however, conventional intravenous delivery…”
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Application Value of ctDNA-based MRD Dedection 
in Early Stage Non-small Cell Lung Cancer after Radical Surgery by Dou, Shihua, Xie, Hongsheng, Yang, Lin

“…Lung cancer is the most common malignant tumor in the world, among which non-small cell lung cancer (NSCLC) accounts for about 85% of the total number of lung…”
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Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice by Xie, Hongsheng, Audette, Charlene, Hoffee, Mary, Lambert, John M, Blättler, Walter A

“…The humanized monoclonal antibody maytansinoid conjugate, cantuzumab mertansine (huC242-DM1) that contains on average three to four linked drug molecules per…”
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GTI-2040, an antisense agent targeting the small subunit component (R2) of human ribonucleotide reductase, shows potent antitumor activity against a variety of tumors by LEE, Yoon, VASSILAKOS, Aikaterini, AIPING YOUNG, NINGPING FENG, LAM, Viengthong, HONGSHENG XIE, MING WANG, HONGNAN JIN, KEYONG XIONG, CHENYI LIU, WRIGHT, Jim

“…GTI-2040 is a 20-mer oligonucleotide that is complementary to a coding region in the mRNA of the R2 small subunit component of human ribonucleotide reductase…”
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Tumor-Specific Novel Taxoid−Monoclonal Antibody Conjugates by Ojima, Iwao, Geng, Xudong, Wu, Xinyuan, Qu, Chuanxing, Borella, Christopher P, Xie, Hongsheng, Wilhelm, Sharon D, Leece, Barbara A, Bartle, Laura M, Goldmacher, Victor S, Chari, Ravi V. J

“…Taxoids bearing methyldisulfanyl(alkanoyl) groups for taxoid−antibody immunoconjugates were designed, synthesized and their activities evaluated. A highly…”
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Cantuzumab mertansine in a three-times a week schedule: a phase I and pharmacokinetic study by Rodon, Jordi, Garrison, Mitchell, Hammond, Lisa A., de Bono, Johann, Smith, Lon, Forero, Leonardo, Hao, Desirée, Takimoto, Chris, Lambert, John M., Pandite, Lini, Howard, Maria, Xie, Hongsheng, Tolcher, Anthony W.

“…Purpose Cantuzumab mertansine (SB-408075; huC242–DM1) is a conjugate of the maytansinoid drug DM1 to the antibody huC242, which targets CanAg antigen. In…”
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Affective disorder and brain alterations in children and adolescents exposed to outdoor air pollution by Xie, Hongsheng, Cao, Yuan, Li, Jiafeng, Lyu, Yichen, Roberts, Neil, Jia, Zhiyun

“…Childhood and adolescence are critical periods for the development of the brain. However, a limited number of studies have explored how air pollution may…”
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Abnormal intrinsic brain functional network dynamics in first-episode drug-naïve adolescent major depressive disorder by Wu, Baolin, Long, Xipeng, Cao, Yuan, Xie, Hongsheng, Wang, Xiuli, Roberts, Neil, Gong, Qiyong, Jia, Zhiyun

“…Alterations in brain functional connectivity (FC) have been frequently reported in adolescent major depressive disorder (MDD). However, there are few studies…”
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Disrupted Structural Brain Networks and Structural-Functional Decoupling in First-Episode Drug-Naïve Adolescent Major Depressive Disorder by Wu, Baolin, Zhang, Xun, Xie, Hongsheng, Wang, Xiuli, Gong, Qiyong, Jia, Zhiyun

“…Major depressive disorder (MDD) tends to emerge during adolescence, but the neurobiology of adolescent MDD is still poorly understood. This study aimed to…”
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The role of the orbitofrontal cortex in exercise addiction and exercise motivation: A brain imaging study based on multimodal magnetic resonance imaging by Zhang, Feifei, Xie, Hongsheng, Wang, Song, Li, Fei, Gong, Qiyong, Jia, Zhiyun

“…Excessive exercise may also lead to exercise addiction (EXA), which is harmful to people's physical and mental health. Behavioral and neuroimaging studies have…”
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